메뉴 건너뛰기




Volumn 3, Issue 2, 2011, Pages 1708-1731

Regulatory T cells in colorectal cancer: From biology to prognostic relevance

Author keywords

Colorectal cancer; Immune escape; Prognostic marker; Regulatory T cells

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARCINOEMBRYONIC ANTIGEN; CD103 ANTIGEN; CD4 ANTIGEN; CYCLOOXYGENASE 2; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DENDRITIC CELL VACCINE; DENILEUKIN DIFTITOX; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 35; INTERLEUKIN 6; INTERLEUKIN 7 RECEPTOR; MACROPHAGE DERIVED CHEMOKINE; PROSTAGLANDIN E2; REACTIVE OXYGEN METABOLITE; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TUMOR ANTIGEN;

EID: 79959726907     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers3021708     Document Type: Review
Times cited : (20)

References (143)
  • 1
    • 4143141823 scopus 로고    scopus 로고
    • The immunobiology of cancer immunosurveillance and immunoediting
    • Dunn, G.P.; Old, L.J.; Schreiber, R.D. The immunobiology of cancer immunosurveillance and immunoediting. Immunity 2004, 21, 137-148.
    • (2004) Immunity , vol.21 , pp. 137-148
    • Dunn, G.P.1    Old, L.J.2    Schreiber, R.D.3
  • 2
    • 0031439719 scopus 로고    scopus 로고
    • Human tumor antigens recognized by t-cells
    • Kawakami, Y.; Rosenberg, S.A. Human tumor antigens recognized by t-cells. Immunol. Res. 1997, 16, 313-339.
    • (1997) Immunol. Res , vol.16 , pp. 313-339
    • Kawakami, Y.1    Rosenberg, S.A.2
  • 3
    • 0023663430 scopus 로고
    • T cell tolerance by clonal elimination in the thymus
    • Kappler, J.W.; Roehm, N.; Marrack, P. T cell tolerance by clonal elimination in the thymus. Cell 1987, 49, 273-280.
    • (1987) Cell , vol.49 , pp. 273-280
    • Kappler, J.W.1    Roehm, N.2    Marrack, P.3
  • 4
    • 0005984244 scopus 로고
    • Actively acquired tolerance of foreign cells
    • Billingham, R.E.; Brent, L.; Medawar, P.B. Actively acquired tolerance of foreign cells. Nature 1953, 172, 603-606.
    • (1953) Nature , vol.172 , pp. 603-606
    • Billingham, R.E.1    Brent, L.2    Medawar, P.B.3
  • 5
    • 0015172562 scopus 로고
    • Infectious immunological tolerance
    • Gershon, R.K.; Kondo, K. Infectious immunological tolerance. Immunology 1971, 21, 903-914.
    • (1971) Immunology , vol.21 , pp. 903-914
    • Gershon, R.K.1    Kondo, K.2
  • 6
    • 0014792798 scopus 로고
    • Cell interactions in the induction of tolerance: The role of thymic lymphocytes
    • Gershon, R.K.; Kondo, K. Cell interactions in the induction of tolerance: The role of thymic lymphocytes. Immunology 1970, 18, 723-737.
    • (1970) Immunology , vol.18 , pp. 723-737
    • Gershon, R.K.1    Kondo, K.2
  • 7
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated t cells expressing il-2 receptor alpha-chains (cd25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi, S.; Sakaguchi, N.; Asano, M.; Itoh, M.; Toda, M. Immunologic self-tolerance maintained by activated t cells expressing il-2 receptor alpha-chains (cd25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995, 155, 1151-1164.
    • (1995) J. Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 8
    • 0035413350 scopus 로고    scopus 로고
    • Cd4+cd25high regulatory cells in human peripheral blood
    • Baecher-Allan, C.; Brown, J.A.; Freeman, G.J.; Hafler, D.A. Cd4+cd25high regulatory cells in human peripheral blood. J. Immunol. 2001, 167, 1245-1253.
    • (2001) J. Immunol , vol.167 , pp. 1245-1253
    • Baecher-Allan, C.1    Brown, J.A.2    Freeman, G.J.3    Hafler, D.A.4
  • 9
    • 0035806244 scopus 로고    scopus 로고
    • Ex vivo isolation and characterization of cd4(+)cd25(+) t cells with regulatory properties from human blood
    • Dieckmann, D.; Plottner, H.; Berchtold, S.; Berger, T.; Schuler, G. Ex vivo isolation and characterization of cd4(+)cd25(+) t cells with regulatory properties from human blood. J. Exp. Med. 2001, 193, 1303-1310.
    • (2001) J. Exp. Med , vol.193 , pp. 1303-1310
    • Dieckmann, D.1    Plottner, H.2    Berchtold, S.3    Berger, T.4    Schuler, G.5
  • 10
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of cd4+cd25+ regulatory t cells
    • Fontenot, J.D.; Gavin, M.A.; Rudensky, A.Y. Foxp3 programs the development and function of cd4+cd25+ regulatory t cells. Nat. Immunol. 2003, 4, 330-336.
    • (2003) Nat. Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 15
    • 74049164847 scopus 로고    scopus 로고
    • Regulatory t cells exert checks and balances on self tolerance and autoimmunity
    • Wing, K.; Sakaguchi, S. Regulatory t cells exert checks and balances on self tolerance and autoimmunity. Nat. Immunol. 2010, 11, 7-13.
    • (2010) Nat. Immunol , vol.11 , pp. 7-13
    • Wing, K.1    Sakaguchi, S.2
  • 16
    • 33846900430 scopus 로고    scopus 로고
    • Deficient cd4+cd25high t regulatory cell function in patients with active systemic lupus erythematosus
    • Valencia, X.; Yarboro, C.; Illei, G.; Lipsky, P.E. Deficient cd4+cd25high t regulatory cell function in patients with active systemic lupus erythematosus. J. Immunol. 2007, 178, 2579-2588.
