The role of RanGTP gradient in vertebrate oocyte maturation

Results and Problems in Cell Differentiation

Volumn 53, Issue , 2011, Pages 235-267

  Kaláb, Petr ^a   Šolc, Petr ^b   Motlík, Jan ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b INSTITUTE OF ANIMAL PHYSIOLOGY AND GENETICS   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

KARYOPHERIN BETA; NONHISTONE PROTEIN; RAN PROTEIN;

ANIMAL; ARTICLE; CELL DIFFERENTIATION; COMPARATIVE STUDY; CYTOLOGY; FEMALE; GENETICS; HUMAN; MEIOSIS; METABOLISM; OOCYTE; OOCYTE DEVELOPMENT; PHYSIOLOGY; PRENATAL DEVELOPMENT; VERTEBRATE;

ANIMALS; BETA KARYOPHERINS; CELL DIFFERENTIATION; CHROMOSOMAL PROTEINS, NON-HISTONE; FEMALE; HUMANS; MEIOSIS; OOCYTES; OOGENESIS; RAN GTP-BINDING PROTEIN; VERTEBRATES;

EID: 79959760930     PISSN: 00801844     EISSN: 18610412     Source Type: Book Series    
DOI: 10.1007/978-3-642-19065-0_12     Document Type: Article

References (228)

1. Abu-Arish A, Kalab P, Ng-Kamstra J, Weis K, Fradin C (2009) Spatial distribution and mobility of the Ran GTPase in live interphase cells. Biophys J 97:2164-2178
2. Arnaoutov A, Dasso M (2003) The Ran GTPase regulates kinetochore function. Dev Cell 5:99-111 (Pubitemid 36827345)
3. Arnaoutov A, Dasso M (2005) Ran-GTP regulates kinetochore attachment in somatic cells. Cell Cycle 4:1161-1165 (Pubitemid 41365383)
4. Arnaoutov A, Azuma Y, Ribbeck K, Joseph J, Boyarchuk Y, Karpova T, McNally J, Dasso M (2005) Crm1 is a mitotic effector of Ran-GTP in somatic cells. Nat Cell Biol 7:626-632 (Pubitemid 40796986)
5. Askjaer P, Galy V, Hannak E, Mattaj IW (2002) Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos. Mol Biol Cell 13:4355-4370 (Pubitemid 35471191)
6. Athale CA, Dinarina A, Mora-Coral M, Pugieux C, Nedelec F, Karsenti E (2008) Regulation of microtubule dynamics by reaction cascades around chromosomes. Science 322:1243-1247
7. Azoury J, Verlhac MH, Dumont J (2009) Actin filaments: Key players in the control of asymmetric divisions in mouse oocytes. Biol Cell 101:69-76
8. Bastiaens P, Caudron M, Niethammer P, Karsenti E (2006) Gradients in the self-organization of the mitotic spindle. Trends Cell Biol 16:125-134 (Pubitemid 43358000)
9. Bayliss R, Sardon T, Vernos I, Conti E (2003) Structural basis of Aurora-A activation by TPX2 at the mitotic spindle. Mol Cell 12:851-862 (Pubitemid 37352779)
10. Bednenko J, Cingolani G, Gerace L (2003) Nucleocytoplasmic transport: Navigating the channel. Traffic 4:127-135 (Pubitemid 36621705)
11. Bilbao-Cortes D, Hetzer M, Langst G, Becker PB, Mattaj IW (2002) Ran binds to chromatin by two distinct mechanisms. Curr Biol 12:1151-1156 (Pubitemid 34766940)
12. Binelli M, Murphy BD (2010) Coordinated regulation of follicle development by germ and somatic cells. Reprod Fertil Dev 22:1-12
13. Bischoff FR, Gorlich D (1997) RanBP1 is crucial for the release of RanGTP from importin betarelated nuclear transport factors. FEBS Lett 419:249-254 (Pubitemid 28010820)
14. Blower MD, Nachury M, Heald R, Weis K (2005) A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly. Cell 121:223-234 (Pubitemid 40546390)
15. Bohnsack MT, Stuven T, Kuhn C, Cordes VC, Gorlich D (2006) A selective block of nuclear actin export stabilizes the giant nuclei of Xenopus oocytes. Nat Cell Biol 8:257-263 (Pubitemid 43336067)
16. Bompard G, Rabeharivelo G, Frank M, Cau J, Delsert C, Morin N (2010) Subgroup II PAKmediated phosphorylation regulates Ran activity during mitosis. J Cell Biol 190:807-822
17. Bono F, Cook AG, Grunwald M, Ebert J, Conti E (2010) Nuclear import mechanism of the EJC component Mago-Y14 revealed by structural studies of importin 13. Mol Cell 37:211-222
18. Brown KS, Blower MD, Maresca TJ, Grammer TC, Harland RM, Heald R (2007) Xenopus tropicalis egg extracts provide insight into scaling of the mitotic spindle. J Cell Biol 176: 765-770 (Pubitemid 46425536)
19. Brunet S, Maro B (2005) Cytoskeleton and cell cycle control during meiotic maturation of the mouse oocyte: Integrating time and space. Reproduction 130:801-811 (Pubitemid 41830090)
20. Brunet S, Polanski Z, Verlhac MH, Kubiak JZ, Maro B (1998) Bipolar meiotic spindle formation without chromatin. Curr Biol 8:1231-1234 (Pubitemid 29006664)
21. Brunet S, Maria AS, Guillaud P, Dujardin D, Kubiak JZ, Maro B (1999) Kinetochore fibers are not involved in the formation of the first meiotic spindle in mouse oocytes, but control the exit from the first meiotic M phase. J Cell Biol 146:1-12
22. Brunet S, Dumont J, Lee KW, Kinoshita K, Hikal P, Gruss OJ, Maro B, Verlhac MH (2008) Meiotic regulation of TPX2 protein levels governs cell cycle progression in mouse oocytes. PLoS ONE 3:e3338
23. Busch A, Kiel T, Heupel WM, Wehnert M, Hubner S (2009) Nuclear protein import is reduced in cells expressing nuclear envelopathy-causing lamin A mutants. Exp Cell Res 315:2373-2385
24. Calarco-Gillam PD, Siebert MC, Hubble R, Mitchison T, Kirschner M (1983) Centrosome development in early mouse embryos as defined by an autoantibody against pericentriolar material. Cell 35:621-629 (Pubitemid 14168366)
25. Carabatsos MJ, Combelles CM, Messinger SM, Albertini DF (2000) Sorting and reorganization of centrosomes during oocyte maturation in the mouse. Microsc Res Tech 49:435-444 (Pubitemid 30415702)
