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Volumn 126, Issue 11, 2010, Pages 2635-2643

High frequency of tumor-infiltrating FOXP3+ regulatory T cells predicts improved survival in mismatch repair-proficient colorectal cancer patients

Author keywords

FOXP3; Human colorectal cancer; Regulatory T cells; Tissue microarray; Tumor infiltrating lymphocytes

Indexed keywords

CD3 ANTIGEN; CD8 ANTIGEN; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN;

EID: 77951217044     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.24989     Document Type: Article
Times cited : (294)

References (48)
  • 3
    • 14544300998 scopus 로고    scopus 로고
    • Systematic review of microsatellite instability and colorectal cancer prognosis
    • DOI 10.1200/JCO.2005.01.086
    • Popat S, Hubner R, Houlston RS. Systematic review of microsatellite instability and colorectal cancer prognosis. J Clin Oncol 2005;23:609-618 (Pubitemid 46224239)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.3 , pp. 609-618
    • Popat, S.1    Hubner, R.2    Houlston, R.S.3
  • 4
    • 16844365788 scopus 로고    scopus 로고
    • + regulatory T cells in immunological tolerance to self and non-self
    • DOI 10.1038/ni1178
    • Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005;6:345-352 (Pubitemid 41716771)
    • (2005) Nature Immunology , vol.6 , Issue.4 , pp. 345-352
    • Sakaguchi, S.1
  • 5
    • 33847647528 scopus 로고    scopus 로고
    • Regulatory T cells and cancer
    • Wang HY, Wang RF. Regulatory T cells and cancer. Curr Opin Immunol 2007;19: 217-223
    • (2007) Curr Opin Immunol , vol.19 , pp. 217-223
    • Wang, H.Y.1    Wang, R.F.2
  • 6
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • DOI 10.1126/science.1079490
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299:1057-1061 (Pubitemid 36222930)
    • (2003) Science , vol.299 , Issue.5609 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 7
    • 28544433483 scopus 로고    scopus 로고
    • The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer
    • DOI 10.1158/1078-0432.CCR-05-1244
    • Wolf D, Wolf AM, Rumpold H, Fiegl H, Zeimet AG, Muller-Holzner E, Deibl M, Gastl G, Gunsilius E, Marth C. The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer. Clin Cancer Res 2005;11:8326-8331 (Pubitemid 41746944)
    • (2005) Clinical Cancer Research , vol.11 , Issue.23 , pp. 8326-8331
    • Wolf, D.1    Wolf, A.M.2    Rumpold, H.3    Fiegl, H.4    Zeimet, A.G.5    Muller-Holzner, E.6    Deibl, M.7    Gastl, G.8    Gunsilius, E.9    Marth, C.10
  • 8
    • 34247261531 scopus 로고    scopus 로고
    • Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse
    • DOI 10.1200/JCO.2006.05.9584
    • Bates GJ, Fox SB, Han C, Leek RD, Garcia JF, Harris AL, Banham AH. Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse. J Clin Oncol 2006;24:5373-5380 (Pubitemid 46623168)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.34 , pp. 5373-5380
    • Bates, G.J.1    Fox, S.B.2    Han, C.3    Leek, R.D.4    Garcia, J.F.5    Harris, A.L.6    Banham, A.H.7
  • 10
    • 33845590308 scopus 로고    scopus 로고
    • Tumor infiltrating Foxp3+ regulatory T-cells are associated with recurrence in pathologic stage I NSCLC patients
    • Petersen RP, Campa MJ, Sperlazza J, Conlon D, Joshi MB, Harpole DH, Jr, Patz EF, Jr. Tumor infiltrating Foxp3+ regulatory T-cells are associated with recurrence in pathologic stage I NSCLC patients. Cancer 2006;107:2866-2872
    • (2006) Cancer , vol.107 , pp. 2866-2872
    • Petersen, R.P.1    Campa, M.J.2    Sperlazza, J.3    Conlon, D.4    Joshi, M.B.5    Harpole Jr., D.H.6    Patz Jr., E.F.7
  • 12
    • 33749317518 scopus 로고    scopus 로고
    • + regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions
    • DOI 10.1158/1078-0432.CCR-06-0369
    • Hiraoka N, Onozato K, Kosuge T, Hirohashi S. Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions. Clin Cancer Res 2006;12:5423-5434 (Pubitemid 44497257)
    • (2006) Clinical Cancer Research , vol.12 , Issue.18 , pp. 5423-5434
    • Hiraoka, N.1    Onozato, K.2    Kosuge, T.3    Hirohashi, S.4
  • 16
    • 33745215983 scopus 로고    scopus 로고
    • Tumor-infiltrating cytotoxic T cells but not regulatory T cells predict outcome in anal squamous cell carcinoma
