Targeting thermogenesis and related pathways in anti-obesity drug discovery

Pharmacology and Therapeutics

Volumn 131, Issue 3, 2011, Pages 295-308

  Clapham, John C ^a,b   Arch, Jonathan R S ^b  

^a ASTRAZENECA   (United Kingdom)

^b UNIVERSITY OF BUCKINGHAM   (United Kingdom)

Author keywords

Drug targets; Exercise; Fat oxidation; Obesity; Post obese; Thermogenesis

Indexed keywords

1 (2 ETHYLPHENOXY) 3 (1,2,3,4 TETRAHYDRO 1 NAPHTHYLAMINO) 2 PROPANOL OXALATE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 3 CHLORO 2 METHYL N [4 [2 (4 METHYL 1 PIPERAZINYL) 2 OXOETHYL] 2 THIAZOLYL]BENZENESULFONAMIDE; ACARBOSE; ADIPONECTIN; AMFEBUTAMONE PLUS NALTREXONE; ANTIOBESITY AGENT; AZD 7687; BIOVITRUM; BVT 116429; DRINABANT; EPROTIROME; FATTY ACID; INCB 13739; KB 141; LCQ 908; LEPTIN; LH 21; LIOTHYRONINE; METFORMIN; METRELEPTIN; PF 00915275; PF 04620110; PHENTERMINE PLUS TOPIRAMATE; PLACEBO; PRAMLINTIDE; RIMONABANT; SIBUTRAMINE; SOBETIROME; TARANABANT; TETRAHYDROLIPSTATIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ADIPOSE TISSUE; ADRENERGIC SYSTEM; BARIATRIC SURGERY; BLOOD GLUCOSE MONITORING; BODY BUILD; BODY WEIGHT; CALORIC INTAKE; CARDIOVASCULAR DISEASE; CENTRAL NERVOUS SYSTEM DISEASE; COMORBIDITY; DIABETES MELLITUS; DIET; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG SAFETY; DYSLIPIDEMIA; ENERGY BALANCE; ENERGY EXPENDITURE; EXERCISE; FATTY ACID OXIDATION; FEEDING BEHAVIOR; FOOD INTAKE; GASTRIC BANDING; GASTROPLASTY; GLUCOSE HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; LIFE EXPECTANCY; LIFESTYLE MODIFICATION; LIPID METABOLISM; LIPID STORAGE; LIPOLYSIS; LOW CALORY DIET; MALABSORPTION; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUTRIENT; OBESITY; PANCREAS ISLET BETA CELL; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECIDIVISM; REPEATED DRUG DOSE; REVIEW; ROUX Y ANASTOMOSIS; SINGLE DRUG DOSE; SUBCUTANEOUS FAT; THERMOGENESIS; WAIST HIP RATIO; WEIGHT GAIN; WEIGHT REDUCTION;

ANIMALS; ANTI-OBESITY AGENTS; DRUG DISCOVERY; HUMANS; OBESITY; THERMOGENESIS; WEIGHT LOSS;

EID: 79960130715     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2011.04.004     Document Type: Review

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