Effects of antioxidant polyphenols on TNF-alpha-related diseases

Current Topics in Medicinal Chemistry

Volumn 11, Issue 14, 2011, Pages 1767-1779

  Kawaguchi, Kiichiro ^a   Matsumoto, Tsukasa ^a   Kumazawa, Yoshio ^a,b  

^a IWAKI MEISEI UNIVERSITY   (Japan)

^b Vino Science Japan Inc   (Japan)

Author keywords

Advanced glycation end products (AGEs); Flavonoid; Inflammation; Inflammatory bowel disease (IBD); Obesity; Polyphenols; Rheumatoid arthritis (RA); TNF alpha; Type 2 diabetes

Indexed keywords

ADALIMUMAB; ALPHA TOCOPHEROL; ANTHOCYANIN; ANTIOXIDANT; AURANTIIN; CATECHIN; EPIGALLOCATECHIN GALLATE; ETANERCEPT; FLAVONOID; GALANGIN; GLUCOSAMINE; GRAPE SEED EXTRACT; HERBACEOUS AGENT; HESPERIDIN; HYDROXYTYROSOL; INFLIXIMAB; KAEMPFEROL; LUTEOLIN; NOBILETIN; OLEANOLIC ACID; OLEUROPEIN; OLIVE OIL; POLYPHENOL DERIVATIVE; PREDNISOLONE; PROVINOLS; QUERCETIN; RESVERATROL; STILBENE; TUMOR NECROSIS FACTOR ALPHA; TYROSOL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTICOAGULATION; ANTIHYPERTENSIVE ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTHRITIS; ATHEROSCLEROSIS; CITRUS FRUIT; COLITIS; CROHN DISEASE; CYTOKINE PRODUCTION; DIABETES MELLITUS; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; ENTERITIS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GLYCEMIC CONTROL; GRAPE; HUMAN; IMMUNOPATHOGENESIS; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; LIPID METABOLISM; MORNING DOSAGE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OLIVE; PAW EDEMA; PROTEIN SYNTHESIS INHIBITION; REVIEW; RHEUMATOID ARTHRITIS; STREPTOZOCIN DIABETES; TEA; ULCERATIVE COLITIS;

ANIMALS; ANTIOXIDANTS; ARTHRITIS, RHEUMATOID; BIOLOGICAL AVAILABILITY; DIABETES MELLITUS, TYPE 2; FERMENTATION; FLAVONOIDS; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; INFLAMMATORY BOWEL DISEASES; LACTOBACILLUS PLANTARUM; MICE; OXIDATIVE STRESS; PHENOLS; PLANT EXTRACTS; RATS; SEEDS; TEA; TUMOR NECROSIS FACTOR-ALPHA; VITIS;

EID: 79959933152     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/156802611796235152     Document Type: Review

References (120)

1. Kumazawa, Y.; Kawaguchi, K.; Takimoto, H. Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumor necrosis factor α. Curr. Pharm. Des., 2006, 12, 4271-4279.
2. Yang, J.; Park, Y.; Zhang, H.; Gao, X.; Wilson, E.; Zimmer, W.; Abbott, L.; Zhang, C. Role of MCP-1 in tumor necrosis factor-α-induced endothelial dysfunction in type 2 diabetic mice. Am. J. Physiol. Heart Circ. Physiol., 2009, 297, H1208-1216.
3. Vitseva, O.I.; Tanriverdi, K.; Tchkonia, T.T.; Kirkland, J.L.; McDonnell, M.E.; Apovian, C.M.; Freedman, J.; Gokce N. Inducible Toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue. Obesity (Silver Spring, Md.), 2008, 16, 932-937.
4. Miller, Y.I.; Choi, S.H.; Fang, L.; Harkewicz, R. Toll-like receptor-4 and lipoprotein accumulation in macrophages. Trends Cardiovasc. Med., 2009, 19, 227-232.
5. Fessler, M.B.; Rudel, L.L.; Brown, J.M. Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome. Curr. Opin. Lipidol., 2009, 20, 379-385.
6. Kawaguchi, K.; Maruyama, H.; Hasegawa, H.; Kikuchi, S.; Morita, H.; Kumazawa, Y. Suppression of lipopolysaccharide-induced tumor necrosis factor-release and liver injury in mice by naringin. Eur. J. Pharmacol., 1999, 368, 245-250.
7. Kawaguchi, K.; Kikuchi, S.; Hasunuma, R.; Maruyama, H.; Ryll, R.; Kumazawa, Y. Suppression of infection-induced endotoxin shock in mice by a Citrus flavanone naringin. Planta Med., 2004, 70, 17-22.
