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Volumn 17, Issue 12, 1998, Pages 3448-3460

Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs

Author keywords

ARE; Elav proteins; HuR; mRNA decay; Nuclear cytoplasmic shuttling protein

Indexed keywords

BETA GLOBIN; CARRIER PROTEIN; CYTOKINE; CYTOPLASM PROTEIN; LYMPHOKINE; MESSENGER RNA; NUCLEAR PROTEIN; POLYCLONAL ANTIBODY;

EID: 0032526427     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.12.3448     Document Type: Article
Times cited : (768)

References (84)
  • 1
    • 0030459516 scopus 로고    scopus 로고
    • Two different RNA binding activities for the AU-rich element and the poly(A) sequence of the mouse neuronal protein mHuC
    • Abe, R., Sakashita, E., Yamamoto, K. and Sakamoto, H. (1996) Two different RNA binding activities for the AU-rich element and the poly(A) sequence of the mouse neuronal protein mHuC. Nucleic Acids Res., 24, 4895-4901.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 4895-4901
    • Abe, R.1    Sakashita, E.2    Yamamoto, K.3    Sakamoto, H.4
  • 2
    • 0030867877 scopus 로고    scopus 로고
    • Insights from model systems, embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression
    • Antic, D. and Keene, J.D. (1997) Insights from model systems, embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression. Am. J. Hum. Genet., 61, 273-278.
    • (1997) Am. J. Hum. Genet. , vol.61 , pp. 273-278
    • Antic, D.1    Keene, J.D.2
  • 3
    • 0344351825 scopus 로고    scopus 로고
    • Messenger ribonucleoprotein complexes containing human elav proteins, interactions with cytoskeleton and translational apparatus
    • Antic, D. and Keene, J.D. (1998) Messenger ribonucleoprotein complexes containing human elav proteins, interactions with cytoskeleton and translational apparatus. J. Cell Sci., 111, 183-197.
    • (1998) J. Cell Sci. , vol.111 , pp. 183-197
    • Antic, D.1    Keene, J.D.2
  • 5
    • 0024121631 scopus 로고
    • Nonsense mutations in the human β-globin gene affect mRNA metabolism
    • Baserga, S.J. and Benz, E.J. (1988) Nonsense mutations in the human β-globin gene affect mRNA metabolism. Proc. Natl Acad. Sci. USA, 85, 2056-2060.
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 2056-2060
    • Baserga, S.J.1    Benz, E.J.2
  • 7
    • 0025819310 scopus 로고
    • An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3′ untranslated region of lymphokine mRNA
    • Bohjanen, P.R., Petryniak, B., June, C.H., Thompson, C.B. and Lindsten, T. (1991) An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3′ untranslated region of lymphokine mRNA. Mol. Cell. Biol., 11, 3288-3295.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 3288-3295
    • Bohjanen, P.R.1    Petryniak, B.2    June, C.H.3    Thompson, C.B.4    Lindsten, T.5
  • 8
    • 0026640829 scopus 로고
    • AU RNA-binding factors differ in their binding specificities and affinities
    • Bohjanen, P.R., Petryniak, B., June, C.H., Thompson, C.B. and Lindsten, T. (1992) AU RNA-binding factors differ in their binding specificities and affinities. J. Biol. Chem., 267, 6302-6309.
    • (1992) J. Biol. Chem. , vol.267 , pp. 6302-6309
    • Bohjanen, P.R.1    Petryniak, B.2    June, C.H.3    Thompson, C.B.4    Lindsten, T.5
  • 9
    • 0026337150 scopus 로고
    • An AU-rich element RNA-binding factor regulates c-myc mRNA stability in vitro
    • Brewer, G. (1991) An AU-rich element RNA-binding factor regulates c-myc mRNA stability in vitro. Mol. Cell. Biol., 11, 2460-2466.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 2460-2466
    • Brewer, G.1
  • 10
    • 0028129989 scopus 로고
    • Conserved structures and diversity of functions of RNA-binding proteins
    • Burd, C.G. and Dreyfuss, G. (1994) Conserved structures and diversity of functions of RNA-binding proteins. Science, 265, 615-621.
    • (1994) Science , vol.265 , pp. 615-621
    • Burd, C.G.1    Dreyfuss, G.2
  • 11
    • 0021801475 scopus 로고
    • Mutant alleles at the locus elav in Drosophila melanogaster leads to nervous system detects. a developmental-genetic analysis
    • Campos, A.R. Grossman, D. and White, K. (1985) Mutant alleles at the locus elav in Drosophila melanogaster leads to nervous system detects. A developmental-genetic analysis. J. Neurogen., 2, 197-218.