    • (2007) J. Immunol , vol.178 , pp. 2579-2588
    • Valencia, X.1    Yarboro, C.2    Illei, G.3    Lipsky, P.E.4
  • 17
    • 44449171488 scopus 로고    scopus 로고
    • Natural naive cd4+cd25+cd127low regulatory t cell (treg) development and function are disturbed in multiple sclerosis patients: Recovery of memory treg homeostasis during disease progression
    • Venken, K.; Hellings, N.; Broekmans, T.; Hensen, K.; Rummens, J.L.; Stinissen, P. Natural naive cd4+cd25+cd127low regulatory t cell (treg) development and function are disturbed in multiple sclerosis patients: Recovery of memory treg homeostasis during disease progression. J. Immunol. 2008, 180, 6411-6420.
    • (2008) J. Immunol , vol.180 , pp. 6411-6420
    • Venken, K.1    Hellings, N.2    Broekmans, T.3    Hensen, K.4    Rummens, J.L.5    Stinissen, P.6
  • 18
    • 0018906201 scopus 로고
    • T-cell-mediated suppression of anti-tumor immunity. An explanation for progressive growth of an immunogenic tumor
    • Berendt, M.J.; North, R.J. T-cell-mediated suppression of anti-tumor immunity. An explanation for progressive growth of an immunogenic tumor. J. Exp. Med. 1980, 151, 69-80.
    • (1980) J. Exp. Med , vol.151 , pp. 69-80
    • Berendt, M.J.1    North, R.J.2
  • 19
    • 0017105501 scopus 로고
    • Regualtion of the immune response to tumor antigens. I. Immunosuppressor cells in tumor-bearing hosts
    • Fujimoto, S.; Greene, M.I.; Sehon, A.H. Regualtion of the immune response to tumor antigens. I. Immunosuppressor cells in tumor-bearing hosts. J. Immunol. 1976, 116, 791-799.
    • (1976) J. Immunol , vol.116 , pp. 791-799
    • Fujimoto, S.1    Greene, M.I.2    Sehon, A.H.3
  • 20
    • 0017253166 scopus 로고
    • Regulation of the immune response to tumor antigens. Ii. The nature of immunosuppressor cells in tumor-bearing hosts
    • Fujimoto, S.; Greene, M.I.; Sehon, A.H. Regulation of the immune response to tumor antigens. Ii. The nature of immunosuppressor cells in tumor-bearing hosts. J. Immunol. 1976, 116, 800-806.
    • (1976) J. Immunol , vol.116 , pp. 800-806
    • Fujimoto, S.1    Greene, M.I.2    Sehon, A.H.3
  • 22
    • 0035874949 scopus 로고    scopus 로고
    • Regulatory cd4(+)cd25(+) t cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer
    • Woo, E.Y.; Chu, C.S.; Goletz, T.J.; Schlienger, K.; Yeh, H.; Coukos, G.; Rubin, S.C.; Kaiser, L.R.; June, C.H. Regulatory cd4(+)cd25(+) t cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res. 2001, 61, 4766-4772.
    • (2001) Cancer Res , vol.61 , pp. 4766-4772
    • Woo, E.Y.1    Chu, C.S.2    Goletz, T.J.3    Schlienger, K.4    Yeh, H.5    Coukos, G.6    Rubin, S.C.7    Kaiser, L.R.8    June, C.H.9
  • 25
    • 33747143361 scopus 로고    scopus 로고
    • From vanilla to 28 flavors: Multiple varieties of t regulatory cells
    • Shevach, E.M. From vanilla to 28 flavors: Multiple varieties of t regulatory cells. Immunity 2006, 25, 195-201.
    • (2006) Immunity , vol.25 , pp. 195-201
    • Shevach, E.M.1
  • 26
    • 67649170980 scopus 로고    scopus 로고
    • Foxp3+ regulatory t cells: Differentiation, specification, subphenotypes
    • Feuerer, M.; Hill, J.A.; Mathis, D.; Benoist, C. Foxp3+ regulatory t cells: Differentiation, specification, subphenotypes. Nat. Immunol. 2009, 10, 689-695.
    • (2009) Nat. Immunol , vol.10 , pp. 689-695
    • Feuerer, M.1    Hill, J.A.2    Mathis, D.3    Benoist, C.4
  • 33
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral cd4+cd25- naive t cells to cd4+cd25+ regulatory t cells by tgf-beta induction of transcription factor foxp3
    • Chen, W.; Jin, W.; Hardegen, N.; Lei, K.J.; Li, L.; Marinos, N.; McGrady, G.; Wahl, S.M. Conversion of peripheral cd4+cd25- naive t cells to cd4+cd25+ regulatory t cells by tgf-beta induction of transcription factor foxp3. J. Exp. Med. 2003, 198, 1875-1886.
    • (2003) J. Exp. Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5    Marinos, N.6    McGrady, G.7    Wahl, S.M.8
  • 34
    • 2542420993 scopus 로고    scopus 로고
    • In vivo instruction of suppressor commitment in naive t cells
    • Apostolou, I.; von Boehmer, H. In vivo instruction of suppressor commitment in naive t cells. J. Exp. Med. 2004, 199, 1401-1408.
    • (2004) J. Exp. Med , vol.199 , pp. 1401-1408
    • Apostolou, I.1    von Boehmer, H.2
  • 35
    • 34249814016 scopus 로고    scopus 로고
    • Adaptation of tcr repertoires to self-peptides in regulatory and nonregulatory cd4+ t cells
    • Wong, J.; Obst, R.; Correia-Neves, M.; Losyev, G.; Mathis, D.; Benoist, C. Adaptation of tcr repertoires to self-peptides in regulatory and nonregulatory cd4+ t cells. J. Immunol. 2007, 178, 7032-7041.
