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Volumn 37, Issue 4, 2008, Pages 887-903

Exercise and the Treatment of Diabetes and Obesity

Author keywords

AMPK; Exercise; Gene expression; Insulin resistance; Skeletal muscle; Substrate metabolism

Indexed keywords

ADENYLATE KINASE; FATTY ACID; GLUCOSE; INSULIN; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR; TRIACYLGLYCEROL;

EID: 56549093005     PISSN: 08898529     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ecl.2008.07.006     Document Type: Review
Times cited : (31)

References (138)
  • 1
    • 34248551079 scopus 로고    scopus 로고
    • Body mass index-independent effect of fitness and physical activity for all-cause mortality
    • Pedersen B.K. Body mass index-independent effect of fitness and physical activity for all-cause mortality. Scand J Med Sci Sports 17 (2007) 196-204
    • (2007) Scand J Med Sci Sports , vol.17 , pp. 196-204
    • Pedersen, B.K.1
  • 2
    • 0035985859 scopus 로고    scopus 로고
    • Waging war on physical inactivity: using modern molecular ammunition against an ancient enemy
    • Booth F.W., Chakravarthy M.V., Gordon S.E., et al. Waging war on physical inactivity: using modern molecular ammunition against an ancient enemy. J Appl Physiol 93 (2002) 3-30
    • (2002) J Appl Physiol , vol.93 , pp. 3-30
    • Booth, F.W.1    Chakravarthy, M.V.2    Gordon, S.E.3
  • 3
    • 0041382627 scopus 로고    scopus 로고
    • Physical activity levels among overweight and obese adults in South Carolina
    • Adams S.A., Der Ananian C.A., DuBose K.D., et al. Physical activity levels among overweight and obese adults in South Carolina. South Med J 96 (2003) 539-543
    • (2003) South Med J , vol.96 , pp. 539-543
    • Adams, S.A.1    Der Ananian, C.A.2    DuBose, K.D.3
  • 4
    • 0032749573 scopus 로고    scopus 로고
    • Relationship between low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men
    • Wei M., Kampert J.B., Barlow C.E., et al. Relationship between low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men. JAMA 282 (1999) 1547-1553
    • (1999) JAMA , vol.282 , pp. 1547-1553
    • Wei, M.1    Kampert, J.B.2    Barlow, C.E.3
  • 5
    • 0029792290 scopus 로고    scopus 로고
    • Changes in blood pressure and serum cholesterol following exercise training in Nigerian hypertensive subjects
    • Iyawe V.I., Ighoroje A.D., and Iyawe H.O. Changes in blood pressure and serum cholesterol following exercise training in Nigerian hypertensive subjects. J Hum Hypertens 10 (1996) 483-487
    • (1996) J Hum Hypertens , vol.10 , pp. 483-487
    • Iyawe, V.I.1    Ighoroje, A.D.2    Iyawe, H.O.3
  • 6
    • 0028242749 scopus 로고
    • Low-intensity endurance exercise training, plasma lipoproteins and the risk of coronary heart disease
    • Despres J.P., and Lamarche B. Low-intensity endurance exercise training, plasma lipoproteins and the risk of coronary heart disease. J Intern Med 236 (1994) 7-22
    • (1994) J Intern Med , vol.236 , pp. 7-22
    • Despres, J.P.1    Lamarche, B.2
  • 7
    • 0035850403 scopus 로고    scopus 로고
    • Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials
    • Boule N.G., Haddad E., Kenny G.P., et al. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA 86 (2001) 1218-1227
    • (2001) JAMA , vol.86 , pp. 1218-1227
    • Boule, N.G.1    Haddad, E.2    Kenny, G.P.3
  • 8
    • 0033977444 scopus 로고    scopus 로고
    • Regular exercise enhances insulin activation of IRS-1-associated PI3-kinase in human skeletal muscle
    • Kirwan J.P., del Aguila L.F., Hernandez J.M., et al. Regular exercise enhances insulin activation of IRS-1-associated PI3-kinase in human skeletal muscle. J Appl Physiol 88 (2000) 797-803
    • (2000) J Appl Physiol , vol.88 , pp. 797-803
    • Kirwan, J.P.1    del Aguila, L.F.2    Hernandez, J.M.3
  • 9
    • 22544478168 scopus 로고    scopus 로고
    • Endurance training increases the number of endothelial progenitor cells in patients with cardiovascular risk and coronary artery disease
    • Steiner S., Niessner A., Ziegler S., et al. Endurance training increases the number of endothelial progenitor cells in patients with cardiovascular risk and coronary artery disease. Atherosclerosis 181 (2005) 305-310
    • (2005) Atherosclerosis , vol.181 , pp. 305-310
    • Steiner, S.1    Niessner, A.2    Ziegler, S.3
  • 10
    • 0033387236 scopus 로고    scopus 로고
    • An educational programme for persistent life-style changes in patients with chronic renal disease
    • Bergström K., Barany P., and Holm I. An educational programme for persistent life-style changes in patients with chronic renal disease. EDTNA ERCA J 25 (1999) 42-44
    • (1999) EDTNA ERCA J , vol.25 , pp. 42-44
    • Bergström, K.1    Barany, P.2    Holm, I.3
  • 11
    • 0027079958 scopus 로고
    • Effect of training on insulin-mediated glucose uptake in human muscle
    • Dela F., Mikines K.J., von Linstow M., et al. Effect of training on insulin-mediated glucose uptake in human muscle. Am J Physiol 263 (1992) E1134-E1143
    • (1992) Am J Physiol , vol.263
    • Dela, F.1    Mikines, K.J.2    von Linstow, M.3
  • 12
    • 0023550397 scopus 로고
    • Insulin action and secretion in endurance-trained and untrained humans
    • King D.S., Dalsky G.P., Staten M.A., et al. Insulin action and secretion in endurance-trained and untrained humans. J Appl Physiol 63 (1987) 2247-2252
    • (1987) J Appl Physiol , vol.63 , pp. 2247-2252
    • King, D.S.1    Dalsky, G.P.2    Staten, M.A.3
  • 13
    • 33750918305 scopus 로고    scopus 로고
    • Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes
    • O'Gorman D.J., Karlsson H.K.R., McQuaid S., et al. Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes. Diabetologia 49 (2006) 2983-2992
    • (2006) Diabetologia , vol.49 , pp. 2983-2992
    • O'Gorman, D.J.1    Karlsson, H.K.R.2    McQuaid, S.3
  • 14
    • 0032791143 scopus 로고    scopus 로고
    • Prevention of Type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland. Study design and 1-year interim report on the feasibility of the lifestyle intervention programme
    • Eriksson J., Lindström J., Valle T., et al. Prevention of Type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland. Study design and 1-year interim report on the feasibility of the lifestyle intervention programme. Diabetoloiga 42 (1999) 793-801
    • (1999) Diabetoloiga , vol.42 , pp. 793-801
    • Eriksson, J.1    Lindström, J.2    Valle, T.3
  • 15
    • 0025750835 scopus 로고
    • Prevention of type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise: the 6-year Malmö feasibility study
    • Eriksson K., and Lindgarde F. Prevention of type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise: the 6-year Malmö feasibility study. Diabetologia 34 (1991) 891-898
    • (1991) Diabetologia , vol.34 , pp. 891-898
    • Eriksson, K.1    Lindgarde, F.2
  • 16
    • 0030935652 scopus 로고    scopus 로고
    • Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance: the Da Qing IGT and Diabetes Study