    • (1985) J. Neurogen. , vol.2 , pp. 197-218
    • Campos, A.R.1    Grossman, D.2    White, K.3
  • 12
    • 0000370303 scopus 로고
    • Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators
    • Caput, D., Beutler, B., Hartog, K., Thayer, R., Brown-Shimer, S. and Cerami, A. (1986) Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators. Proc. Natl Acad. Sci. USA, 83, 1670-1674.
    • (1986) Proc. Natl Acad. Sci. USA , vol.83 , pp. 1670-1674
    • Caput, D.1    Beutler, B.2    Hartog, K.3    Thayer, R.4    Brown-Shimer, S.5    Cerami, A.6
  • 13
    • 0028788194 scopus 로고
    • AU-rich elements, characterization and importance in mRNA degradation
    • Chen, C.-Y.A. and Shyu, A.-B. (1995) AU-rich elements, characterization and importance in mRNA degradation. Trends Biochem. Sci., 20, 465-470.
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 465-470
    • Chen, C.-Y.A.1    Shyu, A.-B.2
  • 14
    • 0029126879 scopus 로고
    • mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts, different deadenylation kinetics and uncoupling from translation
    • Chen, C.-Y.A., Xu, N. and Shyu, A.-B. (1995) mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts, different deadenylation kinetics and uncoupling from translation. Mol. Cell. Biol., 15, 5777-5788
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 5777-5788
    • Chen, C.-Y.A.1    Xu, N.2    Shyu, A.-B.3
  • 15
    • 0026547716 scopus 로고
    • Anti-Hu associated paraneoplastic encephalomyelitis/sensory neuropathy, a clinical study of 71 patients
    • Dalmau, J., Graus, F., Rosenblum, M.K. and Posner, J.B. (1991) Anti-Hu associated paraneoplastic encephalomyelitis/sensory neuropathy, a clinical study of 71 patients. Medicine, 71, 59-72.
    • (1991) Medicine , vol.71 , pp. 59-72
    • Dalmau, J.1    Graus, F.2    Rosenblum, M.K.3    Posner, J.B.4
  • 16
    • 0029896951 scopus 로고    scopus 로고
    • Onconeural antigens and the paraneoplastic neurologic disorders, at the intersection of cancer, immunity, and the brain
    • Darnell, R.B. (1996) Onconeural antigens and the paraneoplastic neurologic disorders, at the intersection of cancer, immunity, and the brain. Proc. Natl Acad. Sci. USA, 93, 4529-1536.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 4529-11536
    • Darnell, R.B.1
  • 17
    • 0031807307 scopus 로고    scopus 로고
    • The human HNRPD locus maps to 4q21 and encodes a highly conserved protein
    • in press
    • Dempsev, L. A., Li, M.-J., DePace, A., Bray-Ward, P. and Maizels, N. (1998) The human HNRPD locus maps to 4q21 and encodes a highly conserved protein. Genomics, in press.
    • (1998) Genomics
    • Dempsev, L.A.1    Li, M.-J.2    DePace, A.3    Bray-Ward, P.4    Maizels, N.5
  • 18
    • 0025949412 scopus 로고
    • Nuclear targeting sequence - A consensus?
    • Dingwall, C. and Laskey, R.A. (1991) Nuclear targeting sequence - a consensus? Trends Biochem. Sci., 16, 478-481.
    • (1991) Trends Biochem. Sci. , vol.16 , pp. 478-481
    • Dingwall, C.1    Laskey, R.A.2
  • 19
    • 0027959502 scopus 로고
    • Characterization of cDNAs encoding the murine A+U-nch RNA-binding protein AUF1
    • Ehrenman, K., Long, L., Wagner, B.J. and Brewer G. (1994) Characterization of cDNAs encoding the murine A+U-nch RNA-binding protein AUF1. Gene, 149, 315-319.
    • (1994) Gene , vol.149 , pp. 315-319
    • Ehrenman, K.1    Long, L.2    Wagner, B.J.3    Brewer, G.4
  • 20
    • 0030803671 scopus 로고    scopus 로고
    • AU-rich elements target small nuclear RNAs as well as messenger RNAs for rapid degradation
    • Fan, X.C. Myer, V.E. and Steitz, J.A. (1997) AU-rich elements target small nuclear RNAs as well as messenger RNAs for rapid degradation. Genes Dev., 11, 2557-2568.
    • (1997) Genes Dev. , vol.11 , pp. 2557-2568
    • Fan, X.C.1    Myer, V.E.2    Steitz, J.A.3
  • 21
    • 0030924190 scopus 로고    scopus 로고
    • CRM1 is an export receptor for leucine-rich nuclear export signals
    • Fornerod, M., Ohno, M., Yoshida, M and Mattaj, I. (1997) CRM1 is an export receptor for leucine-rich nuclear export signals. Cell, 90, 1051-1060.
