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Volumn 87, Issue 3, 2007, Pages 261-270

Protection by cAMP and cGMP phosphodiesterase inhibitors of diazinon-induced hyperglycemia and oxidative/nitrosative stress in rat Langerhans islets cells: Molecular evidence for involvement of non-cholinergic mechanisms

Author keywords

Acute; Diazinon; Glucose; Hyperglycemia; Insulin; Langerhans islets; Nitrosative stress; Oxidative stress; Pancreas; Phosphodiesterase inhibitors; Rat; Sildenafil; Theophylline; Toxicity; Tumor necrosis factor

Indexed keywords

RATTUS;

EID: 33846663876     PISSN: 00483575     EISSN: 10959939     Source Type: Journal    
DOI: 10.1016/j.pestbp.2006.08.007     Document Type: Article
Times cited : (46)

References (65)
  • 2
    • 4243148518 scopus 로고    scopus 로고
    • Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets
    • Review
    • Casida J.E., and Quistad G.B. Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets. Chem. Res. Toxicol. 17 (2004) 983-998 Review
    • (2004) Chem. Res. Toxicol. , vol.17 , pp. 983-998
    • Casida, J.E.1    Quistad, G.B.2
  • 3
    • 0034674894 scopus 로고    scopus 로고
    • Evidence for the activation of organophosphate pesticides by cytochromes P450 3A4 and 2D6 in human liver microsomes
    • Sams C., Mason H.J., and Rawbone R. Evidence for the activation of organophosphate pesticides by cytochromes P450 3A4 and 2D6 in human liver microsomes. Toxicol. Lett. 116 (2000) 217-221
    • (2000) Toxicol. Lett. , vol.116 , pp. 217-221
    • Sams, C.1    Mason, H.J.2    Rawbone, R.3
  • 4
    • 0037436019 scopus 로고    scopus 로고
    • Influence of gender on thermoregulation and ChE inhibition in the long-evans rat exposed to diazinon
    • Gordon C.J., and Mack C.M. Influence of gender on thermoregulation and ChE inhibition in the long-evans rat exposed to diazinon. J. Toxicol. Environ. Health A 66 3 (2003) 291-304
    • (2003) J. Toxicol. Environ. Health A , vol.66 , Issue.3 , pp. 291-304
    • Gordon, C.J.1    Mack, C.M.2
  • 5
    • 5044234937 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetic/pharmacodynamic model for the organophosphorus pesticide diazinon
    • Poet T.S., Kousba A.A., Dennison S.L., and Timchalk C. Physiologically based pharmacokinetic/pharmacodynamic model for the organophosphorus pesticide diazinon. NeuroToxicology. 25 (2004) 1013-1030
    • (2004) NeuroToxicology. , vol.25 , pp. 1013-1030
    • Poet, T.S.1    Kousba, A.A.2    Dennison, S.L.3    Timchalk, C.4
  • 7
    • 33344457207 scopus 로고    scopus 로고
    • Sublethal effects of organophosphate diazinon on the brain of Cyprinus carpio
    • Ozcan Oruc E., Uner N., Sevgiler Y., Usta D., and Durmaz H. Sublethal effects of organophosphate diazinon on the brain of Cyprinus carpio. Drug Chem. Toxicol. 29 (2006) 57-67
    • (2006) Drug Chem. Toxicol. , vol.29 , pp. 57-67
    • Ozcan Oruc, E.1    Uner, N.2    Sevgiler, Y.3    Usta, D.4    Durmaz, H.5
  • 8
    • 0037619106 scopus 로고    scopus 로고
    • Biochemical evidence for free radical-induced lipid peroxidation as a mechanism for subchronic toxicity of malathion in blood and liver of rats
    • Akhgari M., Abdollahi M., Kebryaeezadeh A., Hosseini R., and Sabzevari O. Biochemical evidence for free radical-induced lipid peroxidation as a mechanism for subchronic toxicity of malathion in blood and liver of rats. Hum. Exp. Toxicol. 22 (2003) 205-211
    • (2003) Hum. Exp. Toxicol. , vol.22 , pp. 205-211
    • Akhgari, M.1    Abdollahi, M.2    Kebryaeezadeh, A.3    Hosseini, R.4    Sabzevari, O.5
  • 9
    • 0035997882 scopus 로고    scopus 로고