26. Carazo-Salas RE, Guarguaglini G, Gruss OJ, Segref A, Karsenti E, Mattaj IW (1999) Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation. Nature 400:178-181 (Pubitemid 29327548)
27. Carmody SR, Wente SR (2009) mRNA nuclear export at a glance. J Cell Sci 122:1933-1937
28. Caudron M, Bunt G, Bastiaens P, Karsenti E (2005) Spatial coordination of spindle assembly by chromosome-mediated signaling gradients. Science 309:1373-1376 (Pubitemid 41209364)
29. Chen MS, Hurov J, White LS, Woodford-Thomas T, Piwnica-Worms H (2001) Absence of apparent phenotype in mice lacking Cdc25C protein phosphatase. Mol Cell Biol 21:3853-3861 (Pubitemid 32476448)
30. Chen T, Muratore TL, Schaner-Tooley CE, Shabanowitz J, Hunt DF, Macara IG (2007) N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis. Nat Cell Biol 9:596-603 (Pubitemid 46696542)
31. Chiang T, Duncan FE, Schindler K, Schultz RM, Lampson MA (2010) Evidence that weakened centromere cohesion is a leading cause of age-related aneuploidy in oocytes. Curr Biol 20:1522-1528
32. Ciciarello M, Roscioli E, Di Fiore B, Di Francesco L, Sobrero F, Bernard D, Mangiacasale R, Harel A, Schinina ME, Lavia P (2010) Nuclear reformation after mitosis requires downregulation of the Ran GTPase effector RanBP1 in mammalian cells. Chromosoma 119:651-668
33. Cingolani G, Petosa C, Weis K, Muller CW (1999) Structure of importin-beta bound to the IBB domain of importin-alpha. Nature 399:221-229 (Pubitemid 29246445)
34. Clamp M, Fry B, Kamal M, Xie X, Cuff J, Lin MF, Kellis M, Lindblad-Toh K, Lander ES (2007) Distinguishing protein-coding and noncoding genes in the human genome. Proc Natl Acad Sci USA 104:19428-19433
35. Clarke PR (2005) Cell biology. A gradient signal orchestrates the mitotic spindle. Science 309:1334-1335 (Pubitemid 41209355)
36. Clausen T, Ribbeck K (2007) Self-organization of anastral spindles by synergy of dynamic instability, autocatalytic microtubule production, and a spatial signaling gradient. PLoS ONE 2:e244
37. D'Angelo MA, Raices M, Panowski SH, Hetzer MW (2009) Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. Cell 136: 284-295
38. Dallol A, Hesson LB, Matallanas D, Cooper WN, O'Neill E, Maher ER, Kolch W, Latif F (2009) RAN GTPase is a RASSF1A effector involved in controlling microtubule organization. Curr Biol 19:1227-1232
39. Dehmelt L, Bastiaens PI (2010) Spatial organization of intracellular communication: Insights from imaging. Nat Rev Mol Cell Biol 11:440-452
40. Deng M, Suraneni P, Schultz RM, Li R (2007) The Ran GTPase mediates chromatin signaling to control cortical polarity during polar body extrusion in mouse oocytes. Dev Cell 12:301-308 (Pubitemid 46172900)
41. Di Fiore B, Ciciarello M, Mangiacasale R, Palena A, Tassin AM, Cundari E, Lavia P (2003) Mammalian RanBP1 regulates centrosome cohesion during mitosis. J Cell Sci 116:3399-3411 (Pubitemid 37038987)
42. Dishinger JF, Kee HL, Jenkins PM, Fan S, Hurd TW, Hammond JW, Truong YN, Margolis B, Martens JR, Verhey KJ (2010) Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP. Nat Cell Biol 12:703-710
43. Dobrzyński M, Bernatowicz P, Kloc M, Kubiak JZ (2011) Evolution of bet-hedging-like mechanisms in cell cycle and embryo development stimulated by weak linkage of stochastic processes. In: Kubiak JZ (ed) Cell cycle in development. Results and problem in cell differentiation. Springer, Heidelberg
44. Dogterom M, Felix MA, Guet CC, Leibler S (1996) Influence of M-phase chromatin on the anisotropy of microtubule asters. J Cell Biol 133:125-140 (Pubitemid 26107101)
45. Dumont J, Million K, Sunderland K, Rassinier P, Lim H, Leader B, Verlhac MH (2007a) Formin- 2 is required for spindle migration and for the late steps of cytokinesis in mouse oocytes. Dev Biol 301:254-265 (Pubitemid 46001380)
46. Dumont J, Petri S, Pellegrin F, TerretME, BohnsackMT, Rassinier P,Georget V, Kalab P, Gruss OJ, Verlhac MH (2007b) A centriole- and RanGTP-independent spindle assembly pathway in meiosis I of vertebrate oocytes. J Cell Biol 176:295-305 (Pubitemid 46184881)
47. Duncan FE, Chiang T, Schultz RM, Lampson MA (2009) Evidence that a defective spindle assembly checkpoint is not the primary cause of maternal age-associated aneuploidy in mouse eggs. Biol Reprod 81:768-776
48. England JR, Huang J, Jennings MJ, Makde RD, Tan S (2010) RCC1 uses a conformationally diverse loop region to interact with the nucleosome: A model for the RCC1-nucleosome complex. J Mol Biol 398:518-529
49. Eppig JJ, O'Brien MJ (1996) Development in vitro of mouse oocytes from primordial follicles. Biol Reprod 54:197-207 (Pubitemid 126506815)
50. Eyers PA, Erikson E, Chen LG, Maller JL (2003) A novel mechanism for activation of the protein kinase Aurora A. Curr Biol 13:691-697 (Pubitemid 36453320)
51. Feng Y, Yuan JH, Maloid SC, Fisher R, Copeland TD, Longo DL, Conrads TP, Veenstra TD, Ferris A, Hughes S, Dimitrov DS, Ferris DK (2006) Polo-like kinase 1-mediated phosphorylation of the GTP-binding protein Ran is important for bipolar spindle formation. Biochem Biophys Res Commun 349:144-152 (Pubitemid 44331774)
52. Frey S, Gorlich D (2009) FG/FxFG as well as GLFG repeats form a selective permeability barrier with self-healing properties. EMBO J 28:2554-2567
53. Frey S, Richter RP, Gorlich D (2006) FG-rich repeats of nuclear pore proteins form a threedimensional meshwork with hydrogel-like properties. Science 314:815-817 (Pubitemid 44706647)