    • (1997) Cell , vol.90 , pp. 1051-1060
    • Fornerod, M.1    Ohno, M.2    Yoshida, M.3    Mattaj, I.4
  • 22
    • 0030971249 scopus 로고    scopus 로고
    • Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-β
    • Fridell, R.A., Truant, R., Thorne, L., Benson, R.E. and Cullen, B.R. (1997) Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-β. J. Cell Sci., 110, 1325-1331.
    • (1997) J. Cell Sci. , vol.110 , pp. 1325-1331
    • Fridell, R.A.1    Truant, R.2    Thorne, L.3    Benson, R.E.4    Cullen, B.R.5
  • 23
    • 0030831534 scopus 로고    scopus 로고
    • CRM 1 is responsible for intracellular transport mediated by the nuclear export signal
    • Fukuda, M., Asano, S., Nakamura, T., Adachi, M., Yoshida, M., Yanaoida, M. and Nishida, E. (1997) CRM 1 is responsible for intracellular transport mediated by the nuclear export signal. Nature, 390, 308-311.
    • (1997) Nature , vol.390 , pp. 308-311
    • Fukuda, M.1    Asano, S.2    Nakamura, T.3    Adachi, M.4    Yoshida, M.5    Yanaoida, M.6    Nishida, E.7
  • 24
    • 0028054162 scopus 로고
    • Selection of a subset of mRNAs from combinatorial 3′ untranslated region libraries using neuronal RNA-binding protein Hel-N1
    • Gao, F.-B., Carson, C.C., Levine, T.D. and Keene, J.D. (1994) Selection of a subset of mRNAs from combinatorial 3′ untranslated region libraries using neuronal RNA-binding protein Hel-N1. Proc. Natl Acad. Sci. USA. 91, 11207-11211.
    • (1994) Proc. Natl Acad. Sci. USA. , vol.91 , pp. 11207-11211
    • Gao, F.-B.1    Carson, C.C.2    Levine, T.D.3    Keene, J.D.4
  • 25
    • 0029015816 scopus 로고
    • A conserved family of elav-like genes in vertebrates
    • Good, P. (1995) A conserved family of elav-like genes in vertebrates. Proc. Natl Acad. Sci. USA, 92, 4557-1561.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 4557-11561
    • Good, P.1
  • 26
    • 0029984570 scopus 로고    scopus 로고
    • Nucleocytoplasmic transport
    • Gorlich, D. and Mattaj, I.W. (1996) Nucleocytoplasmic transport. Science, 271, 1513-1518.
    • (1996) Science , vol.271 , pp. 1513-1518
    • Gorlich, D.1    Mattaj, I.W.2
  • 27
    • 0027523417 scopus 로고
    • Association of heterogeneous nuclear ribonucleoprotein A1 and C proteins with reiterated AUUUA sequences
    • Hamilton, B.J., Nagy, E., Malter, J.S., Arrick, B.A. and Rigby, W.F.C. (1993) Association of heterogeneous nuclear ribonucleoprotein A1 and C proteins with reiterated AUUUA sequences. J. Biol. Chem., 268, 8881-8887.
    • (1993) J. Biol. Chem. , vol.268 , pp. 8881-8887
    • Hamilton, B.J.1    Nagy, E.2    Malter, J.S.3    Arrick, B.A.4    Rigby, W.F.C.5
  • 28
    • 0030724902 scopus 로고    scopus 로고
    • Modulation of AUUUA response element binding by heterogeneous nuclear ribonucleoprotein A1 in human T lymphocytes
    • Hamilton, B.J., Burns, C.M., Nichols, R.C. and Rigby, W.F.C. (1997) Modulation of AUUUA response element binding by heterogeneous nuclear ribonucleoprotein A1 in human T lymphocytes. J. Biol. Chem., 272, 28732-28741.
    • (1997) J. Biol. Chem. , vol.272 , pp. 28732-28741
    • Hamilton, B.J.1    Burns, C.M.2    Nichols, R.C.3    Rigby, W.F.C.4
  • 29
  • 30
    • 0030856315 scopus 로고    scopus 로고
    • The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus
    • Izaurralde, E., Kutay, U., Von Kobbe, C., Mattaj, I.W. and Gorlich, D. (1997) The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus. EMBO J., 16, 6535-6547.
