BVT.3531 reduces body weight and activates KATP channels in isolated arcuate neurons in rats

Regulatory Peptides

Volumn 141, Issue 1-3, 2007, Pages 19-24

  Mirshamsi, Shirin ^a   Olsson, Madelene ^b   Arnelo, Urban ^b   Kinsella, Jackie M ^a   Permert, Johan ^b   Ashford, Michael L J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Food intake; Hypothalamus; Leptin; Meal pattern

Indexed keywords

2 [1 (HYDRAZINOIMINOMETHYL)HYDRAZINO]ACETIC ACID; ACETIC ACID DERIVATIVE; BVT 3531; POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DATA ANALYSIS; FOOD INTAKE; INSULINOMA; MOLECULAR DYNAMICS; NERVE CELL; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

ACETIC ACIDS; ANIMALS; ARCUATE NUCLEUS; BODY WEIGHT; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; ELECTROPHYSIOLOGY; GUANIDINES; LEPTIN; MALE; MOLECULAR STRUCTURE; NEURONS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROPIONIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; RATTUS;

EID: 33947583003     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2006.12.009     Document Type: Article

References (21)

1. Niswender K.D., and Schwartz M.W. Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities. Front Neuroendocrinol 24 (2003) 1-10
2. Sahu A. Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance. Front Neuroendocrinol 24 (2004) 225-253
3. Bagdade J.D., Bierman E.L., and Porte Jr. D. The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects. J Clin Invest 46 (1967) 1549-1557
4. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., Ohannesian J.P., Marco C.C., McKee L.J., Bauer T.L., and Caro J.F. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334 (1996) 292-295
5. Flier J.S. Obesity wars: molecular progress confronts an expanding epidemic. Cell 116 (2004) 337-350
6. Niswender K.D., Baskin D.G., and Schwartz M.W. Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis. Trends Endocrinol Metab 15 (2004) 362-369
7. Schwartz M.W., Woods S.C., Porte Jr. D., Seeley R.J., and Baskin D.G. Central nervous system control of food intake. Nature 404 (2000) 661-671
8. Nisoli E., and Carruba M.O. Emerging aspects of pharmacotherapy for obesity and metabolic syndrome. Pharmacol Res 50 (2004) 453-469
9. Vaillancourt V.A., Larsen S.D., Tanis S.P., Burr J.E., Connell M.A., Cudahy M.M., Evans B.R., Fisher P.V., May P.D., Meglasson M.D., Robinson D.D., Stevens F.C., Tucker J.A., Vidmar T.J., and Yu J.H. Synthesis and biological activity of aminoguanidine and diaminoguanidine analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid. J Med Chem 44 (2001) 1231-1248
10. Mirshamsi S., Laidlaw H.A., Ning K., Anderson E., Burgess L.A., Gray A., Sutherland C., and Ashford M.L. Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurons: PI3K dependent actin reorganization and KATP channel activation. BMC Neurosci 5 (2004) 54
11. Spanswick D., Smith M.A., Groppi V.E., Logan S.D., and Ashford M.L.J. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390 (1997) 521-525
12. Spanswick D., Smith M.A., Mirshamsi S., Routh V.H., and Ashford M.L.J. Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats. Nat Neurosci 8 (2000) 757-758
13. Harvey J., Hardie S.C., Irving A.J., and Ashford M.L.J. Leptin activation of ATPsensitive K+ (KATP) channels in rat CRI-G1 insulinoma cells involves disruption of the actin cytoskeleton. J Physiol 527 (2000) 95-107
14. Harvey J., McKay N.G., Van der Kaay J., Downes C.P., and Ashford M.L.J. Essential role of phosphoinositide 3-kinase in leptin-induced KATP channel activation in the rat CRI-G1 insulinoma cell line. J Biol Chem 275 (2000) 4660-4669
15. Harvey J., McKenna F., Herson P.S., Spanswick D., and Ashford M.L.J. Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1. J Physiol 504 (1997) 527-535
16. Ashford M.L.J., Boden P.R., and Treherne J.M. Glucose-induced excitation of hypothalamic neurones is mediated by ATP-sensitive K+ channels. Pflugers Arch 415 (1990) 479-483
17. Lee K., Rowe I.C.M., and Ashford M.L.J. Characterization of an ATP-modulated large conductance Ca2+-activated K+ channel present in rat cortical neurones. J Physiol 488 (1995) 319-337
18. Kinsella J.M., Laidlaw H.A., Tang T., Harvey J., Sutherland C., and Ashford M.L.J. The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1. BMC Pharmacol 4 (2004) 17
19. Mirshamsi S., Laidlaw H.A., Spanswick D., and Ashford M.L.J. Activation of hypothalamic ATP-sensitive K+ channels by the aminoguanidine carboxylate BVT.12777. J Neuroendocrinol 17 (2005) 246-254
20. Walum E, Söderberg C, Adamson L, Hedander J, Lutman M, Schöön A, Rupp-Thuresson E. Aminoguanidine carboxylate induced metabolic changes in human neuroblastoma SH-SY5Y cells. Abstracts of the Keystone Meeting on Diabetes Mellitus: molecular mechanisms, genetics and new therapies, Session on Signal Transduction, Keystone, CO 2002;168: #139.
21. Schuppe-Koistinen I., Frisk A.-L., and Janzon L. Molecular profiling of hepatotoxicity induced by a aminoguanidine carboxylate in the rat: gene expression profiling. Toxicology 179 (2002) 197-219