Endothelial dysfunction and blood pressure alterations in K +-channel transgenic mice

Pflugers Archiv European Journal of Physiology

Volumn 459, Issue 6, 2010, Pages 969-976

  Köhler, Ralf ^a   Ruth, Peter ^b  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Blood pressure; Ca2+ activated potassium channel; Endothelium; Endothelium derived hyperpolarizing factor; Hyperpolarization; Large conductance potassium channel; Smooth muscle; Transgenic mouse

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM ACTIVATED POTASSIUM CHANNEL 2.3; CALCIUM ACTIVATED POTASSIUM CHANNEL 3.1; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1; POTASSIUM CHANNEL; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ADRENAL FUNCTION; ARTERIAL PRESSURE; ARTERY DISEASE; BLOOD PRESSURE; BLOOD PRESSURE REGULATION; BLOOD VESSEL TONE; DIASTOLIC BLOOD PRESSURE; ENDOTHELIAL DYSFUNCTION; HEART RATE; HEMODYNAMICS; KIDNEY FUNCTION; MEAN ARTERIAL PRESSURE; MECHANOTRANSDUCTION; NONHUMAN; PHENOTYPE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PULSE PRESSURE; REVIEW; SMOOTH MUSCLE; SYSTOLIC BLOOD PRESSURE; TRANSGENE;

ANIMALS; BIOLOGICAL FACTORS; BLOOD PRESSURE; ENDOTHELIUM, VASCULAR; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MICE; MICE, TRANSGENIC; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; VASODILATION;

EID: 77952891052     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-010-0819-z     Document Type: Review

References (50)

