Inflammation: Cytokines and RNA-based regulation

Wiley Interdisciplinary Reviews: RNA

Volumn 1, Issue 1, 2010, Pages 60-80

  Stumpo, Deborah J ^a   Lai, Wi S ^a   Blackshear, Perry J ^a,b  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; CYTOKINE; HU ANTIGEN; MESSENGER RNA; RNA; RNA BINDING PROTEIN; T LYMPHOCYTE ANTIGEN; TRISTETRAPROLIN; URIDINE;

3' UNTRANSLATED REGION; BIOSYNTHESIS; CYTOKINE PRODUCTION; HUMAN; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; RNA TRANSCRIPTION; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; REGULATORY RNA SEQUENCE; RNA PROCESSING;

3' UNTRANSLATED REGIONS; ANIMALS; CYTOKINES; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; REGULATORY SEQUENCES, RIBONUCLEIC ACID; RNA; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA-BINDING PROTEINS;

EID: 80052215872     PISSN: 17577004     EISSN: 17577012     Source Type: Journal    
DOI: 10.1002/wrna.1     Document Type: Review

References (195)

1. Ryan GB, Majno G. Acute inflammation: A review. Am J Pathol 1977, 86: 183-276.
2. Serhan CN, Brain SD, Buckley CD, Gilroy DW, Haslett C, et al. Resolution of inflammation: state of the art, definitions and terms. FASEB J 2007, 21: 325-332.
3. Chin AC, Parkos CA. Pathobiology of neutrophil transepithelial migration: implications in mediating epithelial injury. Annu Rev Pathol 2007, 2: 111-143.
4. Calder PC, Albers R, Antoine JM, Blum S, Bourdet-Sicard R, et al. Inflammatory disease processes and interactions with nutrition. Br J Nutr 2009, 101(suppl 1): S1-45.
5. Stramer BM, Mori R, Martin P. The inflammation-fibrosis link? A Jekyll and Hyde role for blood cells during wound repair. J Invest Dermatol 2007, 127: 1009-1017.
6. Hao S, Baltimore D. The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules. Nat Immunol 2009, 10: 281-288.
7. Stoecklin G, Anderson P. Posttranscriptional mechanisms regulating the inflammatory response. Adv Immunol 2006, 89: 1-37.
8. Katsanou V, Dimitriou M, Kontoyiannis DL. Post-transcriptional regulators in inflammation: exploring new avenues in biological therapeutics. Ernst Schering Found Symp Proc 2006, 4: 37-57.
9. Anderson P. Post-transcriptional control of cytokine production. Nat Immunol 2006, 4: 37-57.
10. Zhang T, Kruys V, Huez G, Gueydan C. AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors. Biochem Soc Trans 2002, 30: 952-958.
11. Saklatvala J, Dean J, Clark A. Control of the expression of inflammatory response genes. Biochem Soc Symp 2003, 70: 95-106.
12. Hollams EM, Giles KM, Thomson AM, Leedman PJ. MRNA stability and the control of gene expression: implications for human disease. Neurochem Res 2002, 27: 957-980.
13. Caput D, Beutler B, Hartog K, Thayer R, Brown-Shimer S, et al. Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators. Proc Natl Acad Sci U S A 1986, 83: 1670-1674.
14. Shaw G, Kamen R. A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 1986, 46: 659-667.
15. Vassalli P. The pathophysiology of tumor necrosis factors. Annu Rev Immunol 1992, 10: 411-452.
16. Taylor PC, Feldmann M. Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis. Nat Rev Rheumatol 2009, 5: 578-582.
17. Bradley JR. TNF-mediated inflammatory disease. J Pathol 2008, 214: 149-160.
18. Beutler B, Cerami A. The biology of cachectin/TNF-a primary mediator of the host response. Annu Rev Immunol 1989, 7: 625-655.
19. Keffer J, Probert L, Cazlaris H, Georgopoulos S, Kaslaris E, et al. Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J 1991, 10: 4025-4031.
20. Kontoyiannis D, Pasparakis M, Pizarro TT, Cominelli F, Kollias G. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 1999, 10: 387-398.
21. Han J, Brown T, Beutler B. Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level. J Exp Med 1990, 171: 465-475.
22. Kruys V, Kemmer K, Shakhov A, Jongeneel V, Beutler B. Constitutive activity of the tumor necrosis factor promoter is canceled by the 3' untranslated region in nonmacrophage cell lines; a trans-dominant factor overcomes this suppressive effect. Proc Natl Acad Sci U S A 1992, 89: 673-677.
23. Kruys V, Huez G. Translational control of cytokine expression by 3' UA-rich sequences. Biochimie 1994, 76: 862-866.
24. Chen CY, Shyu AB. AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem Sci 1995, 20: 465-470.
25. Bakheet T, Frevel M, Williams BR, Greer W, Khabar KS. ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins. Nucleic Acids Res 2001, 29: 246-254.
