The therapeutic potential of leptin

Expert Opinion on Investigational Drugs

Volumn 12, Issue 3, 2003, Pages 373-378

  Proietto, Joseph ^a   Thorburn, Anne W ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Blood brain barrier; Obesity; Weight loss

Indexed keywords

ACARBOSE; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA GLUCOSIDASE INHIBITOR; ENDOTHELIN 1; FENPROPOREX; HEMOGLOBIN A1C; INSULIN; LEPTIN; LEPTIN RECEPTOR; METFORMIN; PIOGLITAZONE; RECOMBINANT LEPTIN; SIBUTRAMINE; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL;

ARTERY THROMBOSIS; BLOOD BRAIN BARRIER; BODY MASS; BODY WEIGHT; CEREBROSPINAL FLUID; DIABETES MELLITUS; DRUG HYPERSENSITIVITY; DRUG POTENTIATION; ERYTHEMA; FATTY LIVER; FOOD INTAKE; HORMONE BLOOD LEVEL; HORMONE RESISTANCE; HORMONE TRANSPORT; HUMAN; HYPERPHAGIA; HYPERTRIGLYCERIDEMIA; INJECTION SITE; INSULIN RESISTANCE; LIPODYSTROPHY; NONHUMAN; OBESITY; REVIEW; SKIN MANIFESTATION; TREATMENT FAILURE; UPREGULATION; WEIGHT REDUCTION;

ANIMALS; APPETITE DEPRESSANTS; CLINICAL TRIALS; HUMANS; LEPTIN; LIPODYSTROPHY; TREATMENT FAILURE; WEIGHT LOSS;

EID: 0037342396     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.12.3.373     Document Type: Review

References (53)

