-
1
-
-
4043181214
-
Cancer genes and the pathways they control
-
Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004;10:789-99.
-
(2004)
Nat Med
, vol.10
, pp. 789-799
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
2
-
-
9244222261
-
Targeted cancer therapy
-
Sawyers C. Targeted cancer therapy. Nature 2004;432:294-7.
-
(2004)
Nature
, vol.432
, pp. 294-297
-
-
Sawyers, C.1
-
3
-
-
33751106653
-
New approaches to molecular cancer therapeutics
-
Collins I, Workman P. New approaches to molecular cancer therapeutics. Nat Chem Biol 2006;2:689-700.
-
(2006)
Nat Chem Biol
, vol.2
, pp. 689-700
-
-
Collins, I.1
Workman, P.2
-
4
-
-
33746961739
-
Mechanisms of disease: Oncogene addiction - a rationale for molecular targeting in cancer therapy
-
Weinstein IB, Joe AK. Mechanisms of disease: oncogene addiction - a rationale for molecular targeting in cancer therapy. Nat Clin Pract Oncol 2006;3:448-57.
-
(2006)
Nat Clin Pract Oncol
, vol.3
, pp. 448-457
-
-
Weinstein, I.B.1
Joe, A.K.2
-
6
-
-
0035754080
-
To cycle or not to cycle: A critical decision in cancer
-
Malumbres M, Barbacid M. To cycle or not to cycle: a critical decision in cancer. Nat Rev Cancer 2001;1:222-31.
-
(2001)
Nat Rev Cancer
, vol.1
, pp. 222-231
-
-
Malumbres, M.1
Barbacid, M.2
-
7
-
-
4143066950
-
Mitotic spindle assembly and chromosome segregation: Refocusing on microtubule dynamics
-
Kline-Smith SL, Walczak CE. Mitotic spindle assembly and chromosome segregation: refocusing on microtubule dynamics. Mol Cell 2004;15:317-27.
-
(2004)
Mol Cell
, vol.15
, pp. 317-327
-
-
Kline-Smith, S.L.1
Walczak, C.E.2
-
8
-
-
0035146128
-
The spindle: A dynamic assembly of microtubules and motors
-
Wittmann T, Hyman A, Desai A. The spindle: a dynamic assembly of microtubules and motors. Nat Cell Biol 2001;3:E28-34.
-
(2001)
Nat Cell Biol
, vol.3
-
-
Wittmann, T.1
Hyman, A.2
Desai, A.3
-
9
-
-
0038699131
-
The small GTPase Ran: Interpreting the signs
-
Quimby BB, Dasso M. The small GTPase Ran: interpreting the signs. Curr Opin Cell Biol 2003;15:338-44.
-
(2003)
Curr Opin Cell Biol
, vol.15
, pp. 338-344
-
-
Quimby, B.B.1
Dasso, M.2
-
10
-
-
0035090344
-
Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly
-
Carazo-Salas RE, Gruss OJ, Mattaj IW, Karsenti E. Ran-GTP coordinates regulation of microtubule nucleation and dynamics during mitotic-spindle assembly. Nat Cell Biol 2001;3:228-34.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 228-234
-
-
Carazo-Salas, R.E.1
Gruss, O.J.2
Mattaj, I.W.3
Karsenti, E.4
-
11
-
-
0036849137
-
Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells
-
Gruss OJ, Wittmann M, Yokoyama H, et al. Chromosome-induced microtubule assembly mediated by TPX2 is required for spindle formation in HeLa cells. Nat Cell Biol 2002;4:871-9.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 871-879
-
-
Gruss, O.J.1
Wittmann, M.2
Yokoyama, H.3
-
12
-
-
4644233153
-
The mechanism of spindle assembly: Functions of Ran and its target TPX2
-
Gruss OJ, Vernos I. The mechanism of spindle assembly: functions of Ran and its target TPX2. J Cell Biol 2004;166:949-55.
-
(2004)
J Cell Biol
, vol.166
, pp. 949-955
-
-
Gruss, O.J.1
Vernos, I.2
-
13
-
-
8644262258
-
Importin h: Conducting a much larger cellular symphony
-
Harel A, Forbes DJ. Importin h: conducting a much larger cellular symphony. Mol Cell 2004;16:319-30.