8. Kawaguchi, K.; Kikuchi, S.; Hasunuma, R.; Maruyama, H.; Yoshikawa, T.; Kumazawa, Y. A Citrus flavonoid hesperidin suppresses infection-induced endotoxin shock in mice. Biol. Pharm. Bull., 2004, 27, 679-683.
9. Fujioka, K.; Greenway, F.; Sheard, J.; Ying, Y. The effects of grapefruit on weight and insulin resistance: relationship to the metabolic syndrome. J. Med. Food., 2006, 9, 49-54.
10. Jung, U.J.; Lee, M.K.; Jeong, K.S.; Choi, M.S. The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice. J. Nutr., 2004, 134, 2499-2503.
11. Ali, M.M.; El Kader, M.A. The influence of naringin on the oxidative state of rats with streptozotocin-induced acute hyperglycaemia. Z. Naturforsch C., 2004, 59, 726-733.
12. Mulvihill, E.E.; Allister, E.M.; Sutherland, B.G.; Telford, D.E.; Sawyez, C.G.; Edwards, J. Y.; Markle, J.M.; Hegele, R.A.; Huff, M.W. Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance. Diabetes, 2009, 58, 2198-2210.
13. Mulvihill, E.E.; Assini, J.M.; Sutherland, B.G.; Dimattia, A.S.; Khami, M.; Koppes, J.B.; Sawyez, C.G.; Whitman, S.C.; Huff, M.W. Naringenin decreases progression of atherosclerosis by improving dyslipidemia in high-fat-fed low-density lipoprotein receptor-null mice. Arterioscler. Thromb. Vasc. Biol., 2010, 30, 742-748.
14. Akiyama, S.; Katsumata, S.; Suzuki, K.; Ishimi, Y.; Wu, J.; Uehara, M. Dietary hesperidin exerts hypoglycemic and hypolipidemic effects in streptozotocin-induced marginal type 1 diabetic rats. J. Clin. Biochem. Nutr., 2010, 46, 87-92.
15. Yoshida, H.; Takamura, N.; Shuto, T.; Ogata, K.; Tokunaga, J.; Kawai, K.; Kai, H. The citrus flavonoids hesperetin and naringenin block the lipolytic actions of TNF-α in mouse adipocytes. Biochem. Biophys. Res. Commun., 2010, 394, 728-732.
16. Zunino, S. Type 2 diabetes and glycemic response to grapes or grape products. J. Nutr., 2009, 139, 1794S-1800S.
17. Overman, A.; Bumrungpert, A.; Kennedy, A.; Martinez, K.; Chuang, C.C.; West, T.; Dawson, B.; Jia, W.; McIntosh, M. Polyphenol-rich grape powder extract (GPE) attenuates inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media. Int. J. Obes (Lond)., 2010, 34, 800-808.
18. Sakurai, T.; Kitadate, K.; Nishioka, H.; Fujii, H.; Kizaki, T.; Kondoh, Y.; Izawa, T.; Ishida, H.; Radák, Z.; Ohno, H. Oligomerized grape seed polyphenols attenuate inflammatory changes due to antioxidative properties in coculture of adipocytes and macrophages. J. Nutr. Biochem., 2009, 21, 47-54.
19. Chacón, M.R.; Ceperuelo-Mallafré, V.; Maymó-Masip, E.; Mateo-Sanz, J.M.; Arola, L.; Guitiérrez, C.; Fernandez-Real, J.M.; Ardèvol, A.; Simón, I.; Vendrell, J. Grape-seed procyanidins modulate inflammation on human differentiated adipocytes in vitro. Cytokine, 2009, 47, 137-142.
20. Moreno, D.A.; Ilic, N.; Poulev, A.; Brasaemle, D.L.; Fried, S.K.; Raskin, I. Inhibitory effects of grape seed extract on lipases. Nutrition, 2003, 19, 876-879.
21. Décordé, K.; Teissèdre, P.L.; Sutra, T.; Ventura, E.; Cristol, J.P.; Rouanet, J.M. Chardonnay grape seed procyanidin extract supplementation prevents high-fat diet-induced obesity in hamsters by improving adipokine imbalance and oxidative stress markers. Mol. Nutr. Food Res., 2009, 53, 659-666.
22. Park, S.H.; Park, T.S.; Cha, Y.S. Grape seed extract (Vitis vinifera) partially reverses high fat diet-induced obesity in C57BL/6J mice. Nutr. Res. Pract., 2008, 2, 227-233.