    • X P., Li G., Hu Y., et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance: the Da Qing IGT and Diabetes Study. Diabetes Care 20 (1997) 537-544
    • (1997) Diabetes Care , vol.20 , pp. 537-544
    • X, P.1    Li, G.2    Hu, Y.3
  • 17
    • 0035799806 scopus 로고    scopus 로고
    • Prevention of Type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    • Tuomilehto J., Lindstrom J., Eriksson J.G., et al. Prevention of Type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344 (2001) 1343-1350
    • (2001) N Engl J Med , vol.344 , pp. 1343-1350
    • Tuomilehto, J.1    Lindstrom, J.2    Eriksson, J.G.3
  • 18
    • 0029798824 scopus 로고    scopus 로고
    • Early lifestyle intervention in patients with non-insulin-dependent diabetes mellitus and impaired glucose tolerance
    • Uusitupa M.I. Early lifestyle intervention in patients with non-insulin-dependent diabetes mellitus and impaired glucose tolerance. Annu Mediaev 28 (1996) 445-449
    • (1996) Annu Mediaev , vol.28 , pp. 445-449
    • Uusitupa, M.I.1
  • 20
    • 0030852228 scopus 로고    scopus 로고
    • Effects of physical training on metabolic control in elderly type 2 diabetes mellitus patients
    • Ligtenberg P.C., Hoekstra J.B.L., Bol E., et al. Effects of physical training on metabolic control in elderly type 2 diabetes mellitus patients. Clin Sci (Colch) 93 (1997) 127-135
    • (1997) Clin Sci (Colch) , vol.93 , pp. 127-135
    • Ligtenberg, P.C.1    Hoekstra, J.B.L.2    Bol, E.3
  • 21
    • 0023546385 scopus 로고
    • Physical training as treatment for type 2 (non-insulin-dependent) diabetes in elderly men. A feasibility study over 2 years
    • Skarfors E.T., Wegener T.A., Lithell H., et al. Physical training as treatment for type 2 (non-insulin-dependent) diabetes in elderly men. A feasibility study over 2 years. Diabetologia 30 (1987) 930-933
    • (1987) Diabetologia , vol.30 , pp. 930-933
    • Skarfors, E.T.1    Wegener, T.A.2    Lithell, H.3
  • 22
    • 12244309110 scopus 로고    scopus 로고
    • Reduction of risk factors following lifestyle modification programme in subjects with type 2 (non-insulin dependent) diabetes mellitus
    • Krook A., Holm I., Pettersson S., et al. Reduction of risk factors following lifestyle modification programme in subjects with type 2 (non-insulin dependent) diabetes mellitus. Clin Physiol Funct Imaging 23 (2003) 21-30
    • (2003) Clin Physiol Funct Imaging , vol.23 , pp. 21-30
    • Krook, A.1    Holm, I.2    Pettersson, S.3
  • 23
    • 0016888751 scopus 로고
    • Biochemical adaptations to endurance exercise in muscle
    • Holloszy J.O., and Booth F.W. Biochemical adaptations to endurance exercise in muscle. Annu Rev Physiol 38 (1976) 273-291
    • (1976) Annu Rev Physiol , vol.38 , pp. 273-291
    • Holloszy, J.O.1    Booth, F.W.2
  • 24
    • 0034807891 scopus 로고    scopus 로고
    • Postexercise muscle glycogen resynthesis in obese insulin-resistant Zucker rats
    • Bruce C.R., Lee J.S., and Hawley J.A. Postexercise muscle glycogen resynthesis in obese insulin-resistant Zucker rats. J Appl Physiol 91 (2001) 1512-1519
    • (2001) J Appl Physiol , vol.91 , pp. 1512-1519
    • Bruce, C.R.1    Lee, J.S.2    Hawley, J.A.3
  • 25
    • 0027977019 scopus 로고
    • Human muscle glycogen resynthesis after exercise: insulin-dependent and -independent phases
    • Price T.B., Rothman D.L., Taylor R., et al. Human muscle glycogen resynthesis after exercise: insulin-dependent and -independent phases. J Appl Physiol 76 (1994) 104-111
    • (1994) J Appl Physiol , vol.76 , pp. 104-111
    • Price, T.B.1    Rothman, D.L.2    Taylor, R.3
  • 26
    • 0032802835 scopus 로고    scopus 로고
    • Effects of endurance exercise training on muscle glycogen accumulation in humans
    • Greiwe J.S., Hickner R.C., Hansen P.A., et al. Effects of endurance exercise training on muscle glycogen accumulation in humans. J Appl Physiol 87 (1999) 222-226
    • (1999) J Appl Physiol , vol.87 , pp. 222-226
    • Greiwe, J.S.1    Hickner, R.C.2    Hansen, P.A.3
  • 27
    • 0042321037 scopus 로고    scopus 로고
    • Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity
    • Goodpaster B.H., Katsiaras A., and Kelley D.E. Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity. Diabetes 52 (2003) 2191-2197
    • (2003) Diabetes , vol.52 , pp. 2191-2197
    • Goodpaster, B.H.1    Katsiaras, A.2    Kelley, D.E.3
  • 28
    • 33644824890 scopus 로고    scopus 로고
    • Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training
    • DiPietro L., Dziura J., Yeckel C.W., et al. Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training. J Appl Physiol 100 (2006) 142-149
    • (2006) J Appl Physiol , vol.100 , pp. 142-149
    • DiPietro, L.1    Dziura, J.2    Yeckel, C.W.3
  • 29
    • 0027304679 scopus 로고
    • Strenuous endurance training increases lipolysis and triglyceride-fatty acid cycling at rest
    • Romijn J.A., Klein S., Coyle E.F., et al. Strenuous endurance training increases lipolysis and triglyceride-fatty acid cycling at rest. J Appl Physiol 75 (1993) 108-113
    • (1993) J Appl Physiol , vol.75 , pp. 108-113
    • Romijn, J.A.1    Klein, S.2    Coyle, E.F.3
  • 30
    • 0028576946 scopus 로고
    • Fat metabolism during low-intensity exercise in endurance-trained and untrained men
    • Klein S., Coyle E.F., and Wolfe R.R. Fat metabolism during low-intensity exercise in endurance-trained and untrained men. Am J Physiol 267 (1994) E934-E940
    • (1994) Am J Physiol , vol.267
    • Klein, S.1    Coyle, E.F.2    Wolfe, R.R.3
  • 31
    • 0033837861 scopus 로고    scopus 로고
    • Lipid metabolism during endurance exercise
    • Horowitz J.F., and Klein S. Lipid metabolism during endurance exercise. Am J Clin Nutr 72 (2000) 558S-563S
    • (2000) Am J Clin Nutr , vol.72
    • Horowitz, J.F.1    Klein, S.2
  • 32
    • 0141918772 scopus 로고    scopus 로고
    • Effect of endurance training on muscle fat metabolism during prolonged exercise: agreements and disagreements
    • Smekal G., von Duvillard S.P., Pokan R., et al. Effect of endurance training on muscle fat metabolism during prolonged exercise: agreements and disagreements. Nutrition 19 (2003) 891-900
    • (2003) Nutrition , vol.19 , pp. 891-900
    • Smekal, G.1    von Duvillard, S.P.2    Pokan, R.3
  • 33
    • 0022234140 scopus 로고
    • Muscle triglyceride utilization during exercise: effect of training
    • Hurley B.F., Nemeth P.M., Martin III W.H., et al. Muscle triglyceride utilization during exercise: effect of training. J Appl Physiol 60 (1986) 562-567
    • (1986) J Appl Physiol , vol.60 , pp. 562-567
    • Hurley, B.F.1    Nemeth, P.M.2    Martin III, W.H.3
  • 34
    • 0036076757 scopus 로고    scopus 로고
    • Influence of endurance running and recovery diet on intramyocellular lipid content in women: a 1H NMR study
    • E95-106
    • Larson-Meyer D.E., Newcomer B.R., and Hunter G.R. Influence of endurance running and recovery diet on intramyocellular lipid content in women: a 1H NMR study. Am J Physiol Endocrinol Metab 282 (2002) E95-106
    • (2002) Am J Physiol Endocrinol Metab , vol.282
    • Larson-Meyer, D.E.1    Newcomer, B.R.2    Hunter, G.R.3
