Fluid shear stress and NO decrease the activity of the hydroxy- methylglutaryl coenzyme A reductase in endothelial cells via the AMP-activated protein kinase and FoxO1

Circulation Research

Volumn 100, Issue 2, 2007, Pages

  Fisslthaler, Beate ^a   Fleming, Ingrid ^a   Keserü, Benjamin ^a   Walsh, Kenneth ^b   Busse, Rudi ^a  

^a GOETHE UNIVERSITY   (Germany)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Endothelial cells; HMG CoA reductase; Nitric oxide; Shear stress; Signal transduction

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; BRADYKININ; CERIVASTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MEVALONIC ACID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; RAS PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FKHR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EXERCISE; FEMORAL ARTERY; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SHEAR STRESS; SIGNAL TRANSDUCTION; VASODILATATION;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; NITRIC OXIDE; PROTEIN-SERINE-THREONINE KINASES; SHEAR STRENGTH; STRESS, MECHANICAL; SWINE;

EID: 33846839230     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000257747.74358.1c     Document Type: Article

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