The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements

EMBO Journal

Volumn 21, Issue 1-2, 2002, Pages 165-174

  Mukherjee, Devi ^a   Gao, Min ^a   O'Connor, J Patrick ^a   Raijmakers, Reinout ^b   Pruijn, Ger ^b   Lutz, Carol S ^a   Wilusz, Jeffrey ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

AU rich elements; Exosome; mRNA stability; PM Sc175

Indexed keywords

ADENINE; ANTIBODY; CELL EXTRACT; EXONUCLEASE; MESSENGER RNA; RNA; URACIL;

ADENYLATION; ARTICLE; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN INTERACTION; RNA DEGRADATION; RNA STABILITY;

BASE COMPOSITION; BASE SEQUENCE; CYTOPLASM; EXODEOXYRIBONUCLEASE V; EXODEOXYRIBONUCLEASES; HELA CELLS; HUMANS; MODELS, BIOLOGICAL; MUTATION; RNA STABILITY; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

MAMMALIA;

EID: 0037080834     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.1.165     Document Type: Article

References (67)

1. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits
2. Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: A unique and complete human cDNA encoding an apparent 75-kD acidic protein of the nucleolar complex
3. Functions of the exosome in rRNA, snoRNA and snRNA synthesis
4. The yeast exosome and human PM-Scl are related complexes of 3′-5′ exonucleases
5. Degradation of ribosomal RNA precursors by the exosome
6. DSEF-1 is a member of the hnRNP H family of RNA-binding proteins and stimulates pre-mRNA cleavage and polyadenylation in vitro
7. The poly(A)-poly(A)-binding protein complex is a major determinant of mRNA stability in vitro
8. Identification of a regulated pathway for nuclear pre-mRNA turnover
9. An A + U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro
10. Evidence for a 3′-5′ decay pathway for c-myc mRNA in mammalian cells
11. Rrp6p, the yeast homologue of the human PM-Scl 100-kDa autoantigen, is essential for efficient 5.8S rRNA 3′ end formation
12. Three novel components of the human exosome
13. The human exosome: An autoantigenic complex of exoribonucleases in myositis and scleroderma
14. Autoantibody profiles in the sera of European patients with myositis
15. A nuclear 3′-5′ exonuclease involved in mRNA degradation interacts with poly(A) polymerase and the hnRNA protein Np13p
16. Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae
17. Poly(A) tail-dependent exonuclease AtRrp41p from Arabidopsis thaliana rescues 5.8S rRNA processing and mRNA decay defects of the yeast ski6 mutant and is found in an exosome-sized complex in plant and yeast cells
18. AU-rich elements: Characterization and importance in mRNA degradation
19. Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation
20. The yeast POP2 gene encodes a nuclease involved in mRNA deadenylation
21. Cap-dependent deadenylation of mRNA
22. Doblp (Mtr4p) is a putative ATP-dependent RNA helicase required for the 3′ end formation of 5.8S rRNA in Saccharomyces cerevisiae
23. The exosome of Trypanosoma brucei
24. Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs
25. U-rich elements target small nuclear RNAs as well as mRNAs for rapid degradation
26. An in vitro system using HeLa cytoplasmic extracts that reproduces regulated mRNA stability
27. The poly(A) tail inhibits the assembly of a 3′-to-5′ exonuclease in an in vitro RNA stability system
28. ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system
29. Interaction between a poly(A)-specific ribonuclease and the 5′ cap influences mRNA deadenylation rates in vitro
30. A novel mRNA-decapping activity in HeLa cytoplasmic extracts is regulated by AU-rich elements
31. Regulation of mRNA stability in mammalian cells
32. The 3′ to 5′ degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SK12 DEVH box protein and 3′ to 5′ exonucleases of the exosome complex
33. Precursors to the U3 small nucleolar RNA lack small nucleolar RNP proteins but are stabilized by La binding
34. Isolation and characterization of Dcplp, the yeast mRNA decapping enzyme
35. Interactions of CCCH zinc finger proteins with mRNA: Tristetraprolin-mediated AU-rich element-dependent mRNA degradation can occur in the absence of a poly(A) tail
36. Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor α mRNA
37. Control of mRNA decay by heat shock-ubiquitin-proteasome pathway
38. He1-N1: An autoimmune RNA-binding protein with specificity for 3′ uridylate-rich untranslated regions of growth factor mRNAs
39. Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element
40. Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein
41. The mRNA cap structure stimulates rate of poly(A) removal and amplifies processivity of degradation
42. Parallel and independent regulation of interleukin-3 mRNA turnover by phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase
43. mRNA stability in eukaryotes
44. Musing on the structural organization of the exosome complex
45. The exosome: A conserved eukaryotic RNA processing complex containing multiple 3′→5′ exoribonucleases
46. Joining of RNAs by splinted ligation
47. Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5′→3′ digestion of the transcript
48. RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein
49. Protein-protein interactions of hCs14p with other human exosome subunits
50. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
51. Cloning and characterization of mouse Dhm2 cDNA, a functional homolog of budding yeast SEP1
52. Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay
53. Update on myositis-specific and myositis-associated autoantibodies
54. Identification and developmental expression of a 5′-3′ exoribonuclease from Drosophila melanogaster
55. Mechanisms and control of mRNA decapping in Saccharomyces cerevisiae
56. The transcription factor associated Ccr4 and Cafl proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae
57. The exosome: A proteasome for RNA?
58. Yeast exosome mutants accumulate 3′-extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs
59. Function of the ski4p (Cs14p) and Ski7p proteins in 3′-to-5′ degradation of mRNA
60. AUUUA sequences direct mRNA deadenylation uncoupled from decay during Xenopus early development
61. 3′ End processing of mRNA
62. Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences
63. The cap-to-tail guide to mRNA turnover
64. Poly(A) binding proteins regulate both mRNA deadenylation and decapping in yeast cytoplasmic extracts
65. A 64 kd nuclear protein binds to RNA segments that include the AAUAAA polyadenylation motif
66. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism
67. The exosome subunit Rrp43p is required for the efficient maturation of 5.8S, 18S and 25S rRNA