23. Terra, X.; Montagut, G.; Bustos, M.; Llopiz, N.; Ardèvol, A.; Bladé, C.; Fernández-Larrea, J.; Pujadas, G.; Salvadó, J.; Arola, L.; Blay, M. Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet. J. Nutr. Biochem., 2008, 20, 210-218.
24. Agouni, A.; Lagrue-Lak-Hal, A.H.; Mostefai, H.A.; Tesse, A.; Mulder, P.; Rouet, P.; Desmoulin, F.; Heymes, C.; Martínez, M.C.; Andriantsitohaina, R. Red wine polyphenols prevent metabolic and cardiovascular alterations associated with obesity in Zucker fatty rats (Fa/Fa). PLoS One, 2009, 4, e5557.
25. Kar, P.; Laight, D.; Rooprai, H.K.; Shaw, K.M.; Cummings, M. Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabet Med., 2009, 26, 526-531.
26. Yunoki, K.; Sasaki, G.; Tokuji, Y.; Kinoshita, M.; Naito, A.; Aida, K.; Ohnishi, M. Effect of dietary wine pomace extract and oleanolic acid on plasma lipids in rats fed high-fat diet and its DNA microarray analysis. J. Agric. Food Chem., 2008, 56, 12052-12058.
27. de Melo, C.L.; Queiroz, M.G.; Fonseca, S.G.; Bizerra, A.M.; Lemos, T.L.; Melo, T.S.; Santos, F.A.; Rao, V.S. Oleanolic acid, a natural triterpenoid improves blood glucose tolerance in normal mice and ameliorates visceral obesity in mice fed a high-fat diet. Chem. Biol. Interact., 2010, 185, 59-65.
28. Alcaín, F.J.; Villalba, J.M. Sirtuin activators. Expert Opin. Ther. Pat., 2009, 4, 403-414.
29. Knutson, M.D.; Leeuwenburgh, C. Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases. Nutr. Rev., 2008, 66, 591-596.
30. Elliott, P.J.; Jirousek, M. Sirtuins: novel targets for metabolic disease. Curr. Opin. Investig. Drugs, 2008, 9, 371-378.
31. Lagouge, M.; Argmann, C.; Gerhart-Hines, Z.; Meziane, H.; Lerin, C.; Daussin, F.; Messadeq, N.; Milne, J.; Lambert, P.; Elliott, P.; Geny, B.; Laakso, M.; Puigserver, P.; Auwerx, J. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell, 2006, 127, 1109-1122.
32. Labinskyy, N.; Csiszar, A.; Veress, G.; Stef, G.; Pacher, P.; Oroszi, G.; Wu, J.; Ungvari, Z. Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen. Curr. Med. Chem., 2006, 13, 989-996.
33. Boon, N. Health potential for functional green teas? Int. J. Vitam. Nutr. Res., 2006, 78, 275-281.
34. Wolfram, S.; Wang, Y.; Thielecke, F. Anti-obesity effects of green tea: from bedside to bench. Mol. Nutr. Food Res., 2006, 50, 176-187.
35. Bose, M.; Lambert, J.D.; Ju, J.; Reuhl, K.R.; Shapses, S.A.; Yang, C.S. The major green tea polyphenol, (-)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice. J. Nutr., 2008, 38, 1677-1683.
36. Thielecke, F.; Boschmann, M. The potential role of green tea catechins in the prevention of the metabolic syndrome-a review. Phytochemistry, 2009, 70, 11-24.
37. Nagle, D.G.; Ferreira, D.; Zhou, Y.D. Epigallocatechin-3-gallate (EGCG): chemical and biomedical perspectives. Phytochemistry, 2006, 67, 1849-1855.
38. Murase, T.; Misawa, K.; Haramizu, S.; Hase, T. Catechin-induced activation of the LKB1/AMP-activated protein kinase pathway. Biochem. Pharmacol., 2009, 78, 78-84.
39. García-Lafuente, A.; Guillamón, E.; Villares, A.; Rostagno, M.A.; Martínez, J.A. Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease. Inflamm. Res., 2009, 58, 537-552.
40. Tuñón, M.J.; García-Mediavilla, M.V.; Sánchez-Campos, S.; González-Gallego, J. Potential of flavonoids as anti-inflammatory agents: modulation of pro-inflammatory gene expression and signal transduction pathways. Curr. Drug Metab., 2009, 10, 256-271.
41. Egert, S.; Boesch-Saadatmandi, C.; Wolffram, S.; Rimbach, G.; Müller, M.J. Serum lipid and blood pressure responses to quercetin vary in overweight patients by apolipoprotein E genotype. J. Nutr., 2009, 140, 278-284.
42. Perez-Vizcaino, F.; Duarte, J.; Jimenez, R.; Santos-Buelga, C.; Osuna, A. Antihypertensive effects of the flavonoid quercetin. Pharmacol. Rep., 2009, 61, 67-75.
