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Volumn 8, Issue 9, 2011, Pages 491-501

Alcoholic liver disease: Pathogenesis and new targets for therapy

Author keywords

[No Author keywords available]

Indexed keywords

ACAMPROSATE; ALPHA TOCOPHEROL; BACLOFEN; CARBOHYDRATE DEFICIENT TRANSFERRIN; COLCHICINE; CORTICOSTEROID; CYTOCHROME P450 2E1; DISULFIRAM; ETANERCEPT; GAMMA GLUTAMYLTRANSFERASE; GLUCAGON; INFLIXIMAB; INSULIN; INTERLEUKIN 17; INTERLEUKIN 22; NALTREXONE; OSTEOPONTIN; PENTOXIFYLLINE; PREDNISOLONE; PREDNISONE; PROPYLTHIOURACIL; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SILIBININ; STAT PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN; STRESS ACTIVATED PROTEIN KINASE; VERY LOW DENSITY LIPOPROTEIN; VON WILLEBRAND FACTOR CLEAVING PROTEINASE;

EID: 80052433519     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2011.134     Document Type: Review
Times cited : (248)

References (146)
  • 2
    • 1942470397 scopus 로고    scopus 로고
    • Review article: Current management of alcoholic liver disease
    • DOI 10.1111/j.1365-2036.2004.01881.x
    • Tome, S. & Lucey, M. R. Review article: current management of alcoholic liver disease. Aliment. Pharmacol. Ther. 19, 707-714 (2004). (Pubitemid 38496636)
    • (2004) Alimentary Pharmacology and Therapeutics , vol.19 , Issue.7 , pp. 707-714
    • Tome, S.1    Lucey, M.R.2
  • 5
    • 33644930840 scopus 로고    scopus 로고
    • HFE genotypes in decompensated alcoholic liver disease: Phenotypic expression and comparison with heavy drinking and with normal controls
    • DOI 10.1111/j.1572-0241.2006.00439.x
    • Gleeson, D. et al. HFE genotypes in decompensated alcoholic liver disease: phenotypic expression and comparison with heavy drinking and with normal controls. Am. J. Gastroenterol. 101, 304-310 (2006). (Pubitemid 43381672)
    • (2006) American Journal of Gastroenterology , vol.101 , Issue.2 , pp. 304-310
    • Gleeson, D.1    Evans, S.2    Bradley, M.3    Jones, J.4    Peck, R.J.5    Dube, A.6    Rigby, E.7    Dalton, A.8
  • 6
    • 79951944435 scopus 로고    scopus 로고
    • Impact of hepatitis C virus infection on the course and outcome of patients with acute alcoholic hepatitis
    • Singal, A. K., Sagi, S., Kuo, Y. F. & Weinman, S. Impact of hepatitis C virus infection on the course and outcome of patients with acute alcoholic hepatitis. Eur. J. Gastroenterol. Hepatol. 23, 204-209 (2011).
    • (2011) Eur. J. Gastroenterol. Hepatol. , vol.23 , pp. 204-209
    • Singal, A.K.1    Sagi, S.2    Kuo, Y.F.3    Weinman, S.4
  • 8
    • 34249723678 scopus 로고    scopus 로고
    • Steatosis as a Cofactor in Other Liver Diseases: Hepatitis C Virus, Alcohol, Hemochromatosis, and Others
    • DOI 10.1016/j.cld.2007.02.007, PII S1089326107000086, Non-Alcoholic Steatohepatitis and Non-Alcoholic Fatty Liver Disease
    • Clouston, A. D., Jonsson, J. R. & Powell, E. E. Steatosis as a cofactor in other liver diseases: hepatitis C virus, alcohol, hemochromatosis, and others. Clin. Liver Dis. 11, 173-189 (2007). (Pubitemid 46829972)
    • (2007) Clinics in Liver Disease , vol.11 , Issue.1 , pp. 173-189
    • Clouston, A.D.1    Jonsson, J.R.2    Powell, E.E.3
  • 9
    • 0003731907 scopus 로고    scopus 로고
    • The world health report 2002-reducing risks promoting healthy life
    • The world health report (2002)-reducing risks, promoting healthy life. World Health Organization [online], http://www.who.int/whr/2002/en/(2002).
    • (2002) World Health Organization
  • 10
    • 77954933959 scopus 로고    scopus 로고
    • The burden of disease and the cost of illness attributable to alcohol drinking-results of a national study
    • Cortez-Pinto, H. et al. The burden of disease and the cost of illness attributable to alcohol drinking-results of a national study. Alcohol. Clin. Exp. Res. 34, 1442-1449 (2010).
    • (2010) Alcohol. Clin. Exp. Res. , vol.34 , pp. 1442-1449
    • Cortez-Pinto, H.1
  • 11
    • 67649116613 scopus 로고    scopus 로고
    • Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders
    • Rehm, J. et al. Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders. Lancet 373, 2223-2233 (2009).
    • (2009) Lancet , vol.373 , pp. 2223-2233
    • Rehm, J.1
  • 12
    • 77955431404 scopus 로고    scopus 로고
    • Alcoholic liver disease-related mortality in the United States: 1980-2003
    • Paula, H. et al. Alcoholic liver disease-related mortality in the United States: 1980-2003. Am. J. Gastroenterol. 105, 1782-1787 (2010).
    • (2010) Am. J. Gastroenterol. , vol.105 , pp. 1782-1787
    • Paula, H.1
  • 13
    • 84856093195 scopus 로고    scopus 로고
    • European liver transplant registry
    • online
    • European liver transplant registry. ELTR.org [online], http://www.eltr.org/spip.php?spip0 (2011).
    • (2011) ELTR.org
  • 14
    • 0034985079 scopus 로고    scopus 로고
    • Orthotopic liver transplantation for alcoholic liver disease: A retrospective analysis of survival, recidivism, and risk factors predisposing to recidivism
    • DOI 10.1053/jlts.2001.23789
    • Mackie, J. et al. Orthotopic liver transplantation for alcoholic liver disease: a retrospective analysis of survival, recidivism, and risk factors predisposing to recidivism. Liver Transplant. 7, 418-427 (2001). (Pubitemid 32496144)
    • (2001) Liver Transplantation , vol.7 , Issue.5 , pp. 418-427
    • Mackie, J.1    Groves, K.2    Hoyle, A.3    Garcia, C.4    Garcia, R.5    Gunson, B.6    Neuberger, J.7
  • 15
  • 16
    • 72549116736 scopus 로고    scopus 로고
    • Liver transplantation for alcoholic liver disease in Europe: A study from the ELTR european liver transplant registry
    • Burra, P. et al. Liver transplantation for alcoholic liver disease in Europe: a study from the ELTR (European Liver Transplant Registry).Am. J. Transplant. 10, 138-148 (2010).