    • (1997) EMBO J. , vol.16 , pp. 6535-6547
    • Izaurralde, E.1    Kutay, U.2    Von Kobbe, C.3    Mattaj, I.W.4    Gorlich, D.5
  • 31
    • 0031038858 scopus 로고    scopus 로고
    • Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT 1) expression in 3T3-L1 adipocytes
    • Jain, R. G., Andrews, L.G., McGowan, K.M., Pekala, P.H. and Keene, J.D. (1997) Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT 1) expression in 3T3-L1 adipocytes. Mol. Cell. Biol., 17, 954-962.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 954-962
    • Jain, R.G.1    Andrews, L.G.2    McGowan, K.M.3    Pekala, P.H.4    Keene, J.D.5
  • 32
    • 0029111578 scopus 로고
    • The UUAG-specific RNA binding protein, heterogeneous nuclear ribonucleoprotein D0
    • Kajita, Y., Nakayama, J., Aizawa, M. and Ishikawa, F. (1995) The UUAG-specific RNA binding protein, heterogeneous nuclear ribonucleoprotein D0. J. Biol. Chem., 270, 22167-22175.
    • (1995) J. Biol. Chem. , vol.270 , pp. 22167-22175
    • Kajita, Y.1    Nakayama, J.2    Aizawa, M.3    Ishikawa, F.4
  • 33
    • 0028285260 scopus 로고
    • AU-A, an RNA-binding activity distinct from hnRNP A1, is selective for AUUUA repeats and shuttles between the nucleus and the cytoplasm
    • Katz, D.A., Theodorakis, N.G., Cleveland, D.W., Lindsten, T. and Thompson, C.B. (1994) AU-A, an RNA-binding activity distinct from hnRNP A1, is selective for AUUUA repeats and shuttles between the nucleus and the cytoplasm. Nucleic Acids Res., 22, 238-246.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 238-246
    • Katz, D.A.1    Theodorakis, N.G.2    Cleveland, D.W.3    Lindsten, T.4    Thompson, C.B.5
  • 35
    • 0030475890 scopus 로고    scopus 로고
    • ELAV, a Drosophila neuron-specific protein, mediates the generation of an alternatively spliced neural protein isoform
    • Koushika, S.P., Lisbin, M.J. and White, K. (1996) ELAV, a Drosophila neuron-specific protein, mediates the generation of an alternatively spliced neural protein isoform. Curr. Biol., 6, 1634-1641.
    • (1996) Curr. Biol. , vol.6 , pp. 1634-1641
    • Koushika, S.P.1    Lisbin, M.J.2    White, K.3
  • 36
  • 37
    • 0025287361 scopus 로고
    • Herpesvirus saimiri U RNAs are expressed and assembled into ribonucleoprotein particles in the absence of other viral genes
    • Lee, S.I. and Steitz, J.A. (1990) Herpesvirus saimiri U RNAs are expressed and assembled into ribonucleoprotein particles in the absence of other viral genes. J. Virol., 64, 3905-3915.
    • (1990) J. Virol. , vol.64 , pp. 3905-3915
    • Lee, S.I.1    Steitz, J.A.2
  • 39
    • 0023781398 scopus 로고
    • Activation of the transforming potential of the human fos proto-oncogene requires message stabilization and results in increased amounts of partially modified fos protein
    • Lee, W.M., Lin, C. and Curran, T. (1988) Activation of the transforming potential of the human fos proto-oncogene requires message stabilization and results in increased amounts of partially modified fos protein. Mol. Cell. Biol., 8, 5521-5527.
    • (1988) Mol. Cell. Biol. , vol.8 , pp. 5521-5527
    • Lee, W.M.1    Lin, C.2    Curran, T.3
  • 40
    • 0019570066 scopus 로고
    • Monoclonal antibodies to nucleic acid-containing cellular constituents, probes for molecular biology and autoimmune disease
    • Lerner, E.A., Lerner, M.R., Janeway, C.A., Jr and Steitz, J.A. (1981) Monoclonal antibodies to nucleic acid-containing cellular constituents, probes for molecular biology and autoimmune disease. Proc. Natl Acad Sci. USA, 78, 2737-2741.
    • (1981) Proc. Natl Acad Sci. USA , vol.78 , pp. 2737-2741
    • Lerner, E.A.1    Lerner, M.R.2    Janeway Jr., C.A.3    Steitz, J.A.4
  • 41
    • 0027314350 scopus 로고
    • Hel-N1, an autoimmune RNA-binding protein with specificity for 3′ uridylate-rich untranslated regions of growth factor mRNAs
    • Levine, T.D., Gao, F., King, P.H., Andrews, L.G. and Keene, J.D. (1993) Hel-N1, an autoimmune RNA-binding protein with specificity for 3′ uridylate-rich untranslated regions of growth factor mRNAs. Mol. Cell. Biol., 13, 3494-3504.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 3494-3504
    • Levine, T.D.1    Gao, F.2    King, P.H.3    Andrews, L.G.4    Keene, J.D.5
  • 42
    • 0032513043 scopus 로고    scopus 로고
    • Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR
    • Levy, N.S., Chung, S., Furneaux, H. and Levy, A.P. (1998) Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR. J. Biol. Chem., 273, 6417-6423.