-
(2004)
Mol Cell
, vol.16
, pp. 319-330
-
-
Harel, A.1
Forbes, D.J.2
-
14
-
-
33646024346
-
HURP is part of a Ran-dependent complex involved in spindle formation
-
Koffa MD, Casanova CM, Santarella R, et al. HURP is part of a Ran-dependent complex involved in spindle formation. Curr Biol 2006;16:743-54.
-
(2006)
Curr Biol
, vol.16
, pp. 743-754
-
-
Koffa, M.D.1
Casanova, C.M.2
Santarella, R.3
-
15
-
-
33646061361
-
HURP is a Ran-importin β-regulated protein that stabilizes kinetochore microtubules in the vicinity of chromosomes
-
Sillje HH, Nagel S, Korner R, Nigg EA. HURP is a Ran-importin β-regulated protein that stabilizes kinetochore microtubules in the vicinity of chromosomes. Curr Biol 2006;16:731-42.
-
(2006)
Curr Biol
, vol.16
, pp. 731-742
-
-
Sillje, H.H.1
Nagel, S.2
Korner, R.3
Nigg, E.A.4
-
16
-
-
0037341906
-
A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly
-
Tsai MY, Wiese C, Cao K, et al. A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly. Nat Cell Biol 2003;5:242-8.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 242-248
-
-
Tsai, M.Y.1
Wiese, C.2
Cao, K.3
-
17
-
-
34249285532
-
Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen
-
Morgan-Lappe SE, Tucker LA, Huang X, et al. Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen. Cancer Res 2007;67:4390-8.
-
(2007)
Cancer Res
, vol.67
, pp. 4390-4398
-
-
Morgan-Lappe, S.E.1
Tucker, L.A.2
Huang, X.3
-
18
-
-
34250892539
-
Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection
-
Dohi T, Xia F, Altieri DC. Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection. Mol Cell 2007;27:17-28.
-
(2007)
Mol Cell
, vol.27
, pp. 17-28
-
-
Dohi, T.1
Xia, F.2
Altieri, D.C.3
-
19
-
-
1642377561
-
ONCOMINE: A cancer microarray database and integrated data-mining platform
-
Rhodes DR, Yu J, Shanker K, et al. ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia 2004;6:1-6.
-
(2004)
Neoplasia
, vol.6
, pp. 1-6
-
-
Rhodes, D.R.1
Yu, J.2
Shanker, K.3
-
20
-
-
33745037941
-
Deciphering cellular states of innate tumor drug responses
-
Graudens E, Boulanger V, Mollard C, et al. Deciphering cellular states of innate tumor drug responses. Genome Biol 2006;7:R19.
-
(2006)
Genome Biol
, vol.7
-
-
Graudens, E.1
Boulanger, V.2
Mollard, C.3
-
21
-
-
0035300437
-
Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays
-
Notterman DA, Alon U, Sierk AJ, Levine AJ. Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays. Cancer Res 2001;61:3124-30.
-
(2001)
Cancer Res
, vol.61
, pp. 3124-3130
-
-
Notterman, D.A.1
Alon, U.2
Sierk, A.J.3
Levine, A.J.4
-
22
-
-
0033536012
-
Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays
-
Alon U, Barkai N, Notterman DA, et al. Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays. Proc Natl Acad Sci U S A 1999;96:6745-50.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 6745-6750
-
-
Alon, U.1
Barkai, N.2
Notterman, D.A.3
-
23
-
-
33845884027
-
Integrative molecular concept modeling of prostate cancer progression
-
Tomlins SA, Mehra R, Rhodes DR, et al. Integrative molecular concept modeling of prostate cancer progression. Nat Genet 2007;39:41-51.
