Intragastric ethanol infusion model for cellular and molecular studies of alcoholic liver disease

Journal of Biomedical Science

Volumn 8, Issue 1, 2001, Pages 20-27

  French, S W ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

Apoptosis; CYP2E1; Cytokine; Hypoxia; Neoantigens; NF B; Oxidative stress; Oxidized proteins; Proteasome

Indexed keywords

ALCOHOL; ANTIGEN; ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEASOME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN;

ALCOHOL BLOOD LEVEL; ALCOHOL LIVER DISEASE; ANIMAL MODEL; AUTOIMMUNITY; KUPFFER CELL; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; RAT; REVIEW; STEADY STATE;

ANIMALS; DISEASE MODELS, ANIMAL; ETHANOL; INFUSIONS, PARENTERAL; LIVER DISEASES, ALCOHOLIC; RATS;

EID: 0035138847     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1159/000054009     Document Type: Review

References (62)

1. Role of cytochrome P450 2E1-dependent formation of hydroxyethyl free radical in the development of liver damage in rats intragastrically fed with ethanol
2. Hydroxyethyl radicals in ethanol hepatotoxicity
3. Pulsatile blood alcohol and CYP2E1 induction during chronic alcohol infusion in rats
4. Identification of a ubiquitination-target/substrate-interaction domain of cytochrome P-450 (CYP)2E1
5. Toxicity of ethanol in HEPG2 cells expressing CYP2E1
6. Peptidase activities of the multicatalytic proteasome in rat liver after voluntary and intragastric ethanol administration
7. Fibrogenesis. I. New insights into hepatic stellate cell activation: The simple becomes complex
8. Kupffer cell-derived prostaglandin E2 is involved in alcohol-induced fat accumulation in rat liver
9. Effects of chronic ethanol administration on rat liver proteasome activities
10. Hypoxic-reperfusion liver injury in an alcohol binge drinking rat model
11. Mechanisms of alcoholic liver injury
12. The ubiquitin-proteasome 26s pathway in liver cell protein turnover. Effect of ethanol and drugs
13. Centrilobular liver necrosis induced by hypoxia in chronic ethanol-fed rats
14. Effect of ethanol on cytochrome P450 2E1 (CYP2E1) lipid peroxidation and serum protein adduct formation in relation to liver pathology pathogenesis
15. Pathogenesis of experimental liver disease in the rat
16. Ethanol-induced hepatic fibrosis in the rat. Role of the amount of dietary fat
17. Role of the Ito cell in liver parenchymal fibrosis in rats fed alcohol and a high fat-low protein diet
18. Lipid peroxidation, CYP2E1, and fatty acid metabolism in alcoholic liver disease
19. Lipid peroxidation, CYP2E1, and fatty acid metabolism in alcoholic liver disease
20. The role of CYP2E1 induction by ethanol in the pathogenesis of alcoholic liver disease as determined by inhibitors of CYP2E1 transcription and post translational modulating factors
21. Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole
22. Role of CYP2E1 in the pathogenesis of alcoholic liver disease: Modifications by cAMP and ubiquitin-proteasome pathway
23. CYP2E1 is not involved in early alcohol-induced liver injury
24. Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite induction of CYP2E1
25. Cellular signals in alcohol-induced liver injury: A review
26. Mechanism of the cyclic pattern of urinary ethanol levels in rats fed ethanol. The role of the hypothalamic-pituitary-thyroid axis
27. Acetaldehyde prevents nuclear factor-kappa B activation and hepatic inflammation in ethanol-fed rats
28. Autoantibodies against cytochrome P450 2E1 and P-4503A in alcoholics
29. Hepatic adenine nucleotide metabolism measured in vivo in rats fed ethanol and a high fat-low protein diet: Relation to the pathogenesis of alcohol-induced liver injury in the rat
30. Hepatic adenosine in rats fed ethanol: Effect of acute hyperoxia or hypoxia
31. Role of cytochrome P450 2E1 in alcoholic liver disease pathogenesis
32. Modulation of experimental alcoholic liver disease by cytochrome P450 2E1 inhibitors
33. Fatty acid composition in hepatic lipids in rats fed ethanol and high fat diet intragastrically. Effect of CYP2E1 inhibitors
34. Fish oil, alcohol and liver pathology: Role of cytochrome P450 2E1
35. Dietary linoleic acid is required for development of experimental alcoholic liver disease
36. Activation of nuclear factor kappa B and cytokine imbalance in experimental alcoholic liver disease in the rat
37. Effect of chronic carbon monoxide exposure on progression of experimental alcoholic liver injury
38. Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver disease
39. Severity of liver injury in experimental alcoholic liver disease: Correlation with plasma endotoxin, prostaglandin E2, leukotriene B4 and thromboxane B2
40. Beef fat prevents alcoholic liver disease in the rat
41. Relationship between fatty liver and subsequent development of necrosis, inflammation and fibrosis in experimental alcoholic liver disease
42. Dietary saturated fatty acids downregulate cyclooxygenase-2 and tumor necrosis factor α and reverse fibrosis in alcohol-induced liver disease in the rat
43. Changes in microsomal phospholipases and arachidonic acid in experimental alcoholic liver injury: Relationship to cytochrome P-450 2E1 induction and conjugated diene formation
44. 2 and cyclooxygenase-2
45. An intragastric pair-feeding model for ethanol administration
46. Role of endotoxin in the hypermetabolic state after acute ethanol exposure
47. Effect of chronic ethanol feeding on lipid peroxidation and protein oxidation in relation to liver pathology
48. Ethanol-induced oxidative liver protein alterations
49. 31P nuclear magnetic resonance study in rats
50. Effects of dietary fat composition on activities of the microsomal ethanol oxidizing system and ethanol-inducible cytochrome P450 in liver of rats chronically fed ethanol
51. Effect of dietary fat on Ito cell activation by chronic ethanol intake: A long term serial morphometric study on alcohol-fed and control rats
52. Antibodies to tumor necrosis factor alpha attenuates hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat
53. Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet
54. Cyclic pattern of blood alcohol levels during continuous intragastric ethanol infusion in rats
55. Insight into the pathogenesis of alcoholic liver necrosis and fibrosis: Use of Tsukamoto-French rat model of alcoholic liver disease
56. Experimental liver cirrhosis induced by alcohol and iron
57. Iron primes hepatic macrophages for NF-B activation in alcoholic liver injury
58. Ethanol-induced liver fibrosis in rats fed high fat diet
59. Incomplete compensation of enhanced hepatic oxygen consumption in rats with alcoholic centrilobular liver necrosis
60. Expression of peroxisome proliferator-activated receptor gene is decreased in experimental alcoholic liver disease
61. Essential role of tumor necrosis factor in alcohol-induced liver injury in mice
62. Alcohol induces Mallory body formation in drug primed mice