    • Induction of oxidative stress and acetylcholinesterase inhibition in organophosphorous pesticide manufacturing workers
    • Ranjbar A., Pasalar P., and Abdollahi M. Induction of oxidative stress and acetylcholinesterase inhibition in organophosphorous pesticide manufacturing workers. Hum. Exp. Toxicol. 21 (2002) 179-182
    • (2002) Hum. Exp. Toxicol. , vol.21 , pp. 179-182
    • Ranjbar, A.1    Pasalar, P.2    Abdollahi, M.3
  • 10
    • 3042645473 scopus 로고    scopus 로고
    • A review on blood glucose variations and affecting parameters
    • Abdollahi M., Soleimani F., and Kangarlou S. A review on blood glucose variations and affecting parameters. M.E. Pharmacy 11 (2003) 6-10
    • (2003) M.E. Pharmacy , vol.11 , pp. 6-10
    • Abdollahi, M.1    Soleimani, F.2    Kangarlou, S.3
  • 11
    • 3042561798 scopus 로고    scopus 로고
    • Hyperglycemia associated with increased hepatic glycogen phosphorylase and phosphoenolpyruvate carboxykinase activities in rat following subchronic exposure to malathion
    • Abdollahi M., Donyavi M., Pournourmohammadi S., and Saadat M. Hyperglycemia associated with increased hepatic glycogen phosphorylase and phosphoenolpyruvate carboxykinase activities in rat following subchronic exposure to malathion. Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 137 (2004) 343-347
    • (2004) Comp. Biochem. Physiol. C. Toxicol. Pharmacol. , vol.137 , pp. 343-347
    • Abdollahi, M.1    Donyavi, M.2    Pournourmohammadi, S.3    Saadat, M.4
  • 13
    • 33646356506 scopus 로고    scopus 로고
    • Stimulatory effects of malathion on the key enzymes activities of insulin secretion in Langerhans islets, glutamate dehydrogenase and glucokinase
    • Panahi P., Vosough-Ghanbari S., Pournourmohammadi S., Ostad S.N., Nikfar S., Minaie B., and Abdollah M. Stimulatory effects of malathion on the key enzymes activities of insulin secretion in Langerhans islets, glutamate dehydrogenase and glucokinase. Toxicol. Mech. Methods 16 (2006) 161-167
    • (2006) Toxicol. Mech. Methods , vol.16 , pp. 161-167
    • Panahi, P.1    Vosough-Ghanbari, S.2    Pournourmohammadi, S.3    Ostad, S.N.4    Nikfar, S.5    Minaie, B.6    Abdollah, M.7
  • 19
    • 23644451505 scopus 로고    scopus 로고
    • Cytokines affect PDX-1 expression, insulin and proinsulin secretion from iNOS deficient murine islets
    • Andersson A.K., Borjesson A., Sandgren J., and Sandler S. Cytokines affect PDX-1 expression, insulin and proinsulin secretion from iNOS deficient murine islets. Mol. Cell. Endocrinol. 240 (2005) 50-57
    • (2005) Mol. Cell. Endocrinol. , vol.240 , pp. 50-57
    • Andersson, A.K.1    Borjesson, A.2    Sandgren, J.3    Sandler, S.4
  • 21
    • 30344432980 scopus 로고    scopus 로고
    • Nitric oxide involvement in pancreatic beta cell apoptosis by glibenclamide
    • Ansar M.M., and Ansari M. Nitric oxide involvement in pancreatic beta cell apoptosis by glibenclamide. Nitric Oxide 14 (2006) 39-44
    • (2006) Nitric Oxide , vol.14 , pp. 39-44
    • Ansar, M.M.1    Ansari, M.2
  • 23
    • 24044513942 scopus 로고    scopus 로고
    • A review on the role of antioxidants in the management of diabetes and its complications
    • Rahimi R., Nikfar S., Larijani B., and Abdollahi M. A review on the role of antioxidants in the management of diabetes and its complications. Biomed. Pharmacother. 59 7 (2005) 365-373
    • (2005) Biomed. Pharmacother. , vol.59 , Issue.7 , pp. 365-373
    • Rahimi, R.1    Nikfar, S.2    Larijani, B.3    Abdollahi, M.4
  • 24
    • 19944390194 scopus 로고    scopus 로고
    • Diazinon-induced hepatotoxicity and protective effect of vitamin E on some biochemical indices and ultrastructural changes
