The effects of rimonabant on brown adipose tissue in rat: Implications for energy expenditure

Obesity

Volumn 17, Issue 2, 2009, Pages 254-261

  Verty, Aaron N A ^a   Allen, Andrew M ^b   Oldfield, Brian J ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID; ION CHANNEL; MESSENGER RNA; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN; PIPERIDINE DERIVATIVE; PYRAZOLE DERIVATIVE; RIMONABANT;

ANIMAL; ANIMAL MODEL; ARTICLE; BODY WEIGHT; BROWN ADIPOSE TISSUE; CENTRAL NERVOUS SYSTEM; DRUG ANTAGONISM; DRUG EFFECT; EATING; ENERGY METABOLISM; INNERVATION; MALE; METABOLISM; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; THERMOGENESIS;

ADIPOSE TISSUE, BROWN; ANIMALS; BODY WEIGHT; CANNABINOIDS; CENTRAL NERVOUS SYSTEM; EATING; ENERGY METABOLISM; ION CHANNELS; MALE; MITOCHONDRIAL PROTEINS; MODELS, ANIMAL; PIPERIDINES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; THERMOGENESIS;

RATTUS;

EID: 58849117501     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2008.509     Document Type: Article

References (28)

1. Williams CM, Kirkham TC. Observational analysis of feeding induced by Delta9-THC and anandamide. Physiol Behav2002;76:241-250.
2. 9-THC hyperphagia by SR141716 and naloxone but not dexfenfluramine. Pharmacol Biochem Behav2002;71:341-348.
3. 1) receptors. Psychopharmacology (Berl) 1999;143:315-317.
4. 9-tetrahydrocannabinol. Neuropharmacology 2005;49:1101-1109.
5. Jamshidi N, Taylor DA. Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats. Br J Pharmacol 2001;134: 1151-1154.
6. Kirkham TC, Williams CM, Fezza F, Di Marzo V. Endocannabinoid levels in rat limbic forebrain and hypothalamus in relation to fasting, feeding, and satiation: stimulation of eating by 2-arachidonoyl glycerol. Br J Pharmacol 2002;136:550-557.
7. Ravinet Trillou C, Arnone M, Delgorge C et al. Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice. Am J Physiol 2003;284:R345-R353.
8. Di Marzo V, Goparaju SK, Wang L et al. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 2001;410:822-825.
9. Berthoud HR. Homeostatic and non-homeostatic pathways involved in the control of food intake and energy balance. Obesity (Silver Spring) 2006;14(Suppl 5):197S-200S.
10. Rinaldi-Carmona M, Barth F, Héaulme M et al. SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett 1994;350:240-244.
11. Colombo G, Agabio R, Diaz G et al. Appetite suppression and weight loss after the cannabinoid antagonist SR141716. Life Sci 1998;63: PL113-PL117.
12. Gardner A, Mallet PE. Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor "silent antagonist". Eur J Pharmacol 2006;530:103-106.
13. Verty ANA, McGregor IS, Mallet PE. Consumption of high carbohydrate, high fat, and normal chow is equally suppressed by a cannabinoid receptor antagonist in non-deprived rats. Neurosci Lett 2004;354:217-220.
14. Cota D, Marsicano G, Tschop M et al. The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J Clin Invest 2003;112:423-431.
15. Jbilo O, Ravinet-Trillou C, Arnone M et al. The CB1 receptor antagonist rimonabant reverses the diet-induced obesity phenotype through the regulation of lipolysis and energy balance. FASEB J 2005;19:1567-1569.
16. Shearman LP, Zhou D, Rosko KM et al. Multiple day CB1R inverse agonist effects on hypothalamic gene expression and energy balance in diet-induced obese mice. Proc 34th Annual Meeting of the Society for Neuroscience San Diego, CA, 2004; Abstract 76.74.
17. Oldfield BJ, Giles ME, Watson A et al. The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat. Neuroscience 2002;110:515-526.
18. (ob) mice. Int J Obes 2005;29: 183-187.
19. Thornton-Jones ZD, Kennett GA, Benwell KR et al. The cannabinoid CB(1) receptor inverse agonist, rimonabant, modifies body weight and adiponectin function in diet-induced obese rats as a consequence of reduced food intake. Pharmacol Biochem Behav 2006;84:353-359.
20. Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev 2004;84:277-359.
21. Pagotto U, Vicennati V, Pasquali R. The endocannabinoid system and the treatment of obesity. Ann Med 2005;37:270-275.
22. Bamshad M, Song CK, Bartness TJ. CNS origins of the sympathetic nervous system outflow to brown adipose tissue. Am J Physiol 1999;276:R1569- R1578.
23. 1 cannabinoid receptor antagonist SR 141716 (rimonabant) on hypothalamic peptides mediating energy balance. Appetite 2007;49:337.
24. Samec S, Seydoux J, Dulloo AG. Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate? FASEB J 1998;12:715-724.
25. Cavuoto P, McAinch AJ, Hatzinikolas G, Cameron-Smith D, Wittert GA. Effects of cannabinoid receptors on skeletal muscle oxidative pathways. Mol Cell Endocrinol 2007;267:63-69.
26. Verty ANA, McFarlane JR, McGregor IS, Mallet PE. Evidence for an interaction between CB1 cannabinoid and melanocortin MCR-4 receptors in regulating food intake. Endocrinology 2004;145:3224-3231.
27. Verty ANA, Singh ME, McGregor IS, Mallet PE. The cannabinoid receptor antagonist SR 141716 attenuates overfeeding induced by systemic or intracranial morphine. Psychopharmacology (Berl) 2003;168:314-323.
28. Gamber KM, Macarthur H, Westfall TC. Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus. Neuropharmacology 2005;49:646-652.