1. M Absi MP Burnham AH Weston E Harno M Rogers G Edwards 2007 Effects of methyl beta-cyclodextrin on EDHF responses in pig and rat arteries; association between SK(Ca) channels and caveolin-rich domains Br J Pharmacol 151 332 340 10.1038/sj.bjp.0707222 1:CAS:528:DC%2BD2sXlslCqtb8%3D 17450174 (Pubitemid 46842666)
2. VM Bolotina S Najibi JJ Palacino PJ Pagano RA Cohen 1994 Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle Nature 368 850 853 10.1038/368850a0 1:CAS:528:DyaK2cXjtF2qtL4%3D 7512692 (Pubitemid 24137748)
3. + channel subunit, SK3 Science 289 1942 1946 10.1126/science.289.5486.1942 1:CAS:528:DC%2BD3cXms1altbs%3D 10988076
4. RP Brandes FH Schmitz-Winnenthal M Feletou A Godecke PL Huang PM Vanhoutte I Fleming R Busse 2000 An endothelium-derived hyperpolarizing factor distinct from NO and prostacyclin is a major endothelium-dependent vasodilator in resistance vessels of wild-type and endothelial NO synthase knockout mice Proc Natl Acad Sci USA 97 9747 9752 10.1073/pnas.97.17.9747 1:CAS:528: DC%2BD3cXmtVentLk%3D 10944233
5. R Brenner GJ Perez AD Bonev DM Eckman JC Kosek SW Wiler AJ Patterson MT Nelson RW Aldrich 2000 Vasoregulation by the beta1 subunit of the calcium-activated potassium channel Nature 407 870 876 10.1038/35038011 1:CAS:528:DC%2BD3cXns1OgtLY%3D 11057658
6. RM Bryan Jr J You SC Phillips JJ Andresen EE Lloyd PA Rogers SE Dryer SP Marrelli 2006 Evidence for two-pore domain potassium channels in rat cerebral arteries Am J Physiol Heart Circ Physiol 291 H770 H780 10.1152/ajpheart.01377. 2005 1:CAS:528:DC%2BD28XoslWrtbs%3D 16565299 (Pubitemid 44175084)
7. S Brähler A Kaistha VJ Schmidt SE Wolfle C Busch BP Kaistha M Kacik AL Hasenau I Grgic H Si CT Bond JP Adelman H Wulff C de Wit J Hoyer R Köhler 2009 Genetic deficit of SK3 and IK1 channels disrupts the endothelium-derived hyperpolarizing factor vasodilator pathway and causes hypertension Circulation 119 2323 2332 10.1161/CIRCULATIONAHA.108.846634 19380617
8. WB Campbell JR Falck 2007 Arachidonic acid metabolites as endothelium-derived hyperpolarizing factors Hypertension 49 590 596 10.1161/01.HYP.0000255173.50317.fc 1:CAS:528:DC%2BD2sXhslCms7Y%3D 17200437
9. S Chatterjee I Levitan Z Wei AB Fisher 2006 KATP channels are an important component of the shear-sensing mechanism in the pulmonary microvasculature Microcirculation 13 633 644 10.1080/10739680600930255 1:CAS:528:DC%2BD2sXhvVygtA%3D%3D 17085424 (Pubitemid 44688421)
10. KA Dora NT Gallagher A McNeish CJ Garland 2008 Modulation of endothelial cell KCa3.1 channels during endothelium-derived hyperpolarizing factor signaling in mesenteric resistance arteries Circ Res 102 1247 1255 10.1161/CIRCRESAHA. 108.172379 1:CAS:528:DC%2BD1cXlslGltro%3D 18403729
11. M Feletou 2009 Calcium-activated potassium channels and endothelial dysfunction: therapeutic options? Br J Pharmacol 156 545 562 10.1111/j.1476-5381.2009.00052.x 1:CAS:528:DC%2BD1MXpt1WlsL4%3D 19187341
12. M Feletou PM Vanhoutte 2006 Endothelium-derived hyperpolarizing factor: where are we now? Arterioscler Thromb Vasc Biol 26 1215 1225 10.1161/01.ATV.0000217611.81085.c5 1:CAS:528:DC%2BD28XksVGlsr0%3D 16543495 (Pubitemid 44305364)
13. J Feng Y Liu RT Clements NR Sodha KR Khabbaz V Senthilnathan KK Nishimura SL Alper FW Sellke 2008 Calcium-activated potassium channels contribute to human coronary microvascular dysfunction after cardioplegic arrest Circulation 118 S46 S51 10.1161/CIRCULATIONAHA.107.755827 1:CAS:528:DC%2BD1cXhtFKjurjE 18824768
14. J Feng Y Liu KR Khabbaz NR Sodha RM Osipov R Hagberg SL Alper FW Sellke 2009 Large conductance calcium-activated potassium channels contribute to the reduced myogenic tone of peripheral microvasculature after cardiopulmonary bypass J Surg Res 157 123 128 10.1016/j.jss.2009.03.043 1:CAS:528: DC%2BD1MXht1Oru7vK 19765723
15. JM Fernandez-Fernandez M Tomas E Vazquez P Orio R Latorre M Senti J Marrugat MA Valverde 2004 Gain-of-function mutation in the KCNMB1 potassium channel subunit is associated with low prevalence of diastolic hypertension J Clin Invest 113 1032 1039 1:CAS:528:DC%2BD2cXivFCqsLo%3D 15057310
16. B Fisslthaler R Popp L Kiss M Potente DR Harder I Fleming R Busse 1999 Cytochrome P450 2C is an EDHF synthase in coronary arteries Nature 401 493 497 10.1038/46816 1:STN:280:DyaK1MvkslSnsQ%3D%3D 10519554 (Pubitemid 29470209)