54. Fried H, Kutay U (2003) Nucleocytoplasmic transport: Taking an inventory. Cell Mol Life Sci 60:1659-1688 (Pubitemid 37041364)
55. Gavet O, Pines J (2010a) Activation of cyclin B1-Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis. J Cell Biol 189:247-259
56. Gavet O, Pines J (2010b) Progressive activation of CyclinB1-Cdk1 coordinates entry to mitosis. Dev Cell 18:533-543
57. Giet R, Uzbekov R, Cubizolles F, Le Guellec K, Prigent C (1999) The Xenopus laevis aurorarelated protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XlEg5. J Biol Chem 274:15005-15013
58. Goldfarb DS, Corbett AH, Mason DA, Harreman MT, Adam SA (2004) Importin alpha: A multipurpose nuclear-transport receptor. Trends Cell Biol 14:505-514 (Pubitemid 39209358)
59. Gontan C, Guttler T, Engelen E, Demmers J, Fornerod M, Grosveld FG, Tibboel D, Gorlich D, Poot RA, Rottier RJ (2009) Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factors. J Cell Biol 185:27-34
60. Goodman B, Zheng Y (2006) Mitotic spindle morphogenesis: Ran on the microtubule cytoskeleton and beyond. Biochem Soc Trans 34:716-721 (Pubitemid 44810659)
61. Gordo AC, He CL, Smith S, Fissore RA (2001) Mitogen activated protein kinase plays a significant role in metaphase II arrest, spindle morphology, and maintenance of maturation promoting factor activity in bovine oocytes. Mol Reprod Dev 59:106-114
62. Gorlich D, Seewald MJ, Ribbeck K (2003) Characterization of Ran-driven cargo transport and the RanGTPase system by kineticmeasurements and computer simulation.EMBOJ 22:1088-1100 (Pubitemid 36313593)
63. Goshima G, Kimura A (2010) New look inside the spindle: Microtubule-dependent microtubule generation within the spindle. Curr Opin Cell Biol 22:44-49
64. Groen AC, Cameron LA, Coughlin M, Miyamoto DT, Mitchison TJ, Ohi R (2004) XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly. Curr Biol 14:1801-1811 (Pubitemid 39408769)
65. Gruss OJ, Vernos I (2004) The mechanism of spindle assembly: Functions of Ran and its target TPX2. J Cell Biol 166:949-955 (Pubitemid 39304757)
66. Gruss OJ, Carazo-Salas RE, Schatz CA, Guarguaglini G, Kast J, Wilm M, Le Bot N, Vernos I, Karsenti E, Mattaj IW (2001) Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity. Cell 104:83-93 (Pubitemid 32144974)
67. Gruss OJ, Wittmann M, Yokoyama H, Pepperkok R, Kufer T, Sillje H, Karsenti E, Mattaj IW, Vernos I (2002) Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells. Nat Cell Biol 4:871-879 (Pubitemid 35331362)
68. Guarguaglini G, Renzi L, D'Ottavio F, Di Fiore B, Casenghi M, Cundari E, Lavia P (2000) Regulated Ran-binding protein 1 activity is required for organization and function of the mitotic spindle in mammalian cells in vivo. Cell Growth Differ 11:455-465 (Pubitemid 30644369)
69. Gueth-Hallonet C, Antony C, Aghion J, Santa-Maria A, Lajoie-Mazenc I, Wright M, Maro B (1993) Gamma-tubulin is present in acentriolar MTOCs during early mouse development. J Cell Sci 105(Pt 1):157-166 (Pubitemid 23187555)
70. Hassold T, Hunt P (2001) To err (meiotically) is human: The genesis of human aneuploidy. Nat Rev Genet 2:280-291 (Pubitemid 33674776)
71. Hassold T, Hunt P (2009) Maternal age and chromosomally abnormal pregnancies: What we know and what we wish we knew. Curr Opin Pediatr 21:703-708
72. Hetzer MW (2010) The nuclear envelope. Cold Spring Harb Perspect Biol 2:a000539
73. Hetzer MW, Wente SR (2009) Border control at the nucleus: Biogenesis and organization of the nuclear membrane and pore complexes. Dev Cell 17:606-616
74. Hintersteiner M, Ambrus G, Bednenko J, Schmied M, Knox AJ, Meisner NC, Gstach H, Seifert JM, Singer EL, Gerace L, Auer M (2010) Identification of a small molecule inhibitor of importin beta mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries. ACS Chem Biol 5:967-979
75. Hitakomate E, Hood FE, Sanderson HS, Clarke PR (2010) The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells. BMC Cell Biol 11:43
76. Holt JE, Weaver J, Jones KT (2010) Spatial regulation of APCCdh1-induced cyclin B1 degradation maintains G2 arrest in mouse oocytes. Development 137:1297-1304
77. Hood FE, Clarke PR (2007) RCC1 isoforms differ in their affinity for chromatin, molecular interactions and regulation by phosphorylation. J Cell Sci 120:3436-3445 (Pubitemid 350028351)
78. Hu J, Wang F, Yuan Y, Zhu X, Wang Y, Zhang Y, Kou Z, Wang S, Gao S (2010) The novel importin-alpha family member KPNA7, is required for normal fertility and fecundity in the mouse. J Biol Chem 285:33113-33122
79. Huber J, Cronshagen U, Kadokura M, Marshallsay C, Wada T, Sekine M, Luhrmann R (1998) Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structure. EMBO J 17:4114-4126 (Pubitemid 28333995)
80. Huenniger K, Kramer A, Soom M, Chang I, Kohler M, Depping R, Kehlenbach RH, Kaether C (2010) Notch1 signaling is mediated by importins alpha 3, 4, and 7. Cell Mol Life Sci 67:3187-3196
81. Hutchins JR, Moore WJ, Hood FE, Wilson JS, Andrews PD, Swedlow JR, Clarke PR (2004) Phosphorylation regulates the dynamic interaction of RCC1 with chromosomes during mitosis. Curr Biol 14:1099-1104 (Pubitemid 38791573)
82. Illingworth C, Pirmadjid N, Serhal P, Howe K, Fitzharris G (2010) MCAK regulates chromosome alignment but is not necessary for preventing aneuploidy in mouse oocyte meiosis I. Development 137:2133-2138
