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Volumn 25, Issue 7, 2010, Pages 1207-1217

The evolving place of incretin-based therapies in type 2 diabetes

Author keywords

Antidiabetic therapy; DPP 4 inhibitors; GLP 1; Incretin mimetics; Incretins; Type 2 diabetes

Indexed keywords

ANTIDIABETIC AGENT; AVE 0010; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GLIMEPIRIDE; GLITAZONE DERIVATIVE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1 AGONIST; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCOSE; INCRETIN; INSULIN; LIRAGLUTIDE; METFORMIN; METFORMIN PLUS SITAGLIPTIN; METFORMIN PLUS VILDAGLIPTIN; PIOGLITAZONE; SAXAGLIPTIN; SITAGLIPTIN; SULFONYLUREA; TASPOGLUTIDE; UNCLASSIFIED DRUG; VILDAGLIPTIN;

EID: 77954536869     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-009-1435-z     Document Type: Review
Times cited : (31)

References (108)
  • 1
    • 77954537310 scopus 로고    scopus 로고
    • International Diabetes Federation (IDF), Available at
    • International Diabetes Federation (IDF) (2009) Diabetes Atlas. Available at http://www.diabetesatlas.org
    • (2009)
  • 2
    • 67650242231 scopus 로고    scopus 로고
    • Update on nonautoimmune diabetes in children
    • Zeitler P (2009) Update on nonautoimmune diabetes in children. J Clin Endocrinol Metab 94:2215-2220
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 2215-2220
    • Zeitler, P.1
  • 5
    • 33745780301 scopus 로고    scopus 로고
    • Management of hyperglycaemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy - A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes
    • DOI 10.1007/s00125-006-0316-2
    • Nathan DM, Buse JB, Davidson MB, Heine RJ, Holman RR, Sherwin R, Zinman B (2006) Management of hyperglycaemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 49:1711-1721 (Pubitemid 44025023)
    • (2006) Diabetologia , vol.49 , Issue.8 , pp. 1711-1721
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3    Heine, R.J.4    Holman, R.R.5    Sherwin, R.6    Zinman, B.7
  • 6
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: Glucagonlike peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker DJ, Nauck MA (2006) The incretin system: glucagonlike peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 368:1696-1705
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 7
    • 69549111756 scopus 로고    scopus 로고
    • Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients
    • Wellendorph P, Johansen LD, Brauner-Osborne H (2009) Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients. Mol Pharmacol 76:453-465
    • (2009) Mol Pharmacol , vol.76 , pp. 453-465
    • Wellendorph, P.1    Johansen, L.D.2    Brauner-Osborne, H.3
  • 8
    • 0018758893 scopus 로고
    • The incretin concept today
    • Creutzfeldt W (1979) The incretin concept today. Diabetologia 16:75-85
    • (1979) Diabetologia , vol.16 , pp. 75-85
    • Creutzfeldt, W.1
  • 9
    • 0022617246 scopus 로고
    • Reduced incretin effect in type 2 (non-insulin-dependent) diabetes
    • Nauck M, Stockmann F, Ebert R, Creutzfeldt W (1986) Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia 29:46-52
    • (1986) Diabetologia , vol.29 , pp. 46-52
    • Nauck, M.1    Stockmann, F.2    Ebert, R.3    Creutzfeldt, W.4
  • 10
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
    • Nauck MA, Heimesaat MM, Orskov C, Holst JJ, Ebert R, Creutzfeldt W (1993) Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 91:301-307
    • (1993) J Clin Invest , vol.91 , pp. 301-307
    • Nauck, M.A.1    Heimesaat, M.M.2    Orskov, C.3    Holst, J.J.4    Ebert, R.5    Creutzfeldt, W.6
  • 12
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients
    • Nauck MA, Kleine N, Orskov C, Holst JJ, Willms B, Creutzfeldt W (1993) Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (noninsulin-dependent) diabetic patients. Diabetologia 36:741-744 (Pubitemid 23218642)
    • (1993) Diabetologia , vol.36 , Issue.8 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Orskov, C.3    Holst, J.J.4    Willms, B.5    Creutzfeldt, W.6
  • 13
    • 2542479899 scopus 로고    scopus 로고
    • Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system
    • Brubaker PL, Drucker DJ (2004) Minireview: glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinology 145:2653-2659
    • (2004) Endocrinology , vol.145 , pp. 2653-2659
    • Brubaker, P.L.1    Drucker, D.J.2
  • 14
    • 0026535588 scopus 로고
    • Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells
    • Fehmann HC, Habener JF (1992) Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells. Endocrinology 130:159-166
    • (1992) Endocrinology , vol.130 , pp. 159-166
    • Fehmann, H.C.1    Habener, J.F.2
  • 15
    • 50649110233 scopus 로고    scopus 로고
    • Beneficial effects of once-daily liraglutide, a human glucagonlike peptide-1 analogue, on cardiovascular risk biomarkers in patients with Type 2 diabetes
    • Courreges JP, Vilsboll T, Zdravkovic M, Le-Thi T, Krarup T, Schmitz O, Verhoeven R, Buganova I, Madsbad S (2008) Beneficial effects of once-daily liraglutide, a human glucagonlike peptide-1 analogue, on cardiovascular risk biomarkers in patients with Type 2 diabetes. Diabet Med 25:1129-1131
    • (2008) Diabet Med , vol.25 , pp. 1129-1131
    • Courreges, J.P.1    Vilsboll, T.2    Zdravkovic, M.3    Le-Thi, T.4    Krarup, T.5    Schmitz, O.6    Verhoeven, R.7    Buganova, I.8    Madsbad, S.9
  • 16
    • 38549162147 scopus 로고    scopus 로고
    • Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years
    • Klonoff DC, Buse JB, Nielsen LL, Guan X, Bowlus CL, Holcombe JH, Wintle ME, Maggs DG (2008) Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years. Curr Med Res Opin 24:275-286
    • (2008) Curr Med Res Opin , vol.24 , pp. 275-286
    • Klonoff, D.C.1    Buse, J.B.2    Nielsen, L.L.3    Guan, X.4    Bowlus, C.L.5    Holcombe, J.H.6    Wintle, M.E.7    Maggs, D.G.8
  • 17
    • 33845293219 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure
    • Sokos GG, Nikolaidis LA, Mankad S, Elahi D, Shannon RP (2006) Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure. J Card Fail 12:694-699
    • (2006) J Card Fail , vol.12 , pp. 694-699
    • Sokos, G.G.1    Nikolaidis, L.A.2    Mankad, S.3    Elahi, D.4    Shannon, R.P.5
  • 18
    • 34447103388 scopus 로고    scopus 로고
    • Increase in DPP-IV in the intestine, liver and kidney of the rat treated with high fat diet and streptozotocin
    • Yang J, Campitelli J, Hu G, Lin Y, Luo J, Xue C (2007) Increase in DPP-IV in the intestine, liver and kidney of the rat treated with high fat diet and streptozotocin. Life Sci 81:272-279
    • (2007) Life Sci , vol.81 , pp. 272-279
    • Yang, J.1    Campitelli, J.2    Hu, G.3    Lin, Y.4    Luo, J.5    Xue, C.6
  • 20
    • 33751009626 scopus 로고    scopus 로고
    • Exenatide in type 2 diabetes: Treatment effects in clinical studies and animal study data
    • Gallwitz B (2006) Exenatide in type 2 diabetes: treatment effects in clinical studies and animal study data. Int J Clin Pract 60:1654-1661
    • (2006) Int J Clin Pract , vol.60 , pp. 1654-1661
    • Gallwitz, B.1
  • 21
    • 0026648961 scopus 로고
    • Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas
    • Eng J, Kleinman WA, Singh L, Singh G, Raufman JP (1992) Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas. J Biol Chem 267:7402-7405
    • (1992) J Biol Chem , vol.267 , pp. 7402-7405
    • Eng, J.1    Kleinman, W.A.2    Singh, L.3    Singh, G.4    Raufman, J.P.5
  • 22
    • 23944488440 scopus 로고    scopus 로고
    • Doseresponse for glycaemic and metabolic changes 28 days after single injection of long-acting release exenatide in diabetic fatty Zucker rats
    • Gedulin BR, Smith P, Prickett KS, Tryon M, Barnhill S, Reynolds J, Nielsen LL, Parkes DG, Young AA (2005) Doseresponse for glycaemic and metabolic changes 28 days after single injection of long-acting release exenatide in diabetic fatty Zucker rats. Diabetologia 48:1380-1385
    • (2005) Diabetologia , vol.48 , pp. 1380-1385
    • Gedulin, B.R.1    Smith, P.2    Prickett, K.S.3    Tryon, M.4    Barnhill, S.5    Reynolds, J.6    Nielsen, L.L.7    Parkes, D.G.8    Young, A.A.9
  • 23
    • 34249891874 scopus 로고    scopus 로고
    • Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes
    • Kim D, MacConell L, Zhuang D, Kothare PA, Trautmann M, Fineman M, Taylor K (2007) Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes. Diabetes Care 30:1487-1493
    • (2007) Diabetes Care , vol.30 , pp. 1487-1493
    • Kim, D.1    MacConell, L.2    Zhuang, D.3    Kothare, P.A.4    Trautmann, M.5    Fineman, M.6    Taylor, K.7
  • 24
    • 53249142132 scopus 로고    scopus 로고
    • Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: A randomised, openlabel, non-inferiority study
    • Drucker DJ, Buse JB, Taylor K, Kendall DM, Trautmann M, Zhuang D, Porter L (2008) Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, openlabel, non-inferiority study. Lancet 372:1240-1250
