Stellate cell activation in alcoholic fibrosis - An overview

Alcoholism: Clinical and Experimental Research

Volumn 23, Issue 5, 1999, Pages 904-910

  Friedman, Scott L ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Alcohol; Cirrhosis; Extracellular Matrix; Hepatic Fibrosis; Stellate Cells

Indexed keywords

ACETALDEHYDE; ALCOHOL; CYTOKINE; LIPID PEROXIDE; MATRIX PROTEIN; RETINOL;

ALCOHOL CONSUMPTION; ALCOHOL LIVER DISEASE; CELL ACTIVATION; CELL MIGRATION; CELL PROLIFERATION; CONFERENCE PAPER; EXTRACELLULAR MATRIX; FIBROGENESIS; HUMAN; KUPFFER CELL; LIVER FIBROSIS; LIVER INJURY; LIVER ISCHEMIA; MESENCHYME CELL; PRIORITY JOURNAL; STELLATE CELL;

EID: 0032989347     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1999.tb04201.x     Document Type: Conference Paper

References (76)

1. Vyalov SL, Gabbiani G, Kapanci Y (1993) Rat alveolar myofibroblasts acquire alpha-smooth muscle actin expression during bleomycin-induced pulmonary fibrosis. Am J Pathol 143:1754-1765.
2. Border WA (1994) Transforming growth factor-beta and the pathogenesis of glomerular diseases. Curr Opin Nephrol Hypertens 3:54-58.
3. Gressner AM, Bachem MG (1995) Molecular mechanisms of liver fibrogenesis - A homage to the role of activated fat-storing cells. Digestion 56:335-346.
4. Rojkind M, Giambrone MA, Biempica L (1979) Collagen types in normal and cirrhotic liver. Gastroenterology 76:710-719.
5. Van Waes L, Lieber CS (1977) Early perivenular sclerosis in alcoholic fatty liver: An index of progressive liver injury. Gastroenterology 73:646-650.
6. Reeves HL, Burt AD, Wood S, Day CP (1996) Hepatic stellate cell activation occurs in the absence of hepatitis in alcoholic liver disease and correlates with the severity of steatosis. J Hepatol 25:677-683.
7. Blomhoff R, Wake K (1991) Perisinusoidal stellate cells of the liver: Important roles in retinol metabolism and fibrosis. FASEB J 5:271-277.
8. Okuno M, Moriwaki H, Imai S, Muto Y, Kawada N, Suzuki Y, Kojima S (1997) Retinoids exacerbate rat liver fibrosis by inducing the activation of latent TGF-beta in liver stellate cells (see comments). Hepatology 26:913-921.
9. Okuno M, Sato T, Kitamoto T, Imai S, Nagase S, Suzuki Y, Yoshimuri H, Moriwaki H, Masushige S, Muto Y, Friedman SL, Kato S, Kojima S (1999) Increased 9,13-di-cis-retinoic acid in rat hepatic fibrosis: A potential link between retinoid loss and TGF-beta mediated fibrogenesis via RARa activation. J Hepatology, in press.
10. Jarnagin WR, Rockey DC, Koteliansky VE, Wang SS, Bissell DM (1994) Expression of variant fibronectins in wound healing: Cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis. J Cell Biol 127:2037-2048.
11. Paradis V, Kollinger M, Fabre M, Holstege A, Poynard T, Bedossa P (1997) In situ detection of lipid peroxidation by-products in chronic liver diseases. Hepatology 26:135-142.
12. Paradis V, Mathurin P, Kollinger M, Imbert-Bismut F, Charlotte F, Piton A, Opolon P, Holstege A, Poynard T, Bedossa P (1997) In situ detection of lipid peroxidation in chronic hepatitis C: Correlation with pathological features. J Clin Pathol 50:401-406.
13. Leo MA, Rosman AS, Lieber CS (1993) Differential depletion of carotenoids and tocopherol in liver disease. Hepatology 17:977-986.
14. Svegliati Baroni G, D'Ambrosio L, Ferretti G, Casini A, Di Sario A, Salzano R, Ridolfi F, Saccomanno S, Jezequel AM, Benedetti A (1998) Fibrogenic effect of oxidative stress on rat hepatic stellate cells. Hepatology 27:720-726.
15. Maher JJ, Tzagarakis C, Gimenez A (1994) Malondialdehyde stimulates collagen production by hepatic lipocytes only upon activation in primary culture. Alcohol Alcohol 29:605-610.
16. Maher JJ, Neuschwander-Tetri BA (1997) Manipulation of glutathione stores in rat hepatic stellate cells does not alter collagen synthesis. Hepatology 26:618-623.
17. Hines JE, Johnson SJ, Burt AD (1993) In vivo responses of macrophages and perisinusoidal cells to cholestatic liver injury. Am J Pathol 142:511-518.