26. Bakheet T, Williams BR, Khabar KS. ARED 2.0: an update of AU-rich element mRNA database. Nucleic Acids Res 2003, 31: 421-423.
27. Bakheet T, Williams BR, Khabar KS. ARED 3.0: the large and diverse AU-rich transcriptome. Nucleic Acids Res 2006, 34: D111-D114.
28. Halees AS, El-Badrawi R, Khabar KS. ARED Organism: expansion of ARED reveals AU-rich element cluster variations between human and mouse. Nucleic Acids Res 2008, 36: D137-D140.
29. Ford LP, Wilusz J. An in vitro system using HeLa cytoplasmic extracts that reproduces regulated mRNA stability. Methods 1999, 17: 21-27.
30. Parker R, Sheth U. P bodies and the control of mRNA translation and degradation. Mol Cell 2007, 25: 635-646.
31. Garneau NL, Wilusz J, Wilusz CJ. The highways and byways of mRNA decay. Nat Rev Mol Cell Biol 2007, 8: 113-126.
32. Mukherjee D, Gao M, O'Connor JP, Raijmakers R, Pruijn G, et al. The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements. EMBO J 2002, 21: 165-174.
33. Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, et al. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell 2001, 107: 451-464.
34. Gao M, Wilusz CJ, Peltz SW, Wilusz J. A novel mRNA-decapping activity in HeLa cytoplasmic extracts is regulated by AU-rich elements. EMBO J 2001, 20: 1134-1143.
35. Anderson P, Kedersha N. Stress granules. Curr Biol 2009, 19: R397-R398.
36. Stoecklin G, Anderson P. In a tight spot: ARE-mRNAs at processing bodies. Genes Dev 2007, 21: 627-631.
37. Sheth U, Parker R. Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 2003, 300: 805-808.
38. Cougot N, Babajko S, Seraphin B. Cytoplasmic foci are sites of mRNA decay in human cells. J Cell Biol 2004, 165: 31-40.
39. Anderson P, Kedersha N. Stress granules: the Tao of RNA triage. Trends Biochem Sci 2008, 33: 141-150.
40. Anderson P, Kedersha N. RNA granules: post-transcriptional and epigenetic modulators of gene expression. Nat Rev Mol Cell Biol 2009, 10: 430-436.
41. Kedersha NL, Gupta M, Li W, Miller I, Anderson P. RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules. J Cell Biol 1999, 147: 1431-1442.
42. Anderson P, Kedersha N. RNA granules. J Cell Biol 2006, 172: 803-808.
43. Kedersha N, Cho MR, Li W, Yacono PW, Chen S, et al. Dynamic shuttling of TIA-1 accompanies the recruitment of mRNA to mammalian stress granules. J Cell Biol 2000, 151: 1257-1268.
44. Kedersha N, Stoecklin G, Ayodele M, Yacono P, Lykke-Andersen J, et al. Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J Cell Biol 2005, 169: 871-884.
45. Lykke-Andersen J, Wagner E. Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1. Genes Dev 2005, 19: 351-361.
46. Fenger-Gron M, Fillman C, Norrild B, Lykke-Andersen J. Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. Mol Cell 2005, 20: 905-915.
47. Hau HH, Walsh RJ, Ogilvie RL, Williams DA, Reilly CS, et al. Tristetraprolin recruits functional mRNA decay complexes to ARE sequences. J Cell Biochem 2007, 100: 1477-1492.
48. Barreau C, Paillard L, Osborne HB. AU-rich elements and associated factors: are there unifying principles? Nucleic Acids Res 2005, 33: 7138-7150.
49. Anant S, MacGinnitie AJ, Davidson NO. apobec-1, the catalytic subunit of the mammalian apolipoprotein B mRNA editing enzyme, is a novel RNA-binding protein. J Biol Chem 1995, 270: 14762-14767.
50. MacGinnitie AJ, Anant S, Davidson NO. Mutagenesis of apobec-1, the catalytic subunit of the mammalian apolipoprotein B mRNA editing enzyme, reveals distinct domains that mediate cytosine nucleoside deaminase, RNA binding, and RNA editing activity. J Biol Chem 1995, 270: 14768-14775.
51. Anant S, Davidson NO. An AU-rich sequence element (UUUN[A/U]U) downstream of the edited C in apolipoprotein B mRNA is a high-affinity binding site for Apobec-1: binding of Apobec-1 to this motif in the 3' untranslated region of c-myc increases mRNA stability. Mol Cell Biol 2000, 20: 1982-1992.
52. Anant S, Murmu N, Houchen CW, Mukhopadhyay D, Riehl TE, et al. Apobec-1 protects intestine from radiation injury through posttranscriptional regulation of cyclooxygenase-2 expression. Gastroenterology 2004, 127: 1139-1149.