    • (2008) Lancet , vol.372 , pp. 1240-1250
    • Drucker, D.J.1    Buse, J.B.2    Taylor, K.3    Kendall, D.M.4    Trautmann, M.5    Zhuang, D.6    Porter, L.7
  • 25
    • 67549112400 scopus 로고    scopus 로고
    • Insights from the liraglutide clinical development program-the liraglutide effect and action in diabetes (LEAD) studies
    • McGill JB (2009) Insights from the liraglutide clinical development program-the Liraglutide Effect and Action in Diabetes (LEAD) studies. Postgrad Med 121:16-25
    • (2009) Postgrad Med , vol.121 , pp. 16-25
    • McGill, J.B.1
  • 26
    • 0036189831 scopus 로고    scopus 로고
    • The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men
    • Agerso H, Jensen LB, Elbrond B, Rolan P, Zdravkovic M (2002) The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men. Diabetologia 45:195-202
    • (2002) Diabetologia , vol.45 , pp. 195-202
    • Agerso, H.1    Jensen, L.B.2    Elbrond, B.3    Rolan, P.4    Zdravkovic, M.5
  • 27
    • 0038353630 scopus 로고    scopus 로고
    • The GLP-1 derivative NN2211 restores beta-cell sensitivity to glucose in type 2 diabetic patients after a single dose
    • Chang AM, Jakobsen G, Sturis J, Smith MJ, Bloem CJ, An B, Galecki A, Halter JB (2003) The GLP-1 derivative NN2211 restores beta-cell sensitivity to glucose in type 2 diabetic patients after a single dose. Diabetes 52:1786-1791
    • (2003) Diabetes , vol.52 , pp. 1786-1791
    • Chang, A.M.1    Jakobsen, G.2    Sturis, J.3    Smith, M.J.4    Bloem, C.J.5    An, B.6    Galecki, A.7    Halter, J.B.8
  • 28
    • 68849092593 scopus 로고    scopus 로고
    • Taspoglutide: A long acting human glucagonlike polypeptide-1 analogue
    • Retterstol K (2009) Taspoglutide: a long acting human glucagonlike polypeptide-1 analogue. Expert Opin Investig Drugs 18:1405-1411
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 1405-1411
    • Retterstol, K.1
  • 29
    • 43049117884 scopus 로고    scopus 로고
    • Preclinical pharmacology of the new GLP-1 receptor agonist AVE0010
    • Werner U (2008) Preclinical pharmacology of the new GLP-1 receptor agonist AVE0010. Ann Endocrinol (Paris) 69:164-165
    • (2008) Ann Endocrinol (Paris) , vol.69 , pp. 164-165
    • Werner, U.1
  • 30
    • 70349664297 scopus 로고    scopus 로고
    • The potential of albiglutide, a long-acting GLP-1 receptor agonist, in type 2 diabetes: A randomized controlled trial exploring weekly, biweekly, and monthly dosing
    • Rosenstock J, Reusch J, Bush M, Yang F, Stewart M (2009) The potential of albiglutide, a long-acting GLP-1 receptor agonist, in type 2 diabetes: a randomized controlled trial exploring weekly, biweekly, and monthly dosing. Diabetes Care 32:1880-1886
    • (2009) Diabetes Care , vol.32 , pp. 1880-1886
    • Rosenstock, J.1    Reusch, J.2    Bush, M.3    Yang, F.4    Stewart, M.5
  • 33
    • 18144401971 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
    • DeFronzo RA, Ratner RE, Han J, Kim DD, Fineman MS, Baron AD (2005) Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care 28:1092-1100
    • (2005) Diabetes Care , vol.28 , pp. 1092-1100
    • DeFronzo, R.A.1    Ratner, R.E.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 34
    • 7444228521 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
    • Buse JB, Henry RR, Han J, Kim DD, Fineman MS, Baron AD (2004) Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care 27:2628-2635
    • (2004) Diabetes Care , vol.27 , pp. 2628-2635
    • Buse, J.B.1    Henry, R.R.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 35
    • 17144371646 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
    • Kendall DM, Riddle MC, Rosenstock J, Zhuang D, Kim DD, Fineman MS, Baron AD (2005) Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care 28:1083-1091
    • (2005) Diabetes Care , vol.28 , pp. 1083-1091
    • Kendall, D.M.1    Riddle, M.C.2    Rosenstock, J.3    Zhuang, D.4    Kim, D.D.5    Fineman, M.S.6    Baron, A.D.7
  • 36
    • 26944477362 scopus 로고    scopus 로고
    • Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes: A randomized trial
    • Heine RJ, Van Gaal LF, Johns D, Mihm MJ, Widel MH, Brodows RG (2005) Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes: a randomized trial. Ann Intern Med 143:559-569
    • (2005) Ann Intern Med , vol.143 , pp. 559-569
    • Heine, R.J.1    Van Gaal, L.F.2    Johns, D.3    Mihm, M.J.4    Widel, M.H.5    Brodows, R.G.6
  • 37