  • 35
    • 0025143220 scopus 로고
    • Exercise induces recruitment of the "insulin responsive" glucose transporter. Evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle
    • Douen A.G., Ramlal T., Rastogi S.A., et al. Exercise induces recruitment of the "insulin responsive" glucose transporter. Evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle. J Biol Chem 265 (1990) 13427-13430
    • (1990) J Biol Chem , vol.265 , pp. 13427-13430
    • Douen, A.G.1    Ramlal, T.2    Rastogi, S.A.3
  • 36
    • 0030062530 scopus 로고    scopus 로고
    • Exercise-induced increase in glucose transport, GLUT-4, and VAMP-2 in plasma membrane from human muscle
    • E197-81
    • Kristiansen S., Hargreaves M., and Richter E.A. Exercise-induced increase in glucose transport, GLUT-4, and VAMP-2 in plasma membrane from human muscle. Am J Physiol Endocrinol Metab 270 (1996) E197-81
    • (1996) Am J Physiol Endocrinol Metab , vol.270
    • Kristiansen, S.1    Hargreaves, M.2    Richter, E.A.3
  • 37
    • 0029064123 scopus 로고
    • Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin
    • Lund S., Holman G.D., Schmitz O., et al. Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin. Proc Natl Acad Sci U S A 92 (1995) 5817-5821
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 5817-5821
    • Lund, S.1    Holman, G.D.2    Schmitz, O.3
  • 38
    • 0036021852 scopus 로고    scopus 로고
    • Exercise effects of muscle insulin signaling and action: invited review: exercise training-induced changes in insulin signaling in skeletal muscle
    • Zierath J.R. Exercise effects of muscle insulin signaling and action: invited review: exercise training-induced changes in insulin signaling in skeletal muscle. J Appl Physiol 93 (2002) 773-781
    • (2002) J Appl Physiol , vol.93 , pp. 773-781
    • Zierath, J.R.1
  • 39
    • 33745815985 scopus 로고    scopus 로고
    • AMP-activated protein kinase signaling in metabolic regulation
    • Long Y.C., and Zierath J.R. AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest 116 (2006) 1776-1783
    • (2006) J Clin Invest , vol.116 , pp. 1776-1783
    • Long, Y.C.1    Zierath, J.R.2
  • 40
    • 0029948964 scopus 로고    scopus 로고
    • The Effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle
    • Kelley D.E., Mintun M.A., Watkins S.C., et al. The Effect of non-insulin-dependent diabetes mellitus and obesity on glucose transport and phosphorylation in skeletal muscle. J Clin Invest 97 (1996) 2705-2713
    • (1996) J Clin Invest , vol.97 , pp. 2705-2713
    • Kelley, D.E.1    Mintun, M.A.2    Watkins, S.C.3
  • 41
    • 0027946529 scopus 로고
    • Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus
    • Kelley D.E., and Simoneau J.-A. Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus. J Clin Invest 94 (1994) 2349-2356
    • (1994) J Clin Invest , vol.94 , pp. 2349-2356
    • Kelley, D.E.1    Simoneau, J.-A.2
  • 42
    • 0029438723 scopus 로고
    • In vitro studies of human skeletal muscle. hormonal and metabolic regulation of glucose transport
    • Zierath J.R. In vitro studies of human skeletal muscle. hormonal and metabolic regulation of glucose transport. Acta Physiol Scand 155 (1995) 1-96
    • (1995) Acta Physiol Scand , vol.155 , pp. 1-96
    • Zierath, J.R.1
  • 43
    • 0029775874 scopus 로고    scopus 로고
    • Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM
    • Zierath J.R., He L., Guma A., et al. Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM. Diabetologia 39 (1996) 1180-1189
    • (1996) Diabetologia , vol.39 , pp. 1180-1189
    • Zierath, J.R.1    He, L.2    Guma, A.3
  • 44
    • 0343314906 scopus 로고    scopus 로고
    • Characterization of signal transduction and glucose transport in skeletal muscle from Type 2 (non-insulin-dependent) diabetic patients
    • Krook A., Björnholm M., Jiang X.-J., et al. Characterization of signal transduction and glucose transport in skeletal muscle from Type 2 (non-insulin-dependent) diabetic patients. Diabetes 49 (2000) 284-292
    • (2000) Diabetes , vol.49 , pp. 284-292
    • Krook, A.1    Björnholm, M.2    Jiang, X.-J.3
  • 45
    • 0025098765 scopus 로고
    • Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy
    • Shulman G.I., Rothman D.L., Jue T., et al. Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. N Engl J Med 322 (1990) 223-228
    • (1990) N Engl J Med , vol.322 , pp. 223-228
    • Shulman, G.I.1    Rothman, D.L.2    Jue, T.3
  • 46
    • 0034112806 scopus 로고    scopus 로고
    • Intramuscular lipid content is increased in obesity and decreased by weight loss
    • Goodpaster B.H., Theriault R., Watkins S.C., et al. Intramuscular lipid content is increased in obesity and decreased by weight loss. Metabolism 49 (2000) 467-472
    • (2000) Metabolism , vol.49 , pp. 467-472
    • Goodpaster, B.H.1    Theriault, R.2    Watkins, S.C.3
  • 47
    • 0033856104 scopus 로고    scopus 로고
    • Plasma FFA utilization and fatty acid-binding protein content are diminished in type 2 diabetic muscle
    • Blaak E.E., Wagenmakers A.J.L., Glatz J.F.C., et al. Plasma FFA utilization and fatty acid-binding protein content are diminished in type 2 diabetic muscle. Am J Physiol Endocrinol Metab 279 (2000) E146-E154
    • (2000) Am J Physiol Endocrinol Metab , vol.279
    • Blaak, E.E.1    Wagenmakers, A.J.L.2    Glatz, J.F.C.3
  • 48
    • 1442300769 scopus 로고    scopus 로고
    • Excess body fat in men decreases plasma fatty acid availability and oxidation during endurance exercise
    • Mittendorfer B., Fields D.A., and Klein S. Excess body fat in men decreases plasma fatty acid availability and oxidation during endurance exercise. Am J Physiol Endocrinol Metab 286 (2004) E354-E362
    • (2004) Am J Physiol Endocrinol Metab , vol.286
    • Mittendorfer, B.1    Fields, D.A.2    Klein, S.3
  • 49
    • 0036634086 scopus 로고    scopus 로고
    • Effects of obesity on substrate utilization during exercise
    • Goodpaster B.H., Wolfe R.R., and Kelley D.E. Effects of obesity on substrate utilization during exercise. Obes Res 10 (2002) 575-584
    • (2002) Obes Res , vol.10 , pp. 575-584
    • Goodpaster, B.H.1    Wolfe, R.R.2    Kelley, D.E.3
  • 50
    • 33746577866 scopus 로고    scopus 로고
    • Effects of obesity phenotype on fat metabolism in obese men during endurance exercise
    • Numao S., Hayashi Y., Katayama Y., et al. Effects of obesity phenotype on fat metabolism in obese men during endurance exercise. Int J Obes 8 (2006) 1189-1196
    • (2006) Int J Obes , vol.8 , pp. 1189-1196
    • Numao, S.1    Hayashi, Y.2    Katayama, Y.3
  • 51
    • 0035259932 scopus 로고    scopus 로고
    • The effect of low-intensity exercise training on fat metabolism of obese women
    • van Aggel-Leijssen D.P., Saris W.H., Wagenmakers A.J., et al. The effect of low-intensity exercise training on fat metabolism of obese women. Obes Res 9 (2001) 86-96
    • (2001) Obes Res , vol.9 , pp. 86-96
    • van Aggel-Leijssen, D.P.1    Saris, W.H.2    Wagenmakers, A.J.3
  • 52
    • 4344693088 scopus 로고    scopus 로고