17. MJ Gardener IT Johnson MP Burnham G Edwards AM Heagerty AH Weston 2004 Functional evidence of a role for two-pore domain potassium channels in rat mesenteric and pulmonary arteries Br J Pharmacol 142 192 202 10.1038/sj.bjp.0705691 1:CAS:528:DC%2BD2cXktFyqt7o%3D 15066906 (Pubitemid 38698208)
18. A Garry B Fromy N Blondeau D Henrion F Brau P Gounon N Guy C Heurteaux M Lazdunski JL Saumet 2007 Altered acetylcholine, bradykinin and cutaneous pressure-induced vasodilation in mice lacking the TREK1 potassium channel: the endothelial link EMBO Rep 8 354 359 10.1038/sj.embor.7400916 1:CAS:528:DC%2BD2sXjs1yqtLk%3D 17347672 (Pubitemid 46519748)
19. M Gollasch M Lohn M Furstenau MT Nelson FC Luft H Haller 2000 Ca2+ channels, Ca2+ sparks, and regulation of arterial smooth muscle function Z Kardiol 89 Suppl 2 15 19 10.1007/s003920070095 1:CAS:528:DC%2BD3cXisF2msLk%3D 10769399
20. M Gollasch J Tank FC Luft J Jordan P Maass C Krasko AM Sharma A Busjahn S Bahring 2002 The BK channel beta1 subunit gene is associated with human baroreflex and blood pressure regulation J Hypertens 20 927 933 10.1097/00004872-200205000-00028 1:CAS:528:DC%2BD38XksVGmt70%3D 12011654 (Pubitemid 34913674)
21. I Grgic BP Kaistha J Hoyer R Kohler 2009 Endothelial Ca∈+∈- activated K∈+∈channels in normal and impaired EDHF-dilator responses-relevance to cardiovascular pathologies and drug discovery Br J Pharmacol 157 509 526 10.1111/j.1476-5381.2009.00132.x 1:CAS:528: DC%2BD1MXptleitrk%3D 19302590
22. PR Grimm DL Irsik DC Settles JD Holtzclaw SC Sansom 2009 Hypertension of Kcnmb1-/- is linked to deficient K secretion and aldosteronism Proc Natl Acad Sci USA 106 11800 11805 10.1073/pnas.0904635106 1:CAS:528:DC%2BD1MXptVWmtLs%3D 19556540
23. AM Gurney ON Osipenko D MacMillan KM McFarlane RJ Tate FE Kempsill 2003 Two-pore domain K channel, TASK-1, in pulmonary artery smooth muscle cells Circ Res 93 957 964 10.1161/01.RES.0000099883.68414.61 1:CAS:528:DC%2BD3sXoslyktbs%3D 14551239 (Pubitemid 37433233)
24. A Huang D Sun MA Carroll H Jiang CJ Smith JA Connetta JR Falck EG Shesely A Koller G Kaley 2001 EDHF mediates flow-induced dilation in skeletal muscle arterioles of female eNOS-KO mice Am J Physiol Heart Circ Physiol 280 H2462 H2469 1:CAS:528:DC%2BD3MXksFCmu7Y%3D 11356599
25. TM Ishii C Silvia B Hirschberg CT Bond JP Adelman J Maylie 1997 A human intermediate conductance calcium-activated potassium channel Proc Natl Acad Sci USA 94 11651 11656 10.1073/pnas.94.21.11651 1:CAS:528:DyaK2sXmslejt78%3D 9326665
26. SD Koh K Monaghan GP Sergeant S Ro RL Walker KM Sanders B Horowitz 2001 TREK-1 regulation by nitric oxide and cGMP-dependent protein kinase. an essential role in smooth muscle inhibitory neurotransmission J Biol Chem 276 44338 44346 10.1074/jbc.M108125200 1:STN:280:DC%2BD3MnmslKltw%3D%3D 11560940
27. Kohler R (2009) Single-nucleotide polymorphisms in vascular Ca(2+)-activated K (+)-channel genes and cardiovascular disease. Pflugers Arch. [Epub ahead of print]. PMID: 20043229. ISSN: 0031-6768 (Print) 1432-2013 (Online)
28. M Köhler B Hirschberg CT Bond JM Kinzie NV Marrion J Maylie JP Adelman 1996 Small-conductance, calcium-activated potassium channels from mammalian brain Science 273 1709 1714 10.1126/science.273.5282.1709 8781233
29. R Köhler S Brakemeier M Kuhn C Behrens R Real C Degenhardt HD Orzechowski AR Pries M Paul J Hoyer 2001 Impaired hyperpolarization in regenerated endothelium after balloon catheter injury Circ Res 89 174 179 10.1161/hh1401.093460 11463725
30. + channels in human mesenteric artery: a single-cell reverse transcriptase-polymerase chain reaction and electrophysiological study in situ Circ Res 87 496 503 10988242
31. J Ledoux MS Taylor AD Bonev RM Hannah V Solodushko B Shui Y Tallini MI Kotlikoff MT Nelson 2008 Functional architecture of inositol 1, 4, 5-trisphosphate signaling in restricted spaces of myoendothelial projections Proc Natl Acad Sci USA 105 9627 9632 10.1073/pnas.0801963105 1:CAS:528:DC%2BD1cXovVOjt7s%3D 18621682 (Pubitemid 352031351)
32. Y Liu EW Sellke J Feng RT Clements NR Sodha KR Khabbaz V Senthilnathan SL Alper FW Sellke 2008 Calcium-activated potassium channels contribute to human skeletal muscle microvascular endothelial dysfunction related to cardiopulmonary bypass Surgery 144 239 244 10.1016/j.surg.2008.03.032 18656631 (Pubitemid 352024387)
