Mechanism of organophosphates (nerve gases and pesticides) and antidotes: Electron transfer and oxidative stress

Current Medicinal Chemistry

Volumn 10, Issue 24, 2003, Pages 2705-2709

  Kovacic, Peter ^a  

^a SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

2 PAM; Alkylation; Captodative effect; DNA; Electron transfer; HI 6; Iminium; Insecticides; Nerve gas; Nerve gas antidotes; Organophosphates; Oxidative stress; Oximes; Pralidoxime; Reduction potentials

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETYLCHOLINESTERASE; ALDOXIME; ANTIDOTE; BENZODIAZEPINE DERIVATIVE; CRYSTAL VIOLET; DAUNORUBICIN DERIVATIVE; DNA; DRUG METABOLITE; EFLORNITHINE; ETHIONAMIDE; GRISEOFULVIN; IMINE; INSECTICIDE; LACTAM DERIVATIVE; NERVE GAS; NICOTINE DERIVATIVE; ORGANOPHOSPHATE; OXIME DERIVATIVE; PESTICIDE; PHANQUINONE; PRALIDOXIME; PRIMAQUINE; PROGABIDE; PYRIDINE DERIVATIVE; PYRIDINIUM DERIVATIVE; REACTIVE OXYGEN METABOLITE; SARIN; UNINDEXED DRUG; ZINVIROXIME;

DNA ALKYLATION; DNA STRAND BREAKAGE; DRUG ACTIVITY; DRUG STRUCTURE; ELECTROCHEMISTRY; ELECTRON TRANSPORT; ENZYME INHIBITION; HUMAN; LIPID PEROXIDATION; METABOLIC REGULATION; MUTAGENICITY; OXIDATION REDUCTION POTENTIAL; OXIDATIVE STRESS; REVIEW; SIDE EFFECT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTIDOTES; CHEMICAL WARFARE AGENTS; CHOLINESTERASE REACTIVATORS; ELECTRON TRANSPORT; HUMANS; INSECTICIDES; ORGANOPHOSPHORUS COMPOUNDS; OXIDATIVE STRESS; PRALIDOXIME COMPOUNDS;

EID: 0345687437     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867033456314     Document Type: Review

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