-
(2007)
Nat Genet
, vol.39
, pp. 41-51
-
-
Tomlins, S.A.1
Mehra, R.2
Rhodes, D.R.3
-
24
-
-
0035184764
-
Identification and classification of differentially expressed genes in renal cell carcinoma by expression profiling on a global human 31,500-element cDNA array
-
Boer JM, Huber WK, Sultmann H, et al. Identification and classification of differentially expressed genes in renal cell carcinoma by expression profiling on a global human 31,500-element cDNA array. Genome Res 2001; 11:1861-70.
-
(2001)
Genome Res
, vol.11
, pp. 1861-1870
-
-
Boer, J.M.1
Huber, W.K.2
Sultmann, H.3
-
25
-
-
2542565666
-
Gene expression in the urinary bladder: A common carcinoma in situ gene expression signature exists disregarding histopathological classification
-
Dyrskjot L, Kruhoffer M, Thykjaer T, et al. Gene expression in the urinary bladder: a common carcinoma in situ gene expression signature exists disregarding histopathological classification. Cancer Res 2004;64:4040-8.
-
(2004)
Cancer Res
, vol.64
, pp. 4040-4048
-
-
Dyrskjot, L.1
Kruhoffer, M.2
Thykjaer, T.3
-
26
-
-
32044453343
-
X chromosomal abnormalities in basal-like human breast cancer
-
Richardson AL, Wang ZC, De Nicolo A, et al. X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell 2006;9:121-32.
-
(2006)
Cancer Cell
, vol.9
, pp. 121-132
-
-
Richardson, A.L.1
Wang, Z.C.2
De Nicolo, A.3
-
27
-
-
0035923521
-
Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses
-
Bhattacharjee A, Richards WG, Staunton J, et al. Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci U S A 2001;98:13790-5.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 13790-13795
-
-
Bhattacharjee, A.1
Richards, W.G.2
Staunton, J.3
-
28
-
-
28444448000
-
Interactome-transcriptome analysis reveals the high centrality of genes differentially expressed in lung cancer tissues
-
Wachi S, Yoneda K, Wu R. Interactome-transcriptome analysis reveals the high centrality of genes differentially expressed in lung cancer tissues. Bioinformatics 2005;21:4205-8.
-
(2005)
Bioinformatics
, vol.21
, pp. 4205-4208
-
-
Wachi, S.1
Yoneda, K.2
Wu, R.3
-
29
-
-
28244499333
-
Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model
-
Stearman RS, Dwyer-Nield L, Zerbe L, et al. Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model. Am J Pathol 2005;167:1763-75.
-
(2005)
Am J Pathol
, vol.167
, pp. 1763-1775
-
-
Stearman, R.S.1
Dwyer-Nield, L.2
Zerbe, L.3
-
30
-
-
33845971510
-
Nuclear export is essential for the tumor-promoting activity of survivin
-
Knauer SK, Kramer OH, Knosel T, et al. Nuclear export is essential for the tumor-promoting activity of survivin. FASEB J 2007;21:207-16.
-
(2007)
FASEB J
, vol.21
, pp. 207-216
-
-
Knauer, S.K.1
Kramer, O.H.2
Knosel, T.3
-
31
-
-
33750611276
-
The case for survivin as a regulator of microtubule dynamics and cell-death decisions
-
Altieri DC. The case for survivin as a regulator of microtubule dynamics and cell-death decisions. Curr Opin Cell Biol 2006;18:609-15.
-
(2006)
Curr Opin Cell Biol
, vol.18
, pp. 609-615
-
-
Altieri, D.C.1
-
32
-
-
18044391525
-
Aurora kinases, aneuploidy and cancer, a coincidence or a real link?
-
Giet R, Petretti C, Prigent C. Aurora kinases, aneuploidy and cancer, a coincidence or a real link? Trends Cell Biol 2005;15:241-50.
-
(2005)
Trends Cell Biol
, vol.15
, pp. 241-250
-
-
Giet, R.1
Petretti, C.2
Prigent, C.3
-
33
-
-
33750434275
-
The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly
-
Joukov V, Groen AC, Prokhorova T, et al. The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly. Cell 2006;127:539-52.
