The distinction of metabolically 'healthy' from 'unhealthy' obese individuals

Current Opinion in Lipidology

Volumn 21, Issue 1, 2010, Pages 38-43

  Blüher, Matthias ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Adipokines; Inflammation; Insulin resistance; Obesity; Visceral adipose tissue

Indexed keywords

ADIPOCYTOKINE;

BODY FAT; CARDIOVASCULAR DISEASE; DYSLIPIDEMIA; GOUT; HUMAN; HYPERTENSION; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; METABOLIC DISORDER; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHENOTYPE; PRIORITY JOURNAL; REVIEW; WEIGHT REDUCTION;

BEHAVIOR; ENVIRONMENT; HEALTH; HUMANS; INTRA-ABDOMINAL FAT; OBESITY;

EID: 77649171169     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOL.0b013e3283346ccc     Document Type: Review

References (37)

1. World Health Organization. Health Report;2005.
2. Adams KF, Schatzkin A, Harris TB, et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N Engl J Med 2006; 355:763-778.
3. Hossain P, Kawar B, El Nahas M. Obesity and diabetes in the developing world-a growing challenge. N Engl J Med 2007; 356:213-215.
4. Olshansky SJ, Passaro DJ, Hershow RC, et al. A potential decline in life expectancy in the United States in the 21st century. N Engl J Med 2005; 352:1138-1145.
5. Mokdad AH, Ford ES, Bowman BA, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001 J Am Med Assoc 2003; 289:76-79.
6. Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature 2006; 444:875-880.
7. Guh DP, Zhang W, BansbackN, et al. The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health 2009; 9:88.
8. Despres JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature 2006; 444:881-887.
9. Abate N,Garg A, PeshockRM, et al. Relationships of generalized and regional adiposity to insulin sensitivity in men. J Clin Invest 1995; 96:88-98.
10. Reaven GM. Importance of identifying the overweight patient who will benefit the most by losing weight. Ann Intern Med 2003; 138:420-423.
11. Sims EAH. Are there persons who are obese, but metabolically healthy? Metabolism 2001; 50:1499-1504.
12. Ferrannini E, Natali A, Bell P, et al. Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR). J Clin Invest 1997; 100:1166-1173.
13. BonoraE, Kiechl S, Willeit J, et al. Prevalence of insulin resistance in metabolic disorders: the Bruneck Study. Diabetes 1998; 47:1643-1649.
14. Sims EAH. Characterization of the syndromes of obesity. In: Brodoff BN, Bleicher SJ, editors. Diabetes mellitus and obesity. Baltimore, MD: Williams and Wilkins; 1982. pp. 219-226.
15. Bell LM, Byrne S, Thompson A, et al. Increasing body mass index z-score is continuously associated with complications of overweight in children, even in the healthy range. J Clin Endocrinol Metab 2007; 92:517-522.
16. Kloting N, Fasshauer M, Dietrich A, et al. Insulin sensitive obesity. Am J Physiol Endocr Metab; (in press).
17. Muscelli E, CamastraS, Gastaldelli A, et al. Influence of duration of obesity on the insulin resistance of obese nondiabetic patients. Int J Obes Relat Metab Disord 1998; 22:262-267.
18. Sjostrom L. Bariatric surgery and reduction in morbidity and mortality: experiencesfrom the SOS study. Int J Obes (Lond) 2008; 32 (Suppl 7):S93-S97.
19. Sjostrom L, Narbro K, Sjostrom CD, et al., Swedish Obese Subjects Study. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 2007; 357:741-752.
20. Bays HE, Laferrere B, Dixon J, et al., Adiposopathy and Bariatric Surgery Working Group. Adiposopathy and bariatric surgery: is 'sick fat' a surgical disease? Int J Clin Pract 2009; 63:1285-1300.
21. Bays HE. 'Sick fat,' metabolic disease, and atherosclerosis. Am J Med 2009; 122:S26-S37.
22. Kuk JL, Katzmarzyk PT, Nichaman MZ, et al. Visceral fat is an independent predictor of all-cause mortality in men. Obesity 2006; 14:336-341.
23. Montague CT,O'RahillyS. The perils of portliness: causes and consequences of visceral adiposity. Diabetes 2000; 49:883-888.
24. Tan CY, Vidal-Puig A. Adipose tissue expandability: the metabolic problems of obesity may arise from the inability to become more obese. Biochem Soc Trans 2008; 36:935-940.
25. Tran TT, Yamamoto Y, Gesta S, Kahn CR. Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab 2008; 7:410-420.
26. Spalding KL, Arner E, Westermark PO, et al. Dynamics of fat cell turnover in humans. Nature 2008; 453:783-787.
27. Wajchenberg BL. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 2000; 21:697-738.
28. Ersek RA, Bell HN 4th, Salisbury AV. Serial and superficial suction for steatopygia (Hottentot bustle). Aesthetic Plast Surg 1994; 18:279-282.
29. Garg A, Misra A. Lipodystrophies: rare disorders causing metabolic syndrome. Endocrinol Metab Clin North Am 2004; 33:305-331.
30. Gesta S, Blüher M, Yamamoto Y, et al. Evidence for a role of developmental genes in the origin of obesity and body fat distribution. Proc Natl Acad Sci U S A 2006; 103:6676-6681.
31. Shai I, Schwarzfuchs D, Henkin Y, et al., Dietary Intervention Randomized Controlled Trial (DIRECT) Group. Weight loss with a low-carbohydrate, Mediterranean, or low-fat diet. N Engl J Med 2008; 359:229-241.
32. Lee DC, Sui X, Church TS, et al. Associations of cardiorespiratory fitness and obesity with risks of impaired fasting glucose and type 2 diabetes in men. Diabetes Care 2009; 32:257-262.
33. O'Donovan G, Thomas EL, McCarthy JP, et al. Fat distribution in men of different waist girth, fitness level and exercise habit. Int J Obes (Lond) 2009. doi:10.1038/ijo.2009.189.
34. Hwang JH, Stein DT, Barzilai N, et al. Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies. Am J Physiol Endocrinol Metab 2007; 293:E1663-E1669.
35. Nicklas BJ, Wang X, You T, et al. Effect of exercise intensity on abdominal fat loss during calorie restriction in overweight and obese postmenopausal women: a randomized, controlled trial. Am J Clin Nutr 2009; 89:1043-1052.
36. BluherM. Adipose tissue dysfunction in obesity. Exp Clin Endocrinol Diabetes 2009; 117:241-250.
37. Hardy OT, Perugini RA, Nicoloro SM, et al. BMI-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity. Am J Physiol Endocr Metab (in revision).