    • Effects of insulin resistance on substrate utilization during exercise in overweight women
    • Braun B., Sharoff C., Chipkin S.R., et al. Effects of insulin resistance on substrate utilization during exercise in overweight women. J Appl Physiol 97 (2004) 991-997
    • (2004) J Appl Physiol , vol.97 , pp. 991-997
    • Braun, B.1    Sharoff, C.2    Chipkin, S.R.3
  • 53
    • 0036092720 scopus 로고    scopus 로고
    • Effect of exercise training at different intensities on fat metabolism of obese men
    • van Aggel-Leijssen D.P., Saris W.H., Wagenmakers A.J., et al. Effect of exercise training at different intensities on fat metabolism of obese men. J Appl Physiol 92 (2002) 1300-1309
    • (2002) J Appl Physiol , vol.92 , pp. 1300-1309
    • van Aggel-Leijssen, D.P.1    Saris, W.H.2    Wagenmakers, A.J.3
  • 54
    • 15444368359 scopus 로고    scopus 로고
    • Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesity
    • Menshikova E.V., Ritov V.B., Toledo F.G., et al. Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesity. Am J Physiol Endocrinol Metab 288 (2005) E818-E825
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Menshikova, E.V.1    Ritov, V.B.2    Toledo, F.G.3
  • 55
    • 34447621360 scopus 로고    scopus 로고
    • Characteristics of skeletal muscle mitochondrial biogenesis induced by moderate-intensity exercise and weight loss in obesity
    • Menshikova E.V., Ritov V.B., Ferrell R.E., et al. Characteristics of skeletal muscle mitochondrial biogenesis induced by moderate-intensity exercise and weight loss in obesity. J Appl Physiol 103 (2007) 21-27
    • (2007) J Appl Physiol , vol.103 , pp. 21-27
    • Menshikova, E.V.1    Ritov, V.B.2    Ferrell, R.E.3
  • 56
    • 12144275294 scopus 로고    scopus 로고
    • Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes
    • Ritov V.B., Menshikova E.V., He J., et al. Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes 54 (2005) 8-14
    • (2005) Diabetes , vol.54 , pp. 8-14
    • Ritov, V.B.1    Menshikova, E.V.2    He, J.3
  • 57
    • 0035020816 scopus 로고    scopus 로고
    • Elevated intramyocellular lipid concentration in obese subjects is not reduced after diet and exercise training
    • Malenfant P., Tremblay A., Doucet E., et al. Elevated intramyocellular lipid concentration in obese subjects is not reduced after diet and exercise training. Am J Physiol Endocrinol Metab 280 (2001) E632-E639
    • (2001) Am J Physiol Endocrinol Metab , vol.280
    • Malenfant, P.1    Tremblay, A.2    Doucet, E.3
  • 58
    • 34249945638 scopus 로고    scopus 로고
    • Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training
    • Burns N., Finucane F.M., Hatunic M., et al. Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training. Diabetologia 50 (2007) 1500-1508
    • (2007) Diabetologia , vol.50 , pp. 1500-1508
    • Burns, N.1    Finucane, F.M.2    Hatunic, M.3
  • 59
    • 0031671077 scopus 로고    scopus 로고
    • Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia
    • Giacca A., Groenewoud Y., Tsui E., et al. Glucose production, utilization, and cycling in response to moderate exercise in obese subjects with type 2 diabetes and mild hyperglycemia. Diabetes 47 (1998) 1763-1770
    • (1998) Diabetes , vol.47 , pp. 1763-1770
    • Giacca, A.1    Groenewoud, Y.2    Tsui, E.3
  • 60
    • 0032900540 scopus 로고    scopus 로고
    • Substrate utilization and glucose turnover during exercise of varying intensities in individuals with NIDDM
    • Kang J., Kelley D.E., Robertson R.J., et al. Substrate utilization and glucose turnover during exercise of varying intensities in individuals with NIDDM. Med Sci Sports Exerc 31 (1999) 82-89
    • (1999) Med Sci Sports Exerc , vol.31 , pp. 82-89
    • Kang, J.1    Kelley, D.E.2    Robertson, R.J.3
  • 61
    • 0028864373 scopus 로고    scopus 로고
    • Insulin-stimulated muscle glucose clearance in patients with NIDDM. Effects of one-legged physical training
    • Dela F., Larsen J.J., Mikines K.J., et al. Insulin-stimulated muscle glucose clearance in patients with NIDDM. Effects of one-legged physical training. Diabetes 44 (1999) 1010-1020
    • (1999) Diabetes , vol.44 , pp. 1010-1020
    • Dela, F.1    Larsen, J.J.2    Mikines, K.J.3
  • 62
    • 0029849462 scopus 로고    scopus 로고
    • Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects
    • Perseghin G., Price T.B., Petersen K.F., et al. Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N Engl J Med 335 (1996) 1357-1362
    • (1996) N Engl J Med , vol.335 , pp. 1357-1362
    • Perseghin, G.1    Price, T.B.2    Petersen, K.F.3
  • 63
    • 0033595120 scopus 로고    scopus 로고
    • Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes
    • Cline G.W., Petersen K.F., Krssak M., et al. Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. N Engl J Med 341 (1999) 240-246
    • (1999) N Engl J Med , vol.341 , pp. 240-246
    • Cline, G.W.1    Petersen, K.F.2    Krssak, M.3
  • 64
    • 3042851621 scopus 로고    scopus 로고
    • Sending the signal: molecular mechanisms regulating glucose uptake
    • Krook A., Wallberg-Henriksson H., and Zierath J.R. Sending the signal: molecular mechanisms regulating glucose uptake. Med Sci Sports Exerc 36 (2004) 1212-1217
    • (2004) Med Sci Sports Exerc , vol.36 , pp. 1212-1217
    • Krook, A.1    Wallberg-Henriksson, H.2    Zierath, J.R.3
  • 65
    • 0343314906 scopus 로고    scopus 로고
    • Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients
    • Krook A., Bjornholm M., Galuska D., et al. Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients. Diabetes 49 (2000) 284-292
    • (2000) Diabetes , vol.49 , pp. 284-292
    • Krook, A.1    Bjornholm, M.2    Galuska, D.3
  • 66
    • 1642377274 scopus 로고    scopus 로고
    • Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
    • Petersen K.F., Dufour S., Befroy D., et al. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 350 (2004) 664-671
    • (2004) N Engl J Med , vol.350 , pp. 664-671
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3
  • 67
    • 0030740621 scopus 로고    scopus 로고
    • Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM
    • Simoneau J.A., and Kelley D.E. Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM. J Appl Physiol 83 (1997) 166-171
    • (1997) J Appl Physiol , vol.83 , pp. 166-171
    • Simoneau, J.A.1    Kelley, D.E.2
  • 68
    • 0036788293 scopus 로고    scopus 로고
    • Dysfunction of mitochondria in human skeletal muscle in Type 2 diabetes
    • Kelley D.E., He J., Menshikova E.V., et al. Dysfunction of mitochondria in human skeletal muscle in Type 2 diabetes. Diabetes 51 (2002) 2944-2950
    • (2002) Diabetes , vol.51 , pp. 2944-2950
    • Kelley, D.E.1    He, J.2    Menshikova, E.V.3
  • 69
    • 12344305124 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and type 2 diabetes
    • Lowell B.B., and Shulman G.I. Mitochondrial dysfunction and type 2 diabetes. Science 307 (2005) 384-387
    • (2005) Science , vol.307 , pp. 384-387
    • Lowell, B.B.1    Shulman, G.I.2
  • 70
    • 38849090672 scopus 로고    scopus 로고
    • Down-Regulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance
    • Chibalin A.V., Leng Y., Vieira E., et al. Down-Regulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance. Cell 132 (2008) 375-386
    • (2008) Cell , vol.132 , pp. 375-386
    • Chibalin, A.V.1    Leng, Y.2    Vieira, E.3
  • 71
    • 33751161929 scopus 로고    scopus 로고
    • Low-intensity exercise increases skeletal muscle protein expression of PPAR delta and UCP3 in type 2 diabetic patients
    • Fritz T., Krämer D.K., Karlsson H.K.R., et al. Low-intensity exercise increases skeletal muscle protein expression of PPAR delta and UCP3 in type 2 diabetic patients. Diabetes Metab Res Rev 22 (2006) 492-498
    • (2006) Diabetes Metab Res Rev , vol.22 , pp. 492-498
    • Fritz, T.1    Krämer, D.K.2    Karlsson, H.K.R.3
  • 72
    • 19444365803 scopus 로고    scopus 로고
    • Endurance training-induced changes in insulin sensitivity and gene expression
    • Teran-Garcia M., Rankinen T., Koza R.A., et al. Endurance training-induced changes in insulin sensitivity and gene expression. Am J Physiol Endocrinol Metab 288 (2005) E1168-E1178
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Teran-Garcia, M.1    Rankinen, T.2    Koza, R.A.3
  • 73
    • 0030740621 scopus 로고    scopus 로고
    • Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM
    • Simoneau J.-A., and Kelley D.E. Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM. J Appl Physiol 83 (1997) 166-171
    • (1997) J Appl Physiol , vol.83 , pp. 166-171
    • Simoneau, J.-A.1    Kelley, D.E.2
  • 74
    • 0021343295 scopus 로고
    • Adaptations of skeletal muscle to endurance exercise and their metabolic consequences
    • Holloszy J.O., and Coyle E.F. Adaptations of skeletal muscle to endurance exercise and their metabolic consequences. J Appl Physiol 56 (1984) 831-838
    • (1984) J Appl Physiol , vol.56 , pp. 831-838
    • Holloszy, J.O.1    Coyle, E.F.2
  • 75
    • 0019929103 scopus 로고
    • Influence of exercise intensity and duration on biochemical adaptations in skeletal muscle
    • Dudley G.A., Abraham W.M., and Terjung R.L. Influence of exercise intensity and duration on biochemical adaptations in skeletal muscle. J Appl Physiol 53 (1982) 844-850
    • (1982) J Appl Physiol , vol.53 , pp. 844-850
    • Dudley, G.A.1    Abraham, W.M.2    Terjung, R.L.3
  • 76
    • 33747702159 scopus 로고    scopus 로고
    • Changes induced by physical activity and weight loss in the morphology of intermyofibrillar mitochondria in obese men and women
    • Toledo F.G., Watkins S., and Kelley D.E. Changes induced by physical activity and weight loss in the morphology of intermyofibrillar mitochondria in obese men and women. J Clin Endocrinol Metab 91 (2006) 3224-3227
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3224-3227
    • Toledo, F.G.1    Watkins, S.2    Kelley, D.E.3
  • 77
    • 0034602675 scopus 로고    scopus 로고
    • Exercise-induced changes in expression and activity of proteins involved in insulin-signal-transduction in skeletal muscle: differential effects on IRS-1 and IRS-2
    • Chibalin A.V., Yu M., Ryder J.W., et al. Exercise-induced changes in expression and activity of proteins involved in insulin-signal-transduction in skeletal muscle: differential effects on IRS-1 and IRS-2. Proc Natl Acad Sci U S A 97 (2000) 38
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 38
    • Chibalin, A.V.1    Yu, M.2    Ryder, J.W.3
  • 78
    • 0025941494 scopus 로고
    • Elevated skeletal muscle glucose transporter levels in exercise-trained middle-aged men
    • Houmard J.A., Egan P.C., Neufer P.D., et al. Elevated skeletal muscle glucose transporter levels in exercise-trained middle-aged men. Am J Physiol 261 (1991) E437-E443
    • (1991) Am J Physiol , vol.261
    • Houmard, J.A.1    Egan, P.C.2    Neufer, P.D.3
  • 79
    • 0027212601 scopus 로고
    • Exercise increases muscle GLUT4-levels and insulin action in subjects with impaired glucose tolerance
    • Hughes V.A., Fiatarone M.A., Fielding R.A., et al. Exercise increases muscle GLUT4-levels and insulin action in subjects with impaired glucose tolerance. Am J Physiol 264 (1993) E855-E862
    • (1993) Am J Physiol , vol.264
    • Hughes, V.A.1    Fiatarone, M.A.2    Fielding, R.A.3
  • 80
    • 0025614980 scopus 로고
    • Effect of endurance training on glucose transport capacity and glucose transporter expression in rat skeletal muscle
    • Ploug T., Stallknecht B.M., Pedersen O., et al. Effect of endurance training on glucose transport capacity and glucose transporter expression in rat skeletal muscle. Am J Physiol 259 (1990) E778-E786
    • (1990) Am J Physiol , vol.259
    • Ploug, T.1    Stallknecht, B.M.2    Pedersen, O.3
  • 81
    • 0028287972 scopus 로고
    • Exercise induces rapid increases in GLUT4 expression, glucose transport capacity, and insulin-stimulated glycogen storage in muscle
    • Ren J.-M., Semenkovich C.F., Gulve E.A., et al. Exercise induces rapid increases in GLUT4 expression, glucose transport capacity, and insulin-stimulated glycogen storage in muscle. J Biol Chem 269 (1994) 14396-14401
    • (1994) J Biol Chem , vol.269 , pp. 14396-14401
    • Ren, J.-M.1    Semenkovich, C.F.2    Gulve, E.A.3
  • 82
    • 0035173610 scopus 로고    scopus 로고
    • Exercise-associated differences in an array of proteins involved in signal transduction and glucose transport
    • Yu M., Blomstrand E., Chibalin A.V., et al. Exercise-associated differences in an array of proteins involved in signal transduction and glucose transport. J Appl Physiol 90 (2001) 29-34
    • (2001) J Appl Physiol , vol.90 , pp. 29-34
    • Yu, M.1    Blomstrand, E.2    Chibalin, A.V.3
  • 83
    • 0033851801 scopus 로고    scopus 로고
    • Effect of endurance training on lipid metabolism in women: a potential role for PPARalpha in the metabolic response to training
    • Horowitz J.F., Leone T.C., Feng W., et al. Effect of endurance training on lipid metabolism in women: a potential role for PPARalpha in the metabolic response to training. Am J Physiol Endocrinol Metab 279 (2000) E348-E355
    • (2000) Am J Physiol Endocrinol Metab , vol.279
    • Horowitz, J.F.1    Leone, T.C.2    Feng, W.3
  • 84
    • 0036288154 scopus 로고    scopus 로고
    • Exercise training increases lipid metabolism gene expression in human skeletal muscle
    • Tunstall R.J., Mehan K.A., Wadley G.D., et al. Exercise training increases lipid metabolism gene expression in human skeletal muscle. Am J Physiol Endocrinol Metab 283 (2002) E66-E72
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • Tunstall, R.J.1    Mehan, K.A.2    Wadley, G.D.3
  • 85
    • 33751274538 scopus 로고    scopus 로고
    • Mitochondrial diabetes and its lessons for common Type 2 diabetes
    • Maassen J.A., t Hart L.M., Janssen G.M., et al. Mitochondrial diabetes and its lessons for common Type 2 diabetes. Biochem Soc Trans 34 (2006) 819-823
    • (2006) Biochem Soc Trans , vol.34 , pp. 819-823
    • Maassen, J.A.1    t Hart, L.M.2    Janssen, G.M.3
  • 86
    • 35548944496 scopus 로고    scopus 로고
    • Is Energy Deficiency Good in Moderation?