    • (2007) J. Immunol , vol.178 , pp. 7032-7041
    • Wong, J.1    Obst, R.2    Correia-Neves, M.3    Losyev, G.4    Mathis, D.5    Benoist, C.6
  • 36
  • 37
    • 46049098560 scopus 로고    scopus 로고
    • A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces cd4(+)cd25(+)foxp3(+) t cells
    • Hoechst, B.; Ormandy, L.A.; Ballmaier, M.; Lehner, F.; Kruger, C.; Manns, M.P.; Greten, T.F.; Korangy, F. A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces cd4(+)cd25(+)foxp3(+) t cells. Gastroenterology 2008, 135, 234-243.
    • (2008) Gastroenterology , vol.135 , pp. 234-243
    • Hoechst, B.1    Ormandy, L.A.2    Ballmaier, M.3    Lehner, F.4    Kruger, C.5    Manns, M.P.6    Greten, T.F.7    Korangy, F.8
  • 38
    • 28244494166 scopus 로고    scopus 로고
    • Tolerogenic treatment of lupus mice with consensus peptide induces foxp3-expressing, apoptosis-resistant, tgfbeta-secreting cd8+ t cell suppressors
    • Hahn, B.H.; Singh, R.P.; La Cava, A.; Ebling, F.M. Tolerogenic treatment of lupus mice with consensus peptide induces foxp3-expressing, apoptosis-resistant, tgfbeta-secreting cd8+ t cell suppressors. J. Immunol. 2005, 175, 7728-7737.
    • (2005) J. Immunol , vol.175 , pp. 7728-7737
    • Hahn, B.H.1    Singh, R.P.2    la Cava, A.3    Ebling, F.M.4
  • 42
    • 34548024379 scopus 로고    scopus 로고
    • Tumor-infiltrating gammadelta t cells suppress t and dendritic cell function via mechanisms controlled by a unique toll-like receptor signaling pathway
    • Peng, G.; Wang, H.Y.; Peng, W.; Kiniwa, Y.; Seo, K.H.; Wang, R.F. Tumor-infiltrating gammadelta t cells suppress t and dendritic cell function via mechanisms controlled by a unique toll-like receptor signaling pathway. Immunity 2007, 27, 334-348.
    • (2007) Immunity , vol.27 , pp. 334-348
    • Peng, G.1    Wang, H.Y.2    Peng, W.3    Kiniwa, Y.4    Seo, K.H.5    Wang, R.F.6
  • 43
    • 64849088870 scopus 로고    scopus 로고
    • Analysis of adhesion molecules, target cells, and role of il-2 in human foxp3+ regulatory t cell suppressor function
    • Tran, D.Q.; Glass, D.D.; Uzel, G.; Darnell, D.A.; Spalding, C.; Holland, S.M.; Shevach, E.M. Analysis of adhesion molecules, target cells, and role of il-2 in human foxp3+ regulatory t cell suppressor function. J. Immunol. 2009, 182, 2929-2938.
    • (2009) J. Immunol , vol.182 , pp. 2929-2938
    • Tran, D.Q.1    Glass, D.D.2    Uzel, G.3    Darnell, D.A.4    Spalding, C.5    Holland, S.M.6    Shevach, E.M.7
  • 44
    • 34547655923 scopus 로고    scopus 로고
    • A unique subset of cd4+cd25highfoxp3+ t cells secreting interleukin-10 and transforming growth factor-beta1 mediates suppression in the tumor microenvironment
    • Strauss, L.; Bergmann, C.; Szczepanski, M.; Gooding, W.; Johnson, J.T.; Whiteside, T.L. A unique subset of cd4+cd25highfoxp3+ t cells secreting interleukin-10 and transforming growth factor-beta1 mediates suppression in the tumor microenvironment. Clin. Cancer Res. 2007, 13, 4345-4354.
    • (2007) Clin. Cancer Res , vol.13 , pp. 4345-4354
    • Strauss, L.1    Bergmann, C.2    Szczepanski, M.3    Gooding, W.4    Johnson, J.T.5    Whiteside, T.L.6
  • 45
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kuhn, R.; Lohler, J.; Rennick, D.; Rajewsky, K.; Muller, W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993, 75, 263-274.
    • (1993) Cell , vol.75 , pp. 263-274
    • Kuhn, R.1    Lohler, J.2    Rennick, D.3    Rajewsky, K.4    Muller, W.5
  • 53
    • 35449006679 scopus 로고    scopus 로고
    • Granzyme b and perforin are important for regulatory t cell-mediated suppression of tumor clearance
    • Cao, X.; Cai, S.F.; Fehniger, T.A.; Song, J.; Collins, L.I.; Piwnica-Worms, D.R.; Ley, T.J. Granzyme b and perforin are important for regulatory t cell-mediated suppression of tumor clearance. Immunity 2007, 27, 635-646.
    • (2007) Immunity , vol.27 , pp. 635-646
    • Cao, X.1    Cai, S.F.2    Fehniger, T.A.3    Song, J.4    Collins, L.I.5    Piwnica-Worms, D.R.6    Ley, T.J.7
  • 54
    • 36248995916 scopus 로고    scopus 로고
    • Involvement of cellular death in trail/dr5-dependent suppression induced by cd4(+)cd25(+) regulatory t cells
    • Ren, X.; Ye, F.; Jiang, Z.; Chu, Y.; Xiong, S.; Wang, Y. Involvement of cellular death in trail/dr5-dependent suppression induced by cd4(+)cd25(+) regulatory t cells. Cell Death Differ. 2007, 14, 2076-2084.
    • (2007) Cell Death Differ , vol.14 , pp. 2076-2084
    • Ren, X.1    Ye, F.2    Jiang, Z.3    Chu, Y.4    Xiong, S.5    Wang, Y.6
  • 57
    • 0034679567 scopus 로고    scopus 로고
    • Cytotoxic t lymphocyte-associated antigen 4 plays an essential role in the function of cd25(+)cd4(+) regulatory cells that control intestinal inflammation
    • Read, S.; Malmstrom, V.; Powrie, F. Cytotoxic t lymphocyte-associated antigen 4 plays an essential role in the function of cd25(+)cd4(+) regulatory cells that control intestinal inflammation. J. Exp. Med. 2000, 192, 295-302.