    • DOI 10.1158/1078-0432.CCR-05-2434
    • Grabenbauer GG, Lahmer G, Distel L, Niedobitek G. Tumor-infiltrating cytotoxic T cells but not regulatory T cells predict outcome in anal squamous cell carcinoma. Clin Cancer Res 2006;12:3355-3360 (Pubitemid 43910879)
    • (2006) Clinical Cancer Research , vol.12 , Issue.11 I , pp. 3355-3360
    • Grabenbauer, G.G.1    Lahmer, G.2    Distel, L.3    Niedobitek, G.4
  • 17
    • 33751194652 scopus 로고    scopus 로고
    • High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma
    • Carreras J, Lopez-Guillermo A, Fox BC, Colomo L, Martinez A, Roncador G, Montserrat E, Campo E, Banham AH. High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma. Blood 2006;108: 2957-2964
    • (2006) Blood , vol.108 , pp. 2957-2964
    • Carreras, J.1    Lopez-Guillermo, A.2    Fox, B.C.3    Colomo, L.4    Martinez, A.5    Roncador, G.6    Montserrat, E.7    Campo, E.8    Banham, A.H.9
  • 20
    • 23244443650 scopus 로고    scopus 로고
    • Cancer risk in hereditary nonpolyposis colorectal cancer syndrome: Later age of onset
    • DOI 10.1016/j.gastro.2005.05.011, PII S0016508505008814
    • Hampel H, Stephens JA, Pukkala E, Sankila R, Aaltonen LA, Mecklin JP, de la Chapelle A. Cancer risk in hereditary nonpolyposis colorectal cancer syndrome: later age of onset. Gastroenterology 2005; 129:415-421 (Pubitemid 41096629)
    • (2005) Gastroenterology , vol.129 , Issue.2 , pp. 415-421
    • Hampel, H.1    Stephens, J.A.2    Pukkala, E.3    Sankila, R.4    Aaltonen, L.A.5    Mecklin, J.-P.6    De La Chapelle, A.7
  • 21
    • 0022453271 scopus 로고
    • The grading of rectal cancer: Historical perspectives and a multivariate analysis of 447 cases
    • Jass JR, Atkin WS, Cuzick J, Bussey HJ, Morson BC, Northover JM, Todd IP. The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases. Histopathology 1986;10:437-459 (Pubitemid 16039125)
    • (1986) Histopathology , vol.10 , Issue.5 , pp. 437-459
    • Jass, J.R.1    Atkin, W.S.2    Cuzick, J.3
  • 22
    • 34848842992 scopus 로고    scopus 로고
    • Selecting immunohistochemical cut-off scores for novel biomarkers of progression and survival in colorectal cancer
    • DOI 10.1136/jcp.2006.044537
    • Zlobec I, Steele R, Terracciano L, Jass JR, Lugli A. Selecting immunohistochemical cut-off scores for novel biomarkers of progression and survival in colorectal cancer. J Clin Pathol 2007;60:1112-1116 (Pubitemid 47612643)
    • (2007) Journal of Clinical Pathology , vol.60 , Issue.10 , pp. 1112-1116
    • Zlobec, I.1    Steele, R.2    Terracciano, L.3    Jass, J.R.4    Lugli, A.5
  • 23
    • 34347340406 scopus 로고    scopus 로고
    • Focus on TILs: Prognostic significance of tumor infiltrating lymphocytes in human colorectal cancer
    • Ohtani H. Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human colorectal cancer. Cancer Immunol 2007;7:4. (Pubitemid 46364317)
    • (2007) Cancer Immunity , vol.7
    • Ohtani, H.1
  • 24
    • 33947216118 scopus 로고    scopus 로고
    • The adaptive immunologic microenvironment in colorectal cancer: A novel perspective
    • DOI 10.1158/0008-5472.CAN-06-4806
    • Galon J, Fridman WH, Pages F. The adaptive immunologic microenvironment in colorectal cancer: a novel perspective. Cancer Res 2007;67:1883-1886 (Pubitemid 46424201)
    • (2007) Cancer Research , vol.67 , Issue.5 , pp. 1883-1886
    • Galon, J.1    Fridman, W.-H.2    Pages, F.3
  • 25
    • 34447277894 scopus 로고    scopus 로고
    • Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection
    • DOI 10.1200/JCO.2006.09.4565
    • Gao Q, Qiu SJ, Fan J, Zhou J, Wang XY, Xiao YS, Xu Y, Li YW, Tang ZY. Intratumoral balance of regulatory and cytotoxic T cells is associated with prognosis of hepatocellular carcinoma after resection. J Clin Oncol 2007;25:2586-2593 (Pubitemid 47041232)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.18 , pp. 2586-2593
    • Gao, Q.1    Qiu, S.-J.2    Fan, J.3    Zhou, J.4    Wang, X.-Y.5    Xiao, Y.-S.6    Xu, Y.7    Li, Y.-W.8    Tang, Z.-Y.9
  • 29
    • 23044463715 scopus 로고    scopus 로고
    • CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients
    • Nishikawa H, Jager E, Ritter G, Old LJ, Gnjatic S. CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients. Blood 2005;106:1008-1011