    • (1998) J. Biol. Chem. , vol.273 , pp. 6417-6423
    • Levy, N.S.1    Chung, S.2    Furneaux, H.3    Levy, A.P.4
  • 43
    • 0024506159 scopus 로고
    • Regulation of lymphokine messenger RNa stability by a surface-mediated T cell activation pathway
    • Lindsten, T., June, C.H., Ledbetter, J.A., Stella, G. and Thompson, C.B. (1989) Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science, 244, 339-343.
    • (1989) Science , vol.244 , pp. 339-343
    • Lindsten, T.1    June, C.H.2    Ledbetter, J.A.3    Stella, G.4    Thompson, C.B.5
  • 44
    • 0029873536 scopus 로고    scopus 로고
    • Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein
    • Ma, W.-J., Cheng, S., Campbell, C., Wright, A. and Furneaux, H. (1996) Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein. J. Biol. Chem., 271, 8144-8151.
    • (1996) J. Biol. Chem. , vol.271 , pp. 8144-8151
    • Ma, W.-J.1    Cheng, S.2    Campbell, C.3    Wright, A.4    Furneaux, H.5
  • 45
    • 0030821226 scopus 로고    scopus 로고
    • The elav-like proteins bind to AU-rich elements and to the poly(A) tail of mRNA
    • Ma, W.-J., Chung, S. and Furneaux, H. (1997) The elav-like proteins bind to AU-rich elements and to the poly(A) tail of mRNA. Nucleic Acids Res., 25, 3564-3569.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 3564-3569
    • Ma, W.-J.1    Chung, S.2    Furneaux, H.3
  • 46
    • 0024424547 scopus 로고
    • Identification of an AUUUA-specific messenger RNA binding protein
    • Malter, J.S. (1989) Identification of an AUUUA-specific messenger RNA binding protein. Science, 246, 664-666.
    • (1989) Science , vol.246 , pp. 664-666
    • Malter, J.S.1
  • 47
    • 0025754285 scopus 로고
    • A redox switch and phosphorylation are involved in the post-translational up-regulation of the adenosine-uridine binding factor by phorbol ester and ionophore
    • Malter, J.S. and Hong, Y. (1991) A redox switch and phosphorylation are involved in the post-translational up-regulation of the adenosine-uridine binding factor by phorbol ester and ionophore. J. Biol. Chem., 266, 3167-3171.
    • (1991) J. Biol. Chem. , vol.266 , pp. 3167-3171
    • Malter, J.S.1    Hong, Y.2
  • 48
    • 0028237441 scopus 로고
    • Fertilization of Xenopus eggs imposes a complete translational arrest of mRNAs containing 3′ UUAUUUAUU elements
    • Marinx, O., Bertrand, S., Karsenti, E., Huez, G. and Kruys, V. (1994) Fertilization of Xenopus eggs imposes a complete translational arrest of mRNAs containing 3′ UUAUUUAUU elements. FEBS Lett., 345, 107-112.
    • (1994) FEBS Lett. , vol.345 , pp. 107-112
    • Marinx, O.1    Bertrand, S.2    Karsenti, E.3    Huez, G.4    Kruys, V.5
  • 49
    • 0344148793 scopus 로고
    • Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene
    • Meijlink, F., Curran, T., Miller, A.D. and Verma, I.M. (1985) Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene. Proc. Natl Acad. Sci. USA, 82, 4987-4991.
    • (1985) Proc. Natl Acad. Sci. USA , vol.82 , pp. 4987-4991
    • Meijlink, F.1    Curran, T.2    Miller, A.D.3    Verma, I.M.4
  • 50
    • 0028845313 scopus 로고
    • A nuclear export signal in hnRNP A1, a signal-mediated, temperature-dependent nuclear protein export pathway
    • Michael, W.M., Choi, M. and Dreyfuss, G. (1995) A nuclear export signal in hnRNP A1, a signal-mediated, temperature-dependent nuclear protein export pathway. Cell, 83, 415-422.
    • (1995) Cell , vol.83 , pp. 415-422
    • Michael, W.M.1    Choi, M.2    Dreyfuss, G.3
  • 51
    • 0030978415 scopus 로고    scopus 로고
    • The K nuclear shuttling domain, a novel signal for nuclear import and nuclear export in the hnRNP K protein
    • Michael, W.M., Eder, P.S. and Dreyfuss, G. (1997) The K nuclear shuttling domain, a novel signal for nuclear import and nuclear export in the hnRNP K protein. EMBO J., 16, 3587-3598.