    • Kalender S., Ogutcu A., Uzunhisarcikli M., Acikgoz F., Durak D., Ulusoy Y., and Kalender Y. Diazinon-induced hepatotoxicity and protective effect of vitamin E on some biochemical indices and ultrastructural changes. Toxicology 211 (2005) 197-206
    • (2005) Toxicology , vol.211 , pp. 197-206
    • Kalender, S.1    Ogutcu, A.2    Uzunhisarcikli, M.3    Acikgoz, F.4    Durak, D.5    Ulusoy, Y.6    Kalender, Y.7
  • 25
    • 33846997221 scopus 로고    scopus 로고
    • S. Shadnia, M. Dasgar, S. Taghikhani, A. Mohammadirad, M. Abdollahi, Protective effects of alpha-tocopherol and N-acetyl-cysteine on diazinon-induced oxidative stress and acetylcholinesterase inhibition in rats, Toxicol. Mech. Methods (2006) in press.
  • 26
    • 0000203434 scopus 로고    scopus 로고
    • Phosphodiesterase 4 inhibitiors, structurally unrelated to rolipram, as promising agents for the treatment of asthuma and other pathologies
    • Dal-Piaz V., and Giovannoni M.P. Phosphodiesterase 4 inhibitiors, structurally unrelated to rolipram, as promising agents for the treatment of asthuma and other pathologies. Eur. J. Med. Chem. 35 (2004) 463-480
    • (2004) Eur. J. Med. Chem. , vol.35 , pp. 463-480
    • Dal-Piaz, V.1    Giovannoni, M.P.2
  • 27
    • 0141505057 scopus 로고    scopus 로고
    • Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and susceptibility to a mitochondrial toxin
    • Abdollahi M., Chan T.S., Subrahmanyam V., and O'Brien P.J. Effects of phosphodiesterase 3,4,5 inhibitors on hepatocyte cAMP levels, glycogenolysis, gluconeogenesis and susceptibility to a mitochondrial toxin. Mol. Cell. Biochem. 252 (2003) 205-211
    • (2003) Mol. Cell. Biochem. , vol.252 , pp. 205-211
    • Abdollahi, M.1    Chan, T.S.2    Subrahmanyam, V.3    O'Brien, P.J.4
  • 28
    • 33745751145 scopus 로고    scopus 로고
    • Effects of sildenafil a phosphodiesterase 5 inhibitor on rat liver cell key enzymes of gluconeogenesis and glycogenolysis
    • Hoseini S., Esmaily H., Mohammadirad A., and Abdollahi M. Effects of sildenafil a phosphodiesterase 5 inhibitor on rat liver cell key enzymes of gluconeogenesis and glycogenolysis. Int. J. Pharmacol. 2 (2006) 280-285
    • (2006) Int. J. Pharmacol. , vol.2 , pp. 280-285
    • Hoseini, S.1    Esmaily, H.2    Mohammadirad, A.3    Abdollahi, M.4
  • 29
    • 0346147023 scopus 로고    scopus 로고
    • Protection by sildenafil and theophylline of lead acetate-induced oxidative stress in rat submandibular gland and saliva
    • Abdollahi M., Fooladian F., Emami B., Zafari K., and Bahreini-Moghadam A. Protection by sildenafil and theophylline of lead acetate-induced oxidative stress in rat submandibular gland and saliva. Hum. Exp. Toxicol. 22 (2003) 587-592
    • (2003) Hum. Exp. Toxicol. , vol.22 , pp. 587-592
    • Abdollahi, M.1    Fooladian, F.2    Emami, B.3    Zafari, K.4    Bahreini-Moghadam, A.5
  • 31
    • 33745746113 scopus 로고    scopus 로고
    • Protective effects of sildenafil and dipyridamol from lead-induced lipid peroxidation in perfused rat liver
    • Aghababaeian R., Ghazi-Khansari M., Abdi K., Taghadosinejad F., and Abdollahi M. Protective effects of sildenafil and dipyridamol from lead-induced lipid peroxidation in perfused rat liver. Int. J. Pharmacol. 1 (2005) 157-160
    • (2005) Int. J. Pharmacol. , vol.1 , pp. 157-160
    • Aghababaeian, R.1    Ghazi-Khansari, M.2    Abdi, K.3    Taghadosinejad, F.4    Abdollahi, M.5
  • 32
  • 33
    • 33846674538 scopus 로고    scopus 로고
    • H.U. Bergmeyer, E. Bernt, F. Schmidt, H. Stork, D-glucose, in: H.U. Bergmeyer, (Ed.), Methods of Enzymatic Analysis, vol. 3, Academic Press, New York, 1974, pp. 1196-1201.