43. Bischoff, S.C. Quercetin: potentials in the prevention and therapy of disease. Curr. Opin. Clin. Nutr. Metab. Care, 2008, 11, 733-740.
44. Ding, L.; Jin, D.; Chen, X. Luteolin enhances insulin sensitivity via activation of PPARgamma transcriptional activity in adipocytes. J. Nutr. Biochem., 2010, 21, 941-947.
45. Ando, C.; Takahashi, N.; Hirai, S.; Nishimura, K.; Lin, S.; Uemura, T.; Goto, T.; Yu, R.; Nakagami, J.; Murakami, S.; Kawada, T. Luteolin, a food-derived flavonoid, suppresses adipocytedependent activation of macrophages by inhibiting JNK activation. FEBS Lett., 2009, 583, 3649-3654.
46. de la Puerta, R.; Martínez Domínguez, M.E.; Ruíz-Gutíerrez, V.; Flavill, J.A.; Hoult, J.R. Effects of virgin olive oil phenolics on scavenging of reactive nitrogen species and upon nitrergic neurotransmission. Life Sci., 2001, 69, 1213-1222.
47. Visioli, F.; Poli, A.; Gall, C. Antioxidant and other biological activities of phenols from olives and olive oil. Med. Res. Rev., 2002, 22, 65-75.
48. Bitler, C.M.; Viale, T.M.; Damaj, B.; Crea, R. Hydrolyzed olive vegetation water in mice has anti-inflammatory activity. J. Nutr., 2005, 135, 1475-1479.
49. Zhang, X.; Cao, J.; Zhong, L. Hydroxytyrosol inhibits proinflammatory cytokines, iNOS, and COX-2 expression in human monocytic cells. Naunyn Schmiedebergs Arch. Pharmacol., 2009, 379, 581-586.
50. Kawaguchi, K.; Maruyama, H.; Kometani, T.; Kumazawa, Y. Suppression of collagen-induced arthritis by oral administration of the Citrus flavonoid hesperidin. Planta Med., 2006, 72, 477-479.
51. Kometani, T.; Fukuda, T.; Kakuma, T.; Kawaguchi, K.; Tamura, W.; Kumazawa, Y.; Nagata, K. Effects of α-glucosylhesperidin, a bioactive food material, on collagen-induced arthritis in mice and rheumatoid arthritis in humans. Immunopharm. Immunotoxicol., 2008, 30, 117-134.
52. Imada, K.; Lin, N.; Liu, C.; Lu, A.; Chen, W.; Yano, M.; Sato, T.; Ito, A. Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and-2 in collageninduced arthritic mice. Biochem. Biophys. Res. Commun., 2008, 373, 181-185.
53. Murakami, A.; Song, M.; Katsumata, S.; Uehara, M.; Suzuki, K.; Ohigashi, H. Citrus nobiletin suppresses bone loss in ovariectomized ddY mice and collagen-induced arthritis in DBA/1J mice: possible involvement of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclastogenesis regulation. Biofactors, 2007, 30, 179-192.
54. Adcocks, C.; Collin, P.; Buttle, D.J. Catechins from green tea (Camellia sinensis) inhibit bovine and human cartilage proteoglycan and type II collagen degradation in vitro. J. Nutr., 2002, 132, 341-346.
55. Tang, L.Q.; Wei, W.; Wang, X.Y. Effects and mechanisms of catechin for adjuvant arthritis in rats. Adv. Ther., 2007, 24, 679-690.
56. Yun, H.J.; Yoo, W.H.; Han, M.K.; Lee, Y.R.; Kim, J.S.; Lee, S.I. Epigallocatechin-3-gallate suppresses TNF-alpha-induced production of MMP-1 and-3 in rheumatoid arthritis synovial fibroblasts. Rheumatol. Int., 2008, 29, 23-29.
57. Morinobu, A.; Biao, W.; Tanaka, S.; Horiuchi, M.; Jun, L.; Tsuji, G.; Sakai, Y.; Kurosaka, M.; Kumagai, S. Epigallocatechin-3-gallate suppresses osteoclast differentiation and ameliorates experimental arthritis in mice. Arthritis Rheum., 2008, 58, 2012-2018.
58. Ahmed, S.; Marotte, H.; Kwan, K.; Ruth, J.H.; Campbell, P.L.; Rabquer, B.J.; Pakozdi, A.; Koch, A.E. Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production. Proc. Natl. Acad. Sci. USA, 2008, 105, 14692-14697.