    • (2000) J. Exp. Med , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 58
    • 5044220930 scopus 로고    scopus 로고
    • Ido expression by dendritic cells: Tolerance and tryptophan catabolism
    • Mellor, A.L.; Munn, D.H. Ido expression by dendritic cells: Tolerance and tryptophan catabolism. Nat. Rev. Immunol. 2004, 4, 762-774.
    • (2004) Nat. Rev. Immunol , vol.4 , pp. 762-774
    • Mellor, A.L.1    Munn, D.H.2
  • 60
    • 40249108222 scopus 로고    scopus 로고
    • Neuropilin-1 expression on regulatory t cells enhances their interactions with dendritic cells during antigen recognition
    • Sarris, M.; Andersen, K.G.; Randow, F.; Mayr, L.; Betz, A.G. Neuropilin-1 expression on regulatory t cells enhances their interactions with dendritic cells during antigen recognition. Immunity 2008, 28, 402-413.
    • (2008) Immunity , vol.28 , pp. 402-413
    • Sarris, M.1    Andersen, K.G.2    Randow, F.3    Mayr, L.4    Betz, A.G.5
  • 65
    • 36248976097 scopus 로고    scopus 로고
    • Cd4+cd25+foxp3+ regulatory t cells induce cytokine deprivation-mediated apoptosis of effector cd4+ t cells
    • Pandiyan, P.; Zheng, L.; Ishihara, S.; Reed, J.; Lenardo, M.J. Cd4+cd25+foxp3+ regulatory t cells induce cytokine deprivation-mediated apoptosis of effector cd4+ t cells. Nat. Immunol. 2007, 8, 1353-1362.
    • (2007) Nat. Immunol , vol.8 , pp. 1353-1362
    • Pandiyan, P.1    Zheng, L.2    Ishihara, S.3    Reed, J.4    Lenardo, M.J.5
  • 66
    • 65549168545 scopus 로고    scopus 로고
    • Selective expression of latency-associated peptide (lap) and il-1 receptor type i/ii (cd121a/cd121b) on activated human foxp3+ regulatory t cells allows for their purification from expansion cultures
    • Tran, D.Q.; Andersson, J.; Hardwick, D.; Bebris, L.; Illei, G.G.; Shevach, E.M. Selective expression of latency-associated peptide (lap) and il-1 receptor type i/ii (cd121a/cd121b) on activated human foxp3+ regulatory t cells allows for their purification from expansion cultures. Blood 2009, 113, 5125-5133.
    • (2009) Blood , vol.113 , pp. 5125-5133
    • Tran, D.Q.1    Andersson, J.2    Hardwick, D.3    Bebris, L.4    Illei, G.G.5    Shevach, E.M.6
  • 67
    • 70349314830 scopus 로고    scopus 로고
    • Extracellular redox modulation by regulatory t cells
    • Yan, Z.; Garg, S.K.; Kipnis, J.; Banerjee, R. Extracellular redox modulation by regulatory t cells. Nat. Chem. Biol. 2009, 5, 721-723.
    • (2009) Nat. Chem. Biol , vol.5 , pp. 721-723
    • Yan, Z.1    Garg, S.K.2    Kipnis, J.3    Banerjee, R.4
  • 68
    • 78650651362 scopus 로고    scopus 로고
    • Regulatory t cells interfere with glutathione metabolism in dendritic cells and t cells
    • Yan, Z.; Garg, S.K.; Banerjee, R. Regulatory t cells interfere with glutathione metabolism in dendritic cells and t cells. J. Biol. Chem. 2010.
    • (2010) J. Biol. Chem
    • Yan, Z.1    Garg, S.K.2    Banerjee, R.3
  • 69
    • 65349093464 scopus 로고    scopus 로고
    • Naturally occurring regulatory t cells show reduced sensitivity toward oxidative stress-induced cell death
    • Mougiakakos, D.; Johansson, C.C.; Kiessling, R. Naturally occurring regulatory t cells show reduced sensitivity toward oxidative stress-induced cell death. Blood 2009, 113, 3542-3545.
    • (2009) Blood , vol.113 , pp. 3542-3545
    • Mougiakakos, D.1    Johansson, C.C.2    Kiessling, R.3
  • 70
    • 78751700887 scopus 로고    scopus 로고
    • Increased thioredoxin-1 production in human naturally occurring regulatory t cells confers enhanced tolerance to oxidative stress
    • Mougiakakos, D.; Johansson, C.C.; Jitschin, R.; Bottcher, M.; Kiessling, R. Increased thioredoxin-1 production in human naturally occurring regulatory t cells confers enhanced tolerance to oxidative stress. Blood 2010, 117, 857-861.
    • (2010) Blood , vol.117 , pp. 857-861
    • Mougiakakos, D.1    Johansson, C.C.2    Jitschin, R.3    Bottcher, M.4    Kiessling, R.5
  • 71
    • 35748975652 scopus 로고    scopus 로고
    • Preferential migration of regulatory t cells mediated by glioma-secreted chemokines can be blocked with chemotherapy
    • Jordan, J.T.; Sun, W.; Hussain, S.F.; DeAngulo, G.; Prabhu, S.S.; Heimberger, A.B. Preferential migration of regulatory t cells mediated by glioma-secreted chemokines can be blocked with chemotherapy. Cancer Immunol. Immunother. 2008, 57, 123-131.
    • (2008) Cancer Immunol. Immunother , vol.57 , pp. 123-131
    • Jordan, J.T.1    Sun, W.2    Hussain, S.F.3    Deangulo, G.4    Prabhu, S.S.5    Heimberger, A.B.6
  • 73
    • 42149152160 scopus 로고    scopus 로고
    • Ccl17 and ccl22 chemokines within tumor microenvironment are related to accumulation of foxp3+ regulatory t cells in gastric cancer
    • Mizukami, Y.; Kono, K.; Kawaguchi, Y.; Akaike, H.; Kamimura, K.; Sugai, H.; Fujii, H. Ccl17 and ccl22 chemokines within tumor microenvironment are related to accumulation of foxp3+ regulatory t cells in gastric cancer. Int. J. Cancer 2008, 122, 2286-2293.
