Effects of in utero exposure to the organophosphate insecticide fenitrothion on androgen-dependent reproductive development in the Crl:CD(SD)BR rat

Toxicological Sciences

Volumn 68, Issue 1, 2002, Pages 174-183

  Turner, Katie J ^a   Barlow, Norman J ^a   Struve, Melanie F ^a   Wallace, Duncan G ^a   Gaido, Kevin W ^a   Dorman, David C ^a   Foster, Paul M D ^a  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

Androgen receptor antagonist; Anogenital distance; Fenitrothion; In utero exposure; Nipple retention; Reproductive development

Indexed keywords

ANDROGEN; FENITROTHION; FLUTAMIDE; LINURON; ORGANOPHOSPHATE INSECTICIDE; VINCLOZOLIN; ANTIANDROGEN; INSECTICIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSAY; BREAST AREOLA; CONTROLLED STUDY; FEEDING; FEMALE; FETOTOXICITY; FETUS DEATH; GESTATIONAL AGE; IN VITRO STUDY; IN VIVO STUDY; MALE; MATERNAL DISEASE; NONHUMAN; PERINATAL PERIOD; PHENOTYPE; PRENATAL EXPOSURE; PROGENY; RAT; REPRODUCTIVE TOXICITY; SEX DIFFERENTIATION; SEXUAL DEVELOPMENT; TREMOR; WEIGHT GAIN; ANIMAL; ANIMAL BEHAVIOR; CHEMICALLY INDUCED DISORDER; CONGENITAL MALFORMATION; DRUG EFFECT; ENVIRONMENTAL EXPOSURE; MALE GENITAL SYSTEM; PATHOLOGY; PHYSIOLOGY; PREGNANCY; SEXUAL MATURATION; SPRAGUE DAWLEY RAT;

ABNORMALITIES, DRUG-INDUCED; ANDROGEN ANTAGONISTS; ANDROGENS; ANIMAL; BEHAVIOR, ANIMAL; FEMALE; FENITROTHION; FETAL DEATH; GENITALIA, MALE; INSECTICIDES, ORGANOTHIOPHOSPHATE; MALE; MATERNAL EXPOSURE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; SEX MATURATION; SUPPORT, NON-U.S. GOV'T; ANIMALS; INSECTICIDES; SEXUAL MATURATION;

ANIMALIA;

EID: 0035996074     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/68.1.174     Document Type: Article

References (47)

1. The relationship between maternal and fetal effects following maternal organophosphate exposure during gestation in the rat
2. [Disturbances of prenatal development in rats exposed to fenitrothion]
3. External genitalia abnormalities in male rats exposed in utero to finasteride, a 5 α-reductase inhibitor
4. Investigation of a mechanism for Leydig cell tumorigenesis by linuron in rats
5. Fertility and developmental neurotoxicity effects of inhaled hydrogen sulfide in Sprague-Dawley rats
6. Exposures of children to organophosphate pesticides and their potential adverse health effects
7. Effects of phthalate esters on the developing reproductive tract of male rats
8. Sex determination and differentiation
9. Tiered screening and testing strategy for xenoestrogens and antiandrogens
10. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat
11. Developmental effects of an environmental antiandrogen: The fungicide vinclozolin alters sex differentiation of the male rat
12. Environmental antiandrogens: Low doses of the fungicide vinclozolin alter sexual differentiation of the male rat
13. Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p′-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane during sexual differentiation produces diverse profiles of reproductive malformations in the male rat
14. Pre- and postnatal oral toxicity of vinclozolin in Wistar and Long-Evans rats
15. Antiandrogens as environmental endocrine disruptors
16. Vinclozolin and p,p′-DDE alter androgen-dependent gene expression: In vivo confirmation of an androgen receptor-mediated mechanism
17. Environmental hormone disruptors: Evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites
18. Persistent DDT metabolite, p,p′-DDE is a potent androgen receptor antagonist
19. Recent developments in regulatory requirements for developmental toxicology
20. Cellular and molecular mechanisms of action of linuron: An antiandrogenic herbicide that produces reproductive malformations in male rats
21. Pesticides and inner-city children: Exposures, risks, and prevention
22. Pesticides: Multiple mechanisms of demasculinization
23. Behavioral consequences of prenatal exposure to the organophosphate insecticide sumithion
24. Differences in oxidative dearylation and desulfuration of fenitrothion by cytochrome P-450 isozymes and in subsequent inhibition of monooxygenase activity
25. Biological monitoring survey of organophosphorus pesticide exposure among pre-school children in the Seattle metropolitan area
26. Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells
27. Androgen-mediated development in male rat offspring exposed to flutamide in utero: Permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations in androgen-dependent tissues
28. Male rats exposed to linuron in utero exhibit permanent changes in anogenital distance, nipple retention, and epididymal malformations that results in subsequent testicular atrophy
29. Effects of in utero exposure to linuron on androgen-dependent reproductive development in the male Crl:CD(SD)BR rat
30. Comparison of chlordimeform and carbaryl using a functional observational battery
31. Male reproductive tract malformations in rats following gestational and lactational exposure to di(n-butyl) phthalate: An antiandrogenic mechanism?
32. Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide
33. Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to di(n-butyl) phthalate during late gestation
34. Pharmacology and pharmacokinetics of flutamide
35. The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen-receptor antagonist in vivo and in vitro
36. The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat
37. Organophosphorus pesticides: Do they all have the same mechanism of toxicity
38. Altered gene profiles in fetal rat testes after in utero exposure to di(n-butyl) phthalate
39. Possible androgenic/anti-androgenic activity of the insecticide fenitrothion
40. Mammalian toxicology of organophosphorus pesticides
41. Evaluation of a 5-day Hershberger assay using young mature male rats: Methyltestosterone and p,p′-DDE, but not fenitrothion, exhibited androgenic or antiandrogenic activity in vivo
42. Androgen receptor antagonism by the organophosphate insecticide fenitrothion
43. HED chapter of the reregistration eligibility decision document for fenitrothion
44. Fenitrothion-FQPA requirement-report of the hazard identification assessment review committee
45. Endocrine disruptor screening and testing advisory committee
46. Impaired male sexual development in perinatal Sprague-Dawley and Long-Evans hooded rats exposed in utero and lactationally to p,p′-DDE