Nuclear transport and the mitotic apparatus: An evolving relationship

Cellular and Molecular Life Sciences

Volumn 67, Issue 13, 2010, Pages 2215-2230

  Wozniak, Richard ^c   Burke, Brian ^a   Doye, Valérie ^b  

^a INSTITUTE OF MEDICAL BIOLOGY   (Singapore)

^b INSTITUT JACQUES MONOD   (France)

^c NONE

Author keywords

Checkpoint; Kinetochores; Mitosis; Nuclear pore complexes; Nucleoporin; Spindle; Transport

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); NUCLEOPORIN; CELL CYCLE PROTEIN;

CELL COMPARTMENTALIZATION; CELL NUCLEUS; CELL TRANSPORT; CENTROMERE; CHROMOSOME SEGREGATION; CYTOKINESIS; CYTOPLASM; MACROMOLECULE; MICROTUBULE ASSEMBLY; MITOSIS; MITOSIS SPINDLE; NONHUMAN; NUCLEAR PORE COMPLEX; PROTEIN LOCALIZATION; REVIEW; ACTIVE TRANSPORT; ANIMAL; HUMAN; METABOLISM; PHYSIOLOGY;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL CYCLE PROTEINS; CELL NUCLEUS; HUMANS; KINETOCHORES; MITOSIS; MITOTIC SPINDLE APPARATUS; NUCLEAR PORE COMPLEX PROTEINS;

EID: 77954043950     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-010-0325-7     Document Type: Review

References (114)