    • (1997) EMBO J. , vol.16 , pp. 3587-3598
    • Michael, W.M.1    Eder, P.S.2    Dreyfuss, G.3
  • 52
    • 0021355180 scopus 로고
    • c-fos protein can induce cellular transformation, a novel mechanism of activation of a cellular oncogene
    • Miller, A.D., Curran, T. and Verma, I.M. (1984) c-fos protein can induce cellular transformation, a novel mechanism of activation of a cellular oncogene. Cell, 36, 51-60.
    • (1984) Cell , vol.36 , pp. 51-60
    • Miller, A.D.1    Curran, T.2    Verma, I.M.3
  • 53
    • 0016718010 scopus 로고
    • Mouse-human heterokaryon analysis with a 33258 Hoechst-Giemsa technique
    • Moser, F.G., Dorman, B.P. and Ruddle, F.H. (1975) Mouse-human heterokaryon analysis with a 33258 Hoechst-Giemsa technique. J. Cell Biol., 66, 676-680.
    • (1975) J. Cell Biol. , vol.66 , pp. 676-680
    • Moser, F.G.1    Dorman, B.P.2    Ruddle, F.H.3
  • 54
    • 0029284338 scopus 로고
    • Isolation and characterization of a novel low abundance hnRNP protein, A0
    • Myer, V.E. and Steitz, J.A. (1995) Isolation and characterization of a novel low abundance hnRNP protein, A0. RNA, 1, 171-182.
    • (1995) RNA , vol.1 , pp. 171-182
    • Myer, V.E.1    Steitz, J.A.2
  • 55
    • 0026501571 scopus 로고
    • Viral small nuclear ribonucleoproteins bind a protein implicated in messenger RNa destabilization
    • Myer, V.E., Lee, S.I. and Steitz, J.A. (1992) Viral small nuclear ribonucleoproteins bind a protein implicated in messenger RNA destabilization. Proc. Natl Acad. Sci. USA, 89, 1296-1300.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 1296-1300
    • Myer, V.E.1    Lee, S.I.2    Steitz, J.A.3
  • 56
    • 0030933006 scopus 로고    scopus 로고
    • Identification of HuR as a protein implicated in AUUUA-mediated mRNA decay
    • Myer, V.E., Fan, X.C. and Steitz, J.A. (1997) Identification of HuR as a protein implicated in AUUUA-mediated mRNA decay. EMBO J., 16, 2130-2139.
    • (1997) EMBO J. , vol.16 , pp. 2130-2139
    • Myer, V.E.1    Fan, X.C.2    Steitz, J.A.3
  • 57
  • 58
    • 0029797247 scopus 로고    scopus 로고
    • The hnRNP C proteins contain a nuclear retention sequence that can override nuclear export signals
    • Nakielny, S. and Dreyfuss, G. (1996) The hnRNP C proteins contain a nuclear retention sequence that can override nuclear export signals. J. Cell Biol., 134, 1365-1373.
    • (1996) J. Cell Biol. , vol.134 , pp. 1365-1373
    • Nakielny, S.1    Dreyfuss, G.2
  • 59
    • 0031005687 scopus 로고    scopus 로고
    • Nuclear export of proteins and RNAs
    • Nakielny, S. and Dreyfuss, G. (1997) Nuclear export of proteins and RNAs. Curr. Opin. Cell Biol., 9, 420-129.
    • (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 420-1129
    • Nakielny, S.1    Dreyfuss, G.2
  • 60
    • 0030909816 scopus 로고    scopus 로고
    • A hierarchy of Hu RNA binding proteins in developing and adult neurons
    • Okano, H.J and Darnell, R.B. (1997) A hierarchy of Hu RNA binding proteins in developing and adult neurons. J. Neurol., 17, 3024-3037.
    • (1997) J. Neurol. , vol.17 , pp. 3024-3037
    • Okano, H.J.1    Darnell, R.B.2
  • 61
    • 0032526417 scopus 로고    scopus 로고
    • RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein
    • Peng, S.S.-Y., Chen, C.-Y.A., Xu, N. and Shyu, A.-B. (1998) RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein. EMBO J., 17, 3461-3470.
    • (1998) EMBO J. , vol.17 , pp. 3461-3470
    • Peng, S.S.-Y.1    Chen, C.-Y.A.2    Xu, N.3    Shyu, A.-B.4
  • 62
    • 0026339487 scopus 로고
    • Transcription-dependent and transcription-independent nuclear transport of hnRNP proteins
    • Pinol-Roma, S. and Dreyfuss, G. (1992) Transcription-dependent and transcription-independent nuclear transport of hnRNP proteins. Science, 253, 312-314.