83. Jakel S, Albig W, Kutay U, Bischoff FR, Schwamborn K, Doenecke D, Gorlich D (1999) The importin beta/importin 7 heterodimer is a functional nuclear import receptor for histone H1. EMBO J 18:2411-2423 (Pubitemid 29213275)
84. Jang YJ, Ji JH, Ahn JH, Hoe KL, Won M, Im DS, Chae SK, Song S, Yoo HS (2004) Polo-box motif targets a centrosome regulator, RanGTPase. Biochem Biophys Res Commun 325: 257-264 (Pubitemid 39441187)
85. Joseph J, Tan SH, Karpova TS, McNally JG, Dasso M (2002) SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles. J Cell Biol 156:595-602 (Pubitemid 34839875)
86. Joukov V, Groen AC, Prokhorova T, Gerson R, White E, Rodriguez A, Walter JC, Livingston DM (2006) The BRCA1/BARD1 heterodimer modulates Ran-dependent mitotic spindle assembly. Cell 127:539-552 (Pubitemid 44647427)
87. Kalab P, Heald R (2008) The RanGTP gradient - a GPS for the mitotic spindle. J Cell Sci 121:1577-1586 (Pubitemid 351911814)
88. Kalab P, Pralle A (2008) Chapter 21: Quantitative fluorescence lifetime imaging in cells as a tool to design computational models of ran-regulated reaction networks. Methods Cell Biol 89: 541-568
89. Kalab P, Soderholm J (2010) The design of Forster (fluorescence) resonance energy transfer (FRET)-based molecular sensors for Ran GTPase. Methods 51:220-232
90. Kalab P, Pu RT, Dasso M (1999) The Ran GTPase regulates mitotic spindle assembly. Curr Biol 9:481-484 (Pubitemid 29228620)
91. Kalab P, Weis K, Heald R (2002) Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts. Science 295:2452-2456 (Pubitemid 34270259)
92. Kalab P, Pralle A, Isacoff EY, Heald R, Weis K (2006) Analysis of a RanGTP-regulated gradient in mitotic somatic cells. Nature 440:697-701
93. Karsenti E, Vernos I (2001) The mitotic spindle: A self-made machine. Science 294:543-547
94. Karsenti E, Newport J, Kirschner M (1984) Respective roles of centrosomes and chromatin in the conversion of microtubule arrays from interphase to metaphase. J Cell Biol 99:47s-54s (Pubitemid 14074763)
95. Kelley JB, Paschal BM (2007) Hyperosmotic stress signaling to the nucleus disrupts the Ran gradient and the production of RanGTP. Mol Biol Cell 18:4365-4376 (Pubitemid 350060165)
96. Kelley JB, Talley AM, Spencer A, Gioeli D, Paschal BM (2010) Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors. BMC Cell Biol 11:63
97. Kelly AE, Sampath SC, Maniar TA, Woo EM, Chait BT, Funabiki H (2007) Chromosomal enrichment and activation of the aurora B pathway are coupled to spatially regulate spindle assembly. Dev Cell 12:31-43 (Pubitemid 46002596)
98. Keryer G, Di Fiore B, Celati C, Lechtreck KF, Mogensen M, Delouvee A, Lavia P, Bornens M, Tassin AM (2003) Part of Ran is associated with AKAP450 at the centrosome: Involvement in microtubule-organizing activity. Mol Biol Cell 14:4260-4271 (Pubitemid 37186326)
99. Kim SY, Ryu SJ, Ahn HJ, Choi HR, Kang HT, Park SC (2010) Senescence-related functional nuclear barrier by down-regulation of nucleo-cytoplasmic trafficking gene expression. Biochem Biophys Res Commun 391:28-32
100. Kinoshita K, Noetzel TL, Pelletier L, Mechtler K, Drechsel DN, Schwager A, Lee M, Raff JW, Hyman AA (2005) Aurora A phosphorylation of TACC3/maskin is required for centrosomedependent microtubule assembly in mitosis. J Cell Biol 170:1047-1055 (Pubitemid 41362637)
101. Knauer SK, Bier C, Habtemichael N, Stauber RH (2006) The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function. EMBO Rep 7:1259-1265 (Pubitemid 44835095)
102. Koffa MD, Casanova CM, Santarella R, Kocher T, Wilm M, Mattaj IW (2006) HURP is part of a Ran-dependent complex involved in spindle formation. Curr Biol 16:743-754
103. Kufer TA, Sillje HH, Korner R, Gruss OJ, Meraldi P, Nigg EA (2002) Human TPX2 is required for targeting Aurora-A kinase to the spindle. J Cell Biol 158:617-623 (Pubitemid 34920101)
104. Kumar A, Agarwal S, Heyman JA, Matson S, Heidtman M, Piccirillo S, Umansky L, Drawid A, Jansen R, Liu Y, Cheung KH, Miller P, Gerstein M, Roeder GS, Snyder M (2002) Subcellular localization of the yeast proteome. Genes Dev 16:707-719 (Pubitemid 34274040)
105. Kutay U, Hetzer MW (2008) Reorganization of the nuclear envelope during open mitosis. Curr Opin Cell Biol 20:669-677
106. Kutay U, Izaurralde E, Bischoff FR, Mattaj IW, Gorlich D (1997) Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex. EMBO J 16:1153-1163 (Pubitemid 27136082)
107. la Cour T, Kiemer L, Molgaard A, Gupta R, Skriver K, Brunak S (2004) Analysis and prediction of leucine-rich nuclear export signals. Protein Eng Des Sel 17:527-536 (Pubitemid 39487532)
108. Lau CK, Delmar VA, Chan RC, Phung Q, Bernis C, Fichtman B, Rasala BA, Forbes DJ (2009) Transportin regulates major mitotic assembly events: From spindle to nuclear pore assembly. Mol Biol Cell 20:4043-4058
109. Leader B, Leder P (2000) Formin-2, a novel formin homology protein of the cappuccino subfamily, is highly expressed in the developing and adult central nervous system. Mech Dev 93:221-231 (Pubitemid 30216517)
110. Leader B, Lim H, Carabatsos MJ, Harrington A, Ecsedy J, Pellman D, Maas R, Leder P (2002) Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes. Nat Cell Biol 4:921-928 (Pubitemid 35469421)