    • (2008) Int. J. Cancer , vol.122 , pp. 2286-2293
    • Mizukami, Y.1    Kono, K.2    Kawaguchi, Y.3    Akaike, H.4    Kamimura, K.5    Sugai, H.6    Fujii, H.7
  • 77
    • 70449717294 scopus 로고    scopus 로고
    • Epigenetic mechanisms of regulation of foxp3 expression
    • Lal, G.; Bromberg, J.S. Epigenetic mechanisms of regulation of foxp3 expression. Blood 2009, 114, 3727-3735.
    • (2009) Blood , vol.114 , pp. 3727-3735
    • Lal, G.1    Bromberg, J.S.2
  • 78
    • 0035876913 scopus 로고    scopus 로고
    • A role for TGF-beta in the generation and expansion of cd4+cd25+ regulatory t cells from human peripheral blood
    • Yamagiwa, S.; Gray, J.D.; Hashimoto, S.; Horwitz, D.A. A role for TGF-beta in the generation and expansion of cd4+cd25+ regulatory t cells from human peripheral blood. J. Immunol. 2001, 166, 7282-7289.
    • (2001) J. Immunol , vol.166 , pp. 7282-7289
    • Yamagiwa, S.1    Gray, J.D.2    Hashimoto, S.3    Horwitz, D.A.4
  • 79
    • 52449125138 scopus 로고    scopus 로고
    • T regulatory type 1 cells in squamous cell carcinoma of the head and neck: Mechanisms of suppression and expansion in advanced disease
    • Bergmann, C.; Strauss, L.; Wang, Y.; Szczepanski, M.J.; Lang, S.; Johnson, J.T.; Whiteside, T.L. T regulatory type 1 cells in squamous cell carcinoma of the head and neck: Mechanisms of suppression and expansion in advanced disease. Clin. Cancer Res. 2008, 14, 3706-3715.
    • (2008) Clin. Cancer Res , vol.14 , pp. 3706-3715
    • Bergmann, C.1    Strauss, L.2    Wang, Y.3    Szczepanski, M.J.4    Lang, S.5    Johnson, J.T.6    Whiteside, T.L.7
  • 80
    • 0038155128 scopus 로고    scopus 로고
    • Association of increased levels of heavy-chain ferritin with increased cd4+ cd25+ regulatory t-cell levels in patients with melanoma
    • Gray, C.P.; Arosio, P.; Hersey, P. Association of increased levels of heavy-chain ferritin with increased cd4+ cd25+ regulatory t-cell levels in patients with melanoma. Clin. Cancer Res. 2003, 9, 2551-2559.
    • (2003) Clin. Cancer Res , vol.9 , pp. 2551-2559
    • Gray, C.P.1    Arosio, P.2    Hersey, P.3
  • 81
    • 34548804503 scopus 로고    scopus 로고
    • Expansion of human t regulatory type 1 cells in the microenvironment of cyclooxygenase 2 overexpressing head and neck squamous cell carcinoma
    • Bergmann, C.; Strauss, L.; Zeidler, R.; Lang, S.; Whiteside, T.L. Expansion of human t regulatory type 1 cells in the microenvironment of cyclooxygenase 2 overexpressing head and neck squamous cell carcinoma. Cancer Res. 2007, 67, 8865-8873.
    • (2007) Cancer Res , vol.67 , pp. 8865-8873
    • Bergmann, C.1    Strauss, L.2    Zeidler, R.3    Lang, S.4    Whiteside, T.L.5
  • 82
    • 34249054990 scopus 로고    scopus 로고
    • Cd4+ cd25+ foxp3+ t-cell infiltration and heme oxygenase-1 expression correlate with tumor grade in human gliomas
    • El Andaloussi, A.; Lesniak, M.S. Cd4+ cd25+ foxp3+ t-cell infiltration and heme oxygenase-1 expression correlate with tumor grade in human gliomas. J. Neurooncol. 2007, 83, 145-152.
    • (2007) J. Neurooncol , vol.83 , pp. 145-152
    • El Andaloussi, A.1    Lesniak, M.S.2
  • 85
    • 49649101872 scopus 로고    scopus 로고
    • Colorectal cancer and dysplasia in inflammatory bowel disease
    • Zisman, T.L.; Rubin, D.T. Colorectal cancer and dysplasia in inflammatory bowel disease. World J. Gastroenterol. 2008, 14, 2662-2669.
    • (2008) World J. Gastroenterol , vol.14 , pp. 2662-2669
    • Zisman, T.L.1    Rubin, D.T.2
  • 86
    • 0030628655 scopus 로고    scopus 로고
    • Colorectal cancer and nonsteroidal anti-inflammatory drugs
    • Smalley, W.E.; DuBois, R.N. Colorectal cancer and nonsteroidal anti-inflammatory drugs. Adv. Pharmacol. 1997, 39, 1-20.
    • (1997) Adv. Pharmacol , vol.39 , pp. 1-20
    • Smalley, W.E.1    Dubois, R.N.2
  • 87
    • 58649100056 scopus 로고    scopus 로고
    • Inflammation and cancer: Il-6 and stat3 complete the link
    • Bromberg, J.; Wang, T.C. Inflammation and cancer: Il-6 and stat3 complete the link. Cancer Cell 2009, 15, 79-80.
    • (2009) Cancer Cell , vol.15 , pp. 79-80
    • Bromberg, J.1    Wang, T.C.2
  • 88
    • 16844369607 scopus 로고    scopus 로고
    • Natural regulatory t cells in infectious disease
    • Belkaid, Y.; Rouse, B.T. Natural regulatory t cells in infectious disease. Nat. Immunol. 2005, 6, 353-360.
