Increased granulocyte-macrophage colony-stimulating factor mRNA instability in cord versus adult mononuclear cells is translation-dependent and associated with increased levels of A + U-rich element binding factor

Blood

Volumn 88, Issue 8, 1996, Pages 2889-2897

  Buzby, Jeffrey S ^b   Lee, Sun Min ^b   Van Winkle, Patrick ^b   DeMaria, Christine T ^b   Brewer, Gary ^b   Cairo, Mitchell S ^a  

^a CHILDREN S HOSPITAL OF ORANGE COUNTY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; PHYTOHEMAGGLUTININ; RNA BINDING PROTEIN; URACIL;

ADULT; ARTICLE; HUMAN; HUMAN CELL; MONONUCLEAR CELL; MYELOPOIESIS; NEWBORN; PRIORITY JOURNAL; PROTEIN STABILITY; RNA BINDING; RNA TRANSLATION; UMBILICAL CORD BLOOD;

EID: 10244230822     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.8.2889.bloodjournal8882889     Document Type: Article

References (54)

1. Christensen R: Hematopoiesis in the fetus and neonate. Pediatr Res 26:531, 1989
2. Cairo M: Neonatal neutrophil host defense. Am J Dis Child 143:40, 1989
3. Marodi L, Leijh P, van Furth R: Characteristics and functional capacities of human cord blood granulocytes and monocytes. Pediatr Res 18:1127, 1984
4. Hill H: Biochemical, structural and functional abnormalities of polymorphonuclear leukocytes in the neonate. Pediatr Res 22:375, 1987
5. Gasson J: Molecular physiology of granulocyte-macrophage colony-stimulating factor. Blood 77:1131, 1991
6. Frenck R, Sarman G, Harper T, Buescher E: The ability of recombinant murine granulocyte-macrophage colony-stimulating factor to protect neonatal rats from septic death due to Staphylococcus aureus. J Infect Dis 162:109, 1990
7. Cairo M, Suen Y, Knoppel E, van de Ven C, Nguyen A, Sender L: Decreased stimulated GM-CSF production and GM-CSF gene expression but normal numbers of GM-CSF receptors in human term newborns compared to adults. Pediatr Res 30:362, 1991
8. English K, Hammond W, Lewis D, Brown C, Wilson C: Decreased granulocyte-macrophage colony-stimulating factor production by human neonatal blood mononuclear cells and T cells. Pediatr Res 31:211, 1992
9. Lee S, Knoppel E, van de Ven C, Cairo M: Transcriptional rates of granulocyte-macrophage colony-stimulating factor, granulocyte colony stimulating factor, interleukin-3 and macrophage colony-stimulating factor genes in activated cord vs. adult mononuclear cells: Alteration in cytokine expression may be secondary to post-transcriptional instability. Pediatr Res 34:560, 1993
10. Shaw G, Kamen R: A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46:659, 1986
11. Carter B, Malter J: Biology of disease: Regulation of mRNA stability and its relevance to disease. Lab Invest 65:610, 1991
12. Asson-Batres M, Spurgeon S, Diaz J, DeLoughery T, Bagby G: Evolutionary conservation of the AU-rich 3′ untranslated region of messenger RNA. Proc Natl Acad Sci USA 91:1318, 1994
13. Ross H, Sato N, Ueyama Y, Koeffler H: Cytokine messenger RNA stability is enhanced in tumor cells. Am Soc Hematol 77:1787, 1991
14. Schuler G, Cole M: GM-CSFand oncogene mRNA stabilities are independently regulated in trans in a mouse monocytic tumor. Cell 55:1115, 1988
15. Lindsten T, June C, Ledbetter J, Stella G, Thompson C: Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244:339, 1989
16. Ernst T, Ritchie A, O'Rourke R, Griffin J: Colony-stimulating factor gene expression in human acute myeloblastic leukemia cells is posttranscriptionally regulated. Leukemia 3:620, 1989