  • 35
    • 0018079943 scopus 로고
    • Serum lipid peroxidation in cerebrovascular disorders determined by a new colorimetric method
    • Satho K. Serum lipid peroxidation in cerebrovascular disorders determined by a new colorimetric method. Clin. Chem. Acta 90 (1978) 37-43
    • (1978) Clin. Chem. Acta , vol.90 , pp. 37-43
    • Satho, K.1
  • 36
    • 0002457067 scopus 로고    scopus 로고
    • Ferric reducing antioxidant assay
    • Benzi I.F., and Strains S. Ferric reducing antioxidant assay. Methods Enzymol. 292 (1999) 15-27
    • (1999) Methods Enzymol. , vol.292 , pp. 15-27
    • Benzi, I.F.1    Strains, S.2
  • 37
    • 33846679056 scopus 로고    scopus 로고
    • International Programme on Chemical Safety. Inventory of IPCS and other WHO pesticide evaluations and summary of toxicological evalutions performed by the JMPR, WHO/PCS/02.3. World Health Organization, Geneva, (2003).
  • 38
    • 0034880220 scopus 로고    scopus 로고
    • Nitric oxide modulates high-energy phosphates in brain regions of rats intoxicated with diisopropylphosphorofluoridate or carbofuran: prevention by N-tert-butyl-alpha-phenylnitrone or vitamin E
    • Gupta R.C., Milatovic D., and Dettbarn W.D. Nitric oxide modulates high-energy phosphates in brain regions of rats intoxicated with diisopropylphosphorofluoridate or carbofuran: prevention by N-tert-butyl-alpha-phenylnitrone or vitamin E. Arch. Toxicol. 75 (2001) 346-356
    • (2001) Arch. Toxicol. , vol.75 , pp. 346-356
    • Gupta, R.C.1    Milatovic, D.2    Dettbarn, W.D.3
  • 39
    • 0033617148 scopus 로고    scopus 로고
    • Double-stranded RNA inhibits beta-cell function and induces islet damage by stimulating beta-cell production of nitric oxide
    • Heitmeier M.R., Scarim A.L., and Corbett J.A. Double-stranded RNA inhibits beta-cell function and induces islet damage by stimulating beta-cell production of nitric oxide. J. Biol. Chem. 274 18 (1999) 12531-12536
    • (1999) J. Biol. Chem. , vol.274 , Issue.18 , pp. 12531-12536
    • Heitmeier, M.R.1    Scarim, A.L.2    Corbett, J.A.3
  • 40
    • 33644905017 scopus 로고    scopus 로고
    • Beta cell cytoprotective strategies: establishing the relative roles for iNOS and ROS
    • McCabe C., Samali A., and O'brien T. Beta cell cytoprotective strategies: establishing the relative roles for iNOS and ROS. Biochem. Biophys. Res. Commun. 342 (2006) 1240-1248
    • (2006) Biochem. Biophys. Res. Commun. , vol.342 , pp. 1240-1248
    • McCabe, C.1    Samali, A.2    O'brien, T.3
  • 41
    • 33646775007 scopus 로고    scopus 로고
    • Role of interleukin 18 in nitric oxide production and pancreatic damage during acute pancreatitis
    • Ueno N., Kashiwamura S., Ueda H., Okamura H., Tsuji N.M., Hosohara K., Kotani J., and Marukawa S. Role of interleukin 18 in nitric oxide production and pancreatic damage during acute pancreatitis. Shock 24 (2005) 564-570
    • (2005) Shock , vol.24 , pp. 564-570
    • Ueno, N.1    Kashiwamura, S.2    Ueda, H.3    Okamura, H.4    Tsuji, N.M.5    Hosohara, K.6    Kotani, J.7    Marukawa, S.8
  • 42
    • 0025352370 scopus 로고
    • Modification of diazinon-induced changes in carbohydrate metabolism by adrenalectomy in rats