    • Freyer C., and Larsson N. Is Energy Deficiency Good in Moderation?. Cell 131 (2007) 448-450
    • (2007) Cell , vol.131 , pp. 448-450
    • Freyer, C.1    Larsson, N.2
  • 87
    • 0035665594 scopus 로고    scopus 로고
    • Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis
    • Bergeron R., Ren J.M., Cadman K.S., et al. Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis. Am J Physiol Endocrinol Metab 281 (2001) E1340-E1346
    • (2001) Am J Physiol Endocrinol Metab , vol.281
    • Bergeron, R.1    Ren, J.M.2    Cadman, K.S.3
  • 88
    • 0037389416 scopus 로고    scopus 로고
    • Raising Ca2+ in L6 myotubes mimics effects of exercise on mitochondrial biogenesis in muscle
    • Ojuka E.O., Jones T.E., Han D.H., et al. Raising Ca2+ in L6 myotubes mimics effects of exercise on mitochondrial biogenesis in muscle. FASEB J 17 (2003) 675-681
    • (2003) FASEB J , vol.17 , pp. 675-681
    • Ojuka, E.O.1    Jones, T.E.2    Han, D.H.3
  • 89
    • 0038810035 scopus 로고    scopus 로고
    • An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle
    • 7111-6
    • Handschin C., Rhee J., Lin J., et al. An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. PMID 100 (2003) 7111-6
    • (2003) PMID , vol.100
    • Handschin, C.1    Rhee, J.2    Lin, J.3
  • 90
    • 0037066459 scopus 로고    scopus 로고
    • Regulation of mitochondrial biogenesis in skeletal muscle by CaMK
    • Wu H., Kanatous S.B., Thurmond F.A., et al. Regulation of mitochondrial biogenesis in skeletal muscle by CaMK. Science 296 (2002) 349-352
    • (2002) Science , vol.296 , pp. 349-352
    • Wu, H.1    Kanatous, S.B.2    Thurmond, F.A.3
  • 91
    • 0345327762 scopus 로고    scopus 로고
    • Exercise increases Ca2+-calmodulin-dependent protein kinase II activity in human skeletal muscle
    • Rose A.J., and Hargreaves M. Exercise increases Ca2+-calmodulin-dependent protein kinase II activity in human skeletal muscle. J Physiol 553 (2003) 303-309
    • (2003) J Physiol , vol.553 , pp. 303-309
    • Rose, A.J.1    Hargreaves, M.2
  • 92
    • 0037058977 scopus 로고    scopus 로고
    • AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation
    • 15983-7
    • Zong H., Ren J.M., Young L.H., et al. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. PMID 99 (2002) 15983-7
    • (2002) PMID , vol.99
    • Zong, H.1    Ren, J.M.2    Young, L.H.3
  • 93
    • 0037381848 scopus 로고    scopus 로고
    • Exercise increases nuclear AMPK alpha2 in human skeletal muscle
    • McGee S.L., Howlett K.F., Starkie R.L., et al. Exercise increases nuclear AMPK alpha2 in human skeletal muscle. Diabetes 52 (2003) 926-928
    • (2003) Diabetes , vol.52 , pp. 926-928
    • McGee, S.L.1    Howlett, K.F.2    Starkie, R.L.3
  • 94
    • 0033949848 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle
    • Winder W.W., Holmes B.F., Rubink D.S., et al. Activation of AMP-activated protein kinase increases mitochondrial enzymes in skeletal muscle. J Appl Physiol 88 (2000) 2219-2226
    • (2000) J Appl Physiol , vol.88 , pp. 2219-2226
    • Winder, W.W.1    Holmes, B.F.2    Rubink, D.S.3
  • 95
    • 34547545892 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha
    • Jager S., Handschin C., St-Pierre J., et al. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. PMID 104 (2007) 12017-12022
    • (2007) PMID , vol.104 , pp. 12017-12022
    • Jager, S.1    Handschin, C.2    St-Pierre, J.3
  • 96
    • 0033538473 scopus 로고    scopus 로고
    • Mechnisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
    • Wu Z., Puigserver P., Andersson U., et al. Mechnisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98 (1999) 115-124
    • (1999) Cell , vol.98 , pp. 115-124
    • Wu, Z.1    Puigserver, P.2    Andersson, U.3
  • 97
    • 24144463983 scopus 로고    scopus 로고
    • Metabolic control through the PGC-1 family of transcription coactivators
    • Lin J., Handschin C., and Spiegelman B.M. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab 1 (2005) 361-370
    • (2005) Cell Metab , vol.1 , pp. 361-370
    • Lin, J.1    Handschin, C.2    Spiegelman, B.M.3
  • 98
    • 34447511610 scopus 로고    scopus 로고
    • Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation
    • Crunkhorn S., Dearie F., Mantzoros C., et al. Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation. J Biol Chem 282 (2007) 15439-15450
    • (2007) J Biol Chem , vol.282 , pp. 15439-15450
    • Crunkhorn, S.1    Dearie, F.2    Mantzoros, C.3
  • 99
    • 0038054341 scopus 로고    scopus 로고
    • PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    • Mootha V.K., Lindgren C.M., Eriksson K.F., et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34 (2003) 267-273
    • (2003) Nat Genet , vol.34 , pp. 267-273
    • Mootha, V.K.1    Lindgren, C.M.2    Eriksson, K.F.3
  • 100
    • 0037477855 scopus 로고    scopus 로고
    • Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1
    • Patti M.E., Butte A.J., Crunkhorn S., et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. PNAS 100 (2003) 8466-8471
    • (2003) PNAS , vol.100 , pp. 8466-8471
    • Patti, M.E.1    Butte, A.J.2    Crunkhorn, S.3
  • 101
    • 33646376502 scopus 로고    scopus 로고
    • Inverse relationship between PGC-1alpha protein expression and triacylglycerol accumulation in rodent skeletal muscle
    • Benton C.R., Han X.X., Febbraio M., et al. Inverse relationship between PGC-1alpha protein expression and triacylglycerol accumulation in rodent skeletal muscle. J Appl Physiol 100 (2006) 377-383
    • (2006) J Appl Physiol , vol.100 , pp. 377-383
    • Benton, C.R.1    Han, X.X.2    Febbraio, M.3
  • 102
    • 0037102256 scopus 로고    scopus 로고
    • Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres
    • Lin J., Wu H., Tarr P.T., et al. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 418 (2002) 797-801
    • (2002) Nature , vol.418 , pp. 797-801
    • Lin, J.1    Wu, H.2    Tarr, P.T.3
  • 103
    • 8844276054 scopus 로고    scopus 로고
    • Regulation of muscle fiber type and running endurance by PPARdelta
    • Wang Y.X., Zhang C.L., Yu R.T., et al. Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol 2 (2004) e294
    • (2004) PLoS Biol , vol.2
    • Wang, Y.X.1    Zhang, C.L.2    Yu, R.T.3
  • 104
    • 33644878086 scopus 로고    scopus 로고
    • Differential expression of peroxisomal proliferator activated receptors alpha and delta in skeletal muscle in response to changes in diet and exercise
    • Kannisto K., Chibalin A., Glinghammar B., et al. Differential expression of peroxisomal proliferator activated receptors alpha and delta in skeletal muscle in response to changes in diet and exercise. Int J Mol Med 17 (2006) 45-52
    • (2006) Int J Mol Med , vol.17 , pp. 45-52
    • Kannisto, K.1    Chibalin, A.2    Glinghammar, B.3
  • 105
    • 20444477952 scopus 로고    scopus 로고
    • Regulation of metabolic transcriptional co-activators and transcription factors with acute exercise
    • Russell A.P., Hesselink M.K., Lo S.K., et al. Regulation of metabolic transcriptional co-activators and transcription factors with acute exercise. FASEB J 19 (2005) 986-988
    • (2005) FASEB J , vol.19 , pp. 986-988
    • Russell, A.P.1    Hesselink, M.K.2    Lo, S.K.3
  • 106
    • 7244238303 scopus 로고    scopus 로고
    • Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) alpha and delta and PPAR coactivator 1alpha in human skeletal muscle, but not lipid regulatory genes