    • 34247195226 scopus 로고    scopus 로고
    • A comparison of twicedaily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: A non-inferiority study
    • Nauck MA, Duran S, Kim D, Johns D, Northrup J, Festa A, Brodows R, Trautmann M (2007) A comparison of twicedaily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: a non-inferiority study. Diabetologia 50:259-267
    • (2007) Diabetologia , vol.50 , pp. 259-267
    • Nauck, M.A.1    Duran, S.2    Kim, D.3    Johns, D.4    Northrup, J.5    Festa, A.6    Brodows, R.7    Trautmann, M.8
  • 39
    • 37349008890 scopus 로고    scopus 로고
    • Tolerability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulfonylurea: A multinational, randomized, open-label, two-period, crossover noninferiority trial
    • Barnett AH, Burger J, Johns D, Brodows R, Kendall DM, Roberts A, Trautmann ME (2007) Tolerability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulfonylurea: a multinational, randomized, open-label, two-period, crossover noninferiority trial. Clin Ther 29:2333-2348
    • (2007) Clin Ther , vol.29 , pp. 2333-2348
    • Barnett, A.H.1    Burger, J.2    Johns, D.3    Brodows, R.4    Kendall, D.M.5    Roberts, A.6    Trautmann, M.E.7
  • 42
    • 42949089442 scopus 로고    scopus 로고
    • Exenatide and rare adverse events
    • Ahmad SR, Swann J (2008) Exenatide and rare adverse events. N Engl J Med 358:1970-1971
    • (2008) N Engl J Med , vol.358 , pp. 1970-1971
    • Ahmad, S.R.1    Swann, J.2
  • 43
    • 42949112670 scopus 로고    scopus 로고
    • Exenatide and rare adverse events
    • Cure P, Pileggi A, Alejandro R (2008) Exenatide and rare adverse events. N Engl J Med 358:1969-1970
    • (2008) N Engl J Med , vol.358 , pp. 1969-1970
    • Cure, P.1    Pileggi, A.2    Alejandro, R.3
  • 44
    • 67649304917 scopus 로고    scopus 로고
    • Use of a claimsbased active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide
    • Dore DD, Seeger JD, Arnold Chan K (2009) Use of a claimsbased active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide. Curr Med Res Opin 25:1019-1027
    • (2009) Curr Med Res Opin , vol.25 , pp. 1019-1027
    • Dore, D.D.1    Seeger, J.D.2    Arnold Chan, K.3
  • 45
    • 33749589088 scopus 로고    scopus 로고
    • Exenatide: A new option for the treatment of type 2 diabetes
    • Yoo BK, Triller DM, Yoo DJ (2006) Exenatide: a new option for the treatment of type 2 diabetes. Ann Pharmacother 40:1777-1784
    • (2006) Ann Pharmacother , vol.40 , pp. 1777-1784
    • Yoo, B.K.1    Triller, D.M.2    Yoo, D.J.3
  • 46
    • 77954538452 scopus 로고    scopus 로고
    • Byetta (exenatide)- renal failure. Available at, Accessed on 2 November 2009
    • Food and Drug Administration (FDA) (2009) Byetta (exenatide)- renal failure. Available at http://www.fda.gov/Safety/MedWatch/SafetyInformation/ SafetyAlertsforHumanMedicalProducts/ucm188703.htm. Accessed on 2 November 2009
    • (2009)
  • 47
    • 65549096266 scopus 로고    scopus 로고
    • Pharmacology and tolerability of a single dose of exenatide in adolescent patients with type 2 diabetes mellitus being treated with metformin: A randomized, placebocontrolled, single-blind, dose-escalation, crossover study
    • Malloy J, Capparelli E, Gottschalk M, Guan X, Kothare P, Fineman M (2009) Pharmacology and tolerability of a single dose of exenatide in adolescent patients with type 2 diabetes mellitus being treated with metformin: a randomized, placebocontrolled, single-blind, dose-escalation, crossover study. Clin Ther 31:806-815
    • (2009) Clin Ther , vol.31 , pp. 806-815
    • Malloy, J.1    Capparelli, E.2    Gottschalk, M.3    Guan, X.4    Kothare, P.5    Fineman, M.6
  • 49
    • 33645996998 scopus 로고    scopus 로고
    • Metformin-glibenclamide versus metformin plus rosiglitazone in patients with type 2 diabetes inadequately controlled on metformin monotherapy
    • Garber A, Klein E, Bruce S, Sankoh S, Mohideen P (2006) Metformin-glibenclamide versus metformin plus rosiglitazone in patients with type 2 diabetes inadequately controlled on metformin monotherapy. Diabetes Obes Metab 8:156-163
    • (2006) Diabetes Obes Metab , vol.8 , pp. 156-163
    • Garber, A.1    Klein, E.2    Bruce, S.3    Sankoh, S.4    Mohideen, P.5
  • 50
    • 51949116060 scopus 로고    scopus 로고
    • An overview of incretin clinical trials
    • Garber AJ, Spann SJ (2008) An overview of incretin clinical trials. J Fam Pract 57(Suppl):S10-S18
    • (2008) J Fam Pract , vol.57 , Issue.SUPPL.