1. Tran EJ, Wente SR (2006) Dynamic nuclear pore complexes: life on the edge. Cell 125:1041-1053
2. D'Angelo MA, Hetzer MW (2008) Structure, dynamics and function of nuclear pore complexes. Trends Cell Biol 18:456-466
3. Antonin W, Ellenberg J, Dultz E (2008) Nuclear pore complex assembly through the cell cycle: regulation and membrane organization. FEBS Lett 582:2004-2016
4. Chan GK, Liu ST, Yen TJ (2005) Kinetochore structure and function. Trends Cell Biol 15:589-598
5. Maiato H, DeLuca J, Salmon ED, Earnshaw WC (2004) The dynamic kinetochore-microtubule interface. J Cell Sci 117:5461-5477
6. Santaguida S, Musacchio A (2009) The life and miracles of kinetochores. EMBO J 28:2511-2531
7. Musacchio A, Salmon ED (2007) The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 8:379-393
8. Ciciarello M, Mangiacasale R, Lavia P (2007) Spatial control of mitosis by the GTPase Ran. Cell Mol Life Sci 64:1891-1914
9. Kalab P, Heald R (2008) The RanGTP gradient-a GPS for the mitotic spindle. J Cell Sci 121:1577-1586
10. Li R, Murray AW (1991) Feedback control of mitosis in budding yeast. Cell 66:519-531
11. Hardwick KG, Murray AW (1995) Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast. J Cell Biol 131:709-720
12. Iouk T, Kerscher O, Scott RJ, Basrai MA, Wozniak RW (2002) The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint. J Cell Biol 159:807-819
13. Ikui AE, Furuya K, Yanagida M, Matsumoto T (2002) Control of localization of a spindle checkpoint protein, Mad2, in fission yeast. J Cell Sci 115:1603-1610
14. De Souza CP, Hashmi SB, Nayak T, Oakley B, Osmani SA (2009) Mlp1 acts as a mitotic scaffold to spatially regulate spindle assembly checkpoint proteins in Aspergillus nidulans. Mol Biol Cell 20:2146-2159
15. Scott RJ, Lusk CP, Dilworth DJ, Aitchison JD, Wozniak RW (2005) Interactions between Mad1p and the nuclear transport machinery in the yeast Saccharomyces cerevisiae. Mol Biol Cell 16:4362-4374
16. Quimby BB, Arnaoutov A, Dasso M (2005) Ran GTPase regulates Mad2 localization to the nuclear pore complex. Eukaryot Cell 4:274-280
17. Chen RH, Shevchenko A, Mann M, Murray AW (1998) Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores. J Cell Biol 143:283-295
18. Chen RH, Waters JC, Salmon ED, Murray AW (1996) Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. Science 274:242-246
19. Buffin E, Lefebvre C, Huang J, Gagou ME, Karess RE (2005) Recruitment of Mad2 to the kinetochore requires the Rod/Zw10 complex. Curr Biol 15:856-861
20. Campbell M, Chan G, Yen T (2001) Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase. J Cell Sci 114:953-963
21. Lee SH, Sterling H, Burlingame A, McCormick F (2008) Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint. Genes Dev 22:2926-2931
22. Katsani KR, Karess RE, Dostatni N, Doye V (2008) In vivo dynamics of Drosophila nuclear envelope components. Mol Biol Cell 19:3652-3666
23. Lince-Faria M, Maffini S, Orr B, Ding Y, Claudia F, Sunkel CE, Tavares A, Johansen J, Johansen KM, Maiato H (2009) Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator. J Cell Biol 184:647-657
24. Hawryluk-Gara LA, Shibuya EK, Wozniak RW (2005) Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. Mol Biol Cell 16:2382-2394
25. Johansen KM, Johansen J (2007) Cell and molecular biology of the spindle matrix. Int Rev Cytol 263:155-206
26. Byrd DA, Sweet DJ, Pante N, Konstantinov KN, Guan T, Saphire AC, Mitchell PJ, Cooper CS, Aebi U, Gerace L (1994) Tpr, a large coiled coil protein whose amino terminus is involved in activation of oncogenic kinases, is localized to the cytoplasmic surface of the nuclear pore complex. J Cell Biol 127:1515-1526
27. Tighe A, Staples O, Taylor S (2008) Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores. J Cell Biol 181:893-901
28. De Souza CP, Osmani AH, Hashmi SB, Osmani SA (2004) Partial nuclear pore complex disassembly during closed mitosis in Aspergillus nidulans. Curr Biol 14:1973-1984
29. Qi H, Rath U, Wang D, Xu YZ, Ding Y, Zhang W, Blacketer MJ, Paddy MR, Girton J, Johansen J, Johansen KM (2004) Megator, an essential coiled-coil protein that localizes to the putative spindle matrix during mitosis in Drosophila. Mol Biol Cell 15:4854-4865
30. Gillett ES, Espelin CW, Sorger PK (2004) Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast. J Cell Biol 164:535-546
31. Scott RJ, Cairo LV, Van de Vosse DW, Wozniak RW (2009) The nuclear export factor Xpo1p targets Mad1p to kinetochores in yeast. J Cell Biol 184:21-29
32. Makhnevych T, Lusk CP, Anderson AM, Aitchison JD, Wozniak RW (2003) Cell cycle regulated transport controlled by alterations in the nuclear pore complex. Cell 115:813-823
