The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function

EMBO Reports

Volumn 7, Issue 12, 2006, Pages 1259-1265

  Knauer, Shirley K ^a   Bier, Carolin ^a   Habtemichael, Negusse ^a   Stauber, Roland H ^a  

^a INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; EXPORTIN 1; LEPTOMYCIN B; PROTEIN SUBUNIT; RNA; SURVIVIN;

ARTICLE; CELL CYCLE; CENTROMERE; CONTROLLED STUDY; GENE INACTIVATION; GENE MUTATION; GENE TARGETING; GENETIC CONSERVATION; HUMAN; HUMAN CELL; MITOSIS; NUCLEAR EXPORT SIGNAL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE;

CELL LINE, TUMOR; CELL PROLIFERATION; CENTROMERE; CHROMOSOMAL PROTEINS, NON-HISTONE; FATTY ACIDS, UNSATURATED; HELA CELLS; HUMANS; KARYOPHERINS; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; NUCLEAR EXPORT SIGNALS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSFECTION;

MAMMALIA;

EID: 33751549838     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7400824     Document Type: Article

References (18)

1. Arnaoutov A, Azuma Y, Ribbeck K, Joseph J, Boyarchuk Y, Karpova T, McNally J, Dasso M (2005) Crm1 is a mitotic effector of Ran-GTP in somatic cells. Nat Cell Biol 7: 626-632
2. Dasso M (2005) Cell biology: New cog for a familiar machine. Nature 435: 899-900
3. Earnshaw WC (2005) Cell biology. Keeping Survivin nimble at centromeres in mitosis. Science 310: 1443-1444
4. Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (2004) Borealin: A novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol 166: 179-191
5. Heger P, Lohmaier J, Schneider G, Schweimer K, Stauber RH (2001) Qualitative highly divergent nuclear export signals can regulate export by the competition for transport cofactors in vivo. Traffic 2: 544-555
6. Honda R, Korner R, Nigg EA (2003) Exploring the functional interactions between Aurora B, INCENP, and Survivin in mitosis. Mol Biol Cell 14: 3325-3341
7. Klein UR, Nigg EA, Gruneberg U (2006) Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of borealin, Survivin, and the N-terminal domain of INCENP. Mol Biol Cell 17: 2547-2558
8. Knauer SK, Carra G, Stauber RH (2005a) Nuclear export is evolutionarily conserved in CVC paired-like homeobox proteins and influences protein stability, transcriptional activation, and extracellular secretion. Mol Cell Biol 25: 2573-2582
9. Knauer SK, Moodt S, Berg T, Liebel U, Pepperkok R, Stauber RH (2005b) Translocation biosensors to study signal specific nucleo-cytoplasmic transport, protease activity & protein interactions. Traffic 6: 594-606
10. Nousiainen M, Sillje HH, Sauer G, Nigg EA, Korner R (2006) Phosphoproteome analysis of the human mitotic spindle. Proc Natl Acad Sci USA 103: 5391-5396
11. Rodriguez JA, Span SW, Ferreira CG, Kruyt FA, Giaccone G (2002) CRM1-mediated nuclear export determines the cytoplasmic localization of the antiapoptotic protein Survivin. Exp Cell Res 275: 44-53
12. Rodriguez JA, Lens SM, Span SW, Vader G, Medema RH, Kruyt FA, Giaccone G (2006) Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown. Oncogene 25: 4867-4879
13. Stauber RH, Horie K, Carney P, Hudson EA, Tarasova NI, Gaitanaris GA, Pavlakis GN (1998) Development and applications of enhanced green fluorescent protein mutants. BioTechniques 24: 462-471
14. Vagnarelli P, Earnshaw WC (2004) Chromosomal passengers: The four-dimensional regulation of mitotic events. Chromosoma 113: 211-222
15. Wang W, Budhu A, Forgues M, Wang XW (2005) Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication. Nat Cell Biol 7: 823-830
16. Weis K (2003) Regulating access to the genome: Nucleocytoplasmic transport throughout the cell cycle. Cell 112: 441-451
17. Wheatley SP, Henzing AJ, Dodson H, Khaled W, Earnshaw WC (2004) Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo. J Biol Chem 279: 5655-5660
18. Xu L, Massague J (2004) Nucleocytoplasmic shuttling of signal transducers. Nat Rev Mol Cell Biol 5: 209-21