    • (2010) Am. J. Transplant. , vol.10 , pp. 138-148
    • Burra, P.1
  • 17
    • 14844316679 scopus 로고    scopus 로고
    • Morphology of alcoholic liver disease
    • DOI 10.1016/j.cld.2004.11.001, Alcoholic Liver Disease
    • Lefkowitch, J. H. Morphology of alcoholic liver disease. Clin. Liver Dis. 9, 37-53 (2005). (Pubitemid 40341945)
    • (2005) Clinics in Liver Disease , vol.9 , Issue.1 , pp. 37-53
    • Lefkowitch, J.H.1
  • 18
    • 33947707345 scopus 로고    scopus 로고
    • Spectrum of liver histology in presumed decompensated alcoholic liver disease
    • DOI 10.1111/j.1572-0241.2006.01034.x
    • Elphick, D. A., Dube, A. K., McFarlane, E., Jones, J. & Gleeson, D. Spectrum of liver histology in presumed decompensated alcoholic liver disease. Am. J. Gastroenterol. 102, 780-788 (2007). (Pubitemid 46496603)
    • (2007) American Journal of Gastroenterology , vol.102 , Issue.4 , pp. 780-788
    • Elphick, D.A.1    Dube, A.K.2    McFarlane, E.3    Jones, J.4    Gleeson, D.5
  • 19
    • 33644652173 scopus 로고    scopus 로고
    • Clinical syndromes of alcoholic liver disease
    • DOI 10.1159/000090173
    • Adachi, M. & Brenner, D. A. Clinical syndromes of alcoholic liver disease. Dig. Dis. 23, 255-263 (2005). (Pubitemid 43325925)
    • (2005) Digestive Diseases , vol.23 , Issue.3-4 , pp. 255-263
    • Adachi, M.1    Brenner, D.A.2
  • 21
    • 0017809728 scopus 로고
    • Corticosteroid therapy of alcoholic hepatitis
    • Maddrey, W. C. et al. Corticosteroid therapy of alcoholic hepatitis. Gastroenterology 75, 193-199 (1978). (Pubitemid 8372264)
    • (1978) Gastroenterology , vol.75 , Issue.2 , pp. 193-199
    • Maddrey, W.C.1    Boitnott, J.K.2    Bedine, M.S.3
  • 23
    • 55349133034 scopus 로고    scopus 로고
    • A new scoring system for prognostic stratification of patients with alcoholic hepatitis
    • Dominguez, M. et al. A new scoring system for prognostic stratification of patients with alcoholic hepatitis. Am. J. Gastroenterol. 103, 2747-2756 (2008).
    • (2008) Am. J. Gastroenterol. , vol.103 , pp. 2747-2756
    • Dominguez, M.1
  • 26
    • 33747783591 scopus 로고    scopus 로고
    • Carbohydrate-deficient transferrin (CDT) as a marker of alcohol abuse: A critical review of the literature 2001-2005
    • DOI 10.1016/j.jchromb.2006.05.005, PII S1570023206003886, Analysis of Proteins, Peptides and Glycanes by Capillary (Electromigration) Techniques
    • Bortolotti, F., De Paoli, G. & Tagliaro, F. Carbohydrate-deficient transferrin (CDT) as a marker of alcohol abuse: a critical review of the literature 2001-2005. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 841, 96-109 (2006). (Pubitemid 44279557)
    • (2006) Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences , vol.841 , Issue.1-2 , pp. 96-109
    • Bortolotti, F.1    De Paoli, G.2    Tagliaro, F.3
  • 27
    • 33748797671 scopus 로고    scopus 로고
    • Comparison of the combined marker GGT-CDT and the conventional laboratory markers of alcohol abuse in heavy drinkers, moderate dinkers and abstainers
    • DOI 10.1093/alcalc/agl050
    • Hietala, J. et al. Comparison of the combined marker GGT-CDT and the conventional laboratory markers of alcohol abuse in heavy drinkers, moderate drinkers and abstainers. Alcohol Alcohol. 41, 528-533 (2006). (Pubitemid 44404470)
    • (2006) Alcohol and Alcoholism , vol.41 , Issue.5 , pp. 528-533
    • Hietala, J.1    Koivisto, H.2    Anttila, P.3    Niemela, O.4
  • 28
    • 0037532347 scopus 로고    scopus 로고
    • Five-year survival predictive factors in patients with excessive alcohol intake and cirrhosis. Effect of alcoholic hepatitis, smoking and abstinence
    • Pessione, F. et al. Five-year survival predictive factors in patients with excessive alcohol intake and cirrhosis. Effect of alcoholic hepatitis, smoking and abstinence. Liver Int. 23, 45-53 (2003). (Pubitemid 37265774)
    • (2003) Liver International , vol.23 , Issue.1 , pp. 45-53
    • Pessione, F.1    Ramond, M.-J.2    Peters, L.3    Pham, B.-N.4    Batel, P.5    Rueff, B.6    Valla, D.-C.7
  • 29
    • 0026023501 scopus 로고
    • Prognostic factors in alcoholic liver disease
    • VA Cooperative Study Group.
    • Chedid, A. et al. Prognostic factors in alcoholic liver disease. VA Cooperative Study Group. Am. J. Gastroenterol. 86, 210-216 (1991).
    • (1991) Am. J. Gastroenterol. , vol.86 , pp. 210-216
    • Chedid, A.1
  • 30
    • 78049493390 scopus 로고    scopus 로고
    • Alcoholic hepatitis 2010: A clinician's guide to diagnosis and therapy
    • Amini, M. & Runyon, B. A. Alcoholic hepatitis 2010: a clinician's guide to diagnosis and therapy. World J. Gastroenterol. 16, 4905-4912 (2010).
    • (2010) World J. Gastroenterol. , vol.16 , pp. 4905-4912
    • Amini, M.1    Runyon, B.A.2
  • 32
    • 0033774361 scopus 로고    scopus 로고
    • The long-term cost-effectiveness of improving alcohol abstinence with adjuvant acamprosate
    • Palmer, A. J. et al. The long-term cost-effectiveness of improving alcohol abstinence with adjuvant acamprosate. Alcohol Alcohol. 35, 478-492 (2000).
    • (2000) Alcohol Alcohol. , vol.35 , pp. 478-492
    • Palmer, A.J.1
  • 34
    • 0942268191 scopus 로고    scopus 로고
    • Does disulfiram have a role in alcoholism treatment today?