18. Lalazar A, Wong L, Yamasaki G, Friedman SL (1997) Early genes induced in hepatic stellate cells during wound healing. Gene 195:235-243.
19. Koritschoner NP, Bocco JL, Panzetta-Dutari GM, Dumur CI, Flury A, Patrito LC (1997) A novel human zinc finger protein that interacts with the core promoter element of a TATA box-less gene. J Biol Chem 272:9573-9580.
20. Ratziu V, Lalazar A, Wong L, Dang Q, Collins C, Shaulian E, Jensen S, Friedman SL (1998) Zf9, a Kruppel-like transcription factor upregulated in vivo during early hepatic fibrosis. Proc Natl Acad Sci USA 95:9500-9505.
21. Pinzani M, Milani S, Grappone C, Weber FJ, Gentilini P, Abboud HE (1994) Expression of platelet-derived growth factor in a model of acute liver injury. Hepatology 19:701-707.
22. Wong L, Yamasaki G, Johnson RJ, Friedman SL (1994) Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture. J Clin Invest 94:1563-1569.
23. Rockey DC, Fouassier L, Chung JJ, Carayon A, Vallee P, Rey C, Housset C (1998) Cellular localization of endothelin-1 and increased production in liver injury in the rat: Potential for autocrine and paracrine effects on stellate cells. Hepatology 27:472-480.
24. Pinzani M, Milani S, De Franco R, Grappone C, Caligiuri A, Gentilini A, Tosti-Guerra C, Maggi M, Failli P, Ruocco C, Gentilini P (1996) Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells. Gastroenterology 110: 534-548.
25. Kawada N, Kuroki T, Kobayashi K, Inoue M, Kaneda K, Decker K (1995) Action of endothelins on hepatic stellate cells. J Gastroenterol 30:731-738.
26. Housset C, Rockey DC, Bissell DM (1993) Endothelin receptors in rat liver: Lipocytes as a contractile target for endothelin 1. Proc Natl Acad Sci USA 90:9266-9270.
27. Mallat A, Preaux AM, Serradeil-Le Gal C, Raufaste D, Gallois C, Brenner DA, Bradham C, Maclouf J, Iourgenko V, Fouassier L, Dhumeaux D, Mavier P, Lotersztajn S (1996) Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: A cyclic adenosine monophosphate-mediated pathway. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. J Clin Invest 98:2771-2778.
28. Marra F, Grandaliano G, Valente AJ, Abboud HE (1995) Thrombin stimulates proliferation of liver fat-storing cells and expression of monocyte chemotactic protein-1: Potential role in liver injury. Hepatology 22:780-787.
29. Rosenbaum J, Blazejewski S, Preaux AM, Mallat A, Dhumeaux D, Mavier P (1995) Fibroblast growth factor 2 and transforming growth factor beta 1 interactions in human liver myofibroblasts. Gastroenterology 109:1986-1996.
30. Skrtic S, Wallenius V, Ekberg S, Brenzel A, Gressner AM, Jansson JO (1997) Insulin-like growth factors stimulate expression of hepatocyte growth factor but not transforming growth factor beta 1 in cultured hepatic stellate cells. Endocrinology 138:4683-4689.
31. Pinzani M, Abboud HE, Aron DC (1990) Secretion of insulin-like growth factor-I and binding proteins by rat liver fat-storing cells: Regulatory role of platelet-derived growth factor. Endocrinology 127:2343-2349.
32. Brenzel A, Gressner AM (1996) Characterization of insulin-like growth factor (IGF)-I-receptor binding sites during in vitro transformation of rat hepatic stellate cells to myofibroblasts. Eur J Clin Chem Clin Biochem 34:401-409.
33. Zindy F, Lamas E, Schmidt S, Kirn A, Brechot C (1992) Expression of insulin-like growth factor II (IGF-II) and IGF-II, IGF-I and insulin receptors mRNAs in isolated non-parenchymal rat liver cells. J Hepatol 14:30-34.
34. Pinzani M, Marra F, Carloni V (1998) Signal transduction in hepatic stellate cells. Liver 18:2-13.
35. Friedman SL (1996) Hepatic stellate cells. Progr Liver Dis 14:101-130.
36. Marra F, DeFranco R, Grappone C, Milani S, Pinzani M, Pellegrini G, Laffi G, Gentilini P (1998) Expression of the thrombin receptor in human liver: Up-regulation during acute and chronic injury. Hepatology 27:462-471.
37. Ankoma-Sey V, Matli M, Chang KB, Lalazar A, Donner DB, Wong L, Warren RS, Friedman SL (1998) Coordinated induction of VEGF receptors in mesenchymal cell types during rat hepatic wound healing. Oncogene 17:115-121.
