The A2B adenosine receptor impairs the maturation and immunogenicity of dendritic cells

Journal of Immunology

Volumn 182, Issue 8, 2009, Pages 4616-4623

  Wilson, Jeffrey M ^a   Ross, William G ^a   Agbai, Oma N ^a   Frazier, Renea ^b   Figler, Robert A ^b   Rieger, Jayson ^b   Linden, Joel ^a   Ernst, Peter B ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b Division of Clinical Data   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2 RECEPTOR; ADENOSINE RECEPTOR A2B; CD40 ANTIGEN; CD86 ANTIGEN; CYCLIC AMP; EDELFOSINE; INTERLEUKIN 12; INTERLEUKIN 2; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ADENOSINE A2B RECEPTOR; INTERLEUKIN 10;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; DRUG ACTIVITY; IMMUNOGENICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; BIOSYNTHESIS; BONE MARROW CELL; CELL DIFFERENTIATION; COCULTURE; CYTOLOGY; DRUG EFFECT; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE;

ANIMALS; ANTIGENS, CD86; BONE MARROW CELLS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; COCULTURE TECHNIQUES; CYCLIC AMP; DENDRITIC CELLS; INTERLEUKIN-10; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; MICE; RECEPTOR, ADENOSINE A2B;

EID: 65249184022     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0801279     Document Type: Article

References (41)