    • (2005) Nat. Immunol , vol.6 , pp. 353-360
    • Belkaid, Y.1    Rouse, B.T.2
  • 89
  • 91
    • 33745275219 scopus 로고    scopus 로고
    • Functional cd4+cd25high regulatory t cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity
    • Holmen, N.; Lundgren, A.; Lundin, S.; Bergin, A.M.; Rudin, A.; Sjovall, H.; Ohman, L. Functional cd4+cd25high regulatory t cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity. Inflamm. Bowel Dis. 2006, 12, 447-456.
    • (2006) Inflamm. Bowel Dis , vol.12 , pp. 447-456
    • Holmen, N.1    Lundgren, A.2    Lundin, S.3    Bergin, A.M.4    Rudin, A.5    Sjovall, H.6    Ohman, L.7
  • 93
    • 77952305365 scopus 로고    scopus 로고
    • Roles for inflammation and regulatory t cells in colon cancer
    • Erdman, S.E.; Poutahidis, T. Roles for inflammation and regulatory t cells in colon cancer. Toxicol. Pathol. 2010, 38, 76-87.
    • (2010) Toxicol. Pathol , vol.38 , pp. 76-87
    • Erdman, S.E.1    Poutahidis, T.2
  • 95
    • 0030949463 scopus 로고    scopus 로고
    • Activation of beta-catenin-tcf signaling in colon cancer by mutations in beta-catenin or apc
    • Morin, P.J.; Sparks, A.B.; Korinek, V.; Barker, N.; Clevers, H.; Vogelstein, B.; Kinzler, K.W. Activation of beta-catenin-tcf signaling in colon cancer by mutations in beta-catenin or apc. Science 1997, 275, 1787-1790.
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3    Barker, N.4    Clevers, H.5    Vogelstein, B.6    Kinzler, K.W.7
  • 96
    • 20144375359 scopus 로고    scopus 로고
    • Cd4+cd25+ regulatory lymphocytes induce regression of intestinal tumors in apcmin/+ mice
    • Erdman, S.E.; Sohn, J.J.; Rao, V.P.; Nambiar, P.R.; Ge, Z.; Fox, J.G.; Schauer, D.B. Cd4+cd25+ regulatory lymphocytes induce regression of intestinal tumors in apcmin/+ mice. Cancer Res. 2005, 65, 3998-4004.
    • (2005) Cancer Res , vol.65 , pp. 3998-4004
    • Erdman, S.E.1    Sohn, J.J.2    Rao, V.P.3    Nambiar, P.R.4    Ge, Z.5    Fox, J.G.6    Schauer, D.B.7
  • 99
    • 77954743969 scopus 로고    scopus 로고
    • Cancer inflammation and regulatory t cells
    • Erdman, S.E.; Poutahidis, T. Cancer inflammation and regulatory t cells. Int. J. Cancer 2010, 127, 768-779.
    • (2010) Int. J. Cancer , vol.127 , pp. 768-779
    • Erdman, S.E.1    Poutahidis, T.2
  • 100
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector th17 and regulatory t cells
    • Bettelli, E.; Carrier, Y.; Gao, W.; Korn, T.; Strom, T.B.; Oukka, M.; Weiner, H.L.; Kuchroo, V.K. Reciprocal developmental pathways for the generation of pathogenic effector th17 and regulatory t cells. Nature 2006, 441, 235-238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6    Weiner, H.L.7    Kuchroo, V.K.8
  • 102
    • 67349114782 scopus 로고    scopus 로고
    • Foxp3 and the regulation of treg/th17 differentiation
    • Ziegler, S.F.; Buckner, J.H. Foxp3 and the regulation of treg/th17 differentiation. Microbes. Infect. 2009, 11, 594-598.
    • (2009) Microbes. Infect , vol.11 , pp. 594-598
    • Ziegler, S.F.1    Buckner, J.H.2
  • 103
    • 0037436121 scopus 로고    scopus 로고
    • Immunology. Regulating the regulators
    • Powrie, F.; Maloy, K.J. Immunology. Regulating the regulators. Science 2003, 299, 1030-1031.
    • (2003) Science , vol.299 , pp. 1030-1031
    • Powrie, F.1    Maloy, K.J.2
  • 109
    • 33644789357 scopus 로고    scopus 로고
    • Chemo-immunotherapy of metastatic colorectal carcinoma with gemcitabine plus folfox 4 followed by subcutaneous granulocyte macrophage colony-stimulating factor and interleukin-2 induces strong immunologic and antitumor activity in metastatic colon cancer patients
    • Correale, P.; Cusi, M.G.; Tsang, K.Y.; Del Vecchio, M.T.; Marsili, S.; Placa, M.L.; Intrivici, C.; Aquino, A.; Micheli, L.; Nencini, C.; Ferrari, F.; Giorgi, G.; Bonmassar, E.; Francini, G. Chemo-immunotherapy of metastatic colorectal carcinoma with gemcitabine plus folfox 4 followed by subcutaneous granulocyte macrophage colony-stimulating factor and interleukin-2 induces strong immunologic and antitumor activity in metastatic colon cancer patients. J. Clin. Oncol. 2005, 23, 8950-8958.
    • (2005) J. Clin. Oncol , vol.23 , pp. 8950-8958
    • Correale, P.1    Cusi, M.G.2    Tsang, K.Y.3    del Vecchio, M.T.4    Marsili, S.5    Placa, M.L.6    Intrivici, C.7    Aquino, A.8    Micheli, L.9    Nencini, C.10    Ferrari, F.11    Giorgi, G.12    Bonmassar, E.13    Francini, G.14
  • 113
    • 38649136919 scopus 로고    scopus 로고
    • Tumor-infiltrating macrophages and dendritic cells in human colorectal cancer: Relation to local regulatory t cells, systemic t-cell response against tumor-associated antigens and survival
    • Nagorsen, D.; Voigt, S.; Berg, E.; Stein, H.; Thiel, E.; Loddenkemper, C. Tumor-infiltrating macrophages and dendritic cells in human colorectal cancer: Relation to local regulatory t cells, systemic t-cell response against tumor-associated antigens and survival. J. Transl. Med. 2007, 5, 62.