1. TORRANCE GM, HOOPER MD, REEDER BA: Trends in overweight and obesity among adults in Canada (1970-1992): evidence from national surveys using measured height and weight. Int. J. Obes. Relat. Metab. Disord. (2002) 26:797-804.
2. GUTIERREZ-FISAC JL, BANEGAS BANEGAS JR, ARTALEJO FR, REGIDOR E: Increasing prevalence of overweight and obesity among Spanish adults, 1987-1997. Int. J. Obes. Relat. Metab. Disord. (2000) 24:1677-1682.
3. MCANULTY J, SCRAGG R: Body mass index and cardiovascular risk factors in Pacific Island Polynesians and Europeans in New Zealand. Ethn. Health (1996) 1:187-195.
4. MCDERMOTT R, ROWLEY KG, LEE AJ, KNIGHT S, O'DEA K: Increase in prevalence of obesity and diabetes and decrease in plasma cholesterol in a central Australian aboriginal community. Med. J. Aust. (2000) 172:480-484.
5. LEONARD D, MCDERMOTT R, ODEA K et al.: Obesity, diabetes and associated cardiovascular risk factors among Torres Strait Islander people. Aust. NZ J. Public Health (2002) 26:144-149.
6. KROSNICK A: The diabetes and obesity epidemic among the Pima Indians. N. J. Med. (2000) 97:31-37.
7. PI-SUNYER FX: The medical risks of obesity. Obes. Surg. (2002) 12(Suppl. 1):6S-11S.
8. SCHEEN AJ: Results of obesity treatment. Ann. Endocrinol. (Paris) (2002) 63:163-170.
9. KEIM NL, STERN JS, HAVEL PJ: Relation between circulating leptin concentrations and appetite during a prolonged moderate energy deficit in women. Am. J. Clin. Nutr. (1998) 68:794-801.
10. TORGERSON JS, CARLSSON B, STENLOF K et al.: A low serum leptin level at baseline and a large early decline in leptin predict a large 1-year weight reduction in energy-restricted obese humans. Endocrinology (1999) 84:4197-4203.
11. MONTAGUE CT, FAROOQI IS, WHITEWHEAD JP et al.: Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature (1997) 387:903-908.
12. ZHANG Y, PROENCA R, MAFFEI M et al.: Positional cloning of the mouse obese gene and its human homologue. Nature (1994) 372:425-432.
13. BLAIN H, VUILLEMIN A, GUILLEMIN F et al.: Serum leptin level is a predictor of bone mineral density in postmenopausal women. J. Clin. Endocrinol. Metab. (2002) 87:1030-1035.
14. CEDDIA RB, WILLIAM WN, CURI R: Comparing effects of leptin and insulin on glucose metabolism in skeletal muscle: evidence for an effect of leptin on glucose uptake and decarboxylation. Int. J. Obesity (1999) 23:75-82.
15. LIN C-Y, HIGGINBOTHAM DA, JUDD RL, WHITE BD: Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats. Am. J. Physiol. Endocrinol. Metab. (2002) 282:E1084-E1091.
16. MOSCHOS S, CHAN JL, MANTZOROS CS: Leptin and reproduction: a review. Fertil. Steril. (2002) 77:433-444.
17. FAGGIONI R, FANTUZZI G, GABAY C et al.: Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am. J. Physiol. (1999) 276:R136-R142.
18. FAROOQI IS, JEBB SA, LANGMACK G et al.: Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N. Engl. J. Med. (1999) 341:879-884.
19. HEYMSFIELD SB, GREENBERG AS, FUJIOKA K et al.: Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA (1999) 282:1568-1575.
20. HUKSHORN CJ, SARIS WHM, WESTERTERP-PLANTENGA MS et al.: Weekly subcutaneous pegylated recombinant native human leptin (PEGOB) administration in obese men. J. Clin. Endocrinol. Metab. (2000) 85:4003-4009.
21. CONSIDINE RV, CARO JF: Leptin: genes, concepts and clinical perspective. Horm. Res. (1996) 46:249-256.
22. CARO JF, KOLACZYNSKI JW, NYCE MR et al.: Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet (1996) 348:159-161.
23. SCHWARTZ M, PESKIND E, RASKIND M, BOYKO E, PORTE D: Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat. Med. (1996) 2:589-593.
24. DOTSCH J, ADELMANN M, ENGLARO P et al.: Relation of leptin and neuropeptide Y in human blood and cerebrospinal fluid. J. Neurol Sci. (1997) 151:185-188.
25. KOISTINEN HA, KARONEN SL, IIVANAINEN M, KOIVISTO VA: Circulating leptin has saturable transport into intrathecal space in humans. Eur. J. Clin. Invest. (1998) 28:894-897.
26. WANG Z-W, ZHOU Y-T, KAKUMA T et al.: Comparing the hypothalamic and extrahypothalamic actions of endogenous hyperleptinemia. Proc. Natl. Acad. Sci. USA (1999) 96:10373-10378.
27. BANKS WA, CLEVER CM, FARRELL CL: Partial saturation and regional variation in the blood to brain transport of leptin in normal weight mice. Am. J. Physiol. (2000) 278:E1158-E1165.
