Serum leptin in patients with alcoholic liver disease

Alcoholism: Clinical and Experimental Research

Volumn 30, Issue 8, 2006, Pages 1422-1428

  Naveau, Sylvie ^a,b   Perlemuter, Gabriel ^a   Chaillet, Muriel ^c   Raynard, Bruno ^a   Balian, Axel ^a   Beuzen, Fabienne ^a   Portier, Alain ^b   Galanaud, Pierre ^b   Emilie, Dominique ^b   Chaput, Jean Claude ^a  

^a HÔPITAL ANTOINE BÉCLÈRE   (France)

^b INSERM   (France)

^c HÔPITAL SAINT ANTOINE   (France)

Author keywords

Alcohol Cirrhosis; Body Mass Index; Overweight; Serum Leptin; Steatosis

Indexed keywords

LEPTIN;

ADULT; AGE DISTRIBUTION; ALCOHOL CONSUMPTION; ALCOHOL LIVER DISEASE; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; FATTY LIVER; FEMALE; HUMAN; LIVER CIRRHOSIS; LIVER INJURY; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; PRIORITY JOURNAL; RADIOIMMUNOASSAY; STATISTICAL ANALYSIS; STATISTICAL MODEL; STATISTICAL SIGNIFICANCE;

ADULT; CHI-SQUARE DISTRIBUTION; FEMALE; HUMANS; LEPTIN; LIVER DISEASES, ALCOHOLIC; LOGISTIC MODELS; MALE; MIDDLE AGED; OVERWEIGHT; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 33746360865     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2006.00170.x     Document Type: Article

References (34)

