Effect of the organophosphorus pesticide diazinon on glucose tolerance in type 2 diabetic rats

Toxicology Letters

Volumn 182, Issue 1-3, 2008, Pages 42-47

  Ueyama, Jun ^a,b   Kamijima, Michihiro ^c   Asai, Kazumi ^b   Mochizuki, Aiko ^b   Wang, Dong ^c   Kondo, Takaaki ^b   Suzuki, Toshiaki ^d   Takagi, Kenji ^b   Takagi, Kenzo ^b   Kanazawa, Hiroaki ^e   Miyamoto, Ken ichi ^a   Wakusawa, Shinya ^b   Hasegawa, Takaaki ^f  

^a KANAZAWA UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

^c NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d NAGOYA UNIVERSITY HOSPITAL   (Japan)

^e UNIVERSITY OF SHIZUOKA   (Japan)

^f AICHI MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cholinesterase (ChE) activity; Cytochrome P450; Diazinon; Genetic type 2 diabetes; Goto Kakizaki rats (GK rats)

Indexed keywords

CHOLINESTERASE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2D1; CYTOCHROME P450 3A2; DIMPYLATE; GLUCOSE TRANSPORTER 4; INSULIN; ORGANOPHOSPHATE PESTICIDE;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CELL INFILTRATION; CONTROLLED STUDY; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HISTOPATHOLOGY; LEUKOCYTE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS CELL; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ACETYLCHOLINE; ADIPOSE TISSUE; ANIMALS; BLOTTING, WESTERN; CYTOCHROME P-450 ENZYME SYSTEM; DIABETES MELLITUS, TYPE 2; DIAZINON; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORTER TYPE 4; INSECTICIDES; LIVER; RATS; RATS, WISTAR;

RATTUS;

EID: 54949091463     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2008.08.004     Document Type: Article

References (31)