33. Pemberton LF, Paschal BM (2005) Mechanisms of receptormediated nuclear import and nuclear export. Traffic 6:187-198
34. Cole CN, Hammell CM (1998) Nucleocytoplasmic transport: driving and directing transport. Curr Biol 8:R368-R372
35. Fahrenkrog B, Aebi U (2003) The nuclear pore complex: nucleocytoplasmic transport and beyond. Nat Rev Mol Cell Biol 4:757-766
36. Delphin C, Guan T, Melchior F, Gerace L (1997) RanGTP targets p97 to RanBP2, a filamentous protein localized at the cytoplasmic periphery of the nuclear pore complex. Mol Biol Cell 8:2379-2390
37. Wu J, Matunis MJ, Kraemer D, Blobel G, Coutavas E (1995) Nup358, a cytoplasmically exposed nucleoporin with peptide repeats, Ran-GTP binding sites, zinc fingers, a cyclophilin A homologous domain, and a leucine-rich region. J Biol Chem 270:14209-14213
38. Bernad R, van der Velde H, Fornerod M, Pickersgill H (2004) Nup358/RanBP2 attaches to the nuclear pore complex via association with Nup88 and Nup214/CAN and plays a supporting role in CRM1-mediated nuclear protein export. Mol Cell Biol 24:2373-2384
39. Rexach M, Blobel G (1995) Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins. Cell 83:683-692
40. Matunis MJ, Coutavas E, Blobel G (1996) A novel ubiquitinlike modification modulates the partitioning of the Ran-GTPaseactivating protein RanGAP1 between the cytosol and the nuclear pore complex. J Cell Biol 135:1457-1470
41. Mahajan R, Delphin C, Guan TL (1997) A small ubiquitinrelated polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. Cell 88:97-107
42. Dasso M (2008) Emerging roles of the SUMO pathway in mitosis. Cell Div 3:5
43. Lee GW, Melchior F, Matunis MJ, Mahajan R, Tian Q, Anderson P (1998) Modification of Ran GTPase-activating protein by the small ubiquitin-related modifier SUMO-1 requires Ubc9, an E2-type ubiquitin-conjugating enzyme homologue. J Biol Chem 273:6503-6507
44. Palancade B, Doye V (2008) Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties? Trends Cell Biol 18:174-183
45. Pichler A, Gast A, Seeler JS, Dejean A, Melchior F (2002) The nucleoporin RanBP2 has SUMO1 E3 ligase activity. Cell 108:109-120
46. Zhang H, Saitoh H, Matunis MJ (2002) Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex. Mol Cell Biol 22:6498-6508
47. Swaminathan S, Kiendl F, Korner R, Lupetti R, Hengst L, Melchior F (2004) RanGAP.1.*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly. J Cell Biol 164:965-971
48. Joseph J, Tan SH, Karpova TS, McNally JG, Dasso M (2002) SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles. J Cell Biol 156:595-602
49. Salina D, Enarson P, Rattner JB, Burke B (2003) Nup358 integrates nuclear envelope breakdown with kinetochore assembly. J Cell Biol 162:991-1001
50. Askjaer P, Galy V, Hannak E, Mattaj IW (2002) Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos. Mol Biol Cell 13:4355-4370
51. Joseph J, Liu ST, Jablonski SA, Yen TJ, Dasso M (2004) The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo. Curr Biol 14:611-617
52. Arnaoutov A, Azuma Y, Ribbeck K, Joseph J, Boyarchuk Y, Karpova T, McNally J, Dasso M (2005) Crm1 is a mitotic effector of Ran-GTP in somatic cells. Nat Cell Biol 7:626-632
53. Zuccolo M, Alves A, Galy V, Bolhy S, Formstecher E, Racine V, Sibarita JB, Fukagawa T, Shiekhattar R, Yen T, Doye V (2007) The human Nup107-160 nuclear pore sub-complex contributes to proper kinetochore functions. EMBO J 26:1853-1864
54. Arnaoutov A, Dasso M (2005) Ran-GTP regulates kinetochore attachment in somatic cells. Cell Cycle 4:1161-1165
55. Dasso M (2006) Ran at kinetochores. Biochem Soc Trans 34:711-715
56. Lau CK, Delmar VA, Chan RC, Phung Q, Bernis C, Fichtman B, Rasala BA, Forbes DJ (2009) Transportin regulates major mitotic assembly events: from spindle to nuclear pore assembly. Mol Biol Cell 20:4043-4058
57. Walczak CE, Heald R (2008) Mechanisms of mitotic spindle assembly and function. Int Rev Cytol 265:111-158
58. Cai S, Weaver LN, Ems-McClung SC, Walczak CE (2009) Kinesin-14 family proteins HSET/XCTK2 control spindle length by cross-linking and sliding microtubules. Mol Biol Cell 20:1348-1359
59. Koffa MD, Casanova CM, Santarella R, Kocher T, Wilm M, Mattaj IW (2006) HURP is part of a Ran-dependent complex involved in spindle formation. Curr Biol 16:743-754
60. Ribbeck K, Groen AC, Santarella R, Bohnsack MT, Raemaekers T, Kocher T, Gentzel M, Gorlich D, Wilm M, Carmeliet G, Mitchison TJ, Ellenberg J, Hoenger A, Mattaj IW (2006) Nu-SAP, a mitotic RanGTP target that stabilizes and cross-links microtubules. Mol Biol Cell 17:2646-2660
61. Wong J, Fang G (2006) HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture. J Cell Biol 173:879-891