-
(2006)
Cell
, vol.127
, pp. 539-552
-
-
Joukov, V.1
Groen, A.C.2
Prokhorova, T.3
-
34
-
-
30344479175
-
Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis
-
Landis MW, Pawlyk BS, Li T, Sicinski P, Hinds PW. Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. Cancer Cell 2006;9:13-22.
-
(2006)
Cancer Cell
, vol.9
, pp. 13-22
-
-
Landis, M.W.1
Pawlyk, B.S.2
Li, T.3
Sicinski, P.4
Hinds, P.W.5
-
35
-
-
33644767315
-
Normal cells, but not cancer cells, survive severe Plk1 depletion
-
Liu X, Lei M, Erikson RL. Normal cells, but not cancer cells, survive severe Plk1 depletion. Mol Cell Biol 2006;26:2093-108.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 2093-2108
-
-
Liu, X.1
Lei, M.2
Erikson, R.L.3
-
36
-
-
2342639645
-
VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo
-
Harrington EA, Bebbington D, Moore J, et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat Med 2004;10:262-7.
-
(2004)
Nat Med
, vol.10
, pp. 262-267
-
-
Harrington, E.A.1
Bebbington, D.2
Moore, J.3
-
37
-
-
21444449874
-
Inhibitors of kinesin motor proteins-research and clinical progress
-
Duhl DM, Renhowe PA. Inhibitors of kinesin motor proteins-research and clinical progress. Curr Opin Drug Discov Devel 2005;8:431-6.
-
(2005)
Curr Opin Drug Discov Devel
, vol.8
, pp. 431-436
-
-
Duhl, D.M.1
Renhowe, P.A.2
-
38
-
-
0036306726
-
The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly
-
Hetzer M, Gruss OJ, Mattaj IW. The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly. Nat Cell Biol 2002;4:E177-84.
-
(2002)
Nat Cell Biol
, vol.4
-
-
Hetzer, M.1
Gruss, O.J.2
Mattaj, I.W.3
-
39
-
-
0038686567
-
The Ran GTPase regulates kinetochore function
-
Arnaoutov A, Dasso M. The Ran GTPase regulates kinetochore function. Dev Cell 2003;5:99-111.
-
(2003)
Dev Cell
, vol.5
, pp. 99-111
-
-
Arnaoutov, A.1
Dasso, M.2
-
40
-
-
20444423786
-
Crm1 is a mitotic effector of Ran-GTP in somatic cells
-
Arnaoutov A, Azuma Y, Ribbeck K, et al. Crm1 is a mitotic effector of Ran-GTP in somatic cells. Nat Cell Biol 2005;7:626-32.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 626-632
-
-
Arnaoutov, A.1
Azuma, Y.2
Ribbeck, K.3
-
41
-
-
33748286796
-
A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers
-
Carter SL, Eklund AC, Kohane IS, Harris LN, Szallasi Z. A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers. Nat Genet 2006;38:1043-8.
-
(2006)
Nat Genet
, vol.38
, pp. 1043-1048
-
-
Carter, S.L.1
Eklund, A.C.2
Kohane, I.S.3
Harris, L.N.4
Szallasi, Z.5
-
42
-
-
33745451273
-
Tissue array analysis of expression microarray candidates identifies markers associated with tumor grade and outcome in serous epithelial ovarian cancer
-
Ouellet V, Guyot MC, Le Page C, et al. Tissue array analysis of expression microarray candidates identifies markers associated with tumor grade and outcome in serous epithelial ovarian cancer. Int J Cancer 2006;119:599-607.
-
(2006)
Int J Cancer
, vol.119
, pp. 599-607
-
-
Ouellet, V.1
Guyot, M.C.2
Le Page, C.3
-
43
-
-
27944439305
-
Gene expression profiling in the mammary gland of rats treated with 7,12-dimethylbenz[a] anthracene
-
Papaconstantinou AD, Shanmugam I, Shan L, et al. Gene expression profiling in the mammary gland of rats treated with 7,12-dimethylbenz[a] anthracene. Int J Cancer 2006;118:17-24.
-
(2006)
Int J Cancer
, vol.118
, pp. 17-24
-
-
Papaconstantinou, A.D.1
Shanmugam, I.2
Shan, L.3
|