53. Brewer G. An A + U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro. Mol Cell Biol 1991, 11: 2460-2466.
54. Loflin P, Chen CY, Shyu AB. Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element. Genes Dev 1999, 13: 1884-1897.
55. Raineri I, Wegmueller D, Gross B, Certa U, Moroni C. Roles of AUF1 isoforms, HuR and BRF1 in ARE-dependent mRNA turnover studied by RNA interference. Nucleic Acids Res 2004, 32: 1279-1288.
56. Lal A, Mazan-Mamczarz K, Kawai T, Yang X, Martindale JL, et al. Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs. EMBO J 2004, 23: 3092-3102.
57. Peng SS, Chen CY, Xu N, Shyu AB. RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein. EMBO J 1998, 17: 3461-3470.
58. Xu N, Chen CY, Shyu AB. Modulation of the fate of cytoplasmic mRNA by AU-rich elements: key sequence features controlling mRNA deadenylation and decay. Mol Cell Biol 1997, 17: 4611-4621.
59. Sela-Brown A, Silver J, Brewer G, Naveh-Many T. Identification of AUF1 as a parathyroid hormone mRNA 3'-untranslated region-binding protein that determines parathyroid hormone mRNA stability. J Biol Chem 2000, 275: 7424-7429.
60. Dean JL, Sully G, Wait R, Rawlinson L, Clark AR, et al. Identification of a novel AU-rich-element-binding protein which is related to AUF1. Biochem J 2002, 366: 709-719.
61. Subramaniam D, Natarajan G, Ramalingam S, Ramachandran I, May R, et al. Translation inhibition during cell cycle arrest and apoptosis: Mcl-1 is a novel target for RNA binding protein CUGBP2. Am J Physiol Gastrointest Liver Physiol 2008, 294: G1025-G1032.
62. Mukhopadhyay D, Houchen CW, Kennedy S, Dieckgraefe BK, Anant S. Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2. Mol Cell 2003, 11: 113-126.
63. Garnon J, Lachance C, Di Marco S, Hel Z, Marion D, et al. Fragile X-related protein FXR1P regulates proinflammatory cytokine tumor necrosis factor expression at the post-transcriptional level. J Biol Chem 2005, 280: 5750-5763.
64. Fan XC, Steitz JA. HNS, a nuclear-cytoplasmic shuttling sequence in HuR. Proc Natl Acad Sci U S A 1998, 95: 15293-15298.
65. Dean JL, Wait R, Mahtani KR, Sully G, Clark AR, et al. The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR. Mol Cell Biol 2001, 21: 721-730.
66. Levy NS, Chung S, Furneaux H, Levy AP. Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR. J Biol Chem 1998, 273: 6417-6423.
67. Nabors LB, Suswam E, Huang Y, Yang X, Johnson MJ, et al. Tumor necrosis factor alpha induces angiogenic factor up-regulation in malignant glioma cells: a role for RNA stabilization and HuR. Cancer Res 2003, 63: 4181-4187.
68. Dixon DA, Tolley ND, King PH, Nabors LB, McIntyre TM, et al. Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells. J Clin Invest 2001, 108: 1657-1665.
69. Yang X, Wang W, Fan J, Lal A, Yang D, et al. Prostaglandin A2-mediated stabilization of p21 mRNA through an ERK-dependent pathway requiring the RNA-binding protein HuR. J Biol Chem 2004, 279: 49298-49306.
70. Wang W, Caldwell MC, Lin S, Furneaux H, Gorospe M. HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation. EMBO J 2000, 19: 2340-2350.
71. Rodriguez-Pascual F, Hausding M, Ihrig-Biedert I, Furneaux H, Levy AP, et al. Complex contribution of the 3'-untranslated region to the expressional regulation of the human inducible nitric-oxide synthase gene. Involvement of the RNA-binding protein HuR. J Biol Chem 2000, 275: 26040-26049.
72. Xiao L, Rao JN, Zou T, Liu L, Marasa BS, et al. Polyamines regulate the stability of activating transcription factor-2 mRNA through RNA-binding protein HuR in intestinal epithelial cells. Mol Biol Cell 2007, 18: 4579-4590.
73. Zhang X, Zou T, Rao JN, Liu L, Xiao L, et al. Stabilization of XIAP mRNA through the RNA binding protein HuR regulated by cellular polyamines. Nucleic Acids Res 2009, 37: 7623-7637.
74. Mazan-Mamczarz K, Galban S, Lopez de Silanes I, Martindale JL, Atasoy U, et al. RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. Proc Natl Acad Sci U S A 2003, 100: 8354-8359.
75. Galban S, Martindale JL, Mazan-Mamczarz K, Lopez de Silanes I, Fan J, et al. Influence of the RNA-binding protein HuR in pVHL-regulated p53 expression in renal carcinoma cells. Mol Cell Biol 2003, 23: 7083-7095.
