Mitochondrial ATP synthase inhibition and nitric oxide are involved in muscle weakness that occurs in acute exposure of rats to monocrotophos

Toxicology Mechanisms and Methods

Volumn 19, Issue 3, 2009, Pages 239-245

  Venkatesh, S ^a   Ramachandran, A ^a   Zachariah, A ^a   Oommen, A ^a  

^a CHRISTIAN MEDICAL COLLEGE   (India)

Author keywords

ATP synthase; Electron transport chain; Monocrotophos; Nitric oxide; Organophosphate poisoning; Skeletal muscle

Indexed keywords

CALCIUM; CYSTEINE; DRINKING WATER; ENZYME; MONOCROTOPHOS; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; ORGANOPHOSPHATE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BREATHING; CALCIUM TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVITY; LD 50; MALE; MUSCLE MITOCHONDRION; MUSCLE WEAKNESS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BLOTTING, WESTERN; CALCIUM; CHOLINESTERASE INHIBITORS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FEMALE; INSECTICIDES; MITOCHONDRIA, MUSCLE; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; MONOCROTOPHOS; MUSCLE WEAKNESS; MUSCLE, SKELETAL; NITRIC OXIDE; RATS; RATS, WISTAR;

ANIMALIA; RATTUS;

EID: 70350514305     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.1080/15376510802455354     Document Type: Article

References (35)