33. B Malester X Tong I Ghiu A Kontogeorgis DE Gutstein J Xu KD Hendricks-Munoz WA Coetzee 2007 Transgenic expression of a dominant negative K(ATP) channel subunit in the mouse endothelium: effects on coronary flow and endothelin-1 secretion FASEB J 21 2162 2172 10.1096/fj.06-7821com 1:CAS:528:DC%2BD2sXnvVagsbk%3D 17341678 (Pubitemid 47026451)
34. H Miura RE Wachtel Y Liu FR Loberiza Jr T Saito M Miura DD Gutterman 2001 Flow-induced dilation of human coronary arterioles: important role of Ca(2+)-activated K(+) channels Circulation 103 1992 1998 1:CAS:528: DC%2BD3MXjslKksLs%3D 11306529
35. MT Nelson H Cheng M Rubart LF Santana AD Bonev HJ Knot WJ Lederer 1995 Relaxation of arterial smooth muscle by calcium sparks Science 270 633 637 10.1126/science.270.5236.633 1:CAS:528:DyaK2MXovFGrsrc%3D 7570021
36. B Nilius G Droogmans 2001 Ion channels and their functional role in vascular endothelium Physiol Rev 81 1415 1459 1:CAS:528:DC%2BD38XislCqsA%3D%3D 11581493
37. GJ Perez AD Bonev JB Patlak MT Nelson 1999 Functional coupling of ryanodine receptors to KCa channels in smooth muscle cells from rat cerebral arteries J Gen Physiol 113 229 238 10.1085/jgp.113.2.229 1:CAS:528: DyaK1MXht1yhtr4%3D 9925821 (Pubitemid 29219796)
38. S Plüger J Faulhaber M Furstenau M Lohn R Waldschutz M Gollasch H Haller FC Luft H Ehmke O Pongs 2000 Mice with disrupted BK channel beta1 subunit gene feature abnormal Ca(2+) spark/STOC coupling and elevated blood pressure Circ Res 87 E53 E60 11090555
39. Ca) and connexins: possible relationship to vasodilator function? J Anat 209 689 698 10.1111/j.1469-7580.2006.00647.x 1:CAS:528:DC%2BD28XhtlGiu7jE 17062025 (Pubitemid 44614697)
40. A Sankaranarayanan G Raman C Busch T Schultz PI Zimin J Hoyer R Kohler H Wulff 2009 Naphtho[1, 2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure Mol Pharmacol 75 281 295 10.1124/mol.108.051425 1:CAS:528:DC%2BD1MXhtlGisbc%3D 18955585
41. M Sausbier C Arntz I Bucurenciu H Zhao XB Zhou U Sausbier S Feil S Kamm K Essin CA Sailer U Abdullah P Krippeit-Drews R Feil F Hofmann HG Knaus C Kenyon MJ Shipston JF Storm W Neuhuber M Korth R Schubert M Gollasch P Ruth 2005 Elevated blood pressure linked to primary hyperaldosteronism and impaired vasodilation in BK channel-deficient mice Circulation 112 60 68 10.1161/01.CIR.0000156448.74296.FE 1:CAS:528:DC%2BD2MXlsF2itLk%3D 15867178 (Pubitemid 40962570)
42. R Schubert MT Nelson 2001 Protein kinases: tuners of the BKCa channel in smooth muscle Trends Pharmacol Sci 22 505 512 10.1016/S0165-6147(00)01775-2 1:CAS:528:DC%2BD3MXnt1WisLY%3D 11583807 (Pubitemid 32913559)
43. + channel Circ Res 99 537 544 10.1161/01.RES.0000238377.08219.0c 1:CAS:528:DC%2BD28XosFGnsbw%3D 16873714 (Pubitemid 44337826)
44. B Tang Y Li C Nagaraj RE Morty S Gabor E Stacher R Voswinckel N Weissmann K Leithner H Olschewski A Olschewski 2009 Endothelin-1 inhibits background two-pore domain channel TASK-1 in primary human pulmonary artery smooth muscle cells Am J Respir Cell Mol Biol 41 476 483 10.1165/rcmb.2008-0412OC 1:CAS:528:DC%2BD1MXht1Squ7fL 19188660
45. + (SK3) channels modulates arterial tone and blood pressure Circ Res 93 124 131 10.1161/01.RES.0000081980.63146.69 1:CAS:528:DC%2BD3sXlsVOnsbY%3D 12805243 (Pubitemid 36919699)
46. M Tomas E Vazquez JM Fernandez-Fernandez I Subirana C Plata M Heras J Vila J Marrugat MA Valverde M Senti 2008 Genetic variation in the KCNMA1 potassium channel alpha subunit as risk factor for severe essential hypertension and myocardial infarction J Hypertens 26 2147 2153 10.1097/HJH.0b013e32831103d8 1:CAS:528:DC%2BD1cXht1Cqs7fJ 18854754
47. K Toyama H Wulff KG Chandy P Azam G Raman T Saito Y Fujiwara DL Mattson S Das JE Melvin PF Pratt OA Hatoum DD Gutterman DR Harder H Miura 2008 The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans J Clin Invest 118 9 3025 3037 10.1172/JCI30836 1:CAS:528:DC%2BD1cXhtV2isbzE 18688283
48. AD Wei GA Gutman R Aldrich KG Chandy S Grissmer H Wulff 2005 International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels Pharmacol Rev 57 463 472 10.1124/pr.57.4.9 1:CAS:528:DC%2BD28XhtFWgu7c%3D 16382103 (Pubitemid 43036436)
49. SE Wolfle VJ Schmidt J Hoyer R Kohler C de Wit 2009 Prominent role of KCa3.1 in endothelium-derived hyperpolarizing factor-type dilations and conducted responses in the microcirculation in vivo Cardiovasc Res 82 476 483 19218287
50. JJ Zaritsky DM Eckman GC Wellman MT Nelson TL Schwarz 2000 Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation Circ Res 87 160 166 1:CAS:528:DC%2BD3cXlt1aiur0%3D 10904001