111. Lee J, Kitajima TS, Tanno Y, Yoshida K, Morita T, Miyano T, Miyake M, Watanabe Y (2008) Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells. Nat Cell Biol 10:42-52
112. Lee JY, Lee HS, Wi SJ, Park KY, Schmit AC, Pai HS (2009) Dual functions of Nicotiana benthamiana Rae1 in interphase and mitosis. Plant J 59:278-291
113. Lefebvre C, Terret ME, Djiane A, Rassinier P, Maro B, Verlhac MH (2002) Meiotic spindle stability depends on MAPK-interacting and spindle-stabilizing protein (MISS), a new MAPK substrate. J Cell Biol 157:603-613 (Pubitemid 34839789)
114. Lenart P, Ellenberg J (2003) Nuclear envelope dynamics in oocytes: From germinal vesicle breakdown to mitosis. Curr Opin Cell Biol 15:88-95 (Pubitemid 36044720)
115. Lenart P, Rabut G, Daigle N, Hand AR, Terasaki M, Ellenberg J (2003) Nuclear envelope breakdown in starfish oocytes proceeds by partial NPC disassembly followed by a rapidly spreading fenestration of nuclear membranes. J Cell Biol 160:1055-1068 (Pubitemid 36443874)
116. LeRoy PJ, Hunter JJ, Hoar KM, Burke KE, Shinde V, Ruan J, Bowman D, Galvin K, Ecsedy JA (2007) Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: A novel pharmacodynamic method for measuring Aurora A activity. Cancer Res 67:5362-5370 (Pubitemid 46997276)
117. Li HY, Zheng Y (2004) Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells. Genes Dev 18:512-527 (Pubitemid 38372809)
118. Li HY, Wirtz D, Zheng Y (2003) A mechanism of coupling RCC1 mobility to RanGTP production on the chromatin in vivo. J Cell Biol 160:635-644 (Pubitemid 36298260)
119. Lincoln AJ, Wickramasinghe D, Stein P, Schultz RM, Palko ME, De Miguel MP, Tessarollo L, Donovan PJ (2002) Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation. Nat Genet 30:446-449
120. Lister LM, Kouznetsova A, Hyslop LA, Kalleas D, Pace SL, Barel JC, Nathan A, Floros V, Adelfalk C, Watanabe Y, Jessberger R, Kirkwood TB, Hoog C, Herbert M (2010) Age-related meiotic segregation errors in mammalian oocytes are preceded by depletion of cohesin and sgo2. Curr Biol 20:1511-1521
121. Liu J, Grimison B, Maller JL (2007) New insight into metaphase arrest by cytostatic factor: From establishment to release. Oncogene 26:1286-1289 (Pubitemid 46328464)
122. Liu D, Vleugel M, Backer CB, Hori T, Fukagawa T, Cheeseman IM, Lampson MA (2010) Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase. J Cell Biol 188:809-820
123. Longo FJ, Chen DY (1985) Development of cortical polarity in mouse eggs: Involvement of the meiotic apparatus. Dev Biol 107:382-394 (Pubitemid 15110942)
124. Lonhienne TG, Forwood JK, Marfori M, Robin G, Kobe B, Carroll BJ (2009) Importin-beta is a GDP-to-GTP exchange factor of Ran: Implications for the mechanism of nuclear import. J Biol Chem 284:22549-22558
125. Lott K, Bhardwaj A, Mitrousis G, Pante N, Cingolani G (2010) The importin beta binding domain modulates the avidity of importin beta for the nuclear pore complex. J Biol Chem 285: 13769-13780
126. Lowe AR, Siegel JJ, Kalab P, Siu M, Weis K, Liphardt JT (2010) Selectivity mechanism of the nuclear pore complex characterized by single cargo tracking. Nature 467:600-603
127. Ly TK, Wang J, Pereira R, Rojas KS, Peng X, Feng Q, Cerione RA, Wilson KF (2010) Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation. J Biol Chem 285:5815-5826
128. Ma N, Tulu US, Ferenz NP, Fagerstrom C, Wilde A, Wadsworth P (2010) Poleward transport of TPX2 in the mammalian mitotic spindle requires dynein, Eg5, and microtubule flux. Mol Biol Cell 21:979-988
129. Makde RD, England JR, Yennawar HP, Tan S (2010) Structure of RCC1 chromatin factor bound to the nucleosome core particle. Nature 467:562-566
130. Manandhar G, Schatten H, Sutovsky P (2005) Centrosome reduction during gametogenesis and its significance. Biol Reprod 72:2-13 (Pubitemid 40013748)
131. Marangos P, Carroll J (2004) The dynamics of cyclin B1 distribution during meiosis I in mouse oocytes. Reproduction 128:153-162 (Pubitemid 39162686)
132. Maresca TJ, Groen AC, Gatlin JC, Ohi R, Mitchison TJ, Salmon ED (2009) Spindle assembly in the absence of a RanGTP gradient requires localized CPC activity. Curr Biol 19:1210-1215
133. Maro B, Johnson MH, Webb M, Flach G (1986) Mechanism of polar body formation in the mouse oocyte: An interaction between the chromosomes, the cytoskeleton and the plasma membrane. J Embryol Exp Morphol 92:11-32 (Pubitemid 16133521)
134. Martin JA, Hamilton BE, Sutton PD, Ventura SJ, Menacker F, Kirmeyer S, Munson ML (2007) Births: Final data for 2005. Natl Vital Stat Rep 56:1-103
135. Matunis MJ, Coutavas E, Blobel G (1996) A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. J Cell Biol 135:1457-1470 (Pubitemid 26427644)
136. Matunis MJ, Wu J, Blobel G (1998) SUMO-1 modification and its role in targeting the Ran GTPase-activating protein, RanGAP1, to the nuclear pore complex. J Cell Biol 140:499-509 (Pubitemid 28134055)
137. Mitrousis G, Olia AS, Walker-Kopp N, Cingolani G (2008) Molecular basis for the recognition of snurportin 1 by importin beta. J Biol Chem 283:7877-7884
138. Mohr D, Frey S, Fischer T, Guttler T, Gorlich D (2009) Characterisation of the passive permeability barrier of nuclear pore complexes. EMBO J 28:2541-2553
139. Moore JD (2001) The Ran-GTPase and cell-cycle control. Bioessays 23:77-85 (Pubitemid 32100504)
