The peripheral sympathetic nervous system is the major target of cannabinoids in eliciting cardiovascular depression

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 367, Issue 5, 2003, Pages 434-443

  Niederhoffer, Nathalie ^a   Schmid, Karin ^a   Szabo, Bela ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Anaesthetised rat; Blood pressure; Cannabinoid receptor; Heart rate; Pithed rat; Plasma noradrenaline; Respiration; Sympathetic regulation

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; CANNABINOID 1 RECEPTOR; CANNABINOID DERIVATIVE; CANNABINOID RECEPTOR AGONIST; METHYLATROPINE; NORADRENALIN; RIMONABANT;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ELECTROSTIMULATION THERAPY; HEART FUNCTION; HEART HEMODYNAMICS; HEART RATE; MALE; MEAN ARTERIAL PRESSURE; MEDULLA OBLONGATA; NONHUMAN; NORADRENALIN BLOOD LEVEL; NORADRENALIN RELEASE; PRESYNAPTIC INHIBITION; RAT; SPINAL ANIMAL; SYMPATHETIC TONE; VAGUS TONE;

ANIMALS; ATROPINE DERIVATIVES; BRADYCARDIA; CANNABINOIDS; CARDIOVASCULAR SYSTEM; CYCLOHEXANOLS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPOTENSION; MALE; MEDULLA OBLONGATA; MICROINJECTIONS; MORPHOLINES; NAPHTHALENES; NOREPINEPHRINE; PIPERIDINES; PYRAZOLES; RATS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB1; SYMPATHETIC FIBERS, POSTGANGLIONIC; SYMPATHETIC NERVOUS SYSTEM;

EID: 0038796906     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-003-0755-y     Document Type: Article

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