1. Angulo P, Alba LM, Perovic LM, Adams LA, Lindor KD, Jensen MD (2004) Leptin, insulin resistance, and liver fibrosis in human nonalcoholic fatty liver disease. J Hepatol 41:943-949.
2. Barzilai N, Wang J, Massilon D, Vuguin P, Hawkins M, Rossetti L (1997) Leptin selectively decreases visceral adiposity and enhances insulin action. J Clin Invest 100:3105-3110.
3. Caldwell SH, Crespo DM (2004) The spectrum expanded: cryptogenic cirrhosis and the natural history of non-alcoholic fatty liver disease. J Hepatol 40:578-584.
4. Chalasani N, Crabb DW, Cummings OW, Kwo PY, Asghar A, Pandya PK, Considine RV (2003) Does leptin play a role in the pathogenesis of human nonalcoholic steatohepatitis? Am J Gastroenterol 98:2771-2776.
5. Chitturi S, Farrell G, Frost L, Kriketos A, Lin R, Fung C, Liddle C, Samarasinghe D, George J (2002) Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity? Hepatology 36:403-409.
6. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334:292-295.
7. Day CP, James OF (1998) Hepatic steatosis: innocent bystander or guilty party? Hepatology 27:1463-1466.
8. Friedman JM (1997) Leptin, leptin receptors and the control of body weight. Eur J Med Res 2:7-11.
9. Friedman JM, Halaas JL (1998) Leptin and the regulation of body weights in mammals. Nature 395:763-770.
10. Henriksen JH, Holst JJ, Moller S, Brinch K, Bendtsen F (1999) Increased circulating leptin in alcoholic cirrhosis: relation to release and disposal. Hepatology 29:1818-1824.
11. Hintze JL (2004) NCSS 2004 User's Guide-I and User's Guide-IV. Number Cruncher Statistical Systems, Kaysville, UT.
12. Ikejima K, Honda H, Yoshikawa M, Hirose M, Kitamura T, Takei Y, Sato N (2001) Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals. Hepatology 34:288-297.
13. Ikejima K, Takei Y, Honda H, Hirose M, Yoshikawa M, Zhang YJ, Lang T, Fukuda T, Yamashina S, Kitamura T, Sato N (2002) Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat. Gastroenterology 122:1399-1410.
14. Javor ED, Ghany MG, Cochran EK, Oral EA, DePaoli AM, Premkumar A, Kleiner DE, Gorden P (2005) Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy. Hepatology 41:753-760.
15. Kennedy A, Gettys TW, Watson P, Wallace P, Ganaway E, Pan Q, Garvey WT (1997) The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity and energy expendure. J Clin Endocrinol Metab 82:1293-1300.
16. Leclercq IA, Farrel GC, Schriemer R, Robertson GH (2002) Leptin is essential for the hepatic fibrogenic response to chronic liver injury. J Hepatol 37:206-213.
17. Lin HZ, Yang SQ, Zrldin G, Diehl AM (1998) Chronic ethanol consumption induces the production of tumor necrosis factor-alpha and related cytokines in liver and adipose tissue. Alcohol Clin Exp Res 22 (Suppl): 231S-237S.
18. Maffei N, Halaas S, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM (1995) Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight reduced subjects. Nat Med 1:1155-1160.
19. Naveau S, Chemla P, Chaput JC (2000) Validité relative d'un questionnaire évaluant la consommation d'alcool d'un groupe de buveurs hospitalisés. Cah Nutr Diet 35:121-125.
20. Naveau S, Giraud V, Borotto E, Aubert A, Capron F, Chaput JC (1997) Excess weight risk factor for alcoholic liver disease. Hepatology 25:108-111.
21. Nosadini R, Avogaro A, Mollo F, Marescotti C, Tiengo A, Duner E, Merkel C, Gatta A, Zuin R, de Kreutzenberg S (1984) Carbohydrate and lipid metabolism in cirrhosis. Evidence that hepatic uptake of gluconeogenic precursors and of free fatty acids depends on effective hepatic flow. J Clin Endocrinol Metab 58:1125-1132.
22. Potter JJ, Mezey E (2001) Leptin deficiency reduces hepatic fibrosis in mice infected with schistosoma mansoni. Hepatology 34 Part2: 406A.
23. Potter JJ, Womack L, Mezey E, Anania FA (1998) Transdifferentiation of rat hepatic stellate cells results in leptin expression. Biochem Biophys Res Commun 244:178-182.
24. Purohit V, Russo D, Coates PM (2004) Role of fatty liver, dietary fatty acid supplements, and obesity in the progression of alcoholic liver disease: introduction and summary of the symposium. Alcohol 34:3-8.
25. Raynard B, Balian A, Fallik D, Capron F, Bedossa P, Chaput JC, Naveau S (2002) Risk factors of fibrosis in alcohol-induced liver disease. Hepatology 35:635-638.
26. Roden M, Anderwald C, Furnsinn C, Waldhausl W, Lohninger A (2000) Effects of short-term leptin exposure on triglyceride deposition in rat liver. Hepatology 32:1045-1049.
27. Saxena NK, Ikeda K, Rockey DC, Friedman SL, Anania FA (2002) Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice. Hepatology 35:762-771.
28. Takaya K, Ogawa Y, Isse N, Okazaki T, Satoh N, Masuzaki H, Mori K, Tamura N, Hosoda K, Nakao K (1996) Molecular cloning of rat leptin receptor isoform complementary DNAs-identification of a missense mutation in Zucker fatty (fa/fa) rats. Biochem Biophys Res Commun 225:75-83.
29. Tietge UJ, Boker KH, Manns MP, Bahr MJ (2004) Elevated circulating adiponectin levels in liver cirrhosis are associated with reduced liver function and altered hepatic hemodynamics. Am J Physiol Endocrinol Metab 287:E82-E89.
30. Unger RH (2002) Lipotoxic diseases. Annu Rev Med 53:319-336.
31. Unger RH, Orci L (2001) Diseases of liporegulation: new perspective on obesity and related disorders. FASEB J 15:312-321.
32. Unger RH, Zhou YT, Orci L (1999) Regulation of fatty acid homeostasis in cells: novel role of leptin. Proc Natl Acad Sci U S A 96:2327-2332.
33. Wyatt J, Baker H, Prasad P, Gong YY, Millson C (2004) Steatosis and fibrosis in patients with chronic hepatitis C. J Clin Pathol 57:402-406.
34. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432.