76. Galban S, Kuwano Y, Pullmann R Jr, Martindale JL, Kim HH, et al. RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Mol Cell Biol 2008, 28: 93-107.
77. Katsanou V, Papadaki O, Milatos S, Blackshear PJ, Anderson P, et al. HuR as a negative posttranscriptional modulator in inflammation. Mol Cell 2005, 19: 777-789.
78. Linker K, Pautz A, Fechir M, Hubrich T, Greeve J, et al. Involvement of KSRP in the post-transcriptional regulation of human iNOS expression-complex interplay of KSRP with TTP and HuR. Nucleic Acids Res 2005, 33: 4813-4827.
79. Gherzi R, Lee KY, Briata P, Wegmuller D, Moroni C, et al. A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery. Mol Cell 2004, 14: 571-583.
80. Gherzi R, Trabucchi M, Ponassi M, Ruggiero T, Corte G, et al. The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling. PLoS Biol 2006, 5: e5.
81. Winzen R, Thakur BK, Dittrich-Breiholz O, Shah M, Redich N, et al. Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets. Mol Cell Biol 2007, 27: 8388-8400.
82. Nechama M, Ben-Dov IZ, Briata P, Gherzi R, Naveh-Many T. The mRNA decay promoting factor K-homology splicing regulator protein post-transcriptionally determines parathyroid hormone mRNA levels. FASEB J 2008, 22: 3458-3468.
83. Nechama M, Peng Y, Bell O, Briata P, Gherzi R, et al. KSRP-PMR1-exosome association determines parathyroid hormone mRNA levels and stability in transfected cells. BMC Cell Biol 2009, 10: 70.
84. Shim J, Lim H, Yates JR, Karin M. Nuclear export of NF90 is required for interleukin-2 mRNA stabilization. Mol Cell 2002, 10: 1331-1344.
85. Shi L, Zhao G, Qiu D, Godfrey WR, Vogel H, et al. NF90 regulates cell cycle exit and terminal myogenic differentiation by direct binding to the 3'-untranslated region of MyoD and p21WAF1/CIP1 mRNAs. J Biol Chem 2005, 280: 18981-18989.
86. Shi L, Godfrey WR, Lin J, Zhao G, Kao PN. NF90 regulates inducible IL-2 gene expression in T cells. J Exp Med 2007, 204: 971-977.
87. Vumbaca F, Phoenix KN, Rodriguez-Pinto D, Han DK, Claffey KP. Double-stranded RNA-binding protein regulates vascular endothelial growth factor mRNA stability, translation, and breast cancer angiogenesis. Mol Cell Biol 2008, 28: 772-783.
88. Kuwano Y, Kim HH, Abdelmohsen K, Pullmann R Jr, Martindale JL, et al. MKP-1 mRNA stabilization and translational control by RNA-binding proteins HuR and NF90. Mol Cell Biol 2008, 28: 4562-4575.
89. Kuwano Y, Pullmann R Jr, Marasa BS, Abdelmohsen K, Lee EK, et al. NF90 selectively represses the translation of target mRNAs bearing an AU-rich signature motif. Nucleic Acids Res 2009, 38: 225-238.
90. Tran H, Schilling M, Wirbelauer C, Hess D, Nagamine Y. Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU. Mol Cell 2004, 13: 101-111.
91. Chalupnikova K, Lattmann S, Selak N, Iwamoto F, Fujiki Y, et al. Recruitment of the RNA helicase RHAU to stress granules via a unique RNA-binding domain. J Biol Chem 2008, 283: 35186-35198.
92. Capowski EE, Esnault S, Bhattacharya S, Malter JS. Y box-binding factor promotes eosinophil survival by stabilizing granulocyte-macrophage colony-stimulating factor mRNA. J Immunol 2001, 167: 5970-5976.
93. Coles LS, Bartley MA, Bert A, Hunter J, Polyak S, et al. A multi-protein complex containing cold shock domain (Y-box) and polypyrimidine tract binding proteins forms on the vascular endothelial growth factor mRNA. Potential role in mRNA stabilization. Eur J Biochem 2004, 271: 648-660.
94. Piecyk M, Wax S, Beck AR, Kedersha N, Gupta M, et al. TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha. EMBO J 2000, 19: 4154-4163.
95. Dixon DA, Balch GC, Kedersha N, Anderson P, Zimmerman GA, et al. Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1. J Exp Med 2003, 198: 475-481.
96. Cok SJ, Acton SJ, Morrison AR. The proximal region of the 3'-untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U. J Biol Chem 2003, 278: 36157-36162.
97. Phillips K, Kedersha N, Shen L, Blackshear PJ, Anderson P. Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor alpha, cyclooxygenase 2, and inflammatory arthritis. Proc Natl Acad Sci U S A 2004, 101: 2011-2016.