    • (2005) Blood , vol.106 , pp. 1008-1011
    • Nishikawa, H.1    Jager, E.2    Ritter, G.3    Old, L.J.4    Gnjatic, S.5
  • 34
    • 15244354491 scopus 로고    scopus 로고
    • De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- Cells
    • Walker MR, Carson BD, Nepom GT, Ziegler SF, Buckner JH. De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells. Proc Natl Acad Sci USA 2005;102:4103-4108
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 4103-4108
    • Walker, M.R.1    Carson, B.D.2    Nepom, G.T.3    Ziegler, S.F.4    Buckner, J.H.5
  • 36
    • 33846577890 scopus 로고    scopus 로고
    • Differential significance of tumour infiltrating lymphocytes in sporadic mismatch repair deficient versus proficient colorectal cancers: A potential role for dysregulation of the transforming growth factor-beta pathway
    • DOI 10.1016/j.ejca.2006.11.012, PII S0959804906010264
    • Baker K, Zlobec I, Tornillo L, Terracciano L, Jass JR, Lugli A. Differential significance of tumour infiltrating lymphocytes in sporadic mismatch repair deficient versus proficient colorectal cancers: a potential role for dysregulation of the transforming growth factor-beta pathway. Eur J Cancer 2007;43:624-631 (Pubitemid 46178541)
    • (2007) European Journal of Cancer , vol.43 , Issue.3 , pp. 624-631
    • Baker, K.1    Zlobec, I.2    Tornillo, L.3    Terracciano, L.4    Jass, J.R.5    Lugli, A.6
  • 39
    • 19944365184 scopus 로고    scopus 로고
    • Microsatellite instability in colorectal cancer is associated with local lymphocyte infiltration and low frequency of distant metastases
    • DOI 10.1038/sj.bjc.6602534
    • Buckowitz A, Knaebel HP, Benner A, Blaker H, Gebert J, Kienle P, von Knebel Doeberitz M, Kloor M. Microsatellite instability in colorectal cancer is associated with local lymphocyte infiltration and low frequency of distant metastases. Br J Cancer 2005;92:1746-1753 (Pubitemid 40756487)
    • (2005) British Journal of Cancer , vol.92 , Issue.9 , pp. 1746-1753
    • Buckowitz, A.1    Knaebel, H.-P.2    Benner, A.3    Blaker, H.4    Gebert, J.5    Kienle, P.6    Von Knebel Doeberitz, M.7    Kloor, M.8
  • 41
    • 0027248156 scopus 로고
    • Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review
    • Lynch HT, Smyrk TC, Watson P, Lanspa SJ, Lynch JF, Lynch PM, Cavalieri RJ, Boland CR. Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review. Gastroenterology 1993;104:1535-1549 (Pubitemid 23235432)
    • (1993) Gastroenterology , vol.104 , Issue.5 , pp. 1535-1549
    • Lynch, H.T.1    Smyrk, T.C.2    Watson, P.3    Lanspa, S.J.4    Lynch, J.F.5    Lynch, P.M.6    Cavalieri, R.J.7    Boland, C.R.8
  • 42
    • 0141815907 scopus 로고    scopus 로고
    • Tumor-specific immunological recognition of frameshift-mutated peptides in colon cancer with microsatellite instability
    • Ishikawa T, Fujita T, Suzuki Y, Okabe S, Yuasa Y, Iwai T, Kawakami Y. Tumor-specific immunological recognition of frameshift-mutated peptides in colon cancer with microsatellite instability. Cancer Res 2003;63:5564-5572 (Pubitemid 37139879)
    • (2003) Cancer Research , vol.63 , Issue.17 , pp. 5564-5572
    • Ishikawa, T.1    Fujita, T.2    Suzuki, Y.3    Okabe, S.4    Yuasa, Y.5    Iwai, T.6    Kawakami, Y.7
  • 45
    • 15444377017 scopus 로고    scopus 로고
    • + cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors
    • DOI 10.1084/jem.20041684
    • Yu P, Lee Y, Liu W, Krausz T, Chong A, Schreiber H, Fu YX. Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors. J Exp Med 2005;201: 779-791 (Pubitemid 40395122)
    • (2005) Journal of Experimental Medicine , vol.201 , Issue.5 , pp. 779-791
    • Yu, P.1    Lee, Y.2    Liu, W.3    Krausz, T.4    Chong, A.5    Schreiber, H.6    Fu, Y.-X.7
  • 46
    • 55149094300 scopus 로고    scopus 로고
    • Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells
    • Koenen HJ, Smeets RL, Vink PM, van Rijssen E, Boots AM, Joosten I. Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells. Blood 2008;112:2340-2352
    • (2008) Blood , vol.112 , pp. 2340-2352
    • Koenen, H.J.1    Smeets, R.L.2    Vink, P.M.3    Van Rijssen, E.4    Boots, A.M.5    Joosten, I.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.