59. Lin, S.K.; Chang, H.H.; Chen, Y.J.; Wang, C. C,; Galson, D.L.; Hong, C.Y.; Kok, S.H. Epigallocatechin-3-gallate diminishes CCL2 expression in human osteoblastic cells via up-regulation of phosphatidylinositol 3-Kinase/Akt/Raf-1 interaction: a potential therapeutic benefit for arthritis. Arthritis Rheum., 2008, 58, 3145-3156.
60. Cho, M.L.; Heo, Y.J.; Park, M.K.; Oh, H.J.; Park, J.S.; Woo, Y.J.; Ju, J.H.; Park, S.H.; Kim, H.Y.; Min, J.K. Grape seed proanthocyanidin extract (GSPE) attenuates collagen-induced arthritis. Immunol. Lett., 2009, 124, 102-110.
61. Kawaguchi, K.; Tominaga, T.; Kumazawa, Y. Oral administration of Koshu grape marc fermented with Lactobacillus plantarum suppresses collagen induced arthritis in mice. in preparation.
62. Lättig, J.; Böhl, M.; Fischer, P.; Tischer, S.; Tietböhl, C.; Menschikowski, M.; Gutzeit, H.O.; Metz, P.; Pisabarro, M.T. Mechanism of inhibition of human secretory phospholipase A2 by flavonoids: rationale for lead design. J. Comput. Aided Mol. Des., 2007, 21, 473-483.
63. Choi, E.J.; Bae, S.C.; Yu, R.; Youn, J.; Sung, M.K. Dietary vitamin E and quercetin modulate inflammatory responses of collageninduced arthritis in mice. J. Med. Food., 2009, 12, 770-775.
64. Hou, Y.; Wu, J.; Huang, Q.; Guo, L. Luteolin inhibits proliferation and affects the function of stimulated rat synovial fibroblasts. Cell Biol. Int., 2009, 33, 135-147.
65. Lee, J.D.; Huh, J.E.; Jeon, G.; Yang, H.R.; Woo, H.S.; Choi, D.Y.; Park, D.S. Flavonol-rich RVHxR from Rhus verniciflua Stokes and its major compound fisetin inhibits inflammation-related cytokines and angiogenic factor in rheumatoid arthritic fibroblast-like synovial cells and in vivo models. Int. Immunopharmacol., 2009, 9, 268-276.
66. Rovensk, J.; Stancíková, M.; Rovenská, E.; Stvrtina, S.; Stvrtinová, V.; Svík, K. Treatment of rat adjuvant arthritis with flavonoid (Detralex), methotrexate, and their combination. Ann. N. Y. Acad. Sci., 2009, 1173, 798-804.
67. Dharmani, P.; Chadee, K. Biologic therapies against inflammatory bowel disease: a dysregulated immune system and the cross talk with gastrointestinal mucosa hold the key. Curr. Mol. Pharmacol., 2008, 1, 195-212.
68. Hering, N.A.; Schulzke, J.D. Therapeutic options to modulate barrier defects in inflammatory bowel disease. Dig. Dis., 2009, 27, 450-454.
69. Bonanome, A.; Pagnan, A.; Caruso, D.; Toia, A.; Xamin, A.; Fedeli, E.; Berra, B.; Zamburlini, A.; Ursini, F.; Galli, G. Evidence of postprandial absorption of olive oil phenols in humans. Nutr. Metab. Cardiovasc. Dis., 2000, 10, 111-120.
70. Owen, R.W.; Giacosa, A.; Hull, W.E.; Haubner, R.; Spiegelhalder, B.; Bartsch, H. The antioxidant/anticancer potential of phenolic compounds isolated from olive oil. Eur. J. Cancer, 2000, 36, 1235-1247.
71. Camuesco, D.; Gálvez, J.; Nieto, A.; Comalada, M.; Rodríguez-Cabezas, M. E,; Concha, A.; Xaus, J.; Zarzuelo, A. Dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyunsaturated fatty acids, attenuates colonic inflammation in rats with DSS-induced colitis. J. Nutr., 2005, 135, 687-694.
72. Sánchez-Fidalgo, S.; Villegas, I.; Cárdeno, A.; Talero, E.; Sánchez-Hidalgo, M.; Motilva, V.; Alarcón de la Lastra, C. Extra-virgin olive oil-enriched diet modulates DSS-colitis-associated colon carcinogenesis in mice. Clin. Nutr., 2010, 29, 663-673.
73. Oz, H.S.; Chen, T.S.; McClain, C.J.; de Villiers, W.J. Antioxidants as novel therapy in a murine model of colitis. J. Nutr. Biochem., 2005, 16, 297-304.