140. Moore JD, Yang J,Truant R, Kornbluth S (1999) Nuclear import ofCdk/cyclin complexes: Identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1. J Cell Biol 144:213-224 (Pubitemid 29066026)
141. Mori D, Yano Y, Toyo-oka K, Yoshida N, Yamada M, Muramatsu M, Zhang D, Saya H, Toyoshima YY, Kinoshita K, Wynshaw-Boris A, Hirotsune S (2007) NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment. Mol Cell Biol 27:352-367 (Pubitemid 46013256)
142. Nachury MV, Maresca TJ, Salmon WC, Waterman-Storer CM, Heald R, Weis K (2001) Importin beta is a mitotic target of the small GTPase Ran in spindle assembly. Cell 104:95-106 (Pubitemid 32144975)
143. Nemergut ME, Mizzen CA, Stukenberg T, Allis CD, Macara IG (2001) Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B. Science 292:1540-1543 (Pubitemid 32493421)
144. Nishijima H, Seki T, Nishitani H, Nishimoto T (2000) Premature chromatin condensation caused by loss of RCC1. Prog Cell Cycle Res 4:145-156
145. Nishimoto T, Ajiro K, Hirata M, Yamashita K, Sekiguchi M(1985) The induction of chromosome condensation in tsBN2, a temperature-sensitive mutant of BHK21, inhibited by the calmodulin antagonist, W-7. Exp Cell Res 156:351-358 (Pubitemid 15124023)
146. O'Connell CB, Loncarek J, Kalab P, Khodjakov A (2009) Relative contributions of chromatin and kinetochores to mitotic spindle assembly. J Cell Biol 187:43-51
147. Oh JS, Han SJ, Conti M (2010) Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption. J Cell Biol 188:199-207
148. Ohba T, Nakamura M, Nishitani H, Nishimoto T (1999) Self-organization of microtubule asters induced in Xenopus egg extracts by GTP-bound Ran. Science 284:1356-1358 (Pubitemid 29289661)
149. Ohta S, Bukowski-Wills JC, Sanchez-Pulido L, Alves Fde L, Wood L, Chen ZA, Platani M, Fischer L, Hudson DF, Ponting CP, Fukagawa T, Earnshaw WC, Rappsilber J (2010) The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. Cell 142:810-821
150. Pan H, Ma P, Zhu W, Schultz RM (2008) Age-associated increase in aneuploidy and changes in gene expression in mouse eggs. Dev Biol 316:397-407
151. Pelech S, Jelinkova L, Susor A, Zhang H, Shi X, Pavlok A, Kubelka M, Kovarova H (2008) Antibody microarray analyses of signal transduction protein expression and phosphorylation during porcine oocyte maturation. J Proteome Res 7:2860-2871
152. Pemberton LF, Paschal BM (2005) Mechanisms of receptor-mediated nuclear import and nuclear export. Traffic 6:187-198 (Pubitemid 40298153)
153. Petosa C, Schoehn G, Askjaer P, Bauer U, Moulin M, Steuerwald U, Soler-Lopez M, Baudin F, Mattaj IW, Muller CW (2004) Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex. Mol Cell 16:761-775 (Pubitemid 39586534)
154. Pirino G, Wescott MP, Donovan PJ (2009) Protein kinase A regulates resumption of meiosis by phosphorylation of Cdc25B in mammalian oocytes. Cell Cycle 8:665-670
155. Platani M, Santarella-Mellwig R, Posch M, Walczak R, Swedlow JR, Mattaj IW (2009) The Nup107-160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex. Mol Biol Cell 20:5260-5275
156. Quensel C, Friedrich B, Sommer T, Hartmann E, Kohler M (2004) In vivo analysis of importin alpha proteins reveals cellular proliferation inhibition and substrate specificity. Mol Cell Biol 24:10246-10255 (Pubitemid 39507863)
157. Reis A, Chang HY, Levasseur M, Jones KT (2006) APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division. Nat Cell Biol 8:539-540
158. Ren Y, Seo HS, Blobel G, Hoelz A (2010) Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1. Proc Natl Acad Sci USA 107:10406-10411
159. Renault L, Kuhlmann J, Henkel A, Wittinghofer A (2001) Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1). Cell 105:245-255 (Pubitemid 32429514)
160. Revenkova E, Herrmann K, Adelfalk C, Jessberger R (2010) Oocyte cohesin expression restricted to predictyate stages provides full fertility and prevents
161. Ribbeck K, Gorlich D (2001) Kinetic analysis of translocation through nuclear pore complexes. EMBO J 20:1320-1330 (Pubitemid 32233972)
162. Ribbeck K, Lipowsky G, Kent HM, Stewart M, Gorlich D (1998) NTF2 mediates nuclear import of Ran. EMBO J 17:6587-6598 (Pubitemid 28521793)
163. Saitoh H, Sparrow DB, Shiomi T, Pu RT, Nishimoto T, Mohun TJ, Dasso M(1998) Ubc9p and the conjugation of SUMO-1 to RanGAP1 and RanBP2. Curr Biol 8:121-124 (Pubitemid 28104526)
164. Salina D, Enarson P, Rattner JB, Burke B (2003) Nup358 integrates nuclear envelope breakdown with kinetochore assembly. J Cell Biol 162:991-1001
165. Sardon T, Peset I, Petrova B, Vernos I (2008) Dissecting the role of Aurora A during spindle assembly. EMBO J 27:2567-2579
166. Saskova A, Solc P, Baran V, Kubelka M, Schultz RM, Motlik J (2008) Aurora kinase A controls meiosis I progression in mouse oocytes. Cell Cycle 7:2368-2376
167. Schaner Tooley CE, Petkowski JJ, Muratore-Schroeder TL, Balsbaugh JL, Shabanowitz J, Sabat M, Minor W, Hunt DF, Macara IG (2010) NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein. Nature 466:1125-1128
168. Schuh M, Ellenberg J (2007) Self-Organization of MTOCs replaces centrosome function during acentrosomal spindle assembly in live mouse oocytes. Cell 130:484-498 (Pubitemid 47198301)
169. Schuh M, Ellenberg J (2008) A new model for asymmetric spindle positioning in mouse oocytes. Curr Biol 18:1986-1992