    • Matin M.A., Husain K., and Khan S.N. Modification of diazinon-induced changes in carbohydrate metabolism by adrenalectomy in rats. Biochem. Pharmacol. 39 (1990) 1781-1786
    • (1990) Biochem. Pharmacol. , vol.39 , pp. 1781-1786
    • Matin, M.A.1    Husain, K.2    Khan, S.N.3
  • 43
    • 0842328003 scopus 로고    scopus 로고
    • Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes
    • Green K., Brand M.D., and Murphy M.P. Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes. Diabetes 1 (2004) S110-S118
    • (2004) Diabetes , vol.1
    • Green, K.1    Brand, M.D.2    Murphy, M.P.3
  • 44
    • 2342517248 scopus 로고    scopus 로고
    • Role of oxidative stress in pancreatic β-cell dysfunction
    • Yoshitaka K., and Hideaki K. Role of oxidative stress in pancreatic β-cell dysfunction. Ann. N.Y. Acad. Sci. 1011 (2004) 168-176
    • (2004) Ann. N.Y. Acad. Sci. , vol.1011 , pp. 168-176
    • Yoshitaka, K.1    Hideaki, K.2
  • 46
    • 0034834160 scopus 로고    scopus 로고
    • Toxicologic significance of the hyperglycemia caused by organophosphorous insecticides
    • Seifert J. Toxicologic significance of the hyperglycemia caused by organophosphorous insecticides. Bull. Environ. Contam. Toxicol. 67 (2001) 463-469
    • (2001) Bull. Environ. Contam. Toxicol. , vol.67 , pp. 463-469
    • Seifert, J.1
  • 47
    • 0034786750 scopus 로고    scopus 로고
    • Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function
    • Gilon P., and Henquin J.C. Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function. Endocr. Rev. 22 5 (2001) 565-604
    • (2001) Endocr. Rev. , vol.22 , Issue.5 , pp. 565-604
    • Gilon, P.1    Henquin, J.C.2
  • 49
    • 4744342864 scopus 로고    scopus 로고
    • Update on diabetes mellitus
    • Korc M. Update on diabetes mellitus. Dis. Markers 20 (2004) 161-165
    • (2004) Dis. Markers , vol.20 , pp. 161-165
    • Korc, M.1
  • 50
    • 3042785985 scopus 로고    scopus 로고
    • Muscarinic stimulation of pancreatic insulin and glucagon release is abolished in m3 muscarinic acetylcholine receptor-deficient mice
    • Duttaroy A., Zimliki C.L., Gautam D., Cui Y., Mears D., and Wess J. Muscarinic stimulation of pancreatic insulin and glucagon release is abolished in m3 muscarinic acetylcholine receptor-deficient mice. Diabetes 53 (2004) 1714-1720
    • (2004) Diabetes , vol.53 , pp. 1714-1720
    • Duttaroy, A.1    Zimliki, C.L.2    Gautam, D.3    Cui, Y.4    Mears, D.5    Wess, J.6
  • 51
    • 0019760088 scopus 로고
    • Glycaemia and insulinaemia resulting from dichlorvos intoxication
    • Teichert-Kuliszewska K., Lawecki J., and Szymczyk T. Glycaemia and insulinaemia resulting from dichlorvos intoxication. Acta Med. Pol. 22 (1981) 303-308
    • (1981) Acta Med. Pol. , vol.22 , pp. 303-308
    • Teichert-Kuliszewska, K.1    Lawecki, J.2    Szymczyk, T.3
  • 52
    • 23044512742 scopus 로고    scopus 로고
    • Effects of pentoxifylline on oxidative stress and levels of EGF and NO in blood of diabetic type-2 patients; a randomized, double-blind placebo-controlled clinical trial
    • Radfar M., Larijani B., Hadjibabaie M., Rajabipour B., Mojtahedi A., and Abdollahi M. Effects of pentoxifylline on oxidative stress and levels of EGF and NO in blood of diabetic type-2 patients; a randomized, double-blind placebo-controlled clinical trial. Biomed. Pharmacother. 59 (2005) 302-306