    • DOI 10.1111/j.1360-0443.2004.00597.x
    • Fuller, R. K. & Gordis, E. Does disulfiram have a role in alcoholism treatment today? Addiction 99, 21-24 (2004). (Pubitemid 38142216)
    • (2004) Addiction , vol.99 , Issue.1 , pp. 21-24
    • Fuller, R.K.1    Gordis, E.2
  • 36
    • 0021749036 scopus 로고
    • Short-term and long-term survival in patients with alcoholic hepatitis treated with oxandrolone and prednisolone
    • Mendenhall, C. L. et al. Short-term and long-term survival in patients with alcoholic hepatitis treated with oxandrolone and prednisolone. N. Engl. J. Med. 311, 1464-1470 (1984). (Pubitemid 15211021)
    • (1984) New England Journal of Medicine , vol.311 , Issue.23 , pp. 1464-1470
    • Mendenhall, C.L.1    Anderson, S.2    Garcia-Pont, P.3
  • 37
    • 0347950972 scopus 로고    scopus 로고
    • A randomized placebo controlled trial of vitamin E for alcoholic hepatitis
    • DOI 10.1016/S0168-8278(03)00476-8
    • Mezey, E., Potter, J. J., Rennie-Tankersley, L., Caballeria, J. & Pares, A. A randomized placebo controlled trial of vitamin E for alcoholic hepatitis. J. Hepatol. 40, 40-46 (2004). (Pubitemid 38064711)
    • (2004) Journal of Hepatology , vol.40 , Issue.1 , pp. 40-46
    • Mezey, E.1    Potter, J.J.2    Rennie-Tankersley, L.3    Caballeria, J.4    Pares, A.5
  • 39
    • 0035184867 scopus 로고    scopus 로고
    • Meta-analysis of propylthiouracil for alcoholic liver disease - A Cochrane Hepato-Biliary Group Review
    • DOI 10.1034/j.1600-0676.2001.210606.x
    • Rambaldi, A. & Gluud, C. Meta-analysis of propylthiouracil for alcoholic liver disease-a Cochrane Hepato-Biliary Group Review. Liver 21, 398-404 (2001). (Pubitemid 33095043)
    • (2001) Liver , vol.21 , Issue.6 , pp. 398-404
    • Rambaldi, A.1    Gluud, C.2
  • 41
    • 0026530697 scopus 로고
    • Treatment of severe alcoholic hepatitis by infusion of insulin and glucagon: A multicenter sequential trial
    • Trinchet, J. C. et al. Treatment of severe alcoholic hepatitis by infusion of insulin and glucagon: a multicenter sequential trial. Hepatology 15, 76-81 (1992).
    • (1992) Hepatology , vol.15 , pp. 76-81
    • Trinchet, J.C.1
  • 43
    • 0034465251 scopus 로고    scopus 로고
    • Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: A double-blind, placebo-controlled trial
    • Akriviadis, E. et al. Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial. Gastroenterology 119, 1637-1648 (2000). (Pubitemid 32198689)
    • (2000) Gastroenterology , vol.119 , Issue.6 , pp. 1637-1648
    • Akriviadis, E.1    Botla, R.2    Briggs, W.3    Han, S.4    Reynolds, T.5    Shakil, O.6
  • 44
    • 78651071021 scopus 로고    scopus 로고
    • Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: Meta-analysis of individual patient data
    • Mathurin, P. et al. Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: meta-analysis of individual patient data. Gut 60, 255-260 (2011).
    • (2011) Gut , vol.60 , pp. 255-260
    • Mathurin, P.1
  • 46
    • 0036784414 scopus 로고    scopus 로고
    • Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: A randomized controlled pilot study
    • Spahr, L. et al. Combination of steroids with infliximab or placebo in severe alcoholic hepatitis: a randomized controlled pilot study. J. Hepatol. 37, 448-455 (2002).
    • (2002) J. Hepatol. , vol.37 , pp. 448-455
    • Spahr, L.1
  • 49
    • 73449123375 scopus 로고    scopus 로고
    • Alcoholic liver disease
    • Practice Guideline Committee of the American Association for the Study of Liver Diseases & Practice Parameters Committee of the American College of Gastroenterology
    • O'Shea, R. S., Dasarathy, S. & McCullough, A. J., Practice Guideline Committee of the American Association for the Study of Liver Diseases & Practice Parameters Committee of the American College of Gastroenterology. Alcoholic liver disease. Hepatology 51, 307-328 (2010).
    • (2010) Hepatology , vol.51 , pp. 307-328
    • O'Shea, R.S.1    Dasarathy, S.2    McCullough, A.J.3
  • 50
    • 0019796717 scopus 로고
    • Attenuation of the ethanol-induced hepatic redox change after chronic alcohol consumption in baboons: Metabolic consequences in vivo and in vitro
    • DOI 10.1002/hep.1840010106
    • Salaspuro, M. P., Shaw, S., Jayatilleke, E., Ross, W. A. & Lieber, C. S. Attenuation of the ethanol-induced hepatic redox change after chronic alcohol consumption in baboons: metabolic consequences in vivo and in vitro. Hepatology 1, 33-38 (1981). (Pubitemid 11055586)
    • (1981) Hepatology , vol.1 , Issue.1 , pp. 33-38
    • Salaspuro, M.P.1    Shaw, S.2    Jayatilleke, E.3
  • 51
    • 77958175188 scopus 로고    scopus 로고
    • The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis
    • Sozio, M. S., Liangpunsakul, S. & Crabb, D. The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis. Semin. Liver Dis. 30, 378-390 (2010).
    • (2010) Semin. Liver Dis. , vol.30 , pp. 378-390
    • Sozio, M.S.1    Liangpunsakul, S.2    Crabb, D.3
  • 52
    • 38649096259 scopus 로고    scopus 로고
    • Hepatic fatty acid transporter CD36 is a common target of LXR PXR and PPAR? in promoting steatosis
    • Zhou, J. et al. Hepatic fatty acid transporter CD36 is a common target of, LXR, PXR, and PPAR? in promoting steatosis. Gastroenterology 134, 556-567 (2008).