62. Kraemer D, Blobel G (1997) mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm. Proc Natl Acad Sci USA 94:9119-9124
63. Pritchard CE, Fornerod M, Kasper LH, van Deursen JM (1999) RAE1 is a shuttling mRNA export factor that binds to a GLEBSlike NUP98 motif at the nuclear pore complex through multiple domains. J Cell Biol 145:237-254
64. Kraemer D, Dresbach T, Drenckhahn D (2001) Mrnp41 (Rae 1p) associates with microtubules in HeLa cells and in neurons. Eur J Cell Biol 80:733-740
65. Blower MD, Nachury M, Heald R, Weis K (2005) A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly. Cell 121:223-234
66. Wong RW, Blobel G, Coutavas E (2006) Rae1 interaction with NuMA is required for bipolar spindle formation. Proc Natl Acad Sci USA 103:19783-19787
67. Jeganathan KB, Malureanu L, van Deursen JM (2005) The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation. Nature 438:1036-1039
68. Jeganathan KB, Baker DJ, van Deursen JM (2006) Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition. Cell Cycle 5:366-370
69. Kramer ER, Scheuringer N, Podtelejnikov AV, Mann M, Peters JM (2000) Mitotic regulation of the APC activator proteins CDC20 and CDH1. Mol Biol Cell 11:1555-1569
70. Hagting A, Den Elzen N, Vodermaier HC, Waizenegger IC, Peters JM, Pines J (2002) Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1. J Cell Biol 157:1125-1137
71. Torosantucci L, De Luca M, Guarguaglini G, Lavia P, Degrassi F (2008) Localized RanGTP accumulation promotes microtubule nucleation at kinetochores in somatic mammalian cells. Mol Biol Cell 19:1873-1882
72. Zhang XD, Goeres J, Zhang H, Yen TJ, Porter AC, Matunis MJ (2008) SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis. Mol Cell 29:729-741
73. Dawlaty MM, Malureanu L, Jeganathan KB, Kao E, Sustmann C, Tahk S, Shuai K, Grosschedl R, van Deursen JM (2008) Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha. Cell 133:103-115
74. Shamu CE, Murray AW (1992) Sister chromatid separation in frog egg extracts requires DNA topoisomerase II activity during anaphase. J Cell Biol 117:921-934
75. Ruchaud S, Carmena M, Earnshaw WC (2007) Chromosomal passengers: conducting cell division. Nat Rev Mol Cell Biol 8:798-812
76. Klein UR, Haindl M, Nigg EA, Muller S (2009) RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on borealin. Mol Biol Cell 20:410-418
77. Knauer SK, Bier C, Habtemichael N, Stauber RH (2006) The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function. EMBO Rep 7:1259-1265
78. Xia F, Canovas PM, Guadagno TM, Altieri DC (2008) A survivin-ran complex regulates spindle formation in tumor cells. Mol Cell Biol 28:5299-5311
79. Belgareh N, Rabut G, Bai SW, van Overbeek M, Beaudouin J, Daigle N, Zatsepina OV, Pasteau F, Labas V, Fromont-Racine M, Ellenberg J, Doye V (2001) An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. J Cell Biol 154:1147-1160
80. Vasu S, Shah S, Orjalo A, Park M, Fischer WH, Forbes DJ (2001) Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. J Cell Biol 155:339-354
81. Loiodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita JB, Doye V (2004) The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis. Mol Biol Cell 15:3333-3344
82. Liu HL, De Souza CP, Osmani AH, Osmani SA (2009) The three fungal transmembrane nuclear pore complex proteins of Aspergillus nidulans are dispensable in the presence of an intact An-Nup84-120 complex. Mol Biol Cell 20:616-630
83. Brohawn SG, Partridge JR, Whittle JR, Schwartz TU (2009) The nuclear pore complex has entered the atomic age. Structure 17:1156-1168
84. Rasala BA, Orjalo AV, Shen Z, Briggs S, Forbes DJ (2006) ELYS is a dual nucleoporin/kinetochore protein required for nuclear pore assembly and proper cell division. Proc Natl Acad Sci USA 103:17801-17806
85. Franz C, Walczak R, Yavuz S, Santarella R, Gentzel M, Askjaer P, Galy V, Hetzer M, Mattaj IW, Antonin W (2007) MEL-28/ ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly. EMBO Rep 8:165-172
86. Gillespie PJ, Khoudoli GA, Stewart G, Swedlow JR, Blow JJ (2007) ELYS/MEL-28 chromatin association coordinates nuclear pore complex assembly and replication licensing. Curr Biol 17:1657-1662
87. Gunsalus KC, Ge H, Schetter AJ, Goldberg DS, Han JD, Hao T, Berriz GF, Bertin N, Huang J, Chuang LS, Li N, Mani R, Hyman AA, Sonnichsen B, Echeverri CJ, Roth FP, Vidal M, Piano F (2005) Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis. Nature 436:861-865
88. Galy V, Askjaer P, Franz C, Lopez-Iglesias C, Mattaj IW (2006) MEL-28, a novel nuclear-envelope and kinetochore protein essential for zygotic nuclear-envelope assembly in C. elegans. Curr Biol 16:1748-1756
