Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice

Biochemical and Biophysical Research Communications

Volumn 373, Issue 2, 2008, Pages 181-185

  Imada, Keisuke ^a   Lin, Na ^b   Liu, Chunfang ^b   Lu, Aiping ^b   Chen, Weiheng ^b   Yano, Masamichi ^c   Sato, Takashi ^a   Ito, Akira ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^c NARO Bio oriented Technology Research Advancement Institution   (Japan)

Author keywords

Aggrecanase; Cartilage; Collagen induced arthritis; Extracellular matrix; Inflammation; Matrix metalloproteinase; Nobiletin; Osteoarthritis; Polymethoxy flavonoid; Rheumatoid arthritis

Indexed keywords

AGGRECAN; AGGRECANASE; AGGRECANASE 1; AGGRECANASE 2; COLLAGEN; EPITOPE; INTERLEUKIN 1BETA; MESSENGER RNA; NOBILETIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG EFFICACY; EXTRACELLULAR MATRIX; FIBROBLAST; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SYNOVIUM;

ADAM PROTEINS; AGGRECANS; ANIMALS; ARTHRITIS, EXPERIMENTAL; CARTILAGE; CELLS, CULTURED; CITRUS; FIBROBLASTS; FLAVONES; GENE EXPRESSION; HUMANS; JOINTS; MALE; MICE; MICE, INBRED STRAINS; PROCOLLAGEN N-ENDOPEPTIDASE; RNA, MESSENGER; SYNOVIAL FLUID;

CITRUS; MUS;

EID: 46249083291     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.05.171     Document Type: Article

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