    • (2008) Gastroenterology , vol.134 , pp. 556-567
    • Zhou, J.1
  • 53
    • 0041822088 scopus 로고    scopus 로고
    • Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion
    • DOI 10.1053/jhep.2003.50351
    • Coll, O., Colell, A., Garcia-Ruiz, C., Kaplowitz, N. & Fernández-Checa. J. C. Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion. Hepatology 38, 692-702 (2003). (Pubitemid 37052156)
    • (2003) Hepatology , vol.38 , Issue.3 , pp. 692-702
    • Coll, O.1    Colell, A.2    Garcia-Ruiz, C.3    Kaplowitz, N.4    Fernandez-Checa, J.C.5
  • 54
    • 0036083422 scopus 로고    scopus 로고
    • Alcohol and mitochondria: A dysfunctional relationship
    • Hoek, J. B., Cahill, A. & Pastorino, J. G. Alcohol and mitochondria: a dysfunctional relationship. Gastroenterology 122, 2049-2063 (2002). (Pubitemid 34651446)
    • (2002) Gastroenterology , vol.122 , Issue.7 , pp. 2049-2063
    • Hoek, J.B.1    Cahill, A.2    Pastorino, J.G.3
  • 56
    • 0035808410 scopus 로고    scopus 로고
    • The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor α is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver
    • DOI 10.1074/jbc.M008791200
    • Galli, A., Pinaire, J., Fischer, M., Dorris, R. & Crabb, D. W. The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor α is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver. J. Biol. Chem. 276, 68-75 (2001). (Pubitemid 32050290)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.1 , pp. 68-75
    • Galli, A.1    Pinaire, J.2    Fischer, M.3    Dorris, R.4    Crabb, D.W.5
  • 57
    • 0037047284 scopus 로고    scopus 로고
    • Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein SREBP
    • You, M., Fischer, M., Deeg, M. A. & Crabb, D. W. Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP).J. Biol. Chem. 277, 29342-29347 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 29342-29347
    • You, M.1    Fischer, M.2    Deeg, M.A.3    Crabb, D.W.4
  • 58
    • 9644290860 scopus 로고    scopus 로고
    • The role of AMP-activated protein kinase in the action of ethanol in the liver
    • DOI 10.1053/j.gastro.2004.09.049, PII S0016508504016282
    • You, M., Matsumoto, M., Pacold, C. M., Cho, W. K. & Crabb, D. W. The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology 127, 1798-1808 (2004). (Pubitemid 39575858)
    • (2004) Gastroenterology , vol.127 , Issue.6 , pp. 1798-1808
    • You, M.1    Matsumoto, M.2    Pacold, C.M.3    Cho, W.K.4    Crabb, D.W.5
  • 62
    • 79961024144 scopus 로고    scopus 로고
    • The amount of alcohol consumption negatively impacts short-term mortality in patients with alcoholic hepatitis
    • doi:10.1038/ajg.2011.141.
    • Altamirano, J. et al. The amount of alcohol consumption negatively impacts short-term mortality in patients with alcoholic hepatitis. Am. J. Gastroenterol. doi:10.1038/ajg.2011.141.
    • Am. J. Gastroenterol.
    • Altamirano, J.1
  • 63
    • 0023025701 scopus 로고
    • Histologic spectrum of alcoholic liver disease
    • MacSween, R. N. & Burt, A. D. Histologic spectrum of alcoholic liver disease. Semin. Liver Dis. 6, 221-232 (1986). (Pubitemid 17203551)
    • (1986) Seminars in Liver Disease , vol.6 , Issue.3 , pp. 221-232
    • MacSween, R.N.M.1    Burt, A.D.2
  • 64
    • 0028239023 scopus 로고
    • Collagen-acetaldehyde adducts in alcoholic and nonalcoholic liver diseases
    • DOI 10.1016/0270-9139(94)90142-2
    • Svegliati-Baroni, G., Baraona, E., Rosman, A. S. & Lieber, C. S. Collagen-acetaldehyde adducts in alcoholic and nonalcoholicliver diseases. Hepatology 20, 111-118 (1994). (Pubitemid 24196499)
    • (1994) Hepatology , vol.20 , Issue.1 , pp. 111-118
    • Svegliati-Baroni, G.1    Baraona, E.2    Rosman, A.S.3    Lieber, C.S.4
  • 65
    • 3042550657 scopus 로고    scopus 로고
    • Recent advances in alcoholic liver disease - II. Minireview: Molecular mechanisms of alcoholic fatty liver
    • DOI 10.1152/ajpgi.00056.2004
    • You, M. & Crabb, D. W. Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver. Am. J. Physiol. Gastrointest. Liver Physiol. 287, G1-G6 (2004). (Pubitemid 38802112)
    • (2004) American Journal of Physiology - Gastrointestinal and Liver Physiology , vol.287 , Issue.1
    • You, M.1    Crabb, D.W.2
  • 66
    • 0035408265 scopus 로고    scopus 로고
    • Ethanol-induced apoptosis in mouse liver: Fas- and cytochrome c-mediated caspase-3 activation pathway
    • Zhou, Z., Sun, X. & Kang, Y. J. Ethanol-induced apoptosis in mouse liver: Fas- and cytochrome c-mediated caspase-3 activation pathway. Am. J. Pathol. 159, 329-338 (2001). (Pubitemid 33704218)
    • (2001) American Journal of Pathology , vol.159 , Issue.1 , pp. 329-338
    • Zhou, Z.1    Sun, X.2    Kang, Y.J.3
  • 68
    • 0032696452 scopus 로고    scopus 로고
    • Differential role of ethanol and acetaldehyde in the induction of oxidative stress in HEP G2 cells: Effect on transcription factors AP-1 and NF-kB
    • Romαn, J. et al. Differential role of ethanol and acetaldehyde in the induction of oxidative stress in HEP G2 cells: effect on transcription factors AP-1 and NF-kB. Hepatology 30, 1473-1480 (1999).
    • (1999) Hepatology , vol.30 , pp. 1473-1480
    • Román, J.1
  • 70
    • 0031757931 scopus 로고    scopus 로고
    • Acute and chronic ethanol increases reactive oxygen species generation and decreases viability in fresh isolated rat hepatocytes
    • Bailey, S. M. & Cunningham, C. C. Acute and chronic ethanol increases reactive oxygen species generation and decreases viability in fresh, isolated rat hepatocytes. Hepatology 28, 1318-1328 (1998).
    • (1998) Hepatology , vol.28 , pp. 1318-1328
    • Bailey, S.M.1    Cunningham, C.C.2
  • 72
    • 0037960128 scopus 로고    scopus 로고
    • Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice
    • DOI 10.1016/S0016-5085(03)00276-2
    • Ji, C. & Kaplowitz, N. Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 124, 1488-1499 (2003). (Pubitemid 36531821)
    • (2003) Gastroenterology , vol.124 , Issue.5 , pp. 1488-1499
    • Ji, C.1    Kaplowitz, N.2
  • 75
    • 65249087414 scopus 로고    scopus 로고
    • Hepatic expression of CXC chemokines predicts portal hypertension and survival in patients with alcoholic hepatitis
    • Dominguez, M. et al. Hepatic expression of CXC chemokines predicts portal hypertension and survival in patients with alcoholic hepatitis. Gastroenterology 136, 1639-1650 (2009).
