NF90 regulates inducible IL-2 gene expression in T cells

Journal of Experimental Medicine

Volumn 204, Issue 5, 2007, Pages 971-977

  Shi, Lingfang ^a   Godfrey, Wayne R ^b   Lin, Joseph ^a   Zhao, Guohua ^a   Kao, Peter N ^a  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^b Dendreon   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DNA; DOUBLE STRANDED RNA; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR GAMMA; INTERLEUKIN ENHANCER BINDING FACTOR 3; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN SUBUNIT; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE ACTIVATION; CELL GROWTH; CELL SURVIVAL; CELL TRANSPLANTATION; CELLULAR IMMUNITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; FLOW CYTOMETRY; GENE CONTROL; GENE DISRUPTION; GENE EXPRESSION; GENE SEQUENCE; GENE TARGETING; GENETIC RECOMBINATION; IN VIVO STUDY; LETHALITY; LYMPHOCYTOPENIA; NATURAL KILLER CELL; NONHUMAN; PERIPHERAL CIRCULATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DETERMINATION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; CHROMATIN IMMUNOPRECIPITATION; DNA PRIMERS; DNA-BINDING PROTEINS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; INTERLEUKIN-2; LUCIFERASES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NUCLEAR FACTOR 90 PROTEINS; T-LYMPHOCYTES;

EID: 34249063242     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20052078     Document Type: Article

References (25)

1. Kao, P.N., L. Chen, G. Brock, J. Ng, J. Kenny, A.J. Smith, and B. Corthesy. 1994. Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. J. Biol. Chem. 269:20691-20699.
2. Corthesy, B., and P.N. Kao. 1994. Purification by DNA affinity chromatography of two polypeptides that contact the NF-AT DNA binding site in the interleukin 2 promoter. J. Biol. Chem. 269:20682-20690.
3. Shim, J., H. Lim, J.R. Yates, and M. Karin. 2002. Nuclear export of NF90 is required for interleukin-2 mRNA stabilization. Mol. Cell. 10:1331-1344.
4. Xu, Y.H., and G.A. Grabowski. 1999. Molecular cloning and characterization of a translational inhibitory protein that binds to coding sequences of human acid beta-glucosidase and other mRNAs. Mol. Genet. Metab. 68:441-454.
5. Shi, L., G. Zhao, D. Qiu, W.R. Godfrey, H. Vogel, T.A. Rando, H. Hu, and P.N. Kao. 2005. NF90 regulates cell cycle exit and terminal myogenic diff erentiation by direct binding to the 3′-untranslated region of MyoD and p21WAF1/CIP1 mRNAs. J. Biol. Chem. 280:18981-18989.
6. Ting, N.S., P.N. Kao, D.W. Chan, L.G. Lintott, and S.P. Lees-Miller. 1998. DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45. J. Biol. Chem. 273:2136-2145.
7. Aoki, Y., G. Zhao, D. Qiu, L. Shi, and P.N. Kao. 1998. CsA-sensitive purine-box transcriptional regulator in bronchial epithelial cells contains NF45, NF90, and Ku. Am. J. Physiol. 275:L1164-L1172.
8. Shi, L., D. Qiu, G. Zhao, B. Corthesy, S. Lees-Miller, W.H. Reeves, and P.N. Kao. 2007. Dynamic binding of Ku80, Ku70 and NF90 to the IL-2 promoter in vivo in activated T-cells. Nucleic Acids Res. 10.1093/nar/gkm117.
9. Tian, B., P.C. Bevilacqua, A. Diegelman-Parente, and M.B. Mathews. 2004. The double-stranded-RNA-binding motif: interference and much more. Nat. Rev. Mol. Cell Biol. 5:1013-1023.
10. Saunders, L.R., D.J. Perkins, S. Balachandran, R. Michaels, R. Ford, A. Mayeda, and G.N. Barber. 2001. Characterization of two evolutionarily conserved, alternatively spliced nuclear phosphoproteins, NFAR-1 and -2, that function in mRNA processing and interact with the double-stranded RNA-dependent protein kinase, PKR. J. Biol. Chem. 276:32300-32312.
11. Reichman, T.W., L.C. Muniz, and M.B. Mathews. 2002. The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells. Mol. Cell. Biol. 22:343-356.
12. Nie, Y., L. Ding, P.N. Kao, R. Braun, and J.H. Yang. 2005. ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing. Mol. Cell. Biol. 25:6956-6963.
13. Langland, J.O., P.N. Kao, and B.L. Jacobs. 1999. Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR. Biochemistry. 38:6361-6368.
14. Isken, O., C.W. Grassmann, R.T. Sarisky, M. Kann, S. Zhang, F. Grosse, P.N. Kao, and S.E. Behrens. 2003. Members of the NF90/NFAR protein group are involved in the life cycle of a positive-strand RNA virus. EMBO J. 22:5655-5665.
15. Mouzaki, A., R. Weil, L. Muster, and D. Rungger. 1991. Silencing and trans-activation of the mouse IL-2 gene in Xenopus oocytes by proteins from resting and mitogen-induced primary T-lymphocytes. EMBO J. 10:1399-1406.
16. Shaw, J.P., P.J. Utz, D.B. Durand, J.J. Toole, E.A. Emmel, and G.R. Crabtree. 1988. Identification of a putative regulator of early T cell activation genes. Science. 241:202-205.
17. Randak, C., T. Brabletz, M. Hergenrother, I. Sobotta, and E. Serfling. 1990. Cyclosporin A suppresses the expression of the interleukin 2 gene by inhibiting the binding of lymphocyte-specific factors to the IL-2 enhancer. EMBO J. 9:2529-2536.
18. Garrity, P.A., D. Chen, E.V. Rothenberg, and B.J. Wold. 1994. Interleukin-2 transcription is regulated in vivo at the level of coordinated binding of both constitutive and regulated factors. Mol. Cell. Biol. 14:2159-2169.
19. Novac, O., D. Matheos, F.D. Araujo, G.B. Price, and M. Zannis-Hadjopoulos. 2001. In vivo association of Ku with mammalian origins of DNA replication. Mol. Biol. Cell. 12:3386-3401.
20. Zhao, G., L. Shi, D. Qiu, H. Hu, and P.N. Kao. 2005. NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function. Exp. Cell Res. 305:312-323.
21. Hanisch, U.K., and R. Quirion. 1995. Interleukin-2 as a neuroregulatory cytokine. Brain Res. Brain Res. Rev. 21:246-284.
22. Ogilvie, R.L., M. Abelson, H.H. Hau, I. Vlasova, P.J. Blackshear, and P.R. Bohjanen. 2005. Tristetraprolin down-regulates IL-2 gene expression through AU-rich element-mediated mRNA decay. J. Immunol. 174:953-961.
23. McCaffrey, P.G., B.A. Perrino, T.R. Soderling, and A. Rao. 1993. NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs. J. Biol. Chem. 268:3747-3752.
24. Peng, S.L., A.J. Gerth, A.M. Ranger, and L.H. Glimcher. 2001. NFATc1 and NFATc2 together control both T and B cell activation and diff erentiation. Immunity. 14:13-20.
25. Langland, J.O., P. Kao, and B.L. Jacobs. 2003. Regulation of IL-2 gene expression and nuclear factor-90 translocation in vaccinia virus-infected cells. J. Interferon Cytokine Res. 23:489-500.