    • Watt M.J., Southgate R.J., Holmes A.G., et al. Suppression of plasma free fatty acids upregulates peroxisome proliferator-activated receptor (PPAR) alpha and delta and PPAR coactivator 1alpha in human skeletal muscle, but not lipid regulatory genes. J Mol Endocrinol 33 (2004) 533-544
    • (2004) J Mol Endocrinol , vol.33 , pp. 533-544
    • Watt, M.J.1    Southgate, R.J.2    Holmes, A.G.3
  • 107
    • 0036903174 scopus 로고    scopus 로고
    • Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1
    • Baar K., Wende A.R., Jones T.E., et al. Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1. FASEB J 16 (2002) 1879-1886
    • (2002) FASEB J , vol.16 , pp. 1879-1886
    • Baar, K.1    Wende, A.R.2    Jones, T.E.3
  • 108
    • 23844494686 scopus 로고    scopus 로고
    • Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise
    • Cartoni R., Leger B., Hock M.B., et al. Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise. J Physiol 567 (2005) 349-358
    • (2005) J Physiol , vol.567 , pp. 349-358
    • Cartoni, R.1    Leger, B.2    Hock, M.B.3
  • 109
    • 24644478044 scopus 로고    scopus 로고
    • Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise
    • Mahoney D.J., Parise G., Melov S., et al. Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise. FASEB J 19 (2005) 1498-1500
    • (2005) FASEB J , vol.19 , pp. 1498-1500
    • Mahoney, D.J.1    Parise, G.2    Melov, S.3
  • 110
    • 22744446447 scopus 로고    scopus 로고
    • Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise
    • Pilegaard H., Osada T., Andersen L.T., et al. Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise. Metab Clin Exp 54 (2005) 1048-1055
    • (2005) Metab Clin Exp , vol.54 , pp. 1048-1055
    • Pilegaard, H.1    Osada, T.2    Andersen, L.T.3
  • 111
    • 11244311656 scopus 로고    scopus 로고
    • Are exercise-induced genes induced by exercise?
    • Vissing K., Andersen J.L., and Schjerling P. Are exercise-induced genes induced by exercise?. FASEB J 19 (2005) 94-96
    • (2005) FASEB J , vol.19 , pp. 94-96
    • Vissing, K.1    Andersen, J.L.2    Schjerling, P.3
  • 112
    • 0037322888 scopus 로고    scopus 로고
    • Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle
    • Pilegaard H., Saltin B., and Neufer P.D. Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle. J Physiol 546 (2003) 851-858
    • (2003) J Physiol , vol.546 , pp. 851-858
    • Pilegaard, H.1    Saltin, B.2    Neufer, P.D.3
  • 113
    • 10744228606 scopus 로고    scopus 로고
    • Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle
    • Russell A.P., Feilchenfeldt J., Schreiber S., et al. Endurance training in humans leads to fiber type-specific increases in levels of peroxisome proliferator-activated receptor-gamma coactivator-1 and peroxisome proliferator-activated receptor-alpha in skeletal muscle. Diabetes 52 (2003) 2874-2881
    • (2003) Diabetes , vol.52 , pp. 2874-2881
    • Russell, A.P.1    Feilchenfeldt, J.2    Schreiber, S.3
  • 114
    • 0042266366 scopus 로고    scopus 로고
    • Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity
    • 1886-86
    • Short K.R., Vittone J.L., Bigelow M.L., et al. Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Diabetes 52 (2003) 1886-86
    • (2003) Diabetes , vol.52
    • Short, K.R.1    Vittone, J.L.2    Bigelow, M.L.3
  • 115
    • 11244315114 scopus 로고    scopus 로고
    • Coordinated changes in mitochondrial function and biogenesis in healthy and diseased human skeletal muscle
    • Garnier A., Fortin D., Zoll J., et al. Coordinated changes in mitochondrial function and biogenesis in healthy and diseased human skeletal muscle. FASEB J 19 (2005) 43-52
    • (2005) FASEB J , vol.19 , pp. 43-52
    • Garnier, A.1    Fortin, D.2    Zoll, J.3
  • 116
    • 0347993714 scopus 로고    scopus 로고
    • PGC-1alpha mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle
    • Norrbom J., Sundberg C.J., Ameln H., et al. PGC-1alpha mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle. J Appl Physiol 96 (2004) 189-194
    • (2004) J Appl Physiol , vol.96 , pp. 189-194
    • Norrbom, J.1    Sundberg, C.J.2    Ameln, H.3
  • 117
    • 0034681315 scopus 로고    scopus 로고
    • Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo
    • Naya F.J., Mercer B., Shelton J., et al. Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo. J Biol Chem 275 (2000) 4545-4548
    • (2000) J Biol Chem , vol.275 , pp. 4545-4548
    • Naya, F.J.1    Mercer, B.2    Shelton, J.3
  • 118
    • 22544457463 scopus 로고    scopus 로고
    • Calcineurin Is necessary for the maintenance but not embryonic development of slow muscle fibers
    • Oh M., Rybkin I.I., Copeland V., et al. Calcineurin Is necessary for the maintenance but not embryonic development of slow muscle fibers. Mol Cell Biol 25 (2005) 6629-6638
    • (2005) Mol Cell Biol , vol.25 , pp. 6629-6638
    • Oh, M.1    Rybkin, I.I.2    Copeland, V.3
  • 119
    • 0242582447 scopus 로고    scopus 로고
    • Skeletal muscle reprogramming by activation of calcineurin improves insulin action on metabolic pathways
    • Ryder J.W., Bassel-Duby R., Olson E.N., et al. Skeletal muscle reprogramming by activation of calcineurin improves insulin action on metabolic pathways. J Biol Chem 278 (2003) 44298-44304
    • (2003) J Biol Chem , vol.278 , pp. 44298-44304
    • Ryder, J.W.1    Bassel-Duby, R.2    Olson, E.N.3
  • 120
    • 0036891163 scopus 로고    scopus 로고
    • Calcineurin signaling and neural control of skeletal muscle fiber type and size
    • Schiaffino S., and Serrano A. Calcineurin signaling and neural control of skeletal muscle fiber type and size. Trends Pharmacol Sci 23 (2002) 569-575
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 569-575
    • Schiaffino, S.1    Serrano, A.2
  • 121
    • 0017625162 scopus 로고
    • Fiber types and metabolic potentials of skeletal muscles in sedentary man and endurance runners
    • Saltin B., Henriksson J., Nygaard E., et al. Fiber types and metabolic potentials of skeletal muscles in sedentary man and endurance runners. Ann NY Acad Sci 301 (1977) 3-29
    • (1977) Ann NY Acad Sci , vol.301 , pp. 3-29
    • Saltin, B.1    Henriksson, J.2    Nygaard, E.3
  • 122
    • 0029820334 scopus 로고    scopus 로고
    • Intact glucose transport in morphologically altered denervated skeletal muscle from quadriplegic patients
    • Aksnes A.K., Hjeltnes N., Wahlstrom E.O., et al. Intact glucose transport in morphologically altered denervated skeletal muscle from quadriplegic patients. Am J Physiol 271 (1996) E593-E600
    • (1996) Am J Physiol , vol.271
    • Aksnes, A.K.1    Hjeltnes, N.2    Wahlstrom, E.O.3
  • 123
    • 0017154702 scopus 로고
    • Muscle fiber composition in patients with traumatic cord lesion
    • Grimby G., Broberg C., Krotkiewska I., et al. Muscle fiber composition in patients with traumatic cord lesion. Scand J Rehabil Med 8 (1976) 37-42
    • (1976) Scand J Rehabil Med , vol.8 , pp. 37-42
    • Grimby, G.1    Broberg, C.2    Krotkiewska, I.3
  • 124
    • 33750372568 scopus 로고    scopus 로고
    • Human skeletal muscle fibre type variations correlate with PPARα, PPARδ and PGC-1α mRNA
    • Kramer D.K., Ahlsen M., Norrbom J., et al. Human skeletal muscle fibre type variations correlate with PPARα, PPARδ and PGC-1α mRNA. Acta Physiologica 188 (2006) 207-216
    • (2006) Acta Physiologica , vol.188 , pp. 207-216
    • Kramer, D.K.1    Ahlsen, M.2    Norrbom, J.3
  • 125
    • 0347316400 scopus 로고    scopus 로고
    • Does peroxisome proliferator-activated receptor gamma genotype (Pro12ala) modify the association of physical activity and dietary fat with fasting insulin level?