    • (2009) Gastroenterology , vol.136 , pp. 1639-1650
    • Dominguez, M.1
  • 77
    • 77958112845 scopus 로고    scopus 로고
    • Osteopontin is a novel therapeutic target in patients with alcoholic hepatitis
    • Morales, O. et al. Osteopontin is a novel therapeutic target in patients with alcoholic hepatitis. J. Hepatol. 52 (Suppl. 1), S23 (2010).
    • (2010) J. Hepatol. , vol.52 , Issue.1
    • Morales, O.1
  • 79
    • 77957946415 scopus 로고    scopus 로고
    • Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: Role of signal transducer and activator of transcription 3
    • Ki, S. H. et al. Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3. Hepatology 52, 1291-1300 (2010).
    • (2010) Hepatology , vol.52 , pp. 1291-1300
    • Ki, S.H.1
  • 80
    • 61949356502 scopus 로고    scopus 로고
    • The interleukin-17 pathway is involved in human alcoholic liver disease
    • Lemmers, A. et al. The interleukin-17 pathway is involved in human alcoholic liver disease. Hepatology 49, 646-657 (2009).
    • (2009) Hepatology , vol.49 , pp. 646-657
    • Lemmers, A.1
  • 83
    • 33846616400 scopus 로고    scopus 로고
    • Alcoholic liver disease
    • DOI 10.1053/j.semdp.2006.11.002, PII S0740257006001717, Inflammatory Liver Disease
    • Yip, W. W. & Burt, A. D. Alcoholic liver disease. Semin. Diagn. Pathol. 23, 149-160 (2006). (Pubitemid 46176510)
    • (2006) Seminars in Diagnostic Pathology , vol.23 , Issue.3-4 , pp. 149-160
    • Yip, W.W.1    Burt, A.D.2
  • 84
    • 0032989347 scopus 로고    scopus 로고
    • Stellate cell activation in alcoholic fibrosis - An overview
    • Friedman, S. L. Stellate cell activation in alcoholic fibrosis-an overview. Alcohol. Clin. Exp. Res. 23, 904-910 (1999). (Pubitemid 29256580)
    • (1999) Alcoholism: Clinical and Experimental Research , vol.23 , Issue.5 , pp. 904-910
    • Friedman, S.L.1
  • 85
    • 33751536833 scopus 로고    scopus 로고
    • Role of ethanol in the regulation of hepatic stellate cell function
    • Wang, J. H., Batey, R. G. & George, J. Role of ethanol in the regulation of hepatic stellate cell function. World J. Gastroenterol. 12, 6926-6932 (2006). (Pubitemid 44834881)
    • (2006) World Journal of Gastroenterology , vol.12 , Issue.43 , pp. 6926-6932
    • Wang, J.-H.1    Batey, R.G.2    George, J.3
  • 86
    • 54549098072 scopus 로고    scopus 로고
    • Cytokines and renin-angiotensin system signaling in hepatic fibrosis
    • Moreno, M. & Bataller, R. Cytokines and renin-angiotensin system signaling in hepatic fibrosis. Clin. Liver Dis. 12, 825-852 (2008).
    • (2008) Clin. Liver Dis. , vol.12 , pp. 825-852
    • Moreno, M.1    Bataller, R.2
  • 88
    • 72249114470 scopus 로고    scopus 로고
    • Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition
    • Kluwe, J. et al. Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition. Gastroenterology 138, 347-359 (2010).
    • (2010) Gastroenterology , vol.138 , pp. 347-359
    • Kluwe, J.1
  • 89
    • 33645860825 scopus 로고    scopus 로고
    • Reactive oxygen species have a causal role in multiple forms of insulin resistance
    • Houstis, N., Rosen, E. D. & Lander, E. S. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440, 944-948 (2006).
    • (2006) Nature , vol.440 , pp. 944-948
    • Houstis, N.1    Rosen, E.D.2    Lander, E.S.3
  • 90
    • 44349132732 scopus 로고    scopus 로고
    • Value of fibrosis markers for staging liver fibrosis in patients with precirrhotic alcoholic liver disease
    • DOI 10.1111/j.1530-0277.2008.00664.x
    • Lieber, C. S. et al. Value of fibrosis markers for staging liver fibrosis in patients with precirrhotic alcoholic liver disease. Alcohol. Clin. Exp. Res. 32, 1031-1039 (2008). (Pubitemid 351733086)
    • (2008) Alcoholism: Clinical and Experimental Research , vol.32 , Issue.6 , pp. 1031-1039
    • Lieber, C.S.1    Weiss, D.G.2    Paronetto, F.3
  • 91
    • 0033033426 scopus 로고    scopus 로고
    • Tissue inhibitors of metalloproteinases: Role in liver fibrosis and alcoholic liver disease
    • Arthur, M. J., Iredale, J. P. & Mann, D. A. Tissue inhibitors of metalloproteinases: role in liver fibrosis and alcoholic liver disease. Alcohol. Clin. Exp. Res. 23, 940-943 (1999). (Pubitemid 29256587)
    • (1999) Alcoholism: Clinical and Experimental Research , vol.23 , Issue.5 , pp. 940-943
    • Arthur, M.J.P.1    Iredale, J.P.2    Mann, D.A.3
  • 92
    • 79952254584 scopus 로고    scopus 로고
    • Hepatic deletion of Smad7 in mouse leads to spontaneous liver dysfunction and aggravates alcoholic liver injury
    • Zhu, L. et al. Hepatic deletion of Smad7 in mouse leads to spontaneous liver dysfunction and aggravates alcoholic liver injury. PLoS ONE 6, e17415 (2011).
    • (2011) PLoS ONE , vol.6
    • Zhu, L.1
  • 93
    • 79955478101 scopus 로고    scopus 로고
    • Genetics of liver injury and fibrosis
    • Weber, S. N. & Lammert, F. Genetics of liver injury and fibrosis. Alcohol. Clin. Exp. Res. 35, 800-803 (2011).
    • (2011) Alcohol. Clin. Exp. Res. , vol.35 , pp. 800-803
    • Weber, S.N.1    Lammert, F.2
  • 94
    • 33847008303 scopus 로고    scopus 로고
    • Genetics of alcoholic liver disease and nonalcoholic fatty liver disease
    • Wilfred de Alwis, N. M. & Day, C. P. Genetics of alcoholic liver disease and nonalcoholic fatty liver disease. Semin. Liver Dis. 27, 44-54 (2007).