    • (1992) Science , vol.253 , pp. 312-314
    • Pinol-Roma, S.1    Dreyfuss, G.2
  • 63
    • 0023955859 scopus 로고
    • Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins
    • Pinol-Roma, S., Choi, Y.D., Matunis, M.J. and Dreyfuss, G. (1988) Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins. Genes Dev., 2, 215-227.
    • (1988) Genes Dev. , vol.2 , pp. 215-227
    • Pinol-Roma, S.1    Choi, Y.D.2    Matunis, M.J.3    Dreyfuss, G.4
  • 65
    • 0028926453 scopus 로고
    • Anti-Hu autoantibody-associated sensory neuropathy/encephalomyelitis, a model of paraneoplastic syndrome
    • Posner, J.B. (1995) Anti-Hu autoantibody-associated sensory neuropathy/encephalomyelitis, a model of paraneoplastic syndrome. Perspect. Biol. Med., 38, 167-181.
    • (1995) Perspect. Biol. Med. , vol.38 , pp. 167-181
    • Posner, J.B.1
  • 66
    • 0025369859 scopus 로고
    • Activators and targets
    • Ptashne, M. and Gann, A.A.F. (1990) Activators and targets. Nature, 346, 329-331.
    • (1990) Nature , vol.346 , pp. 329-331
    • Ptashne, M.1    Gann, A.A.F.2
  • 67
    • 0024290216 scopus 로고
    • The elav gene product of Drosophila, required in neurons, has three RNP consensus motifs
    • Robinow, S., Campos, A.R., Yao, K.-M. and White, K. (1988) The elav gene product of Drosophila, required in neurons, has three RNP consensus motifs. Science, 242, 1570-1572.
    • (1988) Science , vol.242 , pp. 1570-1572
    • Robinow, S.1    Campos, A.R.2    Yao, K.-M.3    White, K.4
  • 68
    • 0026648923 scopus 로고
    • Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a >20S degradation complex
    • Savant-Bhonsdale, S. and Cleveland, D.W. (1992) Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a >20S degradation complex. Genes Dev., 6, 1927-1939.
    • (1992) Genes Dev. , vol.6 , pp. 1927-1939
    • Savant-Bhonsdale, S.1    Cleveland, D.W.2
  • 69
    • 0028111481 scopus 로고
    • Multiple elements in the c-fos protein coding region accelerate mRNA deadenylation and decay by a mechanism coupled to translation
    • Schiavi, S.C., Shyu, A.-B., Wellington, C.Y., Chen, C.Y., Greenberg, M.E. and Belasco, J.G. (1994) Multiple elements in the c-fos protein coding region accelerate mRNA deadenylation and decay by a mechanism coupled to translation. J. Biol. Chem., 269, 3441-3448.
    • (1994) J. Biol. Chem. , vol.269 , pp. 3441-3448
    • Schiavi, S.C.1    Shyu, A.-B.2    Wellington, C.Y.3    Chen, C.Y.4    Greenberg, M.E.5    Belasco, J.G.6
  • 70
    • 0024245816 scopus 로고
    • GM-CSF and oncogene mRNA stabilities are independently regulated in trans in a mouse monocytic tumor
    • Schuler, G.D. and Cole, M.D. (1988) GM-CSF and oncogene mRNA stabilities are independently regulated in trans in a mouse monocytic tumor. Cell, 55, 1115-1122.
    • (1988) Cell , vol.55 , pp. 1115-1122
    • Schuler, G.D.1    Cole, M.D.2
  • 71
    • 0023058975 scopus 로고
    • A conserved AU sequence trom the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
    • Shaw, G. and Kamen, R. (1986) A conserved AU sequence trom the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell, 46, 659-667.
    • (1986) Cell , vol.46 , pp. 659-667
    • Shaw, G.1    Kamen, R.2
  • 72
    • 0024488977 scopus 로고
    • The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways
    • Shyu, A.-B., Greenberg, M.E. and Belasco, J.G. (1989) The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways. Genes Dev., 3, 60-72.
    • (1989) Genes Dev. , vol.3 , pp. 60-72
    • Shyu, A.-B.1    Greenberg, M.E.2    Belasco, J.G.3
  • 73
    • 0026027749 scopus 로고
    • Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay
    • Shyu, A.-B., Belasco, J.G. and Greenberg, M.E. (1991) Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay. Genes Dev., 5, 221-231.
    • (1991) Genes Dev. , vol.5 , pp. 221-231
    • Shyu, A.-B.1    Belasco, J.G.2    Greenberg, M.E.3
  • 74
    • 0028930155 scopus 로고
    • A nuclear localization domain in the hnRNP A1 protein
    • Siomi, H. and Dreyfuss, G. (1995) A nuclear localization domain in the hnRNP A1 protein. J. Cell Biol., 129, 551-560.