98. Gueydan C, Droogmans L, Chalon P, Huez G, Caput D, et al. Identification of TIAR as a protein binding to the translational regulatory AU-rich element of tumor necrosis factor alpha mRNA. J Biol Chem 1999, 274: 2322-2326.
99. Yu Q, Cok SJ, Zeng C, Morrison AR. Translational repression of human matrix metalloproteinases-13 by an alternatively spliced form of T-cell-restricted intracellular antigen-related protein (TIAR). J Biol Chem 2003, 278: 1579-1584.
100. Kandasamy K, Joseph K, Subramaniam K, Raymond JR, Tholanikunnel BG. Translational control of beta2-adrenergic receptor mRNA by T-cell-restricted intracellular antigen-related protein. J Biol Chem 2005, 280: 1931-1943.
101. Mazan-Mamczarz K, Lal A, Martindale JL, Kawai T, Gorospe M. Translational repression by RNA-binding protein TIAR. Mol Cell Biol 2006, 26: 2716-2727.
102. Carballo E, Lai WS, Blackshear PJ. Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science 1998, 281: 1001-1005.
103. Lai WS, Carballo E, Thorn JM, Kennington EA, Blackshear PJ. Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA. J Biol Chem 2000, 275: 17827-17837.
104. Lai WS, Blackshear PJ. Interactions of CCCH zinc finger proteins with mRNA: tristetraprolin-mediated AU-rich element-dependent mRNA degradation can occur in the absence of a poly(A) tail. J Biol Chem 2001, 276: 23144-23154.
105. Carballo E, Lai WS, Blackshear PJ. Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability. Blood 2000, 95: 1891-1899.
106. Stoecklin G, Ming XF, Looser R, Moroni C. Somatic mRNA turnover mutants implicate tristetraprolin in the interleukin-3 mRNA degradation pathway. Mol Cell Biol 2000, 20: 3753-3763.
107. Stoecklin G, Stoeckle P, Lu M, Muehlemann O, Moroni C. Cellular mutants define a common mRNA degradation pathway targeting cytokine AU-rich elements. RNA 2001, 7: 1578-1588.
108. Stoecklin G, Gross B, Ming XF, Moroni C. A novel mechanism of tumor suppression by destabilizing AU-rich growth factor mRNA. Oncogene 2003, 22: 3554-3561.
109. Sawaoka H, Dixon DA, Oates JA, Boutaud O. Tristetraprolin binds to the 3'-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site. J Biol Chem 2003, 278: 13928-13935.
110. Briata P, Ilengo C, Corte G, Moroni C, Rosenfeld MG, et al. The Wnt/beta-catenin-> Pitx2 pathway controls the turnover of Pitx2 and other unstable mRNAs. Mol Cell 2003, 12: 1201-1211.
111. Suswam E, Li Y, Zhang X, Gillespie GY, Li X, et al. Tristetraprolin down-regulates interleukin-8 and vascular endothelial growth factor in malignant glioma cells. Cancer Res 2008, 68: 674-682.
112. Sze KL, Lui WY, Lee WM. Post-transcriptional regulation of CLMP mRNA is controlled by tristetraprolin in response to TNFalpha via c-Jun N-terminal kinase signalling. Biochem J 2008, 410: 575-583.
113. Balakathiresan NS, Bhattacharyya S, Gutti U, Long RP, Jozwik C, et al. Tristetraprolin regulates IL-8 mRNA stability in cystic fibrosis lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 2009, 296: L1012-L1018.
114. Essafi-Benkhadir K, Onesto C, Stebe E, Moroni C, Pages G. Tristetraprolin inhibits Ras-dependent tumor vascularization by inducing vascular endothelial growth factor mRNA degradation. Mol Biol Cell 2007, 18: 4648-4658.
115. Frasca D, Landin AM, Alvarez JP, Blackshear PJ, Riley RL, et al. Tristetraprolin, a negative regulator of mRNA stability, is increased in old B cells and is involved in the degradation of E47 mRNA. J Immunol 2007, 179: 918-927.
116. Marderosian M, Sharma A, Funk AP, Vartanian R, Masri J, et al. Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling. Oncogene 2006, 25: 6277-6290.
117. Gringhuis SI, Garcia-Vallejo JJ, van Het Hof B, van Dijk W. Convergent actions of I kappa B kinase beta and protein kinase C delta modulate mRNA stability through phosphorylation of 14-3-3 beta complexed with tristetraprolin. Mol Cell Biol 2005, 25: 6454-6463.
118. Ogilvie RL, Abelson M, Hau HH, Vlasova I, Blackshear PJ, et al. Tristetraprolin down-regulates IL-2 gene expression through AU-rich element-mediated mRNA decay. J Immunol 2005, 174: 953-961.
119. Ogilvie RL, Sternjohn JR, Rattenbacher B, Vlasova IA, Williams DA, et al. Tristetraprolin mediates interferon-gamma mRNA decay. J Biol Chem 2009, 284: 11216-11223.
