A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells

Gastroenterology

Volumn 135, Issue 1, 2008, Pages 234-243

  Hoechst, Bastian ^a,b   Ormandy, Lars A ^a   Ballmaier, Matthias ^a   Lehner, Frank ^a   Krüger, Christine ^a   Manns, Michael P ^a   Greten, Tim F ^a,b   Korangy, Firouzeh ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA FETOPROTEIN; CD14 ANTIGEN; HLA DR ANTIGEN; INTERLEUKIN 10; TRANSCRIPTION FACTOR FOXP3;

ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL ISOLATION; CELL SELECTION; COCULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOREGULATION; LIVER CELL CARCINOMA; LYMPHOCYTE PROLIFERATION; MIXED LYMPHOCYTE REACTION; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; STATISTICAL ANALYSIS; SUPPRESSOR CELL;

EID: 46049098560     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2008.03.020     Document Type: Article

References (30)

1. Swann J.B., and Smyth M.J. Immune surveillance of tumors. J Clin Invest 117 (2007) 1137-1146
2. Serafini P., Borrello I., and Bronte V. Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression. Semin Cancer Biol 16 (2006) 53-65
3. Schmielau J., and Finn O.J. Activated granulocytes and granulocyte-derived hydrogen peroxide are the underlying mechanism of suppression of T-cell function in advanced cancer patients. Cancer Res 61 (2001) 4756-4760
4. Pak A.S., Wright M.A., Matthews J.P., et al. Mechanisms of immune suppression in patients with head and neck cancer: presence of CD34(+) cells which suppress immune functions within cancers that secrete granulocyte-macrophage colony-stimulating factor. Clin Cancer Res 1 (1995) 95-103
5. Zea A.H., Rodriguez P.C., Atkins M.B., et al. Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion. Cancer Res 65 (2005) 3044-3048
6. Mirza N., Fishman M., Fricke I., et al. All-trans-retinoic acid improves differentiation of myeloid cells and immune response in cancer patients. Cancer Res 66 (2006) 9299-9307
7. Almand B., Clark J.I., Nikitina E., et al. Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer. J Immunol 166 (2001) 678-689
8. Korangy F., Ormandy L.A., Bleck J.S., et al. Spontaneous Tumor-Specific Humoral and Cellular Immune Responses to NY-ESO-1 in Hepatocellular Carcinoma. Clin Cancer Res 10 (2004) 4332-4341
9. Ormandy L.A., Hillemann T., Wedemeyer H., et al. Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma. Cancer Res 65 (2005) 2457-2464
10. Ormandy L.A., Farber A., Cantz T., et al. Direct ex vivo analysis of dendritic cells in patients with hepatocellular carcinoma. World J Gastroenterol 12 (2006) 3275-3282
11. Greten T.F., Korangy F., Neumann G., et al. Peptide-beta2-microglobulin-MHC fusion molecules bind antigen-specific T cells and can be used for multivalent MHC-Ig complexes. J Immunol Meth 271 (2002) 125-135
12. Sinha P., Clements V.K., and Ostrand-Rosenberg S. Reduction of myeloid-derived suppressor cells and induction of m1 macrophages facilitate the rejection of established metastatic disease. J Immunol 174 (2005) 636-645
13. Ayaru L., Pereira S.P., Alisa A., et al. Unmasking of alpha-fetoprotein-specific CD4(+) T cell responses in hepatocellular carcinoma patients undergoing embolization. J Immunol 178 (2007) 1914-1922
14. Garbe A.I., Vermeer B., Gamrekelashvili J., et al. Genetically induced pancreatic adenocarcinoma is highly immunogenic and causes spontaneous tumor-specific immune responses. Cancer Res 66 (2006) 508-516
15. Rodriguez P.C., Quiceno D.G., Zabaleta J., et al. Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. Cancer Res 64 (2004) 5839-5849
16. Bronte V., Serafini P., Mazzoni A., et al. L-arginine metabolism in myeloid cells controls T-lymphocyte functions. Trends Immunol 24 (2003) 302-306
17. Greten T.F., Manns M.P., and Korangy F. Immunotherapy of hepatocellular carcinoma. J Hepatol 45 (2006) 868-878
18. Gallina G., Dolcetti L., Serafini P., et al. Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J Clin Invest 116 (2006) 2777-2790
19. Filipazzi P., Valenti R., Huber V., et al. Identification of a new subset of myeloid suppressor cells in peripheral blood of melanoma patients with modulation by a granulocyte-macrophage colony-stimulation factor-based antitumor vaccine. J Clin Oncol 25 (2007) 2546-2553
20. Serafini P., Meckel K., Kelso M., et al. Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. J Exp Med 203 (2006) 2691-2702
21. Zou W. Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 6 (2006) 295-307
22. Curiel T.J., Coukos G., Zou L., et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 10 (2004) 942-949
23. Gao Q., Qiu S.J., Fan J., et al. Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. J Clin Oncol 25 (2007) 2586-2593
24. Lan Y.Y., Wang Z., Raimondi G., et al. "Alternatively activated" dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig. J Immunol 177 (2006) 5868-5877
25. Verhasselt V., Vosters O., Beuneu C., et al. Induction of FOXP3-expressing regulatory CD4pos T cells by human mature autologous dendritic cells. Eur J Immunol 34 (2004) 762-772
26. Banerjee D., Dhodapkar M.V., Matayeva E., et al. Expansion of FOXP3 high regulatory T cells by human dendritic cells (DCs) in vitro and after DC injection of cytokine matured DCs in myeloma patients. Blood 108 (2006) 2655-2661
27. Jonuleit H., Schmitt E., Schuler G., et al. Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med 192 (2000) 1213-1222
28. Sato K., Yamashita N., Baba M., et al. Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells. Blood 101 (2003) 3581-3589
29. Huang B., Pan P.Y., Li Q., et al. Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host. Cancer Res 66 (2006) 1123-1131
30. Nagaraj S., Gupta K., Pisarev V., et al. Altered recognition of antigen is a mechanism of CD8(+) T cell tolerance in cancer. Nat Med 13 (2007) 828-835