메뉴 건너뛰기




Volumn 574, Issue 1, 2006, Pages 63-71

AMPK and cell proliferation - AMPK as a therapeutic target for atherosclerosis and cancer

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; ADIPONECTIN; CHOLESTEROL; FATTY ACID; GROWTH FACTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; MEVALONIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE LKB1; PROTEIN P21; PROTEIN P53; TUBERIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE;

EID: 33745213627     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2006.108324     Document Type: Review
Times cited : (462)

References (79)
  • 1
    • 0037129861 scopus 로고    scopus 로고
    • Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell
    • Arita Y, Kihara S, Ouchi N, Maeda K, Kuriyama H, Okamoto Y et al. (2002). Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation 105, 2893-2898.
    • (2002) Circulation , vol.105 , pp. 2893-2898
    • Arita, Y.1    Kihara, S.2    Ouchi, N.3    Maeda, K.4    Kuriyama, H.5    Okamoto, Y.6
  • 2
    • 4944255743 scopus 로고    scopus 로고
    • Post-translational modification of p53 in tumorigenesis
    • Bode AM & Dong Z (2004). Post-translational modification of p53 in tumorigenesis. Nat Rev Cancer 4, 793-805.
    • (2004) Nat Rev Cancer , vol.4 , pp. 793-805
    • Bode, A.M.1    Dong, Z.2
  • 3
    • 0037025356 scopus 로고    scopus 로고
    • AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through downregulated mTOR signaling
    • Bolster DR, Crozier SJ, Kimball SR & Jefferson LS (2002). AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through downregulated mTOR signaling. J Biol Chem 277, 23977-23980.
    • (2002) J Biol Chem , vol.277 , pp. 23977-23980
    • Bolster, D.R.1    Crozier, S.J.2    Kimball, S.R.3    Jefferson, L.S.4
  • 