    • Garber, A.J.1    Spann, S.J.2
  • 51
    • 67649523294 scopus 로고    scopus 로고
    • Treatment with the human once-weekly glucagon-like peptide-1 analog taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: A double-blind placebo-controlled study
    • Nauck MA, Ratner RE, Kapitza C, Berria R, Boldrin M, Balena R (2009) Treatment with the human once-weekly glucagon-like peptide-1 analog taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: a double-blind placebo-controlled study. Diabetes Care 32:1237-1243
    • (2009) Diabetes Care , vol.32 , pp. 1237-1243
    • Nauck, M.A.1    Ratner, R.E.2    Kapitza, C.3    Berria, R.4    Boldrin, M.5    Balena, R.6
  • 52
    • 62449169287 scopus 로고    scopus 로고
    • Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: The LEAD (liraglutide effect and action in diabetes)-2 study
    • Nauck M, Frid A, Hermansen K, Shah NS, Tankova T, Mitha IH, Zdravkovic M, During M, Matthews DR (2009) Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study. Diabetes Care 32:84-90
    • (2009) Diabetes Care , vol.32 , pp. 84-90
    • Nauck, M.1    Frid, A.2    Hermansen, K.3    Shah, N.S.4    Tankova, T.5    Mitha, I.H.6    Zdravkovic, M.7    During, M.8    Matthews, D.R.9
  • 53
    • 62449129181 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU)
    • Marre M, Shaw J, Brandle M, Bebakar WM, Kamaruddin NA, Strand J, Zdravkovic M, Le Thi TD, Colagiuri S (2009) Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU). Diabet Med 26:268-278
    • (2009) Diabet Med , vol.26 , pp. 268-278
    • Marre, M.1    Shaw, J.2    Brandle, M.3    Bebakar, W.M.4    Kamaruddin, N.A.5    Strand, J.6    Zdravkovic, M.7    Le Thi, T.D.8    Colagiuri, S.9
  • 54
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)
    • Zinman B, Gerich J, Buse JB, Lewin A, Schwartz S, Raskin P, Hale PM, Zdravkovic M, Blonde L (2009) Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). Diabetes Care 32:1224-1230
    • (2009) Diabetes Care , vol.32 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.B.3    Lewin, A.4    Schwartz, S.5    Raskin, P.6    Hale, P.M.7    Zdravkovic, M.8    Blonde, L.9
  • 56
    • 70350621095 scopus 로고    scopus 로고
    • Monotherapy with liraglutide, a once-daily human GLP-1 analog, provides sustained reductions in A1C, FPG, and weight compared with glimepiride in type 2 diabetes: LEAD-3 mono 2-year results
    • OR
    • Garber A, Henry RR, Ratner RE, Hale P, Chang CT, Bode B (2009) Monotherapy with liraglutide, a once-daily human GLP-1 analog, provides sustained reductions in A1C, FPG, and weight compared with glimepiride in type 2 diabetes: LEAD-3 mono 2-year results. Diabetes 58(Suppl 1):162, OR
    • (2009) Diabetes , vol.58 , Issue.SUPPL. 1 , pp. 162
    • Garber, A.1    Henry, R.R.2    Ratner, R.E.3    Hale, P.4    Chang, C.T.5    Bode, B.6
  • 57
    • 67449096006 scopus 로고    scopus 로고
    • Potential of liraglutide in the treatment of patients with type 2 diabetes
    • Deacon CF (2009) Potential of liraglutide in the treatment of patients with type 2 diabetes. Vasc Health Risk Manag 5:199-211
    • (2009) Vasc Health Risk Manag , vol.5 , pp. 199-211
    • Deacon, C.F.1
  • 58
    • 66249143015 scopus 로고    scopus 로고
    • Liraglutide: A new treatment for type 2 diabetes
    • Vilsboll T (2009) Liraglutide: a new treatment for type 2 diabetes. Drugs Today (Barc) 45:101-113
    • (2009) Drugs Today (Barc) , vol.45 , pp. 101-113
    • Vilsboll, T.1
  • 59
    • 67549125152 scopus 로고    scopus 로고
    • Adding liraglutide to oral antidiabetic drug monotherapy: Efficacy and weight benefits
    • Nauck M, Marre M (2009) Adding liraglutide to oral antidiabetic drug monotherapy: efficacy and weight benefits. Postgrad Med 121:5-15
    • (2009) Postgrad Med , vol.121 , pp. 5-15
    • Nauck, M.1    Marre, M.2
  • 60
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • Buse JB, Rosenstock J, Sesti G, Schmidt WE, Montanya E, Brett JH, Zychma M, Blonde L (2009) Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet 374:39-47
    • (2009) Lancet , vol.374 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3    Schmidt, W.E.4    Montanya, E.5    Brett, J.H.6    Zychma, M.7    Blonde, L.8
  • 61
    • 39749143348 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with type 2 diabetes mellitus
    • Vilsboll T, Brock B, Perrild H, Levin K, Lervang HH, Kolendorf K, Krarup T, Schmitz O, Zdravkovic M, Le-Thi T, Madsbad S (2008) Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with Type 2 diabetes mellitus. Diabet Med 25:152-156
    • (2008) Diabet Med , vol.25 , pp. 152-156
    • Vilsboll, T.1    Brock, B.2    Perrild, H.3    Levin, K.4    Lervang, H.H.5    Kolendorf, K.6    Krarup, T.7    Schmitz, O.8    Zdravkovic, M.9    Le-Thi, T.10    Madsbad, S.11
  • 62
    • 58149265313 scopus 로고    scopus 로고
    • Emerging dipeptidyl peptidase-4 inhibitors for the treatment of diabetes