38. Rockey DC (1997) The cellular pathogenesis of portal hypertension: Stellate cell contractility, endothelin, and nitric oxide. Hepatology 25:2-5.
39. Castilla A, Prieto J, Fausto N (1991) Transforming growth factors beta 1 and alpha in chronic liver disease. Effects of interferon alfa therapy (see comments). N Engl J Med 324:933-940.
40. Bissell DM, Wang SS, Jarnagin WR, Roll FJ (1995) Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation. J Clin Invest 96:447-455.
41. Ratziu R, Kim SJ, Kim YS, Dang S, Wong L, Friedman SL (1997) A key role for Zf9 in hepatic fibrosis via its transcriptional activation of TGFbetal and types I and II TGFbeta receptors genes in rat stellate cells. Hepatology 26:185A.
42. Gong W, Gressner AM, Michel K, Roth S (1998) Isoforms and splice variant of transforming growth factor beta-binding protein in rat hepatic stellate cells. Gastroenterology 114:352-363.
43. Michel K, Roth S, Trautwein C, Gong W, Flemming P, Gressner AM (1998) Analysis of the expression pattern of the latent transforming growth factor beta binding protein isoforms in normal and diseased human liver reveals a new splice variant missing the proteinase-sensitive hinge region. Hepatology 27:1592-1599.
44. Friedman SL, Yamasaki G, Wong L (1994) Modulation of transforming growth factor beta receptors of rat lipocytes during the hepatic wound healing response. Enhanced binding and reduced gene expression accompany cellular activation in culture and in vivo. J Biol Chem 269: 10551-10558.
45. Reimann T, Hempel U, Krautwald S, Axmann A, Scheibe R, Seidel D, Wenzel KW (1997) Transforming growth factor-beta 1 induces activation of Ras, Raf-1, MEK and MAPK in rat hepatic stellate cells. FEBS Lett 403:57-60.
46. Milani S, Herbst H, Schuppan D, Grappone C, Pellegrini G, Pinzani M, Casini A, Calabro A, Ciancio G, Stefanini F, et al (1994) Differential expression of matrix-metalloproteinase-1 and -2 genes in normal and fibrotic human liver. Am J Pathol 144:528-537.
47. Arthur MJ, Stanley A, Iredale JP, Rafferty JA, Hembry RM, Friedman SL (1992) Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes. Analysis of gene expression, protein synthesis and proteinase activity. Biochem J 287:701-707.
48. Milani S, Herbst H, Schuppan D, Grappone C, Pellegrini G, Pinzani M, Casini A, Calabro A, Ciancio G, Stefanini F, et al (1994) Differential expression of matrix-metalloproteinase-1 and -2 genes in normal and fibrotic human liver. Am J Pathol 144:528-537.
49. Vyas SK, Leyland H, Gentry J, Arthur MJ (1995) Rat hepatic lipocytes synthesize and secrete transin (stromelysin) in early primary culture. Gastroenterology 109:889-898.
50. Poulos JE, Weber JD, Bellezzo JM, Di Bisceglie AM, Britton RS, Bacon BR, Baldassare JJ (1997) Fibronectin and cytokines increase JNK, ERK, AP-1 activity, and transin gene expression in rat hepatic stellate cells. Am J Physiol 273:G804-G811.
51. Herbst H, Wege T, Milani S, Pellegrini G, Orzechowski HD, Bechstein WO, Neuhaus P, Gressner AM, Schuppan D (1997) Tissue inhibitor of metalloproteinase-1 and -2 RNA expression in rat and human liver fibrosis. Am J Pathol 150:1647-1659.
52. Iredale JP, Goddard S, Murphy G, Benyon RC, Arthur MJ (1995) Tissue inhibitor of metalloproteinase-I and interstitial collagenase expression in autoimmune chronic active hepatitis and activated human hepatic lipocytes. Clin Sci (Colch) 89:75-81.
53. Theret N, Musso O, L'Helgoualc'h A, Clement B (1997) Activation of matrix metalloproteinase-2 from hepatic stellate cells requires interactions with hepatocytes. Am J Pathol 150:51-58.
54. Winwood PJ, Schuppan D, Iredale JP, Kawser CA, Docherty AJ, Arthur MJ (1995) Kupffer cell-derived 95-kd type IV collagenase/gelatinase B: Characterization and expression in cultured cells. Hepatology 22:304-315.