    • (2007) Semin. Liver Dis. , vol.27 , pp. 44-54
    • Wilfred De Alwis, N.M.1    Day, C.P.2
  • 95
    • 77956127298 scopus 로고    scopus 로고
    • Cigarette smoking and chronic liver diseases
    • Altamirano, J. & Bataller, R. Cigarette smoking and chronic liver diseases. Gut 59, 1159-1162 (2010).
    • (2010) Gut , vol.59 , pp. 1159-1162
    • Altamirano, J.1    Bataller, R.2
  • 96
    • 77957196987 scopus 로고    scopus 로고
    • Components of metabolic syndrome are independent predictors of mortality in patients with chronic liver disease: A population-based study
    • Stepanova, M., Rafiq, N. & Younossi, Z. M. Components of metabolic syndrome are independent predictors of mortality in patients with chronic liver disease: a population-based study. Gut 59, 1410-1415 (2010).
    • (2010) Gut , vol.59 , pp. 1410-1415
    • Stepanova, M.1    Rafiq, N.2    Younossi, Z.M.3
  • 97
    • 0019515015 scopus 로고
    • Evidence of genetic predisposition to alcholic cirrhosis and psychosis: Twin concordances for alcholism and its biological end points by zygosity among male veterans
    • Hrubec, Z. & Omenn, G. S. Evidence of genetic predisposition to alcoholic cirrhosis and psychosis: twin concordances for alcoholism and its biological end points by zygosity among male veterans. Alcohol. Clin. Exp. Res. 5, 207-215 (1981). (Pubitemid 11116962)
    • (1981) Alcoholism: Clinical and Experimental Research , vol.5 , Issue.2 , pp. 207-215
    • Hrubec, Z.1    Omenn, G.S.2
  • 98
    • 0037371468 scopus 로고    scopus 로고
    • Genetic polymorphisms and the progression of liver fibrosis: A critical appraisal
    • DOI 10.1053/jhep.2003.50127
    • Bataller, R., North, K. E. & Brenner, D. A. Genetic polymorphisms and the progression of liver fibrosis: a critical appraisal. Hepatology 37, 493-503 (2003). (Pubitemid 36258768)
    • (2003) Hepatology , vol.37 , Issue.3 , pp. 493-503
    • Bataller, R.1    North, K.E.2    Brenner, D.A.3
  • 99
    • 0025787727 scopus 로고
    • Investigation of the role of polymorphisms at the alcohol and aldehyde dehydrogenase loci in genetic predisposition to alcohol-related end-organ damage
    • Day, C. P. et al. Investigation of the role of polymorphisms at the alcohol and aldehyde dehydrogenase loci in genetic predisposition to alcohol-related end-organ damage. Hepatology 14, 798-801 (1991).
    • (1991) Hepatology , vol.14 , pp. 798-801
    • Day, C.P.1
  • 100
    • 33644499201 scopus 로고    scopus 로고
    • Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease
    • Zintzaras, E., Stefanidis, I., Santos, M. & Vidal, F. Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease? Hepatology 43, 352-361 (2006).
    • (2006) Hepatology , vol.43 , pp. 352-361
    • Zintzaras, E.1    Stefanidis, I.2    Santos, M.3    Vidal, F.4
  • 101
    • 0035041058 scopus 로고    scopus 로고
    • Promoter polymorphism of the CD14 endotoxin receptor gene as a risk factor for alcoholic liver disease
    • DOI 10.1053/jhep.2001.24236
    • Jarvelainen, H. A. et al. Promoter polymorphism of the CD14 endotoxin receptor gene as a risk factor for alcoholic liver disease. Hepatology 33, 1148-1153 (2001). (Pubitemid 32378214)
    • (2001) Hepatology , vol.33 , Issue.5 , pp. 1148-1153
    • Jarvelainen, H.A.1    Orpana, A.2    Perola, M.3    Savolainen, V.T.4    Karhunen, P.J.5    Lindros, K.O.6
  • 102
    • 78751536418 scopus 로고    scopus 로고
    • Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians
    • Stickel, F. et al. Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians. Hepatology 53, 86-95 (2011).
    • (2011) Hepatology , vol.53 , pp. 86-95
    • Stickel, F.1
  • 103
    • 79959561798 scopus 로고    scopus 로고
    • Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease
    • doi:10.1016/j.jhep.2011.01.028.
    • Trépo, E. et al. Common polymorphism in the PNPLA3/adiponutrin gene confers higher risk of cirrhosis and liver damage in alcoholic liver disease. J. Hepatol. doi:10.1016/j.jhep.2011.01.028.
    • J. Hepatol.
    • Trépo, E.1
  • 105
    • 84856085952 scopus 로고    scopus 로고
    • Functional analysis of hepatic gene expression profiling from patients with alcoholic hepatitis reveals new targets for therapy
    • Domínguez, M. et al. Functional analysis of hepatic gene expression profiling from patients with alcoholic hepatitis reveals new targets for therapy. J. Hepatol. 50 (Suppl. 1), S39 (2009).
    • (2009) J. Hepatol. , vol.50 , Issue.1
    • Domínguez, M.1
  • 107
    • 84856100762 scopus 로고    scopus 로고
    • Identification of Fn14 a TNF receptor superfamily member as a therapeutic target in patients with alcoholic hepatitis
    • Domínguez, M. et al. Identification of Fn14, a TNF receptor superfamily member, as a therapeutic target in patients with alcoholic hepatitis. Hepatology 50 (Suppl. 4), 609A (2009).
    • (2009) Hepatology , vol.50 , Issue.4
    • Domínguez, M.1
  • 111
    • 74849121386 scopus 로고    scopus 로고
    • Potential role of enhanced cytokinemia and plasma inhibitor on the decreased activity of plasma ADAMTS13 in patients with alcoholic hepatitis: Relationship to endotoxemia
    • Ishikawa, M. et al. Potential role of enhanced cytokinemia and plasma inhibitor on the decreased activity of plasma ADAMTS13 in patients with alcoholic hepatitis: relationship to endotoxemia. Alcohol. Clin. Exp. Res. 34 (Suppl. 1), S25-S33 (2010).