    • Ahren B (2008) Emerging dipeptidyl peptidase-4 inhibitors for the treatment of diabetes. Expert Opin Emerg Drugs 13:593-607
    • (2008) Expert Opin Emerg Drugs , vol.13 , pp. 593-607
    • Ahren, B.1
  • 63
    • 33645780417 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-IV inhibitors can restore glucose homeostasis in type 2 diabetics via incretin enhancement
    • Mest HJ (2006) Dipeptidyl peptidase-IV inhibitors can restore glucose homeostasis in type 2 diabetics via incretin enhancement. Curr Opin Investig Drugs 7:338-343
    • (2006) Curr Opin Investig Drugs , vol.7 , pp. 338-343
    • Mest, H.J.1
  • 64
    • 57349125875 scopus 로고    scopus 로고
    • Saxagliptin, a dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
    • Gallwitz B (2008) Saxagliptin, a dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. IDrugs 12:906-917
    • (2008) IDrugs , vol.12 , pp. 906-917
    • Gallwitz, B.1
  • 65
    • 70349314675 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin added to pioglitazone in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study
    • Pratley RE, Reusch JE, Fleck PR, Wilson CA, Mekki Q (2009) Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin added to pioglitazone in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study. Curr Med Res Opin 25:2361-2371
    • (2009) Curr Med Res Opin , vol.25 , pp. 2361-2371
    • Pratley, R.E.1    Reusch, J.E.2    Fleck, P.R.3    Wilson, C.A.4    Mekki, Q.5
  • 66
    • 67649998759 scopus 로고    scopus 로고
    • Pharmacokinetics, pharmacodynamics and tolerability of multiple oral doses of linagliptin, a dipeptidyl peptidase-4 inhibitor in male type 2 diabetes patients
    • Heise T, Graefe-Mody EU, Huttner S, Ring A, Trommeshauser D, Dugi KA (2009) Pharmacokinetics, pharmacodynamics and tolerability of multiple oral doses of linagliptin, a dipeptidyl peptidase-4 inhibitor in male type 2 diabetes patients. Diabetes Obes Metab 11:786-794
    • (2009) Diabetes Obes Metab , vol.11 , pp. 786-794
    • Heise, T.1    Graefe-Mody, E.U.2    Huttner, S.3    Ring, A.4    Trommeshauser, D.5    Dugi, K.A.6
  • 67
    • 50949113950 scopus 로고    scopus 로고
    • Overviewof glucagon-like peptide-1 analogs and dipeptidyl peptidase-4 inhibitors for type 2 diabetes
    • Pratley RE (2008)Overviewof glucagon-like peptide-1 analogs and dipeptidyl peptidase-4 inhibitors for type 2 diabetes. Medscape J Med 10:171
    • (2008) Medscape J Med , vol.10 , pp. 171
    • Pratley, R.E.1
  • 68
    • 60349099802 scopus 로고    scopus 로고
    • New treatments in type 2 diabetes: A focus on the incretin-based therapies
    • Barnett AH (2009) New treatments in type 2 diabetes: a focus on the incretin-based therapies. Clin Endocrinol (Oxf) 70:343-353
    • (2009) Clin Endocrinol (Oxf) , vol.70 , pp. 343-353
    • Barnett, A.H.1
  • 69
    • 39749169723 scopus 로고    scopus 로고
    • Sitagliptin, a DPP-4 inhibitor for the treatment of patients with type 2 diabetes: A review of recent clinical trials
    • Karasik A, Aschner P, Katzeff H, Davies MJ, Stein PP (2008) Sitagliptin, a DPP-4 inhibitor for the treatment of patients with type 2 diabetes: a review of recent clinical trials. Curr Med Res Opin 24:489-496
    • (2008) Curr Med Res Opin , vol.24 , pp. 489-496
    • Karasik, A.1    Aschner, P.2    Katzeff, H.3    Davies, M.J.4    Stein, P.P.5
  • 70
    • 52249109319 scopus 로고    scopus 로고
    • New combination treatments in the management of diabetes: Focus on sitagliptin-metformin
    • Green J, Feinglos M (2008) New combination treatments in the management of diabetes: focus on sitagliptin-metformin. Vasc Health Risk Manag 4:743-751
    • (2008) Vasc Health Risk Manag , vol.4 , pp. 743-751
    • Green, J.1    Feinglos, M.2
  • 72
    • 33750517754 scopus 로고    scopus 로고
    • Tolerability and pharmacokinetics of metformin and the dipeptidyl peptidase-4 inhibitor sitagliptin when co-administered in patients with type 2 diabetes
    • DOI 10.1185/030079906X132587
    • Herman GA, Bergman A, Yi B, Kipnes M (2006) Tolerability and pharmacokinetics of metformin and the dipeptidyl peptidase-4 inhibitor sitagliptin when co-administered in patients with type 2 diabetes. Curr Med Res Opin 22:1939-1947 (Pubitemid 44663399)
    • (2006) Current Medical Research and Opinion , vol.22 , Issue.10 , pp. 1939-1947
    • Herman, G.A.1    Bergman, A.2    Yi, B.3    Kipnes, M.4
  • 75
    • 33847024333 scopus 로고    scopus 로고
    • Efficacy and tolerability of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes
    • Scott R, Wu M, Sanchez M, Stein P (2007) Efficacy and tolerability of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes. Int J Clin Pract 61:171-180
    • (2007) Int J Clin Pract , vol.61 , pp. 171-180
    • Scott, R.1    Wu, M.2    Sanchez, M.3    Stein, P.4
  • 77
    • 44049094845 scopus 로고    scopus 로고
    • Novel combination treatment of type 2 diabetes DPP-4 inhibition + metformin