55. Marra F, Gentilini A, Pinzani M, Choudhury GG, Parola M, Herbst H, Dianzani MU, Laffi G, Abboud HE, Gentilini P (1997) Phosphatidylinositol 3-kinase is required for platelet-derived growth factor's actions on hepatic stellate cells (see comments). Gastroenterology 112:1297-1306.
56. Marra F, Romanelli RG, Pastacaldi S, Failli P, Pinzani M, Laffi G, Gentilini P (1998) Monocyte chemotactic protein-1 stimulates hepatic stellate cell migration. J Hepatol 28:57.
57. Roth-Eichorn S, Kuhl K, Gressner AM (1998) Subcellular localization of (latent) TGFbeta and latent TGFbeta binding protein (LTBP-1) in rat hepatocytes and hepatic stellate cells. Hepatology 28:1588-1596.
58. Marra F, DeFranco R, Grappone C, Milani S, Pastacaldi S, Pinzani M, Romanelli RG, Laffi G, Gentilini P (1998) Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: Correlation with monocyte infiltration. Am J Pathol 152:423-430.
59. Marra F, Valente AJ, Pinzani M, Abboud HE (1993) Cultured human liver fat-storing cells produce monocyte chemotactic protein-1. Regulation by proinflammatory cytokines. J Clin Invest 92:1674-1680.
60. Marra F, Pastacaldi S, Romanelli RG, Pinzani M, Ticali P, Carloni V, Laffi G, Gentilini P (1997) Integrin-mediated stimulation of monocyte chemotactic protein-1 expression. FEBS Lett 414:221-225.
61. Sprenger H, Kaufmann A, Garn H, Lahme B, Gemsa D, Gressner AM (1997) Induction of neutrophil-attracting chemokines in transforming rat hepatic stellate cells. Gastroenterology 113:277-285.
62. van Hogezand RA, Verspaget HW (1997) New therapies for inflammatory bowel disease: An update on chimeric anti-TNF alpha antibodies and IL-10 therapy. Scand J Gastroenterol 223(Suppl.):105-107.
63. Wang SC, Tsukamoto H, Rippe RA, Schrum L, Ohata M (1998) Expression of interleukin-10 by in vitro and in vivo activated hepatic stellate cells. J Biol Chem 273:302-308.
64. Thompson KC, Trowern A, Fowell A, Marathe M, Haycock K, Arthur MJP, Sheron N (1998) Primary rat and mouse hepatic stellate cells express the macrophage inhibitor cytokine interleukin 10 during the course of activation in vitro. Hepatology 28:1518-1524.
65. Napoli J, Bishop GA, McGuinness PH, Painter DM, McCaughan GW (1996) Progressive liver injury in chronic hepatitis C infection correlates with increased intrahepatic expression of Th1-associated cytokines. Hepatology 24:759-765.
66. Thurman RG, Ji S, Lemasters JJ (1984) Alcohol-induced liver injury. The role of oxygen. Recent Dev Alcohol 2:103-117.
67. Ji S, Lemasters JJ, Christenson V, Thurman RG (1982) Periportal and pericentral pyridine nucleotide fluorescence from the surface of the perfused liver: Evaluation of the hypothesis that chronic treatment with ethanol produces pericentral hypoxia. Proc Natl Acad Sci USA 79:5415-5419.
68. Semenza GL (1998) Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis. J Lab Clin Med 131:207-214.
69. Guillemin K, Krasnow MA (1997) The hypoxic response: Huffing and HIFing. Cell 89:9-12.
70. Bedossa P, Houglum K, Trautwein C, Holstege A, Chojkier M (1994) Stimulation of collagen alpha 1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: A link to tissue fibrosis? Hepatology 19:1262-1271.
71. Shiratori Y, Ichida T, Kawase T, Wisse E (1986) Effect of acetaldehyde on collagen synthesis by fat-storing cells isolated from rats treated with carbon tetrachloride. Liver 6:246-251.
72. Maher JJ, Zia S, Tzagarakis C (1994) Acetaldehyde-induced stimulation of collagen synthesis and gene expression is dependent on conditions of cell culture: studies with rat lipocytes and fibroblasts. Alcohol Clin Exp Res 18:403-409.
73. Friedman SL (1990) Acetaldehyde and alcoholic fibrogenesis: Fuel to the fire, but not the spark. Hepatology 12:609-612.
74. Niemela O, Parkkila S, Yla-Herttuala S, Villanueva J, Ruebner B, Halsted CH (1995) Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease. Hepatology 22:1208-1214.
75. Shi Z, Wakil AE, Rockey DC (1997) Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses. Proc Natl Acad Sci USA 94:10663-10668.
76. Olaso E, Friedman SL (1998) Molecular regulation of hepatic fibrogenesis. J Hepatol 29:836-847.