    • (1995) J. Cell Biol. , vol.129 , pp. 551-560
    • Siomi, H.1    Dreyfuss, G.2
  • 75
    • 0030985459 scopus 로고    scopus 로고
    • Exportin 1 (Crm1p) is an essential nuclear export factor
    • Stade, K., Ford, C.S., Guthrie, C. and Weis, K. (1997) Exportin 1 (Crm1p) is an essential nuclear export factor. Cell, 90, 1041-1050.
    • (1997) Cell , vol.90 , pp. 1041-1050
    • Stade, K.1    Ford, C.S.2    Guthrie, C.3    Weis, K.4
  • 76
    • 0026094583 scopus 로고
    • HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to elav and sex-lethal
    • Szabo, A., Dalmau, J., Manley, G., Rosenfeld, M., Wong, E., Henson, J., Posner, J.B. and Furneaux, H.M. (1991) HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to elav and sex-lethal. Cell, 67, 325-333.
    • (1991) Cell , vol.67 , pp. 325-333
    • Szabo, A.1    Dalmau, J.2    Manley, G.3    Rosenfeld, M.4    Wong, E.5    Henson, J.6    Posner, J.B.7    Furneaux, H.M.8
  • 77
    • 0025756170 scopus 로고
    • A 32-kilodalton protein binds to AU-rich domains in the 3′ untranslated regions of rapidly degraded mRNAs
    • Vakalopoulou, E., Schaack, J. and Shenk, T. (1991)A 32-kilodalton protein binds to AU-rich domains in the 3′ untranslated regions of rapidly degraded mRNAs. Mol. Cell. Biol., 11, 3355-3364.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 3355-3364
    • Vakalopoulou, E.1    Schaack, J.2    Shenk, T.3
  • 78
    • 0027400786 scopus 로고
    • The protein sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA
    • Valcarcel, J., Singh, R., Zamore, P.D. and Green, M.R. (1993) The protein sex-lethal antagonizes the splicing factor U2AF to regulate alternative splicing of transformer pre-mRNA. Nature, 362, 171-175.
    • (1993) Nature , vol.362 , pp. 171-175
    • Valcarcel, J.1    Singh, R.2    Zamore, P.D.3    Green, M.R.4
  • 79
    • 0030827809 scopus 로고    scopus 로고
    • Sequential expression and role of Hu RNA-binding proteins during neurogenesis
    • Wakamatsu, Y. and Weston, J.A. (1997) Sequential expression and role of Hu RNA-binding proteins during neurogenesis. Development, 124, 3449-3460.
    • (1997) Development , vol.124 , pp. 3449-3460
    • Wakamatsu, Y.1    Weston, J.A.2
  • 80
    • 0029114532 scopus 로고
    • A human RNase E-like activity that cleaves RNA sequences involved in mRNA stability control
    • Wennborg, A., Sohlberg, B., Angerer, D., Klein, G. and von Gabain, A. (1995) A human RNase E-like activity that cleaves RNA sequences involved in mRNA stability control. Proc. Natl Acad. Sci. USA, 92, 7322-7326.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 7322-7326
    • Wennborg, A.1    Sohlberg, B.2    Angerer, D.3    Klein, G.4    Von Gabain, A.5
  • 81
    • 0030799124 scopus 로고    scopus 로고
    • The 36-kilodalton embryonic-type cytoplasmic polyadenylation element-binding protein in Xenopus laevis is elrA, a member of the ELAV family of RNA-binding proteins
    • Wu, L., Good, P.J. and Richter, J.D. (1997) The 36-kilodalton embryonic-type cytoplasmic polyadenylation element-binding protein in Xenopus laevis is elrA, a member of the ELAV family of RNA-binding proteins. Mol. Cell. Biol., 17, 6402-6409.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 6402-6409
    • Wu, L.1    Good, P.J.2    Richter, J.D.3
  • 82
    • 0030872398 scopus 로고    scopus 로고
    • Modulation of the fate of cytoplasmic mRNA by AU-rich elements, key sequence features controlling mRNA deadenylation and decay
    • Xu, N., Chen, C.-Y. and Shyu, A.-B. (1997) Modulation of the fate of cytoplasmic mRNA by AU-rich elements, key sequence features controlling mRNA deadenylation and decay. Mol. Cell. Biol., 17, 4611-4621.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4611-4621
    • Xu, N.1    Chen, C.-Y.2    Shyu, A.-B.3
  • 84
    • 0028900073 scopus 로고
    • The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation
    • Zubiaga, A.M., Belasco, J.G. and Greenberg, M.E. (1995) The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation. Mol. Cell. Biol., 15, 2219-2230.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2219-2230
    • Zubiaga, A.M.1    Belasco, J.G.2    Greenberg, M.E.3


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