120. Datta S, Biswas R, Novotny M, Pavicic PG Jr, Herjan T, et al. Tristetraprolin regulates CXCL1 (KC) mRNA stability. J Immunol 2008, 180: 2545-2552.
121. Lai WS, Parker JS, Grissom SF, Stumpo DJ, Blackshear PJ. Novel mRNA targets for tristetraprolin (TTP) identified by global analysis of stabilized transcripts in TTP-deficient fibroblasts. Mol Cell Biol 2006, 26: 9196-9208.
122. Horner TJ, Lai WS, Stumpo DJ, Blackshear PJ. Stimulation of polo-like kinase 3 mRNA decay by tristetraprolin. Mol Cell Biol 2009, 29: 1999-2010.
123. Stoecklin G, Tenenbaum SA, Mayo T, Chittur SV, George AD, et al. Genome-wide analysis identifies interleukin-10 mRNA as target of tristetraprolin. J Biol Chem 2008, 283: 11689-11699.
124. Tudor C, Marchese FP, Hitti E, Aubareda A, Rawlinson L, et al. The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages. FEBS Lett 2009, 583: 1933-1938.
125. Fechir M, Linker K, Pautz A, Hubrich T, Forstermann U, et al. Tristetraprolin regulates the expression of the human inducible nitric-oxide synthase gene. Mol Pharmacol 2005, 67: 2148-2161.
126. Stoecklin G, Colombi M, Raineri I, Leuenberger S, Mallaun M, et al. Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover. EMBO J 2002, 21: 4709-4718.
127. Duan H, Cherradi N, Feige JJ, Jefcoate C. cAMP-dependent posttranscriptional regulation of steroidogenic acute regulatory (STAR) protein by the zinc finger protein ZFP36L1/TIS11b. Mol Endocrinol 2009, 23: 497-509.
128. Bell SE, Sanchez MJ, Spasic-Boskovic O, Santalucia T, Gambardella L, et al. The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression. Dev Dyn 2006, 235: 3144-3155.
129. Stumpo DJ, Broxmeyer HE, Ward T, Cooper S, Hangoc G, et al. Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis. Blood 2009, 114: 2401-2410.
130. Blackshear PJ, Phillips RS, Ghosh S, Ramos SB, Richfield EK, et al. Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins. Biol Reprod 2005, 73: 297-307.
131. Frederick ED, Ramos SB, Blackshear PJ. A unique C-terminal repeat domain maintains the cytosolic localization of the placenta-specific tristetraprolin family member ZFP36L3. J Biol Chem 2008, 283: 14792-14800.
132. Lai WS, Stumpo DJ, Blackshear PJ. Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein. J Biol Chem 1990, 265: 16556-16563.
133. Stumpo DJ, Byrd NA, Phillips RS, Ghosh S, Maronpot RR, et al. Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family. Mol Cell Biol 2004, 24: 6445-6455.
134. DuBois RN, McLane MW, Ryder K, Lau LF, Nathans D. A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence. J Biol Chem 1990, 265: 19185-19191.
135. Ma Q, Herschman HR. A corrected sequence for the predicted protein from the mitogen-inducible TIS11 primary response gene. Oncogene 1991, 6: 1277-1278.
136. Varnum BC, Lim RW, Sukhatme VP, Herschman HR. Nucleotide sequence of a cDNA encoding TIS11, a message induced in Swiss 3T3 cells by the tumor promoter tetradecanoyl phorbol acetate. Oncogene 1989, 4: 119-120.
137. Taylor GA, Thompson MJ, Lai WS, Blackshear PJ. Mitogens stimulate the rapid nuclear to cytosolic translocation of tristetraprolin, a potential zinc-finger transcription factor. Mol Endocrinol 1996, 10: 140-146.
138. Taylor GA, Thompson MJ, Lai WS, Blackshear PJ. Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro. J Biol Chem 1995, 270: 13341-13347.
139. Cao H, Tuttle JS, Blackshear PJ. Immunological characterization of tristetraprolin as a low abundance, inducible, stable cytosolic protein. J Biol Chem 2004, 279: 21489-21499.
140. Blackshear PJ, Lai WS, Kennington EA, Brewer G, Wilson GM, et al. Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates. J Biol Chem 2003, 278: 19947-19955.
141. Lai WS, Carballo E, Strum JR, Kennington EA, Phillips RS, et al. Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA. Mol Cell Biol 1999, 19: 4311-4323.
142. Lai WS, Kennington EA, Blackshear PJ. Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease. Mol Cell Biol 2003, 23: 3798-3812.
143. Carrick DM, Lai WS, Blackshear PJ. The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis. Arthritis Res Ther 2004, 6: 248-264.
144. Lai WS, Carrick DM, Blackshear PJ. Influence of nonameric AU-rich tristetraprolin-binding sites on mRNA deadenylation and turnover. J Biol Chem 2005, 280: 34365-34377.