170. Seki T, Yamashita K, Nishitani H, Takagi T, Russell P, Nishimoto T (1992) Chromosome condensation caused by loss of RCC1 function requires the cdc25C protein that is located in the cytoplasm. Mol Biol Cell 3:1373-1388 (Pubitemid 23091464)
171. Sillje HH, Nagel S, Korner R, Nigg EA (2006) HURP is a Ran-importin beta-regulated protein that stabilizes kinetochore microtubules in the vicinity of chromosomes. Curr Biol 16:731-742
172. Silverman-Gavrila RV, Wilde A (2006) Ran is required before metaphase for spindle assembly and chromosome alignment and after metaphase for chromosome segregation and spindle midbody organization. Mol Biol Cell 17:2069-2080 (Pubitemid 44011619)
173. Smith A, Brownawell A, Macara IG (1998) Nuclear import of Ran is mediated by the transport factor NTF2. Curr Biol 8:1403-1406 (Pubitemid 29020151)
174. Smith AE, Slepchenko BM, Schaff JC, Loew LM, Macara IG (2002) Systems analysis of Ran transport. Science 295:488-491 (Pubitemid 34101637)
175. Soderholm JF, Bird SL, Kalab P, Sampathkumar Y, Hasegawa K, Uehara-Bingen M, Weis K, Heald R (2011) Importazole, a Small Molecule Inhibitor of the Transport Receptor Importin-b. ACS Chem Biol 2011 Apr 21 [Epub ahead of print]
176. Soh S, Byrska M, Kandere-Grzybowska K, Grzybowski BA (2010) Reaction-diffusion systems in intracellular molecular transport and control. Angew Chem Int Ed Engl 49:4170-4198
177. Solc P, Saskova A, Baran V, Kubelka M, Schultz RM, Motlik J (2008) CDC25A phosphatase controls meiosis I progression in mouse oocytes. Dev Biol 317:260-269
178. Solc P, Schultz RM, Motlik J (2010) Prophase I arrest and progression to metaphase I in mouse oocytes: Comparison of resumption of meiosis and recovery from G2-arrest in somatic cells. Mol Hum Reprod 16:654-664
179. Song L, Rape M (2010) Regulated degradation of spindle assembly factors by the anaphasepromoting complex. Mol Cell 38:369-382
180. StewartM(2006) Structural basis for the nuclear protein import cycle. Biochem Soc Trans 34:701-704 (Pubitemid 44796402)
181. Stewart S, Fang G (2005) Anaphase-promoting complex/cyclosome controls the stability of TPX2 during mitotic exit. Mol Cell Biol 25:10516-10527 (Pubitemid 41681972)
182. Stirnimann CU, Petsalaki E, Russell RB, Muller CW (2010) WD40 proteins propel cellular networks. Trends Biochem Sci 35:565-574
183. Stuven T, Hartmann E, Gorlich D (2003) Exportin 6: A novel nuclear export receptor that is specific for profilin.actin complexes. EMBO J 22:5928-5940 (Pubitemid 37408828)
184. Sun SC, Xiong B, Lu SS, Sun QY (2008) MEK1/2 is a critical regulator of microtubule assembly and spindle organization during rat oocyte meiotic maturation. Mol Reprod Dev 75:1542-1548
185. Sun QY, Miao YL, Schatten H (2009) Towards a new understanding on the regulation of mammalian oocyte meiosis resumption. Cell Cycle 8:2741-2747
186. Szollosi D, Calarco P, Donahue RP (1972) Absence of centrioles in the first and second meiotic spindles of mouse oocytes. J Cell Sci 11:521-541
187. Tahara K, Takagi M, Ohsugi M, Sone T, Nishiumi F, Maeshima K, Horiuchi Y, Tokai-Nishizumi N, Imamoto F, Yamamoto T, Kose S, Imamoto N (2008) Importin-beta and the small guanosine triphosphatase Ran mediate chromosome loading of the human chromokinesin kid. J Cell Biol 180:493-506 (Pubitemid 351240699)
188. Takizawa CG, Weis K, Morgan DO (1999) Ran-independent nuclear import of cyclin B1-Cdc2 by importin beta. Proc Natl Acad Sci USA 96:7938-7943 (Pubitemid 29328386)
189. Tejomurtula J, Lee KB, Tripurani SK, Smith GW, Yao J (2009) Role of importin alpha8, a new member of the importin alpha family of nuclear transport proteins, in early embryonic development in cattle. Biol Reprod 81:333-342
190. Terret ME, Lefebvre C, Djiane A, Rassinier P, Moreau J, Maro B, Verlhac MH (2003) DOC1R: A MAP kinase substrate that control microtubule organization of metaphase II mouse oocytes. Development 130:5169-5177 (Pubitemid 37369676)
191. Terry LJ, Shows EB, Wente SR (2007) Crossing the nuclear envelope: Hierarchical regulation of nucleocytoplasmic transport. Science 318:1412-1416 (Pubitemid 350208921)
192. Torosantucci L, De Luca M, Guarguaglini G, Lavia P, Degrassi F (2008) Localized RanGTP accumulation promotes microtubule nucleation at kinetochores in somatic mammalian cells. Mol Biol Cell 19:1873-1882
193. Tsai MY, Zheng Y (2005) Aurora A kinase-coated beads function as microtubule-organizing centers and enhance RanGTP-induced spindle assembly. Curr Biol 15:2156-2163 (Pubitemid 41739750)
194. Tsai MY, Wiese C, Cao K, Martin O, Donovan P, Ruderman J, Prigent C, Zheng YX (2003) A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly. Nat Cell Biol 5:242-248 (Pubitemid 36322252)
195. Tulu US, Fagerstrom C, Ferenz NP, Wadsworth P (2006) Molecular requirements for kinetochoreassociated microtubule formation in mammalian cells. Curr Biol 16:536-541 (Pubitemid 43343717)
196. Tunquist BJ, Maller JL (2003) Under arrest: Cytostatic factor (CSF)-mediated metaphase arrest in vertebrate eggs. Genes Dev 17:683-710 (Pubitemid 36359187)
197. Uchida S, Kuma A, Ohtsubo M, Shimura M, Hirata M, Nakagama H, Matsunaga T, Ishizaka Y, Yamashita K (2004a) Binding of 14-3-3beta but not 14-3-3sigma controls the cytoplasmic localization of CDC25B: Binding site preferences of 14-3-3 subtypes and the subcellular localization of CDC25B. J Cell Sci 117:3011-3020 (Pubitemid 39117675)