74. Varilek, G.W.; Yang, F.; Lee, E.Y.; deVilliers, W.J.; Zhong, J.; Oz, H.S.; Westberry, K.F.; McClain, C.J. Green tea polyphenol extract attenuates inflammation in interleukin-2-deficient mice, a model of autoimmunity. J. Nutr., 2001, 131, 2034-2039.
75. He, P.; Noda, Y.; Sugiyama, K. Green tea suppresses lipopolysaccharide-induced liver injury in D-galactosamine-sensitized rats. J. Nutr., 2001, 131, 1560-1567.
76. Li, W.; Ashok, M.; Li, J.; Yang, H.; Sama, A.E.; Wang, H. A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1. PLoS One, 2007, 2, e1153.
77. Mazzon, E.; Muià, C.; Paola, R.D.; Genovese, T.; Menegazzi, M.; De Sarro, A.; Suzuki, H.; Cuzzocrea, S. Green tea polyphenol extract attenuates colon injury induced by experimental colitis. Free Radic. Res., 2005, 39, 1017-1025.
78. Maity, S.; Ukil, A.; Karmakar, S.; Datta, N.; Chaudhuri, T.; Vedasiromoni, J.R.; Ganguly, D.K.; Das, P.K. Thearubigin, the major polyphenol of black tea, ameliorates mucosal injury in trinitrobenzene sulfonic acid-induced colitis. Eur. J. Pharmacol., 2003, 470, 103-112.
79. Ukil, A.; Maity, S.; Das, P.K. Protection from experimental colitis by theaflavin-3,3'-digallate correlates with inhibition of IKK and NF-kappaB activation. Br. J. Pharmacol., 2006, 149, 121-131.
80. Li, X.L.; Cai, Y.Q.; Qin, H.; Wu, Y.J. Therapeutic effect and mechanism of proanthocyanidins from grape seeds in rats with TNBS-induced ulcerative colitis. Can. J. Physiol. Pharmacol., 2008, 86, 841-849.
81. Tominaga, T.; Kaneko, M.; Yamagata, Y.; Kumazawa, Y. Suppression of dextran sulfate sodium-induced ulcerative colitis in mice by oral administration by Koshu grape marc fermented with Lactobacillus plantarum. In preparation.
82. Martín, A.R.; Villegas, I.; La Casa, C.; de la Lastra, C.A. Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats. Biochem. Pharmacol., 2004, 67, 1399-1410.
83. Singh, U.P.; Singh, N.P.; Singh, B.; Hofseth, L.J.; Price, R.L.; Nagarkatti, M.; Nagarkatti, P.S. Resveratrol (trans-3,5,4'-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factorkappaB activation to abrogate dextran sulfate sodium-induced colitis. J. Pharmacol. Exp. Ther., 2009, 332, 829-839.
84. Kim, Y.H.; Kwon, H.S.; Kim, D.H.; Cho, H.J.; Lee, H.S.; Jun, J.G.; Park, J.H.; Kim, J.K. Piceatannol, a stilbene present in grapes, attenuates dextran sulfate sodium-induced colitis. Int. Immunopharmacol., 2008, 8, 1695-1702.
85. Yoshioka, Y.; Akiyama, H.; Nakano, M.; Shoji, T.; Kanda, T.; Ohtake, Y.; Takita, T.; Matsuda, R.; Maitani, T. Orally administered apple procyanidins protect against experimental inflammatory bowel disease in mice. Int. Immunopharmacol., 2008, 8, 1802-1807.
86. Jung, M.; Triebel, S.; Anke, T.; Richling, E.; Erkel, G. Influence of apple polyphenols on inflammatory gene expression. Mol. Nutr. Food Res., 2009, 53, 1263-1280.
87. Castagnini, C.; Luceri, C.; Toti, S.; Bigagli, E.; Caderni, G.; Femia, A.P.; Giovannelli, L.; Lodovici, M.; Pitozzi, V.; Salvadori, M.; Messerini, L.; Martin, R.; Zoetendal, E.G.; Gaj, S.; Eijssen, L.; Evelo, C, T.; Renard, C.M.; Baron, A.; Dolara, P. Reduction of colonic inflammation in HLA-B27 transgenic rats by feeding Marie Ménard apples, rich in polyphenols. Br. J. Nutr., 2009, 102, 1620-1628.
88. Benavente-García, O.; Castillo, J. Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity. J. Agric. Food Chem., 2008, 56, 6185-6205.
89. Xu, L.; Yang, Z.L.; Li, P.; Zhou, Y.Q. Modulating effect of Hesperidin on experimental murine colitis induced by dextran sulfate sodium. Phytomedicine, 2009, 16, 989-995.