    • Ahren B (2008) Novel combination treatment of type 2 diabetes DPP-4 inhibition + metformin. Vasc Health Risk Manag 4:383-394
    • (2008) Vasc Health Risk Manag , vol.4 , pp. 383-394
    • Ahren, B.1
  • 78
    • 38949195291 scopus 로고    scopus 로고
    • The islet enhancer vildagliptin: Mechanisms of improved glucose metabolism
    • Ahren B, Foley JE (2008) The islet enhancer vildagliptin: mechanisms of improved glucose metabolism. Int J Clin Pract Suppl 175:8-14
    • (2008) Int J Clin Pract Suppl , vol.175 , pp. 8-14
    • Ahren, B.1    Foley, J.E.2
  • 80
    • 42149194313 scopus 로고    scopus 로고
    • Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetes
    • Rosenstock J, Sankoh S, List JF (2008) Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetes. Diabetes Obes Metab 10:376-386
    • (2008) Diabetes Obes Metab , vol.10 , pp. 376-386
    • Rosenstock, J.1    Sankoh, S.2    List, J.F.3
  • 82
    • 73449110944 scopus 로고    scopus 로고
    • Saxagliptin: A new dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes
    • Deacon CF, Holst JJ (2009) Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes. Adv Ther 26:488-499
    • (2009) Adv Ther , vol.26 , pp. 488-499
    • Deacon, C.F.1    Holst, J.J.2
  • 83
    • 73449117555 scopus 로고    scopus 로고
    • Saxagliptin: A new DPP-4 inhibitor for the treatment of type 2 diabetes mellitus
    • Tahrani AA, Piya MK, Barnett AH (2009) Saxagliptin: a new DPP-4 inhibitor for the treatment of type 2 diabetes mellitus. Adv Ther 26:249-262
    • (2009) Adv Ther , vol.26 , pp. 249-262
    • Tahrani, A.A.1    Piya, M.K.2    Barnett, A.H.3
  • 84
    • 68949212458 scopus 로고    scopus 로고
    • Saxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: A randomised controlled trial
    • Chacra AR, Tan GH, Apanovitch A, Ravichandran S, List J, Chen R (2009) Saxagliptin added to a submaximal dose of sulphonylurea improves glycaemic control compared with uptitration of sulphonylurea in patients with type 2 diabetes: a randomised controlled trial. Int J Clin Pract 63:1395-1406
    • (2009) Int J Clin Pract , vol.63 , pp. 1395-1406
    • Chacra, A.R.1    Tan, G.H.2    Apanovitch, A.3    Ravichandran, S.4    List, J.5    Chen, R.6
  • 85
    • 69549135336 scopus 로고    scopus 로고
    • The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone
    • DeFronzo RA, Hissa MN, Garber AJ, Luiz Gross J, Yuyan Duan R, Ravichandran S, Chen RS (2009) The efficacy and safety of saxagliptin when added to metformin therapy in patients with inadequately controlled type 2 diabetes with metformin alone. Diabetes Care 32:1649-1655
    • (2009) Diabetes Care , vol.32 , pp. 1649-1655
    • DeFronzo, R.A.1    Hissa, M.N.2    Garber, A.J.3    Luiz Gross, J.4    Yuyan Duan, R.5    Ravichandran, S.6    Chen, R.S.7
  • 88
    • 77954540071 scopus 로고    scopus 로고
    • National Institute for Health and Clinical Excellence, Available at
    • National Institute for Health and Clinical Excellence (2009) Available at http://guidance.nice.org.uk/CG87
    • (2009)
  • 89
    • 64749114159 scopus 로고    scopus 로고
    • Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus
    • Whitmer RA, Karter AJ, Yaffe K, Quesenberry CP Jr, Selby JV (2009) Hypoglycemic episodes and risk of dementia in older patients with type 2 diabetes mellitus. JAMA 301:1565-1572
    • (2009) JAMA , vol.301 , pp. 1565-1572
    • Whitmer, R.A.1    Karter, A.J.2    Yaffe, K.3    Quesenberry Jr., C.P.4    Selby, J.V.5
  • 90
    • 33846817233 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: A randomized, double-blind, non-inferiority trial
    • Nauck MA, Meininger G, Sheng D, Terranella L, Stein PP (2007) Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, non-inferiority trial. Diabetes Obes Metab 9:194-205
    • (2007) Diabetes Obes Metab , vol.9 , pp. 194-205
    • Nauck, M.A.1    Meininger, G.2    Sheng, D.3    Terranella, L.4    Stein, P.P.5
  • 92
    • 60449089649 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy
    • Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, Zinman B (2009) Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy. Diabetes Care 32:193-203
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3    Ferrannini, E.4    Holman, R.R.5    Sherwin, R.6    Zinman, B.7
  • 94
    • 47049084841 scopus 로고    scopus 로고
    • Sustained efficacy and reduced hypoglycemia during one year of treatment with vildagliptin added to insulin in patients with type 2 diabetes mellitus
    • Fonseca V, Baron M, Shao Q, Dejager S (2008) Sustained efficacy and reduced hypoglycemia during one year of treatment with vildagliptin added to insulin in patients with type 2 diabetes mellitus. Horm Metab Res 40:427-430
    • (2008) Horm Metab Res , vol.40 , pp. 427-430
    • Fonseca, V.1    Baron, M.2    Shao, Q.3    Dejager, S.4
  • 95
    • 33846501672 scopus 로고    scopus 로고
    • Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy
    • Perry T, Holloway HW, Weerasuriya A, Mouton PR, Duffy K, Mattison JA, Greig NH (2007) Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy. Exp Neurol 203:293-301
    • (2007) Exp Neurol , vol.203 , pp. 293-301
    • Perry, T.1    Holloway, H.W.2    Weerasuriya, A.3    Mouton, P.R.4    Duffy, K.5    Mattison, J.A.6    Greig, N.H.7
  • 96
    • 51749088973 scopus 로고    scopus 로고
    • Effects of intravenous glucagon-like peptide-1 on glucose control and hemodynamics after coronary artery bypass surgery in patients with type 2 diabetes
    • Müssig K, Oncu A, Lindauer P, Heininger A, Aebert H, Unertl K, Ziemer G, Häring HU, Holst JJ, Gallwitz B (2008) Effects of intravenous glucagon-like peptide-1 on glucose control and hemodynamics after coronary artery bypass surgery in patients with type 2 diabetes. Am J Cardiol 102:646-647
    • (2008) Am J Cardiol , vol.102 , pp. 646-647
    • Müssig, K.1    Oncu, A.2    Lindauer, P.3    Heininger, A.4    Aebert, H.5    Unertl, K.6    Ziemer, G.7    Häring, H.U.8    Holst, J.J.9    Gallwitz, B.10
  • 97
    • 4344605042 scopus 로고    scopus 로고
    • Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy
    • Nikolaidis LA, Elahi D, Hentosz T, Doverspike A, Huerbin R, Zourelias L, Stolarski C, Shen YT, Shannon RP (2004) Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy. Circulation 110:955-961
    • (2004) Circulation , vol.110 , pp. 955-961
    • Nikolaidis, L.A.1    Elahi, D.2    Hentosz, T.3    Doverspike, A.4    Huerbin, R.5    Zourelias, L.6    Stolarski, C.7    Shen, Y.T.8    Shannon, R.P.9
  • 99
    • 28144441354 scopus 로고    scopus 로고
    • Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy
    • Nikolaidis LA, Elahi D, Shen YT, Shannon RP (2005) Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy. Am J Physiol Heart Circ Physiol 289: H2401-H2408
    • (2005) Am J Physiol Heart Circ Physiol , vol.289
    • Nikolaidis, L.A.1    Elahi, D.2    Shen, Y.T.3    Shannon, R.P.4
  • 100
    • 71449111050 scopus 로고    scopus 로고
    • Regulation of Na+/H+ exchanger NHE3 by the glucagon-like peptide 1 receptor agonist exendin-4 in renal proximal tubule cells
    • Carraro-Lacroix LR, Malnic G, Girardi AC (2009) Regulation of Na+/H+ exchanger NHE3 by the glucagon-like peptide 1 receptor agonist exendin-4 in renal proximal tubule cells. Am J Physiol Renal Physiol 297:F1647-F1655
    • (2009) Am J Physiol Renal Physiol , vol.297
    • Carraro-Lacroix, L.R.1    Malnic, G.2    Girardi, A.C.3
  • 101
    • 33947584619 scopus 로고    scopus 로고
    • Glucagonlike peptide 1 receptor expression in primary porcine proximal tubular cells
    • Schlatter P, Beglinger C, Drewe J, Gutmann H (2007) Glucagonlike peptide 1 receptor expression in primary porcine proximal tubular cells. Regul Pept 141:120-128
    • (2007) Regul Pept , vol.141 , pp. 120-128
    • Schlatter, P.1    Beglinger, C.2    Drewe, J.3    Gutmann, H.4
  • 103
    • 1442350411 scopus 로고    scopus 로고
    • Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects
    • Meier JJ, Nauck MA, Kranz D, Holst JJ, Deacon CF, Gaeckler D, Schmidt WE, Gallwitz B (2004) Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects. Diabetes 53:654-662
    • (2004) Diabetes , vol.53 , pp. 654-662
    • Meier, J.J.1    Nauck, M.A.2    Kranz, D.3    Holst, J.J.4    Deacon, C.F.5    Gaeckler, D.6    Schmidt, W.E.7    Gallwitz, B.8
  • 104
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Baggio LL, Drucker DJ (2007) Biology of incretins: GLP-1 and GIP. Gastroenterology 132:2131-2457
    • (2007) Gastroenterology , vol.132 , pp. 2131-2457
    • Baggio, L.L.1    Drucker, D.J.2
  • 106
    • 56249130403 scopus 로고    scopus 로고
    • Towards a curative therapy in type 1 diabetes: Remission of autoimmunity, maintenance and augmentation of beta cell mass
    • Waldron-Lynch F, Von Herrath M, Herold KC (2008) Towards a curative therapy in type 1 diabetes: remission of autoimmunity, maintenance and augmentation of beta cell mass. Novartis Found Symp 292:146-155
    • (2008) Novartis Found Symp , vol.292 , pp. 146-155
    • Waldron-Lynch, F.1    Von Herrath, M.2    Herold, K.C.3
  • 107
    • 65349115395 scopus 로고    scopus 로고
    • New potential adjuncts to treatment of children with type 1 diabetes mellitus
    • Raman VS, Heptulla RA (2009) New potential adjuncts to treatment of children with type 1 diabetes mellitus. Pediatr Res 65:370-374
    • (2009) Pediatr Res , vol.65 , pp. 370-374
    • Raman, V.S.1    Heptulla, R.A.2
  • 108
    • 0029954211 scopus 로고    scopus 로고
    • Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients
    • Creutzfeldt WO, Kleine N, Willms B, Orskov C, Holst JJ, Nauck MA (1996) Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients. Diabetes Care 19:580-586
    • (1996) Diabetes Care , vol.19 , pp. 580-586
    • Creutzfeldt, W.O.1    Kleine, N.2    Willms, B.3    Orskov, C.4    Holst, J.J.5    Nauck, M.A.6


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