    • (2007) J. Transl. Med , vol.5 , pp. 62
    • Nagorsen, D.1    Voigt, S.2    Berg, E.3    Stein, H.4    Thiel, E.5    Loddenkemper, C.6
  • 116
    • 79251557498 scopus 로고    scopus 로고
    • Foxp3+il-17+ t cells promote development of cancer-initiating cells in colorectal cancer
    • Yang, S.; Wang, B.; Guan, C.; Wu, B.; Cai, C.; Wang, M.; Zhang, B.; Liu, T.; Yang, P. Foxp3+il-17+ t cells promote development of cancer-initiating cells in colorectal cancer. J. Leukoc. Biol. 2011, 89, 85-91.
    • (2011) J. Leukoc. Biol , vol.89 , pp. 85-91
    • Yang, S.1    Wang, B.2    Guan, C.3    Wu, B.4    Cai, C.5    Wang, M.6    Zhang, B.7    Liu, T.8    Yang, P.9
  • 119
    • 70349423483 scopus 로고    scopus 로고
    • Intraepithelial effector (cd3+)/regulatory (foxp3+) t-cell ratio predicts a clinical outcome of human colon carcinoma
    • Sinicrope, F.A.; Rego, R.L.; Ansell, S.M.; Knutson, K.L.; Foster, N.R.; Sargent, D.J. Intraepithelial effector (cd3+)/regulatory (foxp3+) t-cell ratio predicts a clinical outcome of human colon carcinoma. Gastroenterology 2009, 137, 1270-1279.
    • (2009) Gastroenterology , vol.137 , pp. 1270-1279
    • Sinicrope, F.A.1    Rego, R.L.2    Ansell, S.M.3    Knutson, K.L.4    Foster, N.R.5    Sargent, D.J.6
  • 122
    • 38049110724 scopus 로고    scopus 로고
    • Attack on the clones? Human foxp3 detection by pch101, 236a/e7, 206d, and 259d reveals 259d as the outlier with lower sensitivity
    • author reply 464-466
    • Pillai, V.; Karandikar, N.J. Attack on the clones? Human foxp3 detection by pch101, 236a/e7, 206d, and 259d reveals 259d as the outlier with lower sensitivity. Blood 2008, 111, 463-464; author reply 464-466.
    • (2008) Blood , vol.111 , pp. 463-464
    • Pillai, V.1    Karandikar, N.J.2
  • 123
    • 49249105900 scopus 로고    scopus 로고
    • Foxp3 immunohistochemistry on formalin-fixed paraffin-embedded tissue: Poor correlation between different antibodies
    • Woo, Y.L.; Sterling, J.; Crawford, R.; van der Burg, S.H.; Coleman, N.; Stanley, M. Foxp3 immunohistochemistry on formalin-fixed paraffin-embedded tissue: Poor correlation between different antibodies. J. Clin. Pathol. 2008, 61, 969-971.
    • (2008) J. Clin. Pathol , vol.61 , pp. 969-971
    • Woo, Y.L.1    Sterling, J.2    Crawford, R.3    van der Burg, S.H.4    Coleman, N.5    Stanley, M.6
  • 124
    • 58249089749 scopus 로고    scopus 로고
    • Tumor-infiltrating foxp3+ t regulatory cells show strong prognostic significance in colorectal cancer
    • Salama, P.; Phillips, M.; Grieu, F.; Morris, M.; Zeps, N.; Joseph, D.; Platell, C.; Iacopetta, B. Tumor-infiltrating foxp3+ t regulatory cells show strong prognostic significance in colorectal cancer. J. Clin. Oncol. 2009, 27, 186-192.
    • (2009) J. Clin. Oncol , vol.27 , pp. 186-192
    • Salama, P.1    Phillips, M.2    Grieu, F.3    Morris, M.4    Zeps, N.5    Joseph, D.6    Platell, C.7    Iacopetta, B.8
  • 126
    • 77951217044 scopus 로고    scopus 로고
    • High frequency of tumor-infiltrating foxp3(+) regulatory t cells predicts improved survival in mismatch repair-proficient colorectal cancer patients
    • Frey, D.M.; Droeser, R.A.; Viehl, C.T.; Zlobec, I.; Lugli, A.; Zingg, U.; Oertli, D.; Kettelhack, C.; Terracciano, L.; Tornillo, L. High frequency of tumor-infiltrating foxp3(+) regulatory t cells predicts improved survival in mismatch repair-proficient colorectal cancer patients. Int. J. Cancer 2010, 126, 2635-2643.
    • (2010) Int. J. Cancer , vol.126 , pp. 2635-2643
    • Frey, D.M.1    Droeser, R.A.2    Viehl, C.T.3    Zlobec, I.4    Lugli, A.5    Zingg, U.6    Oertli, D.7    Kettelhack, C.8    Terracciano, L.9    Tornillo, L.10
  • 129
    • 77955725489 scopus 로고    scopus 로고
    • Accumulation of foxp3+ t regulatory cells in draining lymph nodes correlates with disease progression and immune suppression in colorectal cancer patients
    • Deng, L.; Zhang, H.; Luan, Y.; Zhang, J.; Xing, Q.; Dong, S.; Wu, X.; Liu, M.; Wang, S. Accumulation of foxp3+ t regulatory cells in draining lymph nodes correlates with disease progression and immune suppression in colorectal cancer patients. Clin. Cancer Res. 2010, 16, 4105-4112.
    • (2010) Clin. Cancer Res , vol.16 , pp. 4105-4112
    • Deng, L.1    Zhang, H.2    Luan, Y.3    Zhang, J.4    Xing, Q.5    Dong, S.6    Wu, X.7    Liu, M.8    Wang, S.9
  • 130
    • 77749317042 scopus 로고    scopus 로고
    • Low foxp3 expression in negative sentinel lymph nodes is associated with node metastases in colorectal cancer
    • Matera, L.; Sandrucci, S.; Mussa, A.; Boffa, C.; Castellano, I.; Cassoni, P. Low foxp3 expression in negative sentinel lymph nodes is associated with node metastases in colorectal cancer. Gut 2010, 59, 419-420.