90. Crespo, M.E.; Gálvez, J.; Cruz, T.; Ocete, M.A.; Zarzuelo, A. Antiinflammatory activity of diosmin and hesperidin in rat colitis induced by TNBS. Planta Med., 1999, 65, 651-653.
91. Romier, B.; Van De Walle, J.; During, A.; Larondelle, Y.; Schneider, Y.J. Modulation of signalling nuclear factor-kappaB activation pathway by polyphenols in human intestinal Caco-2 cells. Br. J. Nutr., 2008, 100, 542-551.
92. Kwon, K.H.; Murakami, A.; Tanaka, T.; Ohigashi, H. Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodiuminduced experimental colitis in mice: attenuation of proinflammatory gene expression. Biochem. Pharmacol., 2004, 69, 395-406.
93. Najafzadeh, M.; Reynolds, P.D.; Baumgartner, A.; Anderson D. Flavonoids inhibit the genotoxicity of hydrogen peroxide (H(2)O(2) and of the food mutagen 2-amino-3-methylimadazo [4,5-f]-quinoline (IQ) in lymphocytes from patients with inflammatory bowel disease (IBD). Mutagenesis, 2009, 24, 405-411.
94. Sánchez de Medina, F.; Vera, B.; Gálvez, J.; Zarzuelo, A. Effect of quercitrin on the early stages of hapten induced colonic inflammation in the rat. Life Sci., 2002, 70, 3097-3108.
95. Zhang, F.L.; Gao, H.Q.; Wu, J.M.; Ma, Y.B.; You, B.A.; Li, B.Y.; Xuan, J.H. Selective inhibition by grape seed proanthocyanidin extracts of cell adhesion molecule expression induced by advanced glycation end products in endothelial cells. J. Cardiovasc. Pharmacol., 2006, 48, 47-53.
96. Ma, L.; Gao, H.Q.; Li, B.Y.; Ma, Y.B.; You, B.A.; Zhang, F.L. Grape seed proanthocyanidin extracts inhibit vascular cell adhesion molecule expression induced by advanced glycation end products through activation of peroxisome proliferators-activated receptor gamma. J. Cardiovasc. Pharmacol., 2007, 49, 293-298.
97. Cheng, M.; Gao, H.Q.; Xu, L.; Li, B.Y.; Zhang, H.; Li, X.H. Cardioprotective effects of grape seed proanthocyanidins extracts in streptozocin induced diabetic rats. J. Cardiovasc. Pharmacol., 2007, 50, 503-509.
98. Zhang, F.L.; Gao, H.Q.; Shen, L. Inhibitory effect of GSPE on RAGE expression induced by advanced glycation end products in endothelial cells. J. Cardiovasc. Pharmacol., 2007, 50, 434-440.
99. Li, B.Y.; Cheng, M.; Gao, H.Q.; Ma, Y.B.; Xu, L.; Li, X.H.; Li, X.L.; You, B.A. Back-regulation of six oxidative stress proteins with grape seed proanthocyanidin extracts in rat diabetic nephropathy. J. Cell. Biochem., 2008, 104, 668-679.
100. Xu, L.; Li, B.; Cheng, M.; Zhang, W.; Pan, J.; Zhang, C.; Gao, H. Oral administration of grape seed proanthocyanidin extracts downregulate RAGE dependant nuclear factor-kappa BP65 expression in the hippocampus of streptozotocin induced diabetic rats. Exp. Clin. Endocrinol Diabetes, 2008, 116, 215-224.
101. Cui, X.P.; Li, B.Y.; Gao, H.Q.; Wei, N.; Wang, W.L.; Lu, M. Effects of grape seed proanthocyanidin extracts on peripheral nerves in streptozocin-induced diabetic rats. J. Nutr. Sci/Vitaminol. (Tokyo), 2008, 54, 321-328.
102. Li, X.; Xu, L.; Gao, H.; Li, B.; Cheng, M. Effects of grape seed proanthocyanidins extracts on AGEs and expression of bone morphogenetic protein-7 in diabetic rats. J. Nephrol., 2008, 21, 722-733.
103. Li, M.; Ma, Y.B.; Gao, H.Q.; Li, B.Y.; Cheng, M.; Xu, L.; Li, X.L.; Li, X.H. A novel approach of proteomics to study the mechanism of action of grape seed proanthocyanidin extracts on diabetic retinopathy in rats. Chin. Med. J. (Engl), 2008, 121, 2544-2552.
104. Li, X.L.; Li, B.Y.; Gao, H.Q.; Cheng, M.; Xu, L.; Li, X.H.; Ma, Y.B. Effects of grape seed proanthocyanidin extracts on aortic pulse wave velocity in streptozocin induced diabetic rats. Biosci. Biotechnol. Biochem., 2009, 73, 1348-1354.