    • Franks P.W., Luan J., Browne P.O., et al. Does peroxisome proliferator-activated receptor gamma genotype (Pro12ala) modify the association of physical activity and dietary fat with fasting insulin level?. Metabolism 53 (2004) 11-16
    • (2004) Metabolism , vol.53 , pp. 11-16
    • Franks, P.W.1    Luan, J.2    Browne, P.O.3
  • 126
    • 21644444035 scopus 로고    scopus 로고
    • PPARGC1A genotype (Gly482Ser) predicts exceptional endurance capacity in European men
    • Lucia A., Gómez-Gallego F., Barroso I., et al. PPARGC1A genotype (Gly482Ser) predicts exceptional endurance capacity in European men. J Appl Physiol 99 (2005) 344-348
    • (2005) J Appl Physiol , vol.99 , pp. 344-348
    • Lucia, A.1    Gómez-Gallego, F.2    Barroso, I.3
  • 127
    • 0345097647 scopus 로고    scopus 로고
    • PGC-1alpha genotype modifies the association of volitional energy expenditure with [OV0312]O2max
    • Franks P.W., Barroso I., Luan J., et al. PGC-1alpha genotype modifies the association of volitional energy expenditure with [OV0312]O2max. Med Sci Sports Exerc 35 (2003) 1998-2004
    • (2003) Med Sci Sports Exerc , vol.35 , pp. 1998-2004
    • Franks, P.W.1    Barroso, I.2    Luan, J.3
  • 128
    • 33747060509 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to Type 2 diabetes: the stop-NIDDM trial
    • Andrulionyte L., Peltola P., Chiasson J.L., et al. Single nucleotide polymorphisms of PPARD in combination with the Gly482Ser substitution of PGC-1A and the Pro12Ala substitution of PPARG2 predict the conversion from impaired glucose tolerance to Type 2 diabetes: the stop-NIDDM trial. Diabetes 55 (2006) 2148-2152
    • (2006) Diabetes , vol.55 , pp. 2148-2152
    • Andrulionyte, L.1    Peltola, P.2    Chiasson, J.L.3
  • 129
    • 34249852535 scopus 로고    scopus 로고
    • Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention
    • Stefan N., Thamer C., Staiger H., et al. Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention. J Clin Endocrinol Metab 92 (2007) 1827-1833
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 1827-1833
    • Stefan, N.1    Thamer, C.2    Staiger, H.3
  • 130
    • 23844479300 scopus 로고    scopus 로고
    • Influence of Pro12Ala peroxisome proliferator-activated receptor gamma2 polymorphism on glucose response to exercise training in type 2 diabetes
    • Adamo K.B., Sigal R.J., Williams K., et al. Influence of Pro12Ala peroxisome proliferator-activated receptor gamma2 polymorphism on glucose response to exercise training in type 2 diabetes. Diabetologia 48 (2005) 1503-1509
    • (2005) Diabetologia , vol.48 , pp. 1503-1509
    • Adamo, K.B.1    Sigal, R.J.2    Williams, K.3
  • 131
    • 0028814439 scopus 로고
    • Physical activity and public health. A recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine
    • Pate R.R., Pratt M., Blair S.N., et al. Physical activity and public health. A recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA 273 (1995) 402-407
    • (1995) JAMA , vol.273 , pp. 402-407
    • Pate, R.R.1    Pratt, M.2    Blair, S.N.3
  • 132
    • 0035014610 scopus 로고    scopus 로고
    • Physical activity, total and regional obesity: dose-response considerations
    • Ross R., and Janssen I. Physical activity, total and regional obesity: dose-response considerations. Med Sci Sports Exerc 33 (2001) S521-S529
    • (2001) Med Sci Sports Exerc , vol.33
    • Ross, R.1    Janssen, I.2
  • 133
    • 34250791554 scopus 로고    scopus 로고
    • The role of physical activity in producing and maintaining weight loss. Nature clinical practice
    • Catenacci V.A., and Wyatt H.R. The role of physical activity in producing and maintaining weight loss. Nature clinical practice. Endocrinology 3 (2007) 518-529
    • (2007) Endocrinology , vol.3 , pp. 518-529
    • Catenacci, V.A.1    Wyatt, H.R.2
  • 134
    • 0021927393 scopus 로고
    • The effects of exercise and weight loss on plasma lipids in young obese men
    • Sopko G., Leon A.S., Jacobs Jr. D.R., et al. The effects of exercise and weight loss on plasma lipids in young obese men. Metab Clin Exp 34 (1985) 227-236
    • (1985) Metab Clin Exp , vol.34 , pp. 227-236
    • Sopko, G.1    Leon, A.S.2    Jacobs Jr., D.R.3
  • 135
    • 0034682621 scopus 로고    scopus 로고
    • Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial
    • Ross R., Dagnone D., Jones P.J., et al. Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial. Ann Intern Med 133 (2000) 92-103
    • (2000) Ann Intern Med , vol.133 , pp. 92-103
    • Ross, R.1    Dagnone, D.2    Jones, P.J.3
  • 136
    • 2442566622 scopus 로고    scopus 로고
    • Chronicle of the Institute of Medicine physical activity recommendation: how a physical activity recommendation came to be among dietary recommendations
    • Brooks G.A., Butte N.F., Rand W.M., et al. Chronicle of the Institute of Medicine physical activity recommendation: how a physical activity recommendation came to be among dietary recommendations. Am J Clin Nutr 79 (2004) 921S-930S
    • (2004) Am J Clin Nutr , vol.79
    • Brooks, G.A.1    Butte, N.F.2    Rand, W.M.3
  • 137
    • 0038394496 scopus 로고    scopus 로고
    • How much physical activity is enough to prevent unhealthy weight gain? Outcome of the IASO 1st Stock Conference and consensus statement
    • Saris W.H., Blair S.N., van Baak M.A., et al. How much physical activity is enough to prevent unhealthy weight gain? Outcome of the IASO 1st Stock Conference and consensus statement. Obes Rev 4 (2003) 101-114
    • (2003) Obes Rev , vol.4 , pp. 101-114
    • Saris, W.H.1    Blair, S.N.2    van Baak, M.A.3
  • 138
    • 35348945293 scopus 로고    scopus 로고
    • Optimizing the therapeutic benefits of exercise in Type 2 diabetes
    • Praet S.F., and van Loon L.J. Optimizing the therapeutic benefits of exercise in Type 2 diabetes. J Appl Physiol 103 (2007) 1113-1120
    • (2007) J Appl Physiol , vol.103 , pp. 1113-1120
    • Praet, S.F.1    van Loon, L.J.2


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