Nucleocytoplasmic transport: Navigating the channel

Traffic

Volumn 4, Issue 3, 2003, Pages 127-135

  Bednenko, Janna ^a   Cingolani, Gino ^a   Gerace, Larry ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Exportin; Importin; NPC; Nucleocytoplasmic transport; Nucleoporin; Ran

Indexed keywords

GLYCINE; NUCLEOCYTOPLASMIC TRANSPORT PROTEIN; NUCLEOPORIN; PHENYLALANINE; RECEPTOR PROTEIN;

CELL STRUCTURE; CELL TRANSPORT; DIFFUSION; HUMAN; MOLECULAR MECHANICS; NONHUMAN; NUCLEAR PORE COMPLEX; NUCLEOCYTOPLASMIC TRANSPORT; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN MOTIF; REVIEW; STRUCTURE ANALYSIS;

EID: 0038701027     PISSN: 13989219     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0854.2003.00109.x     Document Type: Review

References (61)

1. Mattaj IW, Englmeier L. Nucleocytoplasmic transport: the soluble phase. Annu Rev Biochem 1998;67:265-306.
2. Görlich D, Kutay U. Transport between the cell nucleus and the cytoplasm. Annu Rev Cell Dev Biol 1999;15:607-660.
3. Macara IG. Transport into and out of the nucleus. Microbiol Mol Biol Rev 2001;65:570-594.
4. Nakielny S, Dreyfuss G. Transport of proteins and RNAs in and out of the nucleus. Cell 1999;99:677-690.
5. Arts GJ, Fornerod M, Mattaj IW. Identification of a nuclear export receptor for tRNA. Curr Biol 1998;8:305-314.
6. Kutay U, Lipowsky G, Izaurralde E, Bischoff FR, Schwarzmaier P, Hartmann E, Görlich D. Identification of a tRNA-specific nuclear export receptor. Mol Cell 1998;1:359-369.
7. Bohnsack MT, Regener K, Schwappach B, Saffrich R, Paraskeva E, Hartmann E, Görlich D. Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. EMBO J 2002;21:6205-6215.
8. Calado A, Treichel N, Muller EC, Otto A, Kutay U. Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA. EMBO J 2002;21:6216-6224.
9. Görlich D, Dabrowski M, Bischoff FR, Kutay U, Bork P, Hartmann E, Prehn S, Izaurralde E. A novel class of RanGTP binding proteins. J Cell Biol 1997;138:65-80.
10. Fornerod M, Ohno M, Yoshida M, Mattaj IW. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 1997;90:1051-1060.
11. Ohno M, Fornerod M, Mattaj IW. Nucleocytoplasmic transport: the last 200 nanometers. Cell 1998;92:327-336.
12. Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P, Izaurralde E. NXF1 (TAP) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. Mol Cell Biol 2000;20:8996-9008.
13. Stewart M, Baker RP, Bayliss R, Clayton L, Grant RP, Littlewood T, Matsuura Y. Molecular mechanism of translocation through nuclear pore complexes during nuclear protein import. FEBS Lett 2001;498:145-149.
14. Chook YM, Blobel G. Karyopherins and nuclear import. Curr Opin Struct Biol 2001;11:703-715.
15. Görlich D, Pante N, Kutay U, Aebi U, Bischoff FR. Identification of different roles for RanGDP and RanGTP in nuclear protein import. EMBO J 1996;15:5584-5594.
16. Kalab P, Weis K, Heald R. Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts. Science 2002;295:2452-2456.
17. Stoffler D, Fahrenkrog B, Aebi U. The nuclear pore complex: from molecular architecture to functional dynamics. Curr Opin Cell Biol 1999;11:391-401.
18. Vasu SK, Forbes DJ. Nuclear pores and nuclear assembly. Curr Opin Cell Biol 2001;13:363-375.
19. Reichelt R, Holzenburg A, Buhle EL Jr,, Jarnik M, Engel A, Aebi U. Correlation between structure and mass distribution of the nuclear pore complex and of distinct pore complex components. J Cell Biol 1990;110:883-894.
20. Cronshaw JM, Krutchinsky AN, Zhang W, Chait BT, Matunis MJ. Proteomic analysis of the mammalian nuclear pore complex. J Cell Biol 2002;158:915-927.
21. Rout MP, Aitchison JD, Suprapto A, Hjertaas K, Zhao Y, Chait BT. The yeast nuclear pore complex. composition, architecture, and transport mechanism. J Cell Biol 2000;148:635-651.
22. Rout MP, Blobel G. Isolation of the yeast nuclear pore complex. J Cell Biol 1993;123:771-783.
23. Yang Q, Rout MP, Akey CW. Three-dimensional architecture of the isolated yeast nuclear pore complex: functional and evolutionary implications. Mol Cell 1998;1:223-234.
24. Griffis ER, Altan N, Lippincott-Schwartz J, Powers MA. Nup98 is a mobile nucleoporin with transcription-dependent dynamics. Mol Biol Cell 2002;13:1282-1297.
25. Frosst P, Guan T, Subauste C, Hahn K, Gerace L. Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export. J Cell Biol 2002;156:617-630.
26. Daigle N, Beaudouin J, Hartnell L, Imreh G, Hallberg E, Lippincott-Schwartz J, Ellenberg J. Nuclear pore complexes form immobile networks and have a very low turnover in live mammalian cells. J Cell Biol 2001;154:71-84.
27. Zolotukhin AS, Felber BK. Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev. J Virol 1999;73:120-127.
28. Lindsay ME, Plafker K, Smith AE, Clurman BE, Macara IG. Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha: beta-mediated nuclear protein import. Cell 2002;110:349-360.
