Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication

Nature Cell Biology

Volumn 7, Issue 8, 2005, Pages 823-830

  Wang, Wei ^a   Budhu, Anuradha ^a   Forgues, Marshonna ^a   Wang, Xin Wei ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; BINDING PROTEIN; EXPORTIN 1; LEPTOMYCIN B; NUCLEOPHOSMIN; PHOSPHOTRANSFERASE; PROLINE; RAN BINDING PROTEIN 1; RAN PROTEIN; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CENTROSOME; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE MUTATION; HUMAN; HUMAN CELL; HYPOTHESIS; MOUSE; MUTANT; NONHUMAN; NUCLEAR EXPORT SIGNAL; NUCLEOCYTOPLASMIC TRANSPORT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; RNA INTERFERENCE; WILD TYPE;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL FUSION; CELL LINE; CELL NUCLEUS; CENTROSOME; FATTY ACIDS, UNSATURATED; GENE EXPRESSION; HELA CELLS; HUMANS; INTERPHASE; KARYOPHERINS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN TRANSPORT; RAN GTP-BINDING PROTEIN; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, SMALL INTERFERING; SEQUENCE HOMOLOGY, AMINO ACID; THREONINE; TRANS-ACTIVATORS; TRANSFECTION;

ANIMALIA;

EID: 23144449790     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1282     Document Type: Article

References (28)

1. Sluder, G. & Hinchcliffe, E. H. Control of centrosome reproduction: the right number at the right time. Biol. Cell 91, 413-427 (1999).
2. Brinkley, B. R. Managing the centrosome numbers game: from chaos to stability in cancer cell division. Trends Cell Biol. 11, 18-21 (2001).
3. Nigg, E. A. Centrosome aberrations: cause or consequence of cancer progression? Nature Rev. Cancer 2, 815-825 (2002).
4. Doxsey, S. Duplicating dangerously: linking centrosome duplication and aneuploidy. Mol. Cell 10, 439-440 (2002).
5. Lingle, W. L. & Salisbury, J. L. The role of the centrosome in the development of malignant tumors. Curr. Top. Dev. Biol. 49, 313-329 (2000).
6. Forgues, M. et al. Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles. Mol. Cell Biol. 23, 5282-5292 (2003).
7. Keryer, G. et al. Part of Ran is associated with AKAP450 at the centrosome: involvement in microtubule-organizing activity. Mol. Biol Cell 14, 4260-4271 (2003).
8. Di Fiore, B., Ciciarello, M. & Lavia, P. Mitotic functions of the Ran GTPase network: the importance of being in the right place at the right time. Cell Cycle 3, 305-313 (2004).
9. Dasso, M. Running on Ran: nuclear transport and the mitotic spindle. Cell 104, 321-324 (2001).
10. Weis, K. Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle. Cell 112, 441-451 (2003).
11. Di Fiore, B. et al. Mammalian RanBP1 regulates centrosome cohesion during mitosis. J. Cell Sci. 116, 3399-3411 (2003).
12. Kudo, N. et al. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc. Natl Acad. Sci. USA 96, 9112-9117 (1999).
13. Forgues, M. et al. Interaction of the hepatitis b virus x protein with the Crm1-dependent nuclear export pathway. J. Biol. Chem. 276, 22797-22803 (2001).
14. Tarapore, P., Okuda, M. & Fukasawa, K. A mammalian in vitro centriole duplication system: evidence for involvement of CDK2/cyclin E and nucleophosmin/B23 in centrosome duplication. Cell Cycle 1, 75-81 (2002).
15. Okuda, M. et al. Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell 103, 127-140 (2000).
16. Borer, R. A., Lehner, C. F., Eppenberger, H. M. & Nigg, E. A. Major nucleolar proteins shuttle between nucleus and cytoplasm. Cell 56, 379-390 (1989).
17. Tokuyama, Y., Horn, H. F., Kawamura, K., Tarapore, P. & Fukasawa, K. Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication. J. Biol. Chem. 276, 21529-21537 (2001).
18. Zatsepina, O. V. et al. The nucleolar phosphoprotein B23 redistributes in part to the spindle poles during mitosis. J. Cell Sci. 112, 455-466 (1999).
19. Pinol-Roma, S. & Dreyfuss, G. Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm. Nature 355, 730-732 (1992).
20. Roth, J., Dobbelstein, M., Freedman, D. A., Shenk, T. & Levine, A. J. Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. EMBO J. 17, 554-564 (1998).
21. Nishimura, Y., Ohkubo, T., Furuichi, Y. & Umekawa, H. Tryptophans 286 and 288 in the C-terminal region of protein B23.1 are important for its nucleolar localization. Biosci. Biotechnol. Biochem. 66, 2239-2242 (2002).
22. Moudjou, M. & Bornens, M. Cell Biology: A Laboratory Handbook (ed. Celis, J. E.) 111-119 (Academic Press, San Diego, 1998).
23. Itahana, K. et al. Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation. Mol. Cell 12, 1151-1164 (2003).
24. Clarke, P. R. & Zhang, C. Ran GTPase: a master regulator of nuclear structure and function during the eukaryotic cell division cycle? Trends Cell Biol. 11, 366-371 (2001).
25. Stommel, J. M. et al. A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J. 18, 1660-1672 (1999).
26. Colombo, E., Marine, J. C., Danovi, D., Falini, B. & Pelicci, P. G. Nucleophosmin regulates the stability and transcriptional activity of p53. Nature Cell Biol. 4, 529-533 (2002).
27. Butel, J. S. Viral carcinogenesis: revelation of molecular mechanisms and etiology of human disease. Carcinogenesis 21, 405-426 (2000).
28. Okuwaki, M., Tsujimoto, M. & Nagata, K. The RNA binding activity of a ribosome biogenesis factor, nucleophosmin/B23, is modulated by phosphorylation with a cell cycle-dependent kinase and by association with its subtype. Mol. Biol. Cell 13, 2016-2030 (2002).