    • (2010) Alcohol. Clin. Exp. Res. , vol.34 , Issue.1
    • Ishikawa, M.1
  • 112
    • 33846291847 scopus 로고    scopus 로고
    • Increased von Willebrand factor over decreased ADAMTS13 activity may contribute to the development of liver disturbance and multiorgan failure in patients with alcoholic hepatitis
    • Matsuyama, T. et al. Increased von Willebrand factor over decreased ADAMTS13 activity may contribute to the development of liver disturbance and multiorgan failure in patients with alcoholic hepatitis. Alcohol. Clin. Exp. Res. 31 (Suppl. 1), S27-S35 (2007).
    • (2007) Alcohol. Clin. Exp. Res. , vol.31 , Issue.1
    • Matsuyama, T.1
  • 114
    • 0031839001 scopus 로고    scopus 로고
    • Effect of ethanol on the structure and function of rabbit esophageal epithelium
    • Bor, S. et al. Effect of ethanol on the structure and function of rabbit esophageal epithelium. Am. J. Physiol. 274, G819-G826 (1998).
    • (1998) Am. J. Physiol. , vol.274
    • Bor, S.1
  • 116
    • 0020629363 scopus 로고
    • Ethanol-induced mucosal injury in rabbit oesophagus
    • Salo, J. A. Ethanol-induced mucosal injury in rabbit oesophagus. Scand. J. Gastroenterol. 18, 713-721 (1983). (Pubitemid 13005016)
    • (1983) Scandinavian Journal of Gastroenterology , vol.18 , Issue.6 , pp. 713-721
    • Salo, J.A.1
  • 117
    • 0026777042 scopus 로고
    • Effects of ethanol and various alcoholic beverages on the formation of O6-methyldeoxyguanosine from concurrently administered N- nitrosomethylbenzylamine in rats: A dose-response study
    • Yamada, Y., Weller, R. O., Kleihues P & Ludeke, B. I. Effects of ethanol and various alcoholic beverages on the formation of O6- methyldeoxyguanosine from concurrently administered N-nitrosomethylbenzylamine in rats: a dose-response study. Carcinogenesis 13, 1171-1175 (1992).
    • (1992) Carcinogenesis , vol.13 , pp. 1171-1175
    • Yamada, Y.1    Weller, R.O.2    Kleihues, P.3    Ludeke, B.I.4
  • 118
    • 0023819094 scopus 로고
    • Potentiation of ethanol-induced pancreatic injury by dietary fat Induction of chronic pancreatitis by alcohol in rats
    • Tsukamoto, H., Towner, S. J., Yu, G. S. & French, S. W. Potentiation of ethanol-induced pancreatic injury by dietary fat. Induction of chronic pancreatitis by alcohol in rats. Am. J. Pathol. 131, 246-257 (1988).
    • (1988) Am. J. Pathol. , vol.131 , pp. 246-257
    • Tsukamoto, H.1    Towner, S.J.2    Yu, G.S.3    French, S.W.4
  • 121
    • 0021923933 scopus 로고
    • Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet
    • DOI 10.1002/hep.1840050212
    • Tsukamoto, H. et al. Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet. Hepatology 5, 224-232 (1985). (Pubitemid 15115999)
    • (1985) Hepatology , vol.5 , Issue.2 , pp. 224-232
    • Tsukamoto, H.1    French, S.W.2    Benson, N.3
  • 122
    • 0035138847 scopus 로고    scopus 로고
    • Intragastric ethanol infusion model for cellular and molecular studies of alcoholic liver disease
    • DOI 10.1159/000054009
    • French, S. W. Intragastric ethanol infusion model for cellular and molecular studies of alcoholic liver disease. J. Biomed. Sci. 8, 20-27 (2001). (Pubitemid 32098482)
    • (2001) Journal of Biomedical Science , vol.8 , Issue.1 , pp. 20-27
    • French, S.W.1
  • 123
    • 0016210926 scopus 로고
    • An experimental model of alcohol feeding and liver injury in the baboon
    • Lieber, C. S. & DeCarli, L. M. An experimental model of alcohol feeding and liver injury in the baboon. J. Med. Primatol. 3, 153-163 (1974).
    • (1974) J. Med. Primatol. , vol.3 , pp. 153-163
    • Lieber, C.S.1    DeCarli, L.M.2
  • 124
    • 0000156898 scopus 로고
    • Effects of prolonged ethanol intake: Production of fatty liver despite adequate diets
    • Lieber, C. S., Jones, D. P. & DeCarli, L. M. Effects of prolonged ethanol intake: production of fatty liver despite adequate diets. J. Clin. Invest. 44, 1009-1021 (1965).
    • (1965) J. Clin. Invest. , vol.44 , pp. 1009-1021
    • Lieber, C.S.1    Jones, D.P.2    DeCarli, L.M.3
  • 125
    • 3042995161 scopus 로고
    • Sequential production of fatty liver hepatitis and cirrhosis in sub-human primates fed ethanol with adequate diets
    • USA
    • Lieber, C. S., DeCarli, L. & Rubin, E. Sequential production of fatty liver, hepatitis, and cirrhosis in sub-human primates fed ethanol with adequate diets, Proc. Natl Acad. Sci. USA 72, 437-441 (1975).
    • (1975) Proc. Natl Acad. Sci. , vol.72 , pp. 437-441
    • Lieber, C.S.1    DeCarli, L.2    Rubin, E.3
  • 126
    • 0029125812 scopus 로고
    • Sequential acetaldehyde production lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease
    • Niemelä, O. et al. Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease. Hepatology 22, 1208-1214 (1995).
    • (1995) Hepatology , vol.22 , pp. 1208-1214
    • Niemelä, O.1
  • 127
    • 0027685791 scopus 로고
    • Centrilobular distribution of acetaldehyde and collagen in the ethanol-fed micropig
    • Halsted, C. H. et al. Centrilobular distribution of acetaldehyde and collagen in the ethanol-fed micropig. Hepatology 18, 954-960 (1993).