29. Bayliss R, Kent HM, Corbett AH, Stewart M. Crystallization and initial X-ray diffraction characterization of complexes of FxFG nucleoporin repeats with nuclear transport factors. J Struct Biol 2000;131:240-247.
30. Denning DP, Uversky V, Patel SS, Fink AL, Rexach M. The Saccharomyces cerevisiae nucleoporin Nup2p is a natively unfolded protein. J Biol Chem 2002;277:33447-33455.
31. Hart GW. Dynamic O-linked glycosylation of nuclear and cytoskeletal proteins. Annu Rev Biochem 1997;66:315-335.
32. Hanover JA. The nuclear pore: at the crossroads. FASEB J 1992;6:2288-2295.
33. Jentoft N. Why are proteins O-glycosylated? Trends Biochem Sci 1990;15:291-294.
34. Bayliss R, Littlewood T, Stewart M. Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking. Cell 2000;102:99-108.
35. Bayliss R, Littlewood T, Strawn LA, Wente SR, Stewart M. GLFG and FxFG nucleoporins bind to overlapping sites on importin-beta. J Biol Chem 2002;277:50597-50606.
36. Bayliss R, Leung SW, Baker RP, Quimby BB, Corbett AH, Stewart M. Structural basis for the interaction between NTF2 and nucleoporin FxFG repeats. EMBO J 2002;21:2843-2853.
37. Fribourg S, Braun IC, Izaurralde E, Conti E. Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor. Mol Cell 2001;8:645-656.
38. Grant RP, Hurt E, Neuhaus D, Stewart M. Structure of the C-terminal FG-nucleoporin binding domain of Tap/NXF1. Nat Struct Biol 2002;9:247-251.
39. Ribbeck K, Görlich D. Kinetic analysis of translocation through nuclear pore complexes. EMBO J 2001;20:1320-1330.
40. Feldherr CM, Akin D. The location of the transport gate in the nuclear pore complex. J Cell Sci 1997;110:3065-3070.
41. Walther TC, Pickersgill HS, Cordes VC, Goldberg MW, Allen TD, Mattaj IW, Fornerod M. The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import. J Cell Biol 2002;158:63-77.
42. Schwoebel ED, Talcott B, Cushman I, Moore MS. Ran-dependent signal-mediated nuclear import does not require GTP hydrolysis by Ran. J Biol Chem 1998;273:35170-35175.
43. Englmeier L, Olivo JC, Mattaj IW. Receptor-mediated substrate translocation through the nuclear pore complex without nucleotide triphosphate hydrolysis. Curr Biol 1999;9:30-41.
44. Ribbeck K, Kutay U, Paraskeva E, Görlich D. The translocation of transportin-cargo complexes through nuclear pores is independent of both Ran and energy. Curr Biol 1999;9:47-50.
45. Schwoebel ED, Ho TH, Moore MS. The mechanism of inhibition of Ran-dependent nuclear transport by cellular ATP depletion. J Cell Biol 2002;157:963-974.
46. Lyman SK, Guan T, Bednenko J, Wodrich H, Gerace L. Influence of cargo size on Ran and energy requirements for nuclear protein import. J Cell Biol 2002;159:55-67.
47. Huber J, Dickmanns A, Luhrmann R. The importin-beta binding domain of snurportin1 is responsible for the Ran- and energy-independent nuclear import of spliceosomal U snRNPs in vitro. J Cell Biol 2002;156:467-479.
48. Ribbeck K, Görlich D. The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusion. EMBO J 2002;21:2664-2671.
49. Delphin C, Guan T, Melchior F, Gerace L. RanGTP targets p97 to RanBP2, a filamentous protein localized at the cytoplasmic periphery of the nuclear pore complex. Mol Biol Cell 1997;8:2379-2390.
50. Shah S, Tugendreich S, Forbes D. Major binding sites for the nuclear import receptor are the internal nucleoporin Nup153 and the adjacent nuclear filament protein Tpr. J Cell Biol 1998;141:31-49.
51. Ben-Efraim I, Gerace L. Gradient of increasing affinity of importin beta for nucleoporins along the pathway of nuclear import. J Cell Biol 2001;152:411-417.
52. Walther TC, Fornerod M, Pickersgill H, Goldberg M, Allen TD, Mattaj IW. The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins. EMBO J 2001;20:5703-5714.
53. Askjaer P, Bachi A, Wilm M, Bischoff FR, Weeks DL, Ogniewski V, Ohno M, Niehrs C, Kjems J, Mattaj IW, Fornerod M. RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase. Mol Cell Biol 1999;19:6276-6285.
54. Kehlenbach RH, Dickmanns A, Kehlenbach A, Guan T, Gerace L. A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export. J Cell Biol 1999;145:645-657.
55. Rexach M, Blobel G. Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins. Cell 1995;83:683-692.
56. Nachury MV, Weis K. The direction of transport through the nuclear pore can be inverted. Proc Natl Acad Sci USA 1999;96:9622-9627.
57. Bischoff FR, Klebe C, Kretschmer J, Wittinghofer A, Ponstingl H. RanGAP1 induces GTPase activity of nuclear Ras-related Ran. Proc Natl Acad Sci USA 1994;91:2587-2591.
58. Esnouf RM. Further additions to Molscript, Version 1.4 including reading and contouring of electron-density maps. Acta Crystallogr D Biol Crystallogr 1999;55:938-940.
59. Merritt EA, Bacon DJ. Raster3D: photorealistic molecular graphics. Meth Enzymol 1997;277:505-524.
60. Nicholls A, Sharp KA, Honig B. Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins 1991;11:281-296.
61. Shamsher MK, Ploski J, Radu A. Karyopherin beta 2B participates in mRNA export from the nucleus. Proc Natl Acad Sci USA 2002;99:14195-14199.