The Ran-GTPase and cell-cycle control

BioEssays

Volumn 23, Issue 1, 2001, Pages 77-85

  Moore, Jonathan D ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; DNA BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; NUCLEAR PROTEIN; RAN PROTEIN; RCC1 PROTEIN, HUMAN;

ANIMAL; ARTICLE; CELL CYCLE; CELL NUCLEUS; CYTOPLASM; DNA REPLICATION; HUMAN; METABOLISM; MICROTUBULE; MITOSIS; MITOSIS SPINDLE; PHYSIOLOGY; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; CELL CYCLE; CELL CYCLE PROTEINS; CELL NUCLEUS; CYTOPLASM; DNA REPLICATION; DNA-BINDING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; NUCLEAR PROTEINS; RAN GTP-BINDING PROTEIN;

MAMMALIA; SACCHAROMYCETALES; VERTEBRATA;

EID: 0035139121     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-1878(200101)23:1<77::AID-BIES1010>3.0.CO;2-E     Document Type: Article

References (80)

1. Premature chromosome condensation in a ts DNA-mutant of BHK cells
2. Isolation and characterisation of the active cDNA of the human cell Cycle gene (RCC1) involved in the regulation of onset of chromosome condensation
3. The RCC1 protein, a regulator of the onset of chromosome condensation localizes to the nucleus and binds to DNA
4. Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis
5. Mitotic regulator protein RCC1 is complexes with a nuclear ras-related protein
6. Characterisation of four novel RAS-related genes expressed in a human teratocarcinoma cell line
7. Catalysis of guanine nucleotide exchange of Ran by the mitotic regulator RCC1
8. Effects of mutant Ran/TC4 proteins on cell cycle progression
9. Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase
10. RCC1 in the cell cycle: The regulator of chromosome condensation takes on new roles
11. Nuclear protein import in permeablized mamalian cells requires soluble cytoplasmic factors
12. The GTP-binding protein Ran/TC4 is required for protein import into the nucleus
13. The small nuclear GTPase Ran: How much does it run
14. The role of the RanGTPase pathway in cell cycle control and interphase nuclear functions
15. The search for the primary function of the RanGTPase continues
16. Transport between the cell nucleus and the cytoplasm
17. Transport of proteins and RNAs in and out of the nucleus
18. Protein import into nuclei: Association and dissociation reactions involving transport substrate, transport factors and nucleoporins
19. CRM1 is an export receptor for leucine-rich nuclear export signals
20. The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus
21. RNA1p, a Ran/TC4 GTPase activating protein, is required for nuclear import
22. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex
23. Coactivation of RanGTPase and inhibition of GTP dissociation by by RanGTP binding protein RanBP1
24. Mutants in a yeast Ran binding protein are defective in nuclear transport
25. A giant nucleopore protein that binds Ran/TC4
26. The nuclear pore complex: Mediator of translocation between nucleus and cytoplasm
27. The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus
28. NTF2 mediates nuclear import of Ran
29. Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts
30. No longer an also Ran
31. Spindles get the Ran around
32. Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation
33. Stimulation of microtubule aster formation and spindle assembly by the small GTPase Ran
34. When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin
35. Beyond nuclear transport. Ran-GTP as a determinant of spindle assembly
36. Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts
37. Chromatin-independent nuclear envelope assembly induced by Ran GTPase in Xenopus egg extracts
38. GTP hydrolysis by Ran is required for nuclear envelope assembly
39. Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts
40. Early events in DNA replication require cyclin E and are blocked by p21CIP1
41. Cyclin/Cdk-dependent initiation of DNA replication in a human cell-free system
42. Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo
43. Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication
44. Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization
45. Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6
46. G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus
47. CIb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7
48. Emerging mechanisms of eukaryotic DNA replication initiation
49. A fission yeast RCC1-related protein is required for the mitosis to interphase transition
50. Premature chromatin condensation induced by loss of RCC1 is inhibited by GTP-Ran and GTP?S-Ran, but not GDP-Ran
51. Four-dimensional control of the cell cycle
52. Regulation of nuclear localization: A key to a door
53. Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control
54. Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport
55. Cytoplasmic localization of human cdc25C during interphase requires an intact 14-3-3 binding site
56. Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase
57. Nuclear import of Cdk/cyclin complexes: Identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1
58. Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1
59. Binding of 14-3-3 proteins and nuclear export control the intracellular localization of the mitotic inducer Cdc25
60. Maintenance of G2 arrest in the Xenopus oocyte: A role for 14-3-3-mediated inhibition of Cdc25 nuclear import
61. Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal
62. Chromosome condensation caused by loss of RCC1 function requires the cdc25C protein that is located in the cytoplasm
63. Nuclear localization of cyclin B1 controls mitotic entry after DNA damage
64. Nuclear export of cyclin B1 and its possible role in the DNA damaged-induced G2 checkpoint
65. A dual-specificity phosphatase Cdc25B is an unstable protein and triggers p34(cdc2)/cyclin B activation in hamster BHK21 cells arrested with hydroxyurea
66. Cdc25B and Cdc25C differ markedly in their properties as initiators of mitosis
67. Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression
68. Regulation of Cdc2/cyclin B activation by Ran, a ras-related GTPase
69. Cyclin activation of p34cdc2
70. A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation
71. NuMA is required for the normal completion of mitosis
72. Premature mitosis induced in mammalian cells by the protein kinase inhibitors 2-aminopurine and 6-dimethylaminopurine
73. Laser microirradiation of kinetochores in mitotic PtK2 cells: Chromatid separation and micronucleus formation
74. Formation of spindle poles by dynein/dynactin-dependent transport of NuMA
75. The yeast SRM1 protein and human RCC1 protein share analogous functions
76. Ran-binding protein-I is an essential component of the Ran/RCC1 molecular switch system in budding yeast
77. Deregulated expression of the RanBP1 gene alters cell cycle progression in murine fibroblasts
78. The Ran GTPase regulates mitotic spindle assembly
79. A mutation in the RCC1-related protein Pim1 results in nuclear envelope fragmentation in fission yeast
80. The balance of RanBP1 and RCC1 is critical for nuclear assembly and nuclear transport