145. Franks TM, Lykke-Andersen J. TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements. Genes Dev 2007, 21: 719-735.
146. Jing Q, Huang S, Guth S, Zarubin T, Motoyama A, et al. Involvement of microRNA in AU-rich element-mediated mRNA instability. Cell 2005, 120: 623-634.
147. Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R. MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol 2005, 7: 719-723.
148. Taylor GA, Carballo E, Lee DM, Lai WS, Thompson MJ, et al. A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity 1996, 4: 445-454.
149. Cheng J, Turksen K, Yu QC, Schreiber H, Teng M, et al. Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice. Genes Dev 1992, 6: 1444-1456.
150. Ulich TR, Shin SS, del Castillo J. Haematologic effects of TNF. Res Immunol 1993, 144: 347-354.
151. Sheehan KC, Ruddle NH, Schreiber RD. Generation and characterization of hamster monoclonal antibodies that neutralize murine tumor necrosis factors. J Immunol 1989, 142: 3884-3893.
152. Carballo E, Blackshear PJ. Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome. Blood 2001, 98: 2389-2395.
153. Yu H, Stasinopoulos S, Leedman P, Medcalf RL. Inherent instability of plasminogen activator inhibitor type 2 mRNA is regulated by tristetraprolin. J Biol Chem 2003, 278: 13912-13918.
154. Emmons J, Townley-Tilson WH, Deleault KM, Skinner SJ, Gross RH, et al. Identification of TTP mRNA targets in human dendritic cells reveals TTP as a critical regulator of dendritic cell maturation. RNA 2008, 14: 888-902.
155. Lin NY, Lin CT, Chen YL, Chang CJ. Regulation of tristetraprolin during differentiation of 3T3-L1 preadipocytes. FEBS J 2007, 274: 867-878.
156. Carballo E, Gilkeson GS, Blackshear PJ. Bone marrow transplantation reproduces the tristetraprolin-deficiency syndrome in recombination activating gene-2 (-/-) mice. Evidence that monocyte/macrophage progenitors may be responsible for TNFalpha overproduction. J Clin Invest 1997, 100: 986-995.
157. Lai WS, Kennington EA, Blackshear PJ. Interactions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs. J Biol Chem 2002, 277: 9606-9613.
158. Jalonen U, Nieminen R, Vuolteenaho K, Kankaanranta H, Moilanen E. Down-regulation of tristetraprolin expression results in enhanced IL-12 and MIP-2 production and reduced MIP-3alpha synthesis in activated macrophages. Mediators Inflamm 2006, 2006: 40691.
159. Sauer I, Schaljo B, Vogl C, Gattermeier I, Kolbe T, et al. Interferons limit inflammatory responses by induction of tristetraprolin. Blood 2006, 107: 4790-4797.
160. Patino WD, Kang JG, Matoba S, Mian OY, Gochuico BR, et al. Atherosclerotic plaque macrophage transcriptional regulators are expressed in blood and modulated by tristetraprolin. Circ Res 2006, 98: 1282-1289.
161. Ciais D, Cherradi N, Bailly S, Grenier E, Berra E, et al. Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b. Oncogene 2004, 23: 8673-8680.
162. Lee SK, Kim SB, Kim JS, Moon CH, Han MS, et al. Butyrate response factor 1 enhances cisplatin sensitivity in human head and neck squamous cell carcinoma cell lines. Int J Cancer 2005, 117: 32-40.
163. Romagnani P, Lasagni L, Annunziato F, Serio M, Romagnani S. CXC chemokines: the regulatory link between inflammation and angiogenesis. Trends Immunol 2004, 25: 201-209.
164. Novotny M, Datta S, Biswas R, Hamilton T. Functionally independent AU-rich sequence motifs regulate KC (CXCL1) mRNA. J Biol Chem 2005, 280: 30166-30174.
165. Sommer SL, Berndt TJ, Frank E, Patel JB, Redfield MM, et al. Elevated blood pressure and cardiac hypertrophy after ablation of the gly96/IEX-1 gene. J Appl Physiol 2006, 100: 707-716.
166. Xie S, Wu H, Wang Q, Cogswell JP, Husain I, et al. Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway. J Biol Chem 2001, 276: 43305-43312.
167. Winkles JA, Alberts GF. Differential regulation of polo-like kinase 1, 2, 3, and 4 gene expression in mammalian cells and tissues. Oncogene 2005, 24: 260-266.
168. Zimmerman WC, Erikson RL. Polo-like kinase 3 is required for entry into S phase. Proc Natl Acad Sci U S A 2007, 104: 1847-1852.
169. Ramos SB, Stumpo DJ, Kennington EA, Phillips RS, Bock CB, et al. The CCCH tandem zinc-finger protein Zfp36l2 is crucial for female fertility and early embryonic development. Development 2004, 131: 4883-4893.