    • (2010) Gut , vol.59 , pp. 419-420
    • Matera, L.1    Sandrucci, S.2    Mussa, A.3    Boffa, C.4    Castellano, I.5    Cassoni, P.6
  • 131
    • 75149139044 scopus 로고    scopus 로고
    • Combination of ctl-associated antigen-4 blockade and depletion of cd25 regulatory t cells enhance tumour immunity of dendritic cell-based vaccine in a mouse model of colon cancer
    • Saha, A.; Chatterjee, S.K. Combination of ctl-associated antigen-4 blockade and depletion of cd25 regulatory t cells enhance tumour immunity of dendritic cell-based vaccine in a mouse model of colon cancer. Scand. J. Immunol. 2010, 71, 70-82.
    • (2010) Scand. J. Immunol , vol.71 , pp. 70-82
    • Saha, A.1    Chatterjee, S.K.2
  • 132
    • 35548950221 scopus 로고    scopus 로고
    • Regulatory-t-cell inhibition versus depletion: The right choice in cancer immunotherapy
    • Colombo, M.P.; Piconese, S. Regulatory-t-cell inhibition versus depletion: The right choice in cancer immunotherapy. Nat. Rev. Cancer 2007, 7, 880-887.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 880-887
    • Colombo, M.P.1    Piconese, S.2
  • 136
    • 50949115267 scopus 로고    scopus 로고
    • Depletion of human regulatory t cells specifically enhances antigen-specific immune responses to cancer vaccines
    • Morse, M.A.; Hobeika, A.C.; Osada, T.; Serra, D.; Niedzwiecki, D.; Lyerly, H.K.; Clay, T.M. Depletion of human regulatory t cells specifically enhances antigen-specific immune responses to cancer vaccines. Blood 2008, 112, 610-618.
    • (2008) Blood , vol.112 , pp. 610-618
    • Morse, M.A.1    Hobeika, A.C.2    Osada, T.3    Serra, D.4    Niedzwiecki, D.5    Lyerly, H.K.6    Clay, T.M.7
  • 137
    • 64549145119 scopus 로고    scopus 로고
    • Targeting of cd4+cd25high cells while preserving cd4+cd25low cells with low-dose chimeric anti-cd25 antibody in adoptive immunotherapy of cancer
    • Okita, R.; Yamaguchi, Y.; Ohara, M.; Hironaka, K.; Okawaki, M.; Nagamine, I.; Ikeda, T.; Emi, A.; Hihara, J.; Okada, M. Targeting of cd4+cd25high cells while preserving cd4+cd25low cells with low-dose chimeric anti-cd25 antibody in adoptive immunotherapy of cancer. Int. J. Oncol. 2009, 34, 563-572.
    • (2009) Int. J. Oncol , vol.34 , pp. 563-572
    • Okita, R.1    Yamaguchi, Y.2    Ohara, M.3    Hironaka, K.4    Okawaki, M.5    Nagamine, I.6    Ikeda, T.7    Emi, A.8    Hihara, J.9    Okada, M.10
  • 138
    • 70350496784 scopus 로고    scopus 로고
    • Clinical use of anti-cd25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory t cells
    • Rech, A.J.; Vonderheide, R.H. Clinical use of anti-cd25 antibody daclizumab to enhance immune responses to tumor antigen vaccination by targeting regulatory t cells. Ann. N. Y. Acad. Sci. 2009, 1174, 99-106.
    • (2009) Ann. N. Y. Acad. Sci , vol.1174 , pp. 99-106
    • Rech, A.J.1    Vonderheide, R.H.2
  • 139
    • 0036301503 scopus 로고    scopus 로고
    • Ctla-4: New insights into its biological function and use in tumor immunotherapy
    • Egen, J.G.; Kuhns, M.S.; Allison, J.P. Ctla-4: New insights into its biological function and use in tumor immunotherapy. Nat. Immunol. 2002, 3, 611-618.
    • (2002) Nat. Immunol , vol.3 , pp. 611-618
    • Egen, J.G.1    Kuhns, M.S.2    Allison, J.P.3
  • 140
    • 0034679560 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by cd25(+)cd4(+) regulatory t cells constitutively expressing cytotoxic t lymphocyte-associated antigen 4
    • Takahashi, T.; Tagami, T.; Yamazaki, S.; Uede, T.; Shimizu, J.; Sakaguchi, N.; Mak, T.W.; Sakaguchi, S. Immunologic self-tolerance maintained by cd25(+)cd4(+) regulatory t cells constitutively expressing cytotoxic t lymphocyte-associated antigen 4. J. Exp. Med. 2000, 192, 303-310.
    • (2000) J. Exp. Med , vol.192 , pp. 303-310
    • Takahashi, T.1    Tagami, T.2    Yamazaki, S.3    Uede, T.4    Shimizu, J.5    Sakaguchi, N.6    Mak, T.W.7    Sakaguchi, S.8
  • 141
    • 54449091476 scopus 로고    scopus 로고
    • Ctla-4 blockade increases ifngamma-producing cd4+icoshi cells to shift the ratio of effector to regulatory t cells in cancer patients
    • Liakou, C.I.; Kamat, A.; Tang, D.N.; Chen, H.; Sun, J.; Troncoso, P.; Logothetis, C.; Sharma, P. Ctla-4 blockade increases ifngamma-producing cd4+icoshi cells to shift the ratio of effector to regulatory t cells in cancer patients. Proc. Natl. Acad. Sci. USA 2008, 105, 14987-14992.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 14987-14992
    • Liakou, C.I.1    Kamat, A.2    Tang, D.N.3    Chen, H.4    Sun, J.5    Troncoso, P.6    Logothetis, C.7    Sharma, P.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.