198. Uchida S, Ohtsubo M, Shimura M, Hirata M, Nakagama H, Matsunaga T, Yoshida M, Ishizaka Y, Yamashita K (2004b) Nuclear export signal in CDC25B. Biochem Biophys Res Commun 316:226-232 (Pubitemid 38299149)
199. Verlhac MH, Dumont J (2008) Interactions between chromosomes, microfilaments and microtubules revealed by the study of small GTPases in a big cell, the vertebrate oocyte. Mol Cell Endocrinol 282:12-17
200. Verlhac MH, de Pennart H, Maro B, Cobb MH, Clarke HJ (1993) MAP kinase becomes stably activated at metaphase and is associated with microtubule-organizing centers during meiotic maturation of mouse oocytes. Dev Biol 158:330-340 (Pubitemid 23243891)
201. Verlhac MH, Kubiak JZ, Weber M, Geraud G, Colledge WH, Evans MJ, Maro B (1996) Mos is required for MAP kinase activation and is involved in microtubule organization during meiotic maturation in the mouse. Development 122:815-822 (Pubitemid 26095987)
202. Verlhac MH, Lefebvre C, Guillaud P, Rassinier P, Maro B (2000) Asymmetric division in mouse oocytes: With or without Mos. Curr Biol 10:1303-1306
203. Wang W, Budhu A, Forgues M, Wang XW (2005) Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication. Nat Cell Biol 7:823-830 (Pubitemid 41079055)
204. Weis K (2003) Regulating access to the genome: Nucleocytoplasmic transport throughout the cell cycle. Cell 112:441-451 (Pubitemid 36263078)
205. Weis K (2007) The nuclear pore complex: Oily spaghetti or gummy beař Cell 130:405-407 (Pubitemid 47198307)
206. Welburn JP, Vleugel M, Liu D, Yates JR III, Lampson MA, Fukagawa T, Cheeseman IM (2010) Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochoremicrotubule interface. Mol Cell 38:383-392
207. Whitfield ML, Sherlock G, Saldanha AJ, Murray JI, Ball CA, Alexander KE, Matese JC, Perou CM, Hurt MM, Brown PO, Botstein D (2002) Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Mol Biol Cell 13:1977-2000 (Pubitemid 34651487)
208. Wiese C, Wilde A, Moore MS, Adam SA, Merdes A, Zheng Y (2001) Role of importin-beta in coupling Ran to downstream targets in microtubule assembly. Science 291:653-656 (Pubitemid 32150424)
209. Wilde A, Zheng Y (1999) Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran. Science 284:1359-1362 (Pubitemid 29289662)
210. Wollman R, Cytrynbaum EN, Jones JT, Meyer T, Scholey JM, Mogilner A (2005) Efficient chromosome capture requires a bias in the "search-and- capture" process during mitotic-spindle assembly. Curr Biol 15:828-832 (Pubitemid 40689401)
211. Wong RW (2010) Interaction between Rae1 and cohesin subunit SMC1 is required for proper spindle formation. Cell Cycle 9:198-200
212. Wong RW, Blobel G (2008) Cohesin subunit SMC1 associates with mitotic microtubules at the spindle pole. Proc Natl Acad Sci USA 105:15441-15445
213. Wong J, Fang G (2006) HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture. J Cell Biol 173:879-891
214. Wong J, Lerrigo R, Jang CY, Fang G (2008) Aurora A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain. Mol Biol Cell 19:2083-2091
215. Wozniak R, Burke B, Doye V (2010) Nuclear transport and the mitotic apparatus: An evolving relationship. Cell Mol Life Sci 67:2215-2230
216. Wu JQ, Kornbluth S (2008) Across the meiotic divide - CSF activity in the post-Emi2/XErp1 era. J Cell Sci 121:3509-3514
217. Xia F, Lee CW, Altieri DC (2008) Tumor cell dependence on Ran-GTP-directed mitosis. Cancer Res 68:1826-1833 (Pubitemid 351416568)
218. Yang JW, Lei ZL, Miao YL, Huang JC, Shi LH, OuYang YC, Sun QY, Chen DY (2007) Spindle assembly in the absence of chromosomes in mouse oocytes. Reproduction 134:731-738
219. Yaseen NR, Blobel G (1999) GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin nup358. J Biol Chem 274:26493-26502
220. Yasuhara N, Shibazaki N, Tanaka S, Nagai M, Kamikawa Y, Oe S, Asally M, Kamachi Y, Kondoh H, Yoneda Y (2007) Triggering neural differentiation of ES cells by subtype switching of importin-alpha. Nat Cell Biol 9:72-79 (Pubitemid 46024199)
221. Yokoyama H, Gruss OJ, Rybina S, Caudron M, Schelder M, Wilm M, Mattaj IW, Karsenti E (2008) Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate. J Cell Biol 180:867-875 (Pubitemid 351398414)
222. Yokoyama H, Rybina S, Santarella-Mellwig R, Mattaj IW, Karsenti E (2009) ISWI is a RanGTPdependent MAP required for chromosome segregation. J Cell Biol 187:813-829
223. Yu CT, Hsu JM, Lee YC, Tsou AP, Chou CK, Huang CY (2005) Phosphorylation and stabilization of HURP by Aurora-A: Implication of HURP as a transforming target of Aurora-A. Mol Cell Biol 25:5789-5800
224. Zachariae U, Grubmuller H (2008) Importin-beta: Structural and dynamic determinants of a molecular spring. Structure 16:906-915 (Pubitemid 351778376)
225. Zhang H, Saitoh H, Matunis MJ (2002) Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex. Mol Cell Biol 22:6498-6508
226. Zhang X, Ems-McClung SC, Walczak CE (2008a) Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity. Mol Biol Cell 19:2752-2765
227. Zhang Y, Zhang Z, Xu XY, Li XS, Yu M, Yu AM, Zong ZH, Yu BZ (2008b) Protein kinase A modulates Cdc25B activity during meiotic resumption of mouse oocytes. Dev Dyn 237:3777-3786
228. Zuccolo M, Alves A, Galy V, Bolhy S, Formstecher E, Racine V, Sibarita JB, Fukagawa T, Shiekhattar R, Yen T, Doye V (2007) The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions. EMBO J 26:1853-1864 (Pubitemid 46624053)