1. Hasko, G., and B. N. Cronstein. 2004. Adenosine: an endogenous regulator of innate immunity. Trends Immunol. 25: 33-39. (Pubitemid 38032805)
2. 2A adenosine receptor induction. Biochem. J. 391: 575-580.
3. 2A receptors. Annu. Rev. Immunol. 22: 657-682.
4. Ohta, A., and M. Sitkovsky. 2001. Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature 414: 916-920. (Pubitemid 34024743)
5. 3 adenosine receptors in lymphoid organs. Biochem. Pharmacol. 65: 2081-2090.
6. 2B receptor-mediated posttranscriptional mechanism. J. Immunol. 175: 8260-8270.
7. 2B adenosine receptor protects against inflammation and excessive vascular adhesion. J. Clin. Invest. 116: 1913-1923.
8. 3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5′-N-methyluronamide, is protective in two murine models of colitis. Eur. J. Pharmacol. 466: 323-329.
9. Hasko, G., Z. H. Nemeth, E. S. Vizi, A. L. Salzman, and C. Szabo. 1998. An agonist of adenosine A3 receptors decreases interleukin-12 and interferon-γ production and prevents lethality in endotoxemic mice. Eur. J. Pharmacol. 358: 261-268. (Pubitemid 28498186)
10. 2B adenosine receptors. Circulation 115: 1581-1590.
11. 2A receptors in the T cell mediated regulation of colitis. J. Immunol. 177: 2765-2769.
12. 2A receptor signaling promotes peripheral tolerance by inducing T cell anergy and the generation of adaptive regulatory T cells. Blood 111: 251-259.
13. 2A adenosine receptor activation reduces ischemia-reperfusion injury in rat kidney. Am. J. Physiol. 277: F404-F412.
14. 2A adenosine receptors during reperfusion: inhibition of chemokine induction. Am. J. Physiol. 286: G285-G293.
15. Nemeth, Z. H., D. Bleich, B. Csoka, P. Pacher, J. G. Mabley, L. Himer, E. S. Vizi, E. A. Deitch, C. Szabo, B. N. Cronstein, and G. Hasko. 2007. Adenosine receptor activation ameliorates type 1 diabetes. FASEB J. 21: 2379-2388. (Pubitemid 47230668)
16. 2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation. J. Exp. Med. 203: 2639-2648.
17. + T cells. J. Immunol. 174: 1073-1080.
18. 2a extracellular adenosine receptor-mediated signaling in adenosine-mediated inhibition of T-cell activation and expansion. Blood 90: 1600-1610.
19. Deaglio, S., K. M. Dwyer, W. Gao, D. Friedman, A. Usheva, A. Erat, J. F. Chen, K. Enjyoji, J. Linden, M. Oukka, et al. 2007. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J. Exp. Med. 204: 1257-1265. (Pubitemid 46919862)
20. Kobie, J. J., P. R. Shah, L. Yang, J. A. Rebhahn, D. J. Fowell, and T. R. Mosmann. 2006. T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5′-adenosine monophosphate to adenosine. J. Immunol. 177: 6780-6786.
21. + Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood 110: 1225-1232.
22. Kapsenberg, M. L. 2003. Dendritic-cell control of pathogen-driven T-cell polarization. Nat. Rev. Immunol. 3: 984-993.
23. Colonna, M., B. Pulendran, and A. Iwasaki. 2006. Dendritic cells at the hostpathogen interface. Nat. Immunol. 7: 117-120.
24. Steinman, R. M., and H. Hemmi. 2006. Dendritic cells: translating innate to adaptive immunity. Curr. Top. Microbiol. Immunol. 311: 17-58. (Pubitemid 47413194)
25. Panther, E., M. Idzko, Y. Herouy, H. Rheinen, P. J. Gebicke-Haerter, U. Mrowietz, S. Dichmann, and J. Norgauer. 2001. Expression and function of adenosine receptors in human dendritic cells. FASEB J. 15: 1963-1970. (Pubitemid 32848800)
26. Panther, E., S. Corinti, M. Idzko, Y. Herouy, M. Napp, A. la Sala, G. Girolomoni, and J. Norgauer. 2003. Adenosine affects expression of membrane molecules, cytokine and chemokine release, and the T-cell stimulatory capacity of human dendritic cells. Blood 101: 3985-3990. (Pubitemid 36857876)
27. Hofer, S., L. Ivarsson, P. Stoitzner, M. Auffinger, C. Rainer, N. Romani, and C. Heufler. 2003. Adenosine slows migration of dendritic cells but does not affect other aspects of dendritic cell maturation. J. Invest. Dermatol. 121: 300-307. (Pubitemid 36969904)
28. Schnurr, M., T. Toy, A. Shin, G. Hartmann, S. Rothenfusser, J. Soellner, I. D. Davis, J. Cebon, and E. Maraskovsky. 2004. Role of adenosine receptors in regulating chemotaxis and cytokine production of plasmacytoid dendritic cells. Blood 103: 1391-1397. (Pubitemid 38168654)
29. Desrosiers, M. D., K. M. Cembrola, M. J. Fakir, L. A. Stephens, F. M. Jama, A. Shameli, W. Z. Mehal, P. Santamaria, and Y. Shi. 2007. Adenosine deamination sustains dendritic cell activation in inflammation. J. Immunol. 179: 1884-1892.
30. Denning, T. L., Y. C. Wang, S. R. Patel, I. R. Williams, and B. Pulendran. 2007. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat. Immunol. 8: 1086-1094.
31. Hirschfeld, M., Y. Ma, J. H. Weis, S. N. Vogel, and J. J. Weis. 2000. Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine Toll-like receptor 2. J. Immunol. 165: 618-622. (Pubitemid 30484724)
32. Livak, K. J., and T. D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔCT) method. Methods 25: 402-408. (Pubitemid 34164012)
33. 2A receptor agonists. Br. J. Pharmacol. 132: 1017-1026.
34. 2a receptor-dependent and independent mechanisms. FASEB J. 14: 2065-2074.
35. Villadangos, J. A., and P. Schnorrer. 2007. Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo. Nat. Rev. Immunol. 7: 543-555.
36. 2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases. Microbes Infect. 5: 515-526.
37. Lutz, M. B., N. Kukutsch, A. L. Ogilvie, S. Rossner, F. Koch, N. Romani, and G. Schuler. 1999. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 223: 77-92.
38. 2B receptor. Eur. J. Immunol. 38: 1610-1620.
39. Novitskiy, S. V., S. Ryzhov, R. Zaynagetdinov, A. E. Goldstein, Y. Huang, O. Y. Tikhomirov, M. R. Blackburn, I. Biaggioni, D. P. Carbone, I. Feoktistov, and M. M. Dikov. 2008. Adenosine receptors in regulation of dendritic cell differentiation and function. Blood 112: 1822-1831.
40. Reis e Sousa, C. 2006. Dendritic cells in a mature age. Nat. Rev. Immunol. 6: 476-483.
41. Rutella, S., S. Danese, and G. Leone. 2006. Tolerogenic dendritic cells: cytokine modulation comes of age. Blood 108: 1435-1440. (Pubitemid 44316106)