1. Balani S.K., Zhu T., Yang T.J., Liu Z., He B., and Lee F.W. Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in rats, dogs, and monkeys. Drug Metab. Dispos. 30 (2002) 1059-1062
2. Bisbis S., Bailbe D., Tormo M.A., Picarel-Blanchot F., Derouet M., Simon J., and Portha B. Insulin resistance in the GK rat: decreased receptor number but normal kinase activity in liver. Am. J. Physiol. 265 (1993) E807-813
3. Camps M., Castelló A., Muñoz P., Monfar M., Testar X., Palacín M., and Zorzano A. Effect of diabetes and fasting on GLUT-4 (muscle/fat) glucose-transporter expression in insulin-sensitive tissues. Heterogeneous response in heart, red and white muscle. Biochem. J. 282 (1992) 765-772
4. Carcillo J.A., Doughty L., Kofos D., Frye R.F., Kaplan S.S., Sasser H., and Burckart G.J. Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure. Intensive Care Med. 29 (2003) 980-984
5. Casida J.E., and Quistad G.B. Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets. Chem. Res. Toxicol. 17 (2004) 983-998
6. Dixon R.L., Hart L.G., and Fouts J.R. The metabolism of drugs by liver microsomes from alloxan-diabetic rats. J. Pharmacol. Exp. Ther. 133 (1961) 7-11
7. Enan E., Lasley B., Stewart D., Overstreet J., and Vandevoort C.A. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) modulates function of human luteinizing granulosa cells via cAMP signaling and early reduction of glucose transporting activity. Reprod. Toxicol. 10 (1996) 191-198
8. Frick T.W., Dalo S., O'Leary J.F., Runge W., Borner J.W., Baraniewski H., Dressel T., Shearen J.G., and Goodale R.L. Effects of insecticide, diazinon, on pancreas of dog, cat and guinea pig. J. Environ. Pathol. Toxicol. Oncol. 7 (1987) 1-11
9. Frontoni S., Bracaglia D., and Gigli F. Relationship between autonomic dysfunction, insulin resistance and hypertension, in diabetes. Nutr. Metab. Cardiovasc. Dis. 15 (2005) 441-449
10. Goto Y., Suzuki K., Ono T., Sasaki M., and Toyota T. Development of diabetes in the non-obese NIDDM rat (GK rat). Adv. Exp. Med. Biol. 246 (1988) 29-31
11. Hodgson E. In vitro human phase I metabolism of xenobiotics I: pesticides and related compounds used in agriculture and public health. J. Biochem. Mol. Toxicol. 17 (2003) 201-206
12. Hsiao C.T., Yang C.C., Deng J.F., Bullard M.J., and Liaw S.J. Acute pancreatitis following organophosphate intoxication. J. Toxicol. Clin. Toxicol. 34 (1996) 343-347
13. Ibrahim N.A., and El-Gamal B.A. Effect of diazinon, an organophosphate insecticide, on plasma lipid constituents in experimental animals. J. Biochem. Mol. Biol. 36 (2003) 499-504
14. Ikeda H., and Sugiyama Y. Insulin resistance-reducing effect of a new thiazolidinedione derivative, pioglitazone. Nippon Yakurigaku Zasshi 117 (2001) 335-342
15. Lee D.H., Lee I.K., Porta M., Steffes M., and Jacobs. Relationship between serum concentrations of persistent organic pollutants and the prevalence of metabolic syndrome among non-diabetic adults: results from the National Health and Nutrition Examination Survey 1999-2002. Diabetologia 50 (2007) 1841-1851
16. Lee D.H., Lee I.K., Song K., Steffes M., Toscano W., Baker B.A., and Jacobs Jr. D.R. A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999-2002. Diabetes Care 29 (2006) 1638-1644
17. Lotti M., and Moretto A. Organophosphate-induced delayed polyneuropathy. Toxicol. Rev. 24 (2005) 37-49
18. Matin M.A., and Siddiqui R.A. Effect of diacetylmonoxime and atropine on malathion-induced changes in blood glucose level and glycogen content of certain brain structures of rats. Biochem. Pharmacol. 31 (1982) 1801-1803
19. Miyoshi M., Nadai M., Nitta A., Ueyama J., Shimizu A., Takagi K., Nabeshima T., Takagi K., Saito K., and Hasegawa T. Role of tumor necrosis factor-alpha in down-regulation of hepatic cytochrome P450 and P-glycoprotein by endotoxin. Eur. J. Pharmacol. 507 (2005) 229-237
20. Nouyaku-Youran, 2006. Nihon Shokubutsu Boueki Kyoukai. The Ministry of Agriculture, Forestry and Fisheries of Japan (in Japanese).
21. Omura T., and Sato R. The carbon monoxide-binding pigment of liver microsomes. J. Biol. Chem. 239 (1964) 2370-2378
22. Ostenson C.G., Khan A., Abdel-Halim S.M., Guenifi A., Suzuki K., Goto Y., and Efendic S. Abnormal insulin secretion and glucose metabolism in pancreatic islets from the spontaneously diabetic GK rat. Diabetologia 36 (1993) 3-8
23. Quistad G.B., Sparks S.E., Segall Y., Nomura D.K., and Casida J.E. Selective inhibitors of fatty acid amide hydrolase relative to neuropathy target esterase and acetylcholinesterase: toxicological implications. Toxicol. Appl. Pharmacol. 179 (2002) 57-63
24. Rezg R., Mornagui B., Kamoun A., El-Fazaa S., and Gharbi N. Effect of subchronic exposure to malathion on metabolic parameters in the rat. C. R. Biol. 330 (2007) 143-147
25. Sams C., Mason H.J., and Rawbone R. Evidence for the activation of organophosphate pesticides by cytochromes P450 3A4 and 2D6 in human liver microsomes. Toxicol. Lett. 116 (2000) 217-221
26. Seifert J. Toxicologic significance of the hyperglycemia caused by organophosphorous insecticides. Bull. Environ. Contam. Toxicol. 67 (2001) 463-469
27. Teimouri F., Amirkabirian N., Esmaily H., Mohammadirad A., Aliahmadi A., and Abdollahi M. Alteration of hepatic cells glucose metabolism as a non-cholinergic detoxication mechanism in counteracting diazinon-induced oxidative stress. Hum. Exp. Toxicol. 25 (2006) 697-703
28. Thummel K.E., and Schenkman J.B. Effects of testosterone and growth hormone treatment on hepatic microsomal P450 expression in the diabetic rat. Mol. Pharmacol. 37 (1990) 119-129
29. Ueyama J., Wang D., Kondo T., Saito I., Takagi K., Takagi K., Kamijima M., Nakajima T., Miyamoto K., Wakusawa S., and Hasegawa T. Toxicity of diazinon and its metabolites increases in diabetic rats. Toxicol. Lett. 170 (2007) 229-237
30. Voss G., and Sachsse K. Red cell and plasma cholinesterase activities in microsamples of human and animal blood determined simultaneously by a modified acetylthiocholine-DTNB procedure. Toxicol. Appl. Pharmacol. 16 (1970) 764-772
31. Yehia M.A., El-Banna S.G., and Okab A.B. Diazinon toxicity affects histophysiological and biochemical parameters in rabbits. Exp. Toxicol. Pathol. 59 (2007) 215-225