89. Fernandez AG, Piano F (2006) MEL-28 is downstream of the Ran cycle and is required for nuclear-envelope function and chromatin maintenance. Curr Biol 16:1757-1763
90. Rabut G, Doye V, Ellenberg J (2004) Mapping the dynamic organization of the nuclear pore complex inside single living cells. Nat Cell Biol 6:1114-1121
91. Doye V, Hurt E (1997) From nucleoporins to nuclear pore complexes. Curr Opin Cell Biol 9:401-411
92. Bai SW, Rouquette J, Umeda M, Faigle W, Loew D, Sazer S, Doye V (2004) The fission yeast Nup107-120 complex functionally interacts with the small GTPase Ran/Spi1 and is required for mRNA export, nuclear pore distribution, and proper cell division. Mol Cell Biol 24:6379-6392
93. Resendes KK, Rasala BA, Forbes DJ (2008) Centrin 2 localizes to the vertebrate nuclear pore and plays a role in mRNA and protein export. Mol Cell Biol 28:1755-1769
94. D'Angelo MA, Anderson DJ, Richard E, Hetzer MW (2006) Nuclear pores form de novo from both sides of the nuclear envelope. Science 312:440-443
95. Orjalo AV, Arnaoutov A, Shen Z, Boyarchuk Y, Zeitlin SG, Fontoura B, Briggs S, Dasso M, Forbes DJ (2006) The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly. Mol Biol Cell 17:3806-3818
96. Chakraborty P, Wang Y, Wei JH, van Deursen J, Yu H, Malureanu L, Dasso M, Forbes DJ, Levy DE, Seemann J, Fontoura BM (2008) Nucleoporin levels regulate cell cycle progression and phase-specific gene expression. Dev Cell 15:657-667
97. Kutay U, Hetzer MW (2008) Reorganization of the nuclear envelope during open mitosis. Curr Opin Cell Biol 20:669-677
98. Walther TC, Alves A, Pickersgill H, Loiodice I, Hetzer M, Galy V, Hulsmann BB, Kocher T, Wilm M, Allen T, Mattaj IW, Doye V (2003) The conserved Nup107-160 complex is critical for nuclear pore complex assembly. Cell 113:195-206
99. Harel A, Orjalo AV, Vincent T, Lachish-Zalait A, Vasu S, Shah S, Zimmerman E, Elbaum M, Forbes DJ (2003) Removal of a single pore subcomplex results in vertebrate nuclei devoid of nuclear pores. Mol Cell 11:853-864
100. Rasala BA, Ramos C, Harel A, Forbes DJ (2008) Capture of AT-rich chromatin by ELYS recruits POM121 and NDC1 to initiate nuclear pore assembly. Mol Biol Cell 19:3982-3996
101. Walther TC, Askjaer P, Gentzel M, Habermann A, Griffiths G, Wilm M, Mattaj IW, Hetzer M (2003) RanGTP mediates nuclear pore complex assembly. Nature 424:689-694
102. Rotem A, Gruber R, Shorer H, Shaulov L, Klein E, Harel A (2009) Importin beta regulates the seeding of chromatin with initiation sites for nuclear pore assembly. Mol Biol Cell 20:4031-4042
103. Davuluri G, Gong W, Yusuff S, Lorent K, Muthumani M, Dolan AC, Pack M (2008) Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress. PLoS Genet 4:e1000240
104. Osmani AH, Davies J, Liu HL, Nile A, Osmani SA (2006) Systematic deletion and mitotic localization of the nuclear pore complex proteins of Aspergillus nidulans. Mol Biol Cell 17:4946-4961
105. Theisen U, Straube A, Steinberg G (2008) Dynamic rearrangement of nucleoporins during fungal "open" mitosis. Mol Biol Cell 19:1230-1240
106. Feng J, Huang H, Yen TJ (2006) CENP-F is a novel microtubule-binding protein that is essential for kinetochore attachments and affects the duration of the mitotic checkpoint delay. Chromosoma 115:320-329
107. Platani M, Santarella-Mellwig R, Posch M, Walczak R, Swedlow JR, Mattaj IW (2009) The Nup107-160 nucleoporin complex promotes mitotic events via control of the localization state of the chromosome passenger complex. Mol Biol Cell 20:5260-5275
108. Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H (2004) The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell 118:187-202
109. Mackay DR, Elgort SW, Ullman KS (2009) The nucleoporin Nup153 has separable roles in both early mitotic progression and the resolution of mitosis. Mol Biol Cell 20:1652-1660
110. Sabri N, Roth P, Xylourgidis N, Sadeghifar F, Adler J, Samakovlis C (2007) Distinct functions of the Drosophila Nup153 and Nup214 FG domains in nuclear protein transport. J Cell Biol 178:557-565
111. Hase ME, Cordes VC (2003) Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex. Mol Biol Cell 14:1923-1940
112. Hang J, Dasso M (2002) Association of the human SUMO-1 protease SENP2 with the nuclear pore. J Biol Chem 277:19961-19966
113. Glavy JS, Krutchinsky AN, Cristea IM, Berke IC, Boehmer T, Blobel G, Chait BT (2007) Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex. Proc Natl Acad Sci USA 104:3811-3816
114. Mishra RK, Chakraborty P, Arnauoutov A, Fontoura BMA, Dasso M (2010) The Nup107-160 complex and γ-TuRC regulate microtubule polymerization at kinetochores. Nat Cell Biol 12:164-169