28. CARO JF, SINHA MK, KOLACZYNSKI JW, ZHANG PL, CONSIDINE RV: Leptin: the tale of an obesity gene. Diabetes (1996) 45:1455-1462.
29. SAAD MF, DAMANI S, GINGERICH RL et al.: Sexual dimorphism in plasma leptin concentration. J. Clin. Endocrinol. Metab. (1997) 82:579-584.
30. KASTIN AJ, PAN W: Dynamic regulation ofleptin entry into brain by the blood-brain barrier. Regul. Pept. (2000) 92:37-43.
31. BANKS WA, NIEHOFF ML, MARTIN D, FARRELL CL: Leptin transport across the blood-brain barrier of the Koletsky rat is not mediated by a product of the leptin receptor gene. Brain Res. (2002) 950:130-136.
32. KASTIN AJ, PAN W, MANESS LM, KOLETSKY RJ, ERNSBERGER P: Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor. Peptides (1999) 20:1449-1453.
33. BURGUERA B, COUCE ME, CURRAN GL et al.: Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats. Diabetes (2000) 49:1219-1223.
34. HAGAN M, HAVEL P, SEELEY R et al.: Cerebrospinal fluid and plasma leptin measurements: covariability with dopamine and cortisol in fasting humans. J. Clin. Endocrinol. Metab. (1999) 84:3579-3585.
35. ZLOKOVIC BV. JOVANOVIC S, MIAO W et al.: Differential regulation of leptin transport by the choroid plexus and blood-brain barrier and high affinity transport systems for entry into hypothalamus and across the blood-cerebrospinal fluid barrier. Endocrinology (2000) 141:1434-1441.
36. MANESS LM, KASTIN AJ, FARRELL CL, BANKS WA: Fate of leptin after intracerebroventricular injection into the mouse brain. Endocrinology (1998) 139:4556-4562.
37. RAMSEY JJ, KEMNITZ JW, COLMAN RJ, CUNNINGHAM D, SWICK AG: Different central and peripheral responses to leptin in rhesus monkeys: brain transport may be limited. J. Clin. Endocrinol. Metab. (1998) 83:3230-3235.
38. AHIMA RS, PRABAKARAN D, MANTZOROS C et al.: Role of leptin in the neuroendocrine response to fasting. Nature (1996) 382:250-252.
39. FREDERICH RC, HAMANN A, ANDERSON S et al.: Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action. Nat. Med. (1995) 1:1311-1314.
40. VAN HEEK M, COMPTON DS, FRANCE CF et al.: Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J. Clin. Invest. (1997) 99:385-390.
41. HILEMAN SM, PIERROZ DD, MASUSAKI H et al.: Characterization of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology (2002) 143:775-783.
42. EL-HASCHIMI K, PIERROZ DD, HILEMAN SM, BJORBAEK C, FLIER JS: Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity. J. Clin. Invest. (2000) 105:1827-1832.
43. LIN S, THOMAS TC, STORLIEN LH, HUANG XF: Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice. Int. J. Obes. Relat. Metab. Disord. (2000) 24:639-646.
44. BANKS WA, DIPALMA CR, FARRELL CL: Impaired transport of leptin across the blood-brain barrier in obesity. Peptides (1999) 20:1341-1345.
45. WADDEN TA, CONSIDINE RV, FOSTER GD et al.: Short- and long-term changes in serum leptin in dieting obese women: Effects of caloric restriction and weight loss. J. Clin. Endocrinol. Metab. (1998) 83:214-218.
46. GELDSZUS R, MAYR B, HORN R et al.: Serum leptin and weight reduction in female obesity. Eur. J. Endocrinol. (1996) 135:659-662.
47. HAQUE WA, SHIMOMURA I, MATSUZAWA Y, GARG A: Serum adiponectin and leptin levels in patients with lipodystrophies. J. Clin. Endocrinol. Metab. (2002) 87:2395.
48. ORAL EA, SIMHA V, RUIZ E et al.: Leptin-replacement therapy for lipodystrophy. N. Engl. J. Med. (2002) 346:570-578.
49. PETERSEN KF, ORAL EA, DUFOUR S et al.: Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J. Clin. Invest. (2002) 109:1345-1350.
50. QUEHENBERGER P, EXNER M, SUNDER-PLASSMANN R et al.: Leptin induces endothelin-1 in endothelial cells in vitro. Circ. Res. (2002) 90:711-718.
51. KONSTANTINIDES S, SCHAFER K, LOSKUTOFF DJ: The prothrombotic effets of leptin possible implications for the risk, of cardiovascular disease in obesity. Ann. NY Acad. Sci. (2001) 947:134-141.
52. BANKS WA: Leptin transport across the blood-brain barrier: implications for the cause and treatment of obesity. Curr. Pharm. Des. (2001) 7:125-133.
53. RODRIGUES AM, RADOMINSKI RB, SUPLICY HD: The cerebrospinal fluid/serum leptin ratio during pharmacological therapy for obesity. J. Clin. Endocrinol. Metabol. (2002) 87:1621-1626.