Design of a potent and selective inhibitor of the intermediate- conductance Ca2+-activated K+ channel, IKCa1: A potential immunosuppressant

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 14, 2000, Pages 8151-8156

  Wulff, Heike ^a   Miller, Mark J ^a   Hänsel, Wolfram ^b   Grissmer, Stephan ^c   Cahalan, Michael D ^a   Chandy, K George ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF KIEL   (Germany)

^c UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 [(2 CHLOROPHENYL)DIPHENYLMETHYL] 1H PYRAZOLE; ACETONITRILE DERIVATIVE; CLOTRIMAZOLE; CYCLOSPORIN A; CYTOCHROME P450; IMMUNOSUPPRESSIVE AGENT; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; PYRAZOLE DERIVATIVE; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM CONDUCTANCE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CLOTRIMAZOLE; CYCLOSPORINE; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DESIGN; DRUG INTERACTIONS; ELECTRIC CONDUCTIVITY; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; ION CHANNEL GATING; IONOMYCIN; LYMPHOCYTE ACTIVATION; POTASSIUM CHANNELS; PYRAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE;

ANIMALIA;

EID: 0034608869     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.14.8151     Document Type: Article

References (39)