105. Li, X.L.; Li, B.Y.; Gao, H.Q.; Cheng, M.; Xu, L.; Li, X.H.; Zhang, W.D.; Hu, J.W. Proteomics approach to study the mechanism of action of grape seed proanthocyanidin extracts on arterial remodeling in diabetic rats. Int. J. Mol. Med., 2010, 25, 237-248.
106. Urios, P.; Grigorova-Borsos, A.M.; Sternberg, M. Flavonoids inhibit the formation of the cross-linking AGE pentosidine in collagen incubated with glucose, according to their structure. Eur. J. Nutr., 2007, 46, 139-146.
107. Babu, P.V.; Sabitha, K.E.; Srinivasan, P.; Shyamaladevi, C.S. Green tea attenuates diabetes induced Maillard-type fluorescence and collagen cross-linking in the heart of streptozotocin diabetic rats. Pharmacol. Res., 2007, 55, 433-440.
108. Babu, P.V.; Sabitha, K.E.; Shyamaladevi, C.S. Effect of green tea extract on advanced glycation and cross-linking of tail tendon collagen in streptozotocin induced diabetic rats. Food Chem. Toxicol., 2007, 46, 280-285.
109. Burckhardt, I.C.; Gozal, D.; Dayyat, E.; Cheng, Y.; Li, R.C.; Goldbart, A.D.; Row, B.W. Green tea catechin polyphenols attenuate behavioral and oxidative responses to intermittent hypoxia. Am. J. Respir. Crit. Care Med., 2008, 177, 1135-1141.
110. Lee, S.J.; Lee, K.W. Protective effect of (-)-epigallocatechin gallate against advanced glycation endproducts-induced injury in neuronal cells. Biol. Pharm. Bull., 2007, 30, 1369-1373.
111. Oh, C.J.; Yang, E.S.; Shin, S.W.; Choi, S.H.; Park, C.I.; Yang, C.H.; Park, J.W. Epigallocatechin gallate, a constituent of green tea, regulates high glucose-induced apoptosis. Arch. Pharm. Res., 2008, 31, 34-40.
112. Rasheed, Z.; Anbazhagan, A.N.; Akhtar, N.; Ramamurthy, S.; Voss, F.R.; Haqqi, T.M. Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-alpha and matrix metalloproteinase-13 in human chondrocytes. Arthritis Res. Ther., 2009, 11, R71.
113. Wu, C.H.; Wu, C.F.; Huang, H.W.; Jao, Y.C.; Yen, G.C. Naturally occurring flavonoids attenuate high glucose-induced expression of proinflammatory cytokines in human monocytic THP-1 cells. Mol. Nutr. Food Res., 2009, 53, 984-995.
114. Terao, J. Dietary flavonoids as antioxidants in vivo: conjugated metabolites of (-)-epicatechin and quercetin participate in antioxidative defense in blood plasma. J. Med. Invest., 1999, 46, 159-168.
115. Lesser, S.; Cermak, R.; Wolffram, S. The fatty acid pattern of dietary fat influences the oral bioavailability of the flavonol quercetin in pigs. Br. J. Nutr., 2006, 96, 1047-1052.
116. Giunta, B.; Hou, H.; Zhu, Y.; Salemi, J.; Ruscin, A.; Shytle, R.D.; Tan, J. Fish oil enhances anti-amyloidogenic properties of green tea EGCG in Tg2576 mice. Neurosci. Lett., 2010, 471, 134-138.
117. Umathe, S.N.; Dixit, P.V.; Kumar, V.; Bansod, K.U.; Wanjari, M.M. Quercetin pretreatment increases the bioavailability of pioglitazone in rats: involvement of CYP3A inhibition. Biochem. Pharmacol., 2008, 75, 1670-1676.
118. Li, X.; Choi, J.S. Effects of quercetin on the pharmacokinetics of Etoposide after oral or intravenous administration of etoposide in rats. Anticancer Res., 2009, 29, 1411-1415.
119. Mata-Bilbao Mde, L.; Andrés-Lacueva, C.; Roura, E.; Jáuregui, O.; Escribano, E.; Torre, C.; Lamuela-Raventós, R.M. Absorption and pharmacokinetics of green tea catechins in beagles. Br. J. Nutr., 2008, 100, 496-502.
120. Moon, Y.J.; Morris, M.E. Pharmacokinetics and bioavailability of the bioflavonoid biochanin A: effects of quercetin and EGCG on biochanin A disposition in rats. Mol. Pharm., 2007, 4, 865-872.