17. Stocking C, Loliger C, Kawai M, Suciu S, Gough N, Ostertag W: Identification of genes involved in growth autonomy of hemato-poietic cells by analysis of factor-independent mutants. Cell 53:869, 1988
18. Algate P, McCubrey J: Autocrine transformation of hemopoietic cells resulting from cytokine message stabilization after intracisternal A particle transposition. Oncogene 8:1221, 1993
19. Nair A, Hahn S, Babholzer R, Hirsch H, Moroni C: Cyclosporin A inhibits growth of autocrine tumour cell lines by destabilizing interleukin-3 mRNA. Nature 369:239, 1994
20. Wong G, Witek J, Temple P, Wilkkens K, Leary A, Luxemburg D, Jones S, Brown E, Kay R, Orr E, Shoemaker C, Golde D, Kaufman R, Hewick R, Want E, Clark S: Human GM-CSF: Molecular cloning of the complementary DNA and purification of the natural and recombinant proteins. Science 228:810, 1985
21. Suen Y, Lee S, Cairo M: Decreased M-CSF mRNA expression from activated cord versus adult mononuclear cells: Altered post transcriptional stability. Blood 84:4269, 1994
22. Cairo M, Suen Y, Knoppel E, Dana R, Park L, Clark S, van de Ven C, Sender L: Decreased G-CSF and IL-3 production and gene expression from mononuclear cells of newborn infants. Pediatr Res 31:574, 1992
23. Chang M, Suen Y, Lee S, Baly D, Buzby J, Knoppel E, Wolpe S, Cairo MS: Transforming growth factor-β1, macrophage inflammatory protein-1α, and interleukin-8 gene expression is lower in stimulated human neonatal compared to adult mononuclear cells. Blood 84:118, 1994
24. Savant-Bhonsale S, Cleveland D: Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a >20S degradation complex. Genes Dev 6:1927, 1992
25. Aharon T, Schneider R: Selective destabilization of shortlived mRNAs with the granulocyte-macrophage colony-stimulating factor AU-rich 3′ noncoding region is mediated by a cotranslational mechanism. Mol Cell Biol 13:1971, 1993
26. Edwards D, Mahadevan L: Protein synthesis inhibitors differentially superinduce c-fos and c-jun by three distinct mechanisms: Lack of evidence for labile repressors. EMBO J 11:2415, 1992
27. Koeller D, Horowitz J, Casey J, Klausner R, Harford J: Translation and the stability of mRNAs encoding the transferrin receptor and c-fos. Proc Natl Acad Sci USA 88:7778, 1991
28. Jochum C, Voth R, Rossol S, Buschenfelde K, Hess G, Will H, Schroder H, Steffen R, Muller W: Immunosuppressive function of hepatitis B antigens in vitro: Role of endoribonuclease V as one potential trans inactivator for cytokines in macrophages and human hepatoma cells. J Virol 64:1956, 1990
29. Beutler B, Thompson P, Keyes J, Hagerty K, Crawford D: Assay of a ribonuclease that preferentially hydrolyses mRNAs containing cytokine-derived UA-rich instability sequences. Biochem Biophys Res Commun 152:973, 1988
30. Wennborg A, Sohlberg B, Angerer D, Klein G, von Gabain A: A human RNase E-like activity that cleaves RNA sequences involved in mRNA stability control. Proc Natl Acad Sci USA 92:7322, 1995
31. Malter J: Identification of an AUUUA-specific messenger RNA binding protein. Science 246:664, 1989
32. Brewer G: An A + U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro. Mol Cell Biol 11:2460, 1991
33. Vakalopoulou E, Schaack J, Shenk T: A 32-kilodalton protein binds to AU-rich domains in the 3′ untranslated regions of rapidly degraded mRNAs. Mol Cell Biol 11:3355, 1991
34. Bohjanen P, Petryniak B, June C, Thompson C, Lindsten T: AU RNA-binding factors differ in their binding specificities and affinities. J Biol Chem 267:6302, 1992