170. Johnson BA, Stehn JR, Yaffe MB, Blackwell TK. Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms. J Biol Chem 2002, 277: 18029-18036.
171. Brewer G, Ross J. Regulation of c-myc mRNA stability in vitro by a labile destabilizer with an essential nucleic acid component. Mol Cell Biol 1989, 9: 1996-2006.
172. Zhang W, Wagner BJ, Ehrenman K, Schaefer AW, DeMaria CT, et al. Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1. Mol Cell Biol 1993, 13: 7652-7665.
173. Pautz A, Linker K, Altenhofer S, Heil S, Schmidt N, et al. Similar regulation of human inducible nitric-oxide synthase expression by different isoforms of the RNA-binding protein AUF1. J Biol Chem 2009, 284: 2755-2766.
174. Wagner BJ, DeMaria CT, Sun Y, Wilson GM, Brewer G. Structure and genomic organization of the human AUF1 gene: alternative pre-mRNA splicing generates four protein isoforms. Genomics 1998, 48: 195-202.
175. Buzby JS, Lee SM, van Winkle P, DeMaria CT, Brewer G, et al. Increased granulocyte-macrophage colony-stimulating factor mRNA instability in cord versus adult mononuclear cells is translation-dependent and associated with increased levels of A + U-rich element binding factor. Blood 1996, 88: 2889-2897.
176. Sirenko OI, Lofquist AK, DeMaria CT, Morris JS, Brewer G, et al. Adhesion-dependent regulation of an A + U-rich element-binding activity associated with AUF1. Mol Cell Biol 1997, 17: 3898-3906.
177. Sarkar B, Xi Q, He C, Schneider RJ. Selective degradation of AU-rich mRNAs promoted by the p37 AUF1 protein isoform. Mol Cell Biol 2003, 23: 6685-6693.
178. Shyu AB, Wilkinson MF. The double lives of shuttling mRNA binding proteins. Cell 2000, 102: 135-138.
179. Sarkar B, Lu JY, Schneider RJ. Nuclear import and export functions in the different isoforms of the AUF1/heterogeneous nuclear ribonucleoprotein protein family. J Biol Chem 2003, 278: 20700-20707.
180. Lu JY, Sadri N, Schneider RJ. Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAs. Genes Dev 2006, 20: 3174-3184.
181. Sadri N, Schneider RJ. Auf1/Hnrnpd-deficient mice develop pruritic inflammatory skin disease. J Invest Dermatol 2009, 129: 657-670.
182. Ma WJ, Cheng S, Campbell C, Wright A, Furneaux H. Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein. J Biol Chem 1996, 271: 8144-8151.
183. Good PJ. A conserved family of elav-like genes in vertebrates. Proc Natl Acad Sci U S A 1995, 92: 4557-4561.
184. Antic D, Keene JD. Embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression. Am J Hum Genet 1997, 61: 273-278.
185. Fan XC, Myer VE, Steitz JA. AU-rich elements target small nuclear RNAs as well as mRNAs for rapid degradation. Genes Dev 1997, 11: 2557-2568.
186. Fan XC, Steitz JA. Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs. EMBO J 1998, 17: 3448-3460.
187. Katsanou V, Milatos S, Yiakouvaki A, Sgantzis N, Kotsoni A, et al. The RNA-binding protein Elavl1/HuR is essential for placental branching morphogenesis and embryonic development. Mol Cell Biol 2009, 29: 2762-2776.
188. Ghosh M, Aguila HL, Michaud J, Ai Y, Wu MT, et al. Essential role of the RNA-binding protein HuR in progenitor cell survival in mice. J Clin Invest 2009, 119: 3530-3543.
189. Tian Q, Streuli M, Saito H, Schlossman SF, Anderson P. A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells. Cell 1991, 67: 629-639.
190. Kawakami A, Tian Q, Duan X, Streuli M, Schlossman SF, et al. Identification and functional characterization of a TIA-1-related nucleolysin. Proc Natl Acad Sci U S A 1992, 89: 8681-8685.
191. Beck AR, Medley QG, O'Brien S, Anderson P, Streuli M. Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR. Nucleic Acids Res 1996, 24: 3829-3835.
192. Dember LM, Kim ND, Liu KQ, Anderson P. Individual RNA recognition motifs of TIA-1 and TIAR have different RNA binding specificities. J Biol Chem 1996, 271: 2783-2788.
193. Saito K, Chen S, Piecyk M, Anderson P. TIA-1 regulates the production of tumor necrosis factor alpha in macrophages, but not in lymphocytes. Arthritis Rheum 2001, 44: 2879-2887.
194. Kedersha N, Anderson P. Stress granules: sites of mRNA triage that regulate mRNA stability and translatability. Biochem Soc Trans 2002, 30: 963-969.
195. Anderson P, Kedersha N. Stressful initiations. J Cell Sci 2002, 115: 3227-3234.