1. Bernatova, I., Kopincova, J., Puzserova, A., Janega, P., and Babal, P. 2007. Chronic low dose L-NAME treatment increases nitric oxide production and vasorelaxation in normotensive rats. Physiol. Res. 56(Suppl 2):S17-S24.
2. Brookes, P. S., Pinner, A., Ramachandran, A., Coward, L., Barnes, S., Kim, H., and Darley-Usmar, V. M. 2002. High throughput two-dimensional bluenative electrophoresis: a tool for functional proteomics of mitochondria and signaling complexes. Proteomics 2:969-977.
3. Chang, A. Y., Chan, J. Y., Kao, F. J., Huang, C. M., and Chan, S. H. 2001. Engagement of inducible nitric oxide synthase at the rostral ventrolateral medulla during mevinphos intoxication in the rat. J. Biomed. Sci. 8:475-483.
4. Damodaran, T. V., Patel, A. G., Greenfield, S. T., Dressman, H. K., Lin, S. M., and Abou-Donia, M. B. 2006. Gene expression profiles of the rat brain both immediately and 3 months following acute sarin exposure. Biochem. Pharmacol. 7:497-520.
5. Darley-Usmar, V. 1987. The molecular aetiology of human mitochondrial myopathies. Biochem. Soc. Trans. 1:102-103.
6. De Bleecker, J., Willems, J., De Reuck, J., Santens, P., and Lison, D. 1991. Histological and histochemical study of paraoxon myopathy in the rat. Acta Neurol. Belg. 9:255-270.
7. Dedkova, E. N., and Blatter, L. A. 2005. Modulation of mitochondrial Ca2+ by nitric oxide in cultured bovine vascular endothelial cells. Am. J. Physiol. Cell Physiol. 289:C836-C845.
8. DiMauro, S., and Gurgel-Giannetti, J. 2005. The expanding phenotype of mitochondrial myopathy. Curr. Opin. Neurol. 18:538-542.
9. Eddleston, M., and Phillips, M. R. 2004. Self poisoning with pesticides. Br. Med. J. 328:42-44.
10. Ellman, G. L., Courtney, K. D., AndresJr., V. and Feather-Stone, and R. M. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7:88-95.
11. Gupta, R. C., Milatovic, D., and Dettbarn, W. D. 2002. Involvement of nitric oxide in myotoxicity produced by diisopropylphosphorofluoridate (DFP)-induced muscle hyperactivity. Arch. Toxicol. 76:715-726.
12. Jaffrey, S. R., Erdjument-Bromage, H., Ferris, C. D., Tempst, P., and Snyder, S. H. 2001. Protein S-nitrosylation: a physiological signal for neuronal nitric oxide. Nature Cell Biol. 3:193-197.
13. Jeyarasasingam, G., Yeluashvili, M., and Quik, M. 2000. Nitric oxide is involved in acetylcholinesterase inhibitor-induced myopathy in rats. J. Pharmacol. Exp. Ther. 295:314-320.
14. John, M., Oommen, A., and Zachariah, A. 2003. Muscle injury in organophosphorous poisoning and its role in the development of intermediate syndrome. Neurotoxicology 24:43-53.
15. Laemmli, U. 1970. Cleavage of structural proteins during the assembly of the head of bacteriphage T4. Nature 227:680-685.
16. Leonard, J. P., and Salpeter, M. M. 1979. Agonist induced myopathy at the neuromuscular junction is mediated by calcium. J. Cell Biol. 82:811-819.
17. Lowry, O. H., Rosenbrough, N. H., Farr, A. L., and Randall, R. J. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
18. Madesh, M., Ramachandran, A., and Balasubramanian, K. A. 1999. Nitric oxide prevents anoxia-induced apoptosis in colonic HT29 cells. Arch. Biochem. Biophys. 366:240-248.
19. Manhande, S. N., and Chopde, C. 1995. Neurobehavioral effect of acute monocrotophos administration in rats and mice. Indian J. Pharmacol. 27:245-249.
20. Moreau, B., Nelson, C., and Parekh, A. B. 2006. Biphasic regulation of mitochondrial Ca2+ uptake by cytosolic Ca2+ concentration. Curr. Biol. 16:1672-1677.
21. Pennington, R. J. 1961. Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase. Biochem. J. 80:649-654.
22. Samuel, J., Thomas, K., Jeyaseelan, L., Peter, J. V., and Cherian, A. M. 1995. Incidence of intermediate syndrome in organophosphorus poisoning. J. Ass. Physicians India 43:321-323.
23. Sarnat, H. B., and Marin-Garcia, J. 2005. Pathology of mitochondrial encephalomyopathies. Can. J. Neurol. Sci. 32:152-166.
24. Sastry, K. V., Moudgal, R. P., Mohan, J., Tyagi, J. S., and Rao, G. S. 2002. Spectrophotometric determination of serum nitrite and nitrate by copper-cadmium alloy. Anal. Biochem. 306:79-82.
25. Scarpa, A. 1979. Measurements of cation transport with metallochromic indicators. Methods Enzymol. 56:301-338.
26. Schagger, H., and Von Jagow, G. 1991. Blue Native Electrophoresis for isolation of membrane protein complexes in enzymatically active form. Anal. Biochem. 199:223-231.
27. Schagger, H., Cramer, W. A., and von Jagow, G. 1994. Analysis of molecular masses and oligomeric states of protein complexes by blue native electrophoresis and isolation of membrane protein complexes by twodimensional native electrophoresis. Anal. Biochem. 217:220-230.
28. Schild, L., Reinheckel, T., Reiser, M., Horn, T. F. W., Wolf, G., and Augustin, W. 2003. Nitric oxide produced in rat liver mitochondria causes oxidative stress and impairment of respiration after transient hypoxia. FASEB J. 17:2194-2201.
29. Smith, M. A., and Reid, M. B. 2006. Redox modulation of contractile function in respiratory and limb skeletal muscle. Respir. Physiol. Neurobiol. 151:229-241.
30. Soper, J. W., and Pedersen, P. L. 1979. Isolation of an oligomycin-sensitive ATPase complex from rat liver mitochondria. Methods Enzymol. 55:328-333.
31. Takeyama, N., Matsuo, N., and Tanaka, T. 1993. Oxidative damage to mitochondria is mediated by the Ca (2+)-dependent inner-membrane permeability transition. Biochem. J. 294:719-725.
32. Thomas, S., Ramachandran, A., Susama, P., and Balasubramanian, K. A. 2001. Nitric oxide prevents intestinal mitochondrial dysfunction induced by surgical stress. Br. J. Surgery 88:393-399.
33. Towbin, H., Staehelin, T., and Gordon, J. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc. Natl. Acad. Sci. USA 76:4350-4354.
34. Wilkinson, J. H., and Robinson, J. M. 1974. Effect of ATP on release of intracellular enzymes from damaged cells. Nature 249:662-663.
35. Yen, D. H., Chan, J. Y., Tseng, H. P., Huang, C. I., Lee, C. H., Chan, S. H., and Chang, A. Y. 2004. Depression of mitochondrial respiratory enzyme activity in rostral ventrolateral medulla during acute mevinphos intoxication in the rat. Shock 21:358-363.