    • (2005) Biomed. Pharmacother. , vol.59 , pp. 302-306
    • Radfar, M.1    Larijani, B.2    Hadjibabaie, M.3    Rajabipour, B.4    Mojtahedi, A.5    Abdollahi, M.6
  • 56
    • 0019852821 scopus 로고
    • CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse
    • Grankvist K., Marklund S.L., and Taljedal I.B. CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse. Biochem. J. 199 (1981) 393-398
    • (1981) Biochem. J. , vol.199 , pp. 393-398
    • Grankvist, K.1    Marklund, S.L.2    Taljedal, I.B.3
  • 57
    • 0029984682 scopus 로고    scopus 로고
    • Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
    • Lenzen S., Drinkgern J., and Tiedge M. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic. Biol. Med. 20 (1996) 463-466
    • (1996) Free Radic. Biol. Med. , vol.20 , pp. 463-466
    • Lenzen, S.1    Drinkgern, J.2    Tiedge, M.3
  • 59
    • 0029090320 scopus 로고
    • The specific type IV phosphodiesterase inhibitor rolipram differentially regulates the proinflammatory mediators TNF-alpha and nitric oxide
    • Greten T.F., Eigler A., Sinha B., Moeller J., and Endres S. The specific type IV phosphodiesterase inhibitor rolipram differentially regulates the proinflammatory mediators TNF-alpha and nitric oxide. Int. J. Immunopharmacol. 17 (1995) 605-610
    • (1995) Int. J. Immunopharmacol. , vol.17 , pp. 605-610
    • Greten, T.F.1    Eigler, A.2    Sinha, B.3    Moeller, J.4    Endres, S.5
  • 60
    • 33745698667 scopus 로고    scopus 로고
    • Significance of changes in TNF-α and IL-10 levels in the progression of heart failure subsequent to myocardial infarction
    • Kaur K., Sharma A.K., and Singal P.K. Significance of changes in TNF-α and IL-10 levels in the progression of heart failure subsequent to myocardial infarction. Am. J. Physiol. Heart. Circ. Physiol. 291 1 (2006) 106-113
    • (2006) Am. J. Physiol. Heart. Circ. Physiol. , vol.291 , Issue.1 , pp. 106-113
    • Kaur, K.1    Sharma, A.K.2    Singal, P.K.3
  • 62
    • 0029833439 scopus 로고    scopus 로고
    • Anti-inflammatory effects of theophylline: modulation of cytokine production
    • Mascali J.J., Cvietusa P., Negri J., and Borish L. Anti-inflammatory effects of theophylline: modulation of cytokine production. Ann. Allergy Asthma Immunol. 77 (1996) 34-38
    • (1996) Ann. Allergy Asthma Immunol. , vol.77 , pp. 34-38
    • Mascali, J.J.1    Cvietusa, P.2    Negri, J.3    Borish, L.4
  • 64
    • 0036451888 scopus 로고    scopus 로고
    • Non-cholinergic strategies for treating and preventing Alzheimer's disease
    • Doraiswamy P.M. Non-cholinergic strategies for treating and preventing Alzheimer's disease. CNS Drugs 16 (2002) 811-824
    • (2002) CNS Drugs , vol.16 , pp. 811-824
    • Doraiswamy, P.M.1
  • 65
    • 0036239216 scopus 로고    scopus 로고
    • Evidence for the involvement of the muscarinic cholinergic system in the central actions of pentoxifylline
    • Cunha G.M., Farias P.A., and Viana G.S. Evidence for the involvement of the muscarinic cholinergic system in the central actions of pentoxifylline. Behav. Pharmacol. 13 (2002) 149-156
    • (2002) Behav. Pharmacol. , vol.13 , pp. 149-156
    • Cunha, G.M.1    Farias, P.A.2    Viana, G.S.3


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