Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1

Journal of Experimental Medicine

Volumn 198, Issue 3, 2003, Pages 475-481

  Dixon, Dan A ^a   Balch, Glen C ^a   Kedersha, Nancy ^d   Anderson, Paul ^d   Zimmerman, Guy A ^b   Beauchamp, R Daniel ^a   Prescott, Stephen M ^c  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c UNIVERSITY OF UTAH   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

AU rich element; COX 2; Cyclooxygenase 2; Prostaglandins; TIA 1

Indexed keywords

CYCLOOXYGENASE 2; ISOPROTEIN; MESSENGER RNA; TRANSLATIONAL REPRESSOR PROTEIN TIA 1; TRANSLATIONAL SILENCER TIA 1; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; CANCER CELL; COLON CARCINOMA; CONTROLLED STUDY; EMBRYO; FEMALE; FIBROBLAST; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; POLYSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; RNA BINDING; TRANSCRIPTION REGULATION; TURNOVER TIME; WILD TYPE;

ANIMALS; CYCLOOXYGENASE 2; FIBROBLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; MICE; POLY(A)-BINDING PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; PROTEINS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER; RNA-BINDING PROTEINS; SILENCER ELEMENTS, TRANSCRIPTIONAL; TUMOR CELLS, CULTURED;

EID: 0041622806     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20030616     Document Type: Article

References (21)

1. Gupta, R.A., and R.N. Dubois. 2001. Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nat. Rev. Cancer. 1:11-21.
2. Prescott, S.M. 2000. Is cyclooxygenase-2 the alpha and the omega in cancer? J. Clin. Invest. 105:1511-1513.
3. Dixon, D.A. 2003. Regulation of COX-2 expression in human cancer. Prog. Exp. Tumor Res. 37:70-89.
4. Dixon, D.A., C.D. Kaplan, T.M. McIntyre, G.A. Zimmerman, and S.M. Prescott. 2000. Post-transcriptional control of cyclooxygenase-2 gene expression. The role of the 3′-untranslated region. J. Biol. Chem. 273:11750-11757.
5. Sheng, H., J. Shao, D.A. Dixon, C.S. Williams, S.M. Prescott, R.N. DuBois, and R.D. Beauchamp. 2000. Transforming growth factor-beta1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA. J. Biol. Chem. 275:6628-6635.
6. Dixon, D.A., N.D. Tolley, P.H. King, L.B. Nabors, T.M. McIntyre, G.A. Zimmerman, and S.M. Prescott. 2001. Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells. J. Clin. Invest. 108:1657-1665.
7. Lasa, M., K.R. Mahtani, A. Finch, G. Brewer, J. Saklatvala, and A.R. Clark. 2000. Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade. Mol. Cell. Biol. 20:4265-4274.
8. Brewer, G. 2001. Misregulated posttranscriptional check-points: inflammation and tumorigenesis. J. Exp. Med. 193: F1-F4.
9. Piecyk, M., S. Wax, A.R. Beck, N. Kedersha, M. Gupta, B. Maritim, S. Chen, C. Gueydan, V. Kruys, M. Streuli, and P. Anderson. 2000. TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha. EMBO J. 19: 4154-4163.
10. Forch, P., O. Puig, N. Kedersha, C. Martinez, S. Granneman, B. Seraphin, P. Anderson, and J. Valcarcel. 2000. The apoptosis-promoting factor TIA-1 is a regulator of alternative pre-mRNA splicing. Mol. Cell. 6:1089-1098.
11. Pinol-Roma, S., S.A. Adam, Y.D. Choi, and G. Dreyfuss. 1989. Ultraviolet-induced cross-linking of RNA to proteins in vivo. Methods Enzymol. 180:410-418.
12. Chen, C.A., N. Xu, and A. Shyu. 1995. mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts: different deadenylation kinetics and uncoupling from translation. Mol. Cell. Biol. 15:5777-5788.
13. Kruys, V., B. Beutler, and G. Heuz. 1990. Translational control mediated by UA-rich sequences. Enzyme. 44:193-202.
14. Zhang, T., V. Kruys, G. Huez, and C. Gueydan. 2002. AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors. Biochem. Soc. Trans. 30:952-958.
15. Kedersha, N., M. Gupta, W. Li, I. Miller, and P. Anderson. 1999. RNA-binding proteins TIA-1 and TIAR link the phosphorylation of elF-2α to the assembly of mammalian stress granules. J. Cell Biol. 147:1431-1441.
16. Anderson, P., and N. Kedersha. 2002. Stressful initiations. J. Cell Sci. 115:3227-3234.
17. Kruys, V., and G. Huez. 1994. Translational control of cytokine expression by 3′ UA-rich sequences. Biochimie. 76:862-866.
18. Savant-Bhonsale, S., and D.W. Cleveland. 1992. Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a >20S degradation complex. Genes Dev. 6:1927-1939.
19. Kawakami, A., Q. Tian, M. Streuli, M. Poe, S. Edelhoff, C.M. Disteche, and P. Anderson. 1994. Intron-exon organization and chromosomal localization of the human TIA-1 gene. J. Immunol. 152:4937-4945.
20. Gouble, A., S. Grazide, F. Meggetto, P. Mercier, G. Delsol, and D. Morello. 2002. A new player in oncogenesis: AUF1/hnRNPD overexpression leads to tumorigenesis in transgenic mice. Cancer Res. 62:1489-1495.
21. Raghavan, A., R.L. Robison, J. McNabb, C.R. Miller, D.A. Williams, and P.R. Bohjanen. 2001. HuA and tristetraprolin are induced following T cell activation and display distinct but overlapping RNA binding specificities. J. Biol. Chem. 276:47958-47965.