    • (1993) Hepatology , vol.18 , pp. 954-960
    • Halsted, C.H.1
  • 128
    • 0032930763 scopus 로고    scopus 로고
    • Effect of chronic coadministration of endotoxin and ethanol on rat liver pathology and proinflammatory and anti-inflammatory cytokines
    • DOI 10.1002/hep.510290508
    • Järveläinen, H. A., Fang, C., Ingelman-Sundberg, M. & Lindros K. O. Effect of chronic coadministration of endotoxin and ethanol on rat liver pathology and proinflammatory and anti-inflammatory cytokines. Hepatology 29, 1503-1510 (1999). (Pubitemid 29211053)
    • (1999) Hepatology , vol.29 , Issue.5 , pp. 1503-1510
    • Jarvelainen, H.A.1
  • 129
    • 0023274569 scopus 로고
    • Alcohol-induced liver injury after jejunoileal bypass operation in rats
    • Bode, C., Gast, J., Zelder, O., Jerusalem, C. R. & Bode, J. C. Alcohol-induced liver injuries after jejunoileal bypass operation in rats. J. Hepatol. 5, 75-84 (1987). (Pubitemid 17119080)
    • (1987) Journal of Hepatology , vol.5 , Issue.1 , pp. 75-84
    • Bode, C.1    Gast, J.2    Zelder, O.3
  • 130
    • 34547411481 scopus 로고    scopus 로고
    • Multiple pathogenic factor-induced complications of cirrhosis in rats: A new model of hepatopulmonary syndrome with intestinal endotoxemia
    • Zhang, H. Y. et al. Multiple pathogenic factor-induced complications of cirrhosis in rats: a new model of hepatopulmonary syndrome with intestinal endotoxemia. World J. Gastroenterol. 13, 3500-3507 (2007).
    • (2007) World J. Gastroenterol. , vol.13 , pp. 3500-3507
    • Zhang, H.Y.1
  • 133
    • 0033802236 scopus 로고    scopus 로고
    • NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease
    • Kono, H. et al. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J. Clin. Invest. 106, 867-872 (2000).
    • (2000) J. Clin. Invest. , vol.106 , pp. 867-872
    • Kono, H.1
  • 134
    • 0029160569 scopus 로고
    • Experimental liver cirrhosis induced by alcohol and iron
    • Tsukamoto, H. et al. Experimental liver cirrhosis induced by alcohol and iron. J. Clin. Invest. 96, 620-630 (1995).
    • (1995) J. Clin. Invest. , vol.96 , pp. 620-630
    • Tsukamoto, H.1
  • 135
    • 12744267799 scopus 로고    scopus 로고
    • Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor α
    • Crabb, D. W., Galli, A., Fischer, M. & You, M. Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor α. Alcohol 34, 35-38 (2004).
    • (2004) Alcohol. , vol.34 , pp. 35-38
    • Crabb, D.W.1    Galli, A.2    Fischer, M.3    You, M.4
  • 136
    • 80052005701 scopus 로고    scopus 로고
    • Inflammation-associated IL-6/STAT3 activation ameliorates alcoholic and nonalcoholic fatty liver diseases in IL-10 deficient mice
    • doi:10.1002/hep.24517.
    • Miller, A. M. et al. Inflammation-associated IL-6/STAT3 activation ameliorates alcoholic and nonalcoholic fatty liver diseases in IL-10 deficient mice. Hepatology doi:10.1002/hep.24517.
    • Hepatology
    • Miller, A.M.1
  • 137
    • 0034967435 scopus 로고    scopus 로고
    • ICAM-1 is involved in the mechanism of alcohol-induced liver injury: Studies with knockout mice
    • Kono, H. et al. ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout mice. Am. J. Physiol. Gastrointest. Liver Physiol. 280, G1289-G1295 (2001).
    • (2001) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.280
    • Kono, H.1
  • 138
    • 9644290860 scopus 로고    scopus 로고
    • The role of AMP-activated protein kinase in the action of ethanol in the liver
    • DOI 10.1053/j.gastro.2004.09.049, PII S0016508504016282
    • You, M., Matsumoto, M., Pacold, C. M., Cho, W. K. & Crabb, D. W. The role of AMP-activated protein kinase in the action of ethanol in the liver. Gastroenterology 127, 1798-1808 (2004). (Pubitemid 39575858)
    • (2004) Gastroenterology , vol.127 , Issue.6 , pp. 1798-1808
    • You, M.1    Matsumoto, M.2    Pacold, C.M.3    Cho, W.K.4    Crabb, D.W.5
  • 139
    • 41349119138 scopus 로고    scopus 로고
    • Nuclear factor-eythroid 2-related factor 2 prevents alcohol-induced fulminant liver injury
    • Lamlé, J. et al. Nuclear factor-eythroid 2-related factor 2 prevents alcohol-induced fulminant liver injury. Gastroenterology 134, 1159-1168 (2008).
    • (2008) Gastroenterology , vol.134 , pp. 1159-1168
    • Lamlé, J.1
  • 140
    • 0036298103 scopus 로고    scopus 로고
    • Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage
    • DOI 10.1053/jhep.2002.33720
    • Morgan, K., French, S. W. & Morgan, T. R. Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage. Hepatology 36, 122-134 (2002). (Pubitemid 34700769)
    • (2002) Hepatology , vol.36 , Issue.1 , pp. 122-134
    • Morgan, K.1    French, S.W.2    Morgan, T.R.3
  • 141
    • 77953514006 scopus 로고    scopus 로고
    • NFkB cytokines TLR 3 and 7 expression in human end-stage HCV and alcoholic liver disease
    • Stärkel, P., De Saeger, C., Strain, A. J., Leclercq, I. & Horsmans, Y. NFkB, cytokines, TLR 3 and 7 expression in human end-stage HCV and alcoholic liver disease. Eur. J. Clin. Invest. 40, 575-584 (2010).
    • (2010) Eur. J. Clin. Invest. , vol.40 , pp. 575-584
    • Stärkel, P.1    De Saeger, C.2    Strain, A.J.3    Leclercq, I.4    Horsmans, Y.5
  • 142
    • 61949356502 scopus 로고    scopus 로고
    • The interleukin-17 pathway is involved in human alcoholic liver disease
    • Lemmers, A. et al. The interleukin-17 pathway is involved in human alcoholic liver disease. Hepatology 49, 646-657 (2009).
    • (2009) Hepatology , vol.49 , pp. 646-657
    • Lemmers, A.1
  • 143
    • 80052433725 scopus 로고    scopus 로고
    • Proteomic analysis identifies P90RSK as a novel therapeutic target in patients with alcoholic hepatitis
    • Morales-Ibanez, O. et al. Proteomic analysis identifies P90RSK as a novel therapeutic target in patients with alcoholic hepatitis. J. Hepatol. 54 (Suppl. 1), S9 (2011).
    • (2011) J. Hepatol. , vol.54 , Issue.1
    • Morales-Ibanez, O.1
  • 146
    • 77952549747 scopus 로고    scopus 로고
    • Harmful effect of adipose tissue on liver lesions in patients with alcoholic liver disease
    • Naveau, S. et al. Harmful effect of adipose tissue on liver lesions in patients with alcoholic liver disease. J. Hepatol. 52, 895-902 (2010).
    • (2010) J. Hepatol. , vol.52 , pp. 895-902
    • Naveau, S.1


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