35. Hamilton B, Nagy E, Malter J, Arrick B, Rigby W: Association of heterogeneous nuclear ribonucleoprotein A1 and C proteins with reiterated AUUUA sequences. J Biol Chem 268:8881, 1993
36. Levine T, Gao F, King P, Andrews L, Keene J: Hel-N1: An autoimmune RNA-binding protein with specificity for 3′ uridylaterich untranslated regions of growth factor mRNAs. Mol Cell Biol 13:3494, 1993
37. Nakagawa J, Waldner H, Meyer-Monard S, Hofsteenge J, Jeno P, Moroni C: AUH, a gene encoding and AU-specific RNA binding protein with intrinsic enoyl-CoA hydratase activity. Proc Natl Acad Sci USA 92:2051, 1995
38. Zhang W, Wagner B, Ehrenman K, Schaefer A, DeMaria C, Crater D, DeHaven K, Long L, Brewer G: Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1. Mol Cell Biol 13:7652, 1993
39. Ehrenman K, Long L, Wagner BJ, Brewer G: Characterization of cDNAs encoding the murine A + U-rich RNA-binding protein AUF1. Gene 149:315, 1994
40. Wagner BJ, Long L, Rao PN, Pettenati MJ, Brewer G: Localization and physical mapping of genes encoding the A + U-rich element RNA-binding protein AUF1 to human chromosomes 4 and X. Genomics 34:219, 1996
41. DeMaria CT, Brewer G: AUF1 binding affinity to A + U-rich elements correlates with rapid mRNA degradation. J Biol Chem 271:12179, 1996
42. Pende A, Tremmel KD, DeMaria CT, Blaxall BC, Minobe WA, Sherman JA, Bisognano JD, Bristow MR, Brewer G, Port JD: Regulation of the mRNA-binding protein AUF1 by activation of the β-adrenergic receptor signal transduction pathway. J Biol Chem 271:8483, 1996
43. Sambrook J, Fritsch E, Maniatis T: Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, 1989
44. Janssen K (ed): Current Protocols in Molecular Biology. Secaucus, NJ, Wiley, 1990
45. Gupta K: Efficient measurement of radioactivity in oligonucleotides. Biotechniques 12:226, 1992
46. Osborn L, Kunkel S, Nabel G: Tumor necrosis factor α and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor κB. Proc Natl Acad Sci USA 86:2336, 1989
47. Leibold E, Munro H: Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5′ untranslated region of ferritin heavy- and light-subunit mRNAs. Proc Natl Acad Sci USA 85:2171, 1988
48. Buzby J, Yamada T, Tobin E: A light-regulated DNA-binding activity interacts with a conserved region of a Lemna gibba rbcS promoter. Plant Cell 2:805, 1990
49. Akashi M, Shaw G, Hachiya M, Elstner E, Suzuki G, Koeffler P: Number and location of AUUUA motifs: Role in regulating transiently expressed RNAs. Blood 83:3182, 1994
50. Lagnado CA, Brown CY, Goodall GJ: AUUUA is not sufficient to promote poly (A) shortening and degradation of an mRNA: The functional sequence within AU-rich elements may be UUAUUUA(U/A)(U/A). Mol Cell Biol 14:7984, 1994
51. Zubiaga AM, Belasco JG, Greenberg ME: The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation. Mol and Cell Biol 154:2219, 1995
52. Bickel M, Iwai Y, Pluznik D, Cohen R: Binding of sequence-specific proteins to the adenosine-plus uridine-rich sequences of the murine granulocyte/macrophage colony-stimulating factor mRNA. Proc Natl Acad Sci USA 89:10001, 1992
53. Rajagopalan L, Malter J: Modulation of granulocyte-macrophage colony-stimulating factor mRNA stability in vitro by the adenosine-uridine binding factor. J Biol Chem 269:23882, 1994
54. Konradi C, Kobierski L, Nguyen T, Heckers S, Hyman S: The cAMP-response-element-binding protein interacts, but Fos protein does not interact with the proenkephalin enhancer in rat striatum. Proc Natl Acad Sci USA 90:7005, 1993.