Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1

Genes and Development

Volumn 19, Issue 3, 2005, Pages 351-361

  Lykke Andersen, Jens ^a   Wagner, Eileen ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

AU rich elements; Deadenylation; Decapping; Exonuclease; mRNA turnover; TTP

Indexed keywords

EXONUCLEASE; MESSENGER RNA; PROTEIN B RELATED FACTOR 1; PROTEIN TRISTETRAPROLIN; RNA BINDING PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CLINICAL PATHWAY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE CONTROL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION;

BUTYRATE RESPONSE FACTOR 1; DNA-BINDING PROTEINS; ENDORIBONUCLEASES; HUMANS; IMMEDIATE-EARLY PROTEINS; PROTEIN STRUCTURE, TERTIARY; RIBONUCLEASES; RNA, MESSENGER; TATA-BINDING PROTEIN ASSOCIATED FACTORS; TRISTETRAPROLIN;

EID: 13244298460     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1282305     Document Type: Article

References (50)

1. Bakheet, T., Frevel, M., Williams, B.R., Greer, W., and Khabar, K.S. 2001. ARED: Human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins. Nucleic Acids Res. 29: 246-254.
2. Bashkirov, V.I., Scherthan, H., Solinger, J.A., Buerstedde, J.M., and Heyer, W.D. 1997. A mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4 tetraplex substrates. J. Cell Biol. 136: 761-773.
3. Blackshear, P.J. 2002. Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover. Biochem. Soc. Trans. 30: 945-952.
4. Brooks, S.A., Connolly, J.E., Diegel, R.J., Fava, R.A., and Rigby, W.F. 2002. Analysis of the function, expression, and subcellular distribution of human tristetraprolin. Arthritis Rheum. 46: 1362-1370.
5. Chang, T.C., Yamashita, A., Chen, C.Y., Yamashita, Y., Zhu, W., Durdan, S., Kahvejian, A., Sonenberg, N., and Shyu, A.B. 2004. UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant. Genes & Dev. 18: 2010-2023.
6. Chen, C.Y. and Shyu, A.B. 1995. AU-rich elements: Characterization and importance in mRNA degradation. Trends Biochem. Sci. 20: 465-470.
7. Chen, C.Y., Xu, N., and Shyu, A.B. 1995. mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts: Different deadenylation kinetics and uncoupling from translation. Mol. Cell. Biol. 15: 5777-5788.
8. Chen, C.Y., Gherzi, R., Ong, S.E., Chan, E.L., Raijmakers, R., Pruijn, G.J., Stoecklin, G., Moroni, C., Mann, M., and Karin, M. 2001. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell 107: 451-464.
9. Chen, J., Chiang, Y.C., and Denis, C.L. 2002. CCR4, a 3′-5′ poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase. EMBO J. 21: 1414-1426.
10. Chrestensen, C.A., Schroeder, M.J., Shabanowitz, J., Hunt, D.F., Pelo, J.W., Worthington, M.T., and Sturgill, T.W. 2004. MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding. J. Biol. Chem. 279: 10176-10184.
11. Cook, H.L., Mischo, H.E., and Steitz, J.A. 2004. The herpesvirus saimiri small nuclear RNAs recruit AU-rich element-binding proteins but do not alter host AU-rich element-containing mRNA levels in virally transformed T cells. Mol. Cell. Biol. 24: 4522-4533.
12. Cougot, N., Babajko, S., and Seraphin, B. 2004. Cytoplasmic foci are sites of mRNA decay in human cells. J. Cell Biol. 165: 31-40.
13. DeMaria, C.T. and Brewer, G. 1996. AUFl binding affinity to A + U-rich elements correlates with rapid mRNA degradation. J. Biol. Chem. 271: 12179-12184.
14. Fan, X.C. and Steitz, J.A. 1998. Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs. EMBO J. 17: 3448-3460.
15. Ford, L.P., Watson, J., Keene, J.D., and Wilusz, J. 1999. ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system. Genes & Dev. 13: 188-201.
16. Gao, M., Wilusz, C.J., Peltz, P.W., and Wilusz, J. 2001. A novel mRNA-decapping activity in HeLa cytoplasmic extracts is regulated by AU-rich elements. EMBO J. 20: 1134-1143.
17. Gherzi, R., Lee, K.Y., Briata, P., Wegmuller, D., Moroni, C., Karin, M., and Chen, C.Y. 2004. A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery. Mol. Cell 14: 571-583.
18. He, F. and Jacobson, A. 1995. Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes & Dev. 9: 437-454.
19. Hudson, B.P., Martinez-Yamout, M.A., Dyson, H.J., and Wright, P.E. 2004. Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d. Nat. Struct. Mol. Biol. 11: 257-264.
20. Johnson, B.A., Stehn, J.R., Yaffe, M.B., and Blackwell, T.K. 2002. Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms. J. Biol. Chem. 277: 18029-18036.
21. Korner, C.G. and Wahle, E. 1997. Poly(A) tail shortening by a mammalian poly(A)-specific 3′-exoribonuclease. J. Biol. Chem. 272: 10448-10456.
22. Lai, W.S. and Blackshear, P.J. 2001. Interactions of CCCH zinc finger proteins with mRNA: Tristetraprolin-mediated AU-rich element-dependent mRNA degradation can occur in the absence of a poly(A) tail. J. Biol. Chem. 276: 23144-23154.
23. Lai, W.S., Carballo, E., Thorn, J.M., Kennington, E.A., and Blackshear, P.J. 2000. Interactions of CCCH zinc finger proteins with mRNA: Binding of tristetraprolin-related zinc finger proteins to AU-rich elements and destabilization of mRNA. J. Biol. Chem. 275: 17827-17837.
24. Lai, W.S., Kennington, E.A., and Blackshear, P.J. 2002. Interactions of CCCH zinc finger proteins with mRNA: Non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs. J. Biol. Chem. 277: 9606-9613.
25. _. 2003. Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease. Mol. Cell. Biol. 23: 3798-3812.
26. Lejeune, F., Li, X., and Maquat, L.E. 2003. Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. Mol. Cell 12: 675-687.
27. Lykke-Andersen, J. 2002. Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. Mol. Cell. Biol. 22: 8114-8121.
28. Lykke-Andersen, J., Shu, M.D., and Steitz, J.A. 2000. Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. Cell 103: 1121-1131.
29. Miller, A.D., Curran, T., and Verma, I.M. 1984. c-fos protein can induce cellular transformation: A novel mechanism of activation of a cellular oncogene. Cell 36: 51-60.
30. Mitchell, P., Petfalski, E., Shevchenko, A., Mann, M., and Tollervey, D. 1997. The exosome: A conserved eukaryotic RNA processing complex containing multiple 3′ → 5′ exoribonucleases. Cell 91: 457-466.
31. Muhlrad, D. and Parker, R. 1994. Premature translational termination triggers mRNA decapping. Nature 370: 578-581.
32. Mukherjee, D., Gao, M., O'Connor, J.P., Raijmakers, R., Pruijn, G., Lutz, C.S., and Wilusz, J. 2002. The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements. EMBO J. 21: 165-174.
33. Parker, R. and Song, H. 2004. The enzymes and control of eukaryotic mRNA turnover. Nat. Struct. Mol. Biol. 11: 121-127.
34. Peng, S.S., Chen, C.Y., Xu, N., and Shyu, A.B. 1998. RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein. EMBO J. 17: 3461-3470.
35. Raineri, I., Wegmueller, D., Gross, B., Certa, U., and Moroni, C. 2004. Roles of AUF1 isoforms, HuR and BRF1 in ARE-dependent mRNA turnover studied by RNA interference. Nucleic Acids Res. 32: 1279-1288.
36. Ramos, S.B., Stumpo, D.J., Kennington, E.A., Phillips, R.S., Bock, C.B., Ribeiro-Neto, F., and Blackshear, P.J. 2004. The CCCH tandem zinc-finger protein Zfp3612 is crucial for female fertility and early embryonic development. Development 131: 4883-4893.
37. Sheth, U. and Parker, R. 2003. Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science 300: 805-808.
38. Shim, J. and Karin, M. 2002. The control of mRNA stability in response to extracellular stimuli. Mol. Cell 14: 323-331.
39. Stoecklin, G., Colombi, M., Raineri, I., Leuenberger, S., Mallaun, M., Schmidlin, M., Gross, B., Lu, M., Kitamura, T., and Moroni, C. 2002. Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover. EMBO J. 21: 4709-4718.
40. Stoecklin, G., Stubbs, T., Kedersha, N., Wax, S., Rigby, W.F., Blackwell, T.K., and Anderson, P. 2004. MK2-induced tris-tetraprolin: 14-3-3 complexes prevent stress granule association and ARE-mRNA decay. EMBO J. 23: 1313-1324.
41. Stumpo, D.J., Byrd, N.A., Phillips, R.S., Ghosh, S., Maronpot, R.R., Castranio, T., Meyers, E.N., Mishina, Y., and Blackshear, P.J. 2004. Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the tristetraprolin family. Mol. Cell. Biol. 24: 6445-6455.
42. Taylor, G.A., Carballo, E., Lee, D.M., Lai, W.S., Thompson, M.J., Patel, D.D., Schenkman, D.I., Gilkeson, G.S., Broxmeyer, H.E., Haynes, B.F., et al. 1996. A pathogenetic role for TNF α in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity 4: 445-454.
43. Tharun, S. and Parker, R. 2001. Targeting an mRNA for decapping: Displacement of translation factors and association of the Lsm1p-7p complex on deadenylated yeast mRNAs. Mol Cell 8: 1075-1083.
44. Tran, H., Schilling, M., Wirbelauer, C., Hess, D., and Nagamine, Y. 2004. Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU. Mol. Cell 13: 101-111.
45. van Dijk, E., Cougot, N., Meyer, S., Babajko, S., Wahle, E., and Seraphin, B. 2002. Human Dcp2: A catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. EMBO J. 21: 6915-6924.
46. Voeltz, G.K. and Steitz, J.A. 1998. AUUUA sequences direct mRNA deadenylation uncoupled from decay during Xenopus early development. Mol. Cell. Biol. 18: 7537-7545.
47. Wang, Z. and Kiledjian, M. 2001. Functional link between the mammalian exosome and mRNA decapping. Cell 107: 751-762.
48. Wang, Z., Jiao, X., Carr-Schmid, A., and Kiledjian, M. 2002. The hDcp2 protein is a mammalian mRNA decapping enzyme. Proc. Natl. Acad. Sci. 99: 12663-12668.
49. Wilusz, C.J., Wormington, M., and Peltz, S.W. 2001. The capto-tail guide to mRNA turnover. Nat. Rev. Mol. Cell Biol. 2: 237-246.
50. Xu, N., Chen, C.Y., and Shyu, A.B. 2001. Versatile role for hnRNP D isoforms in the differential regulation of cytoplasmic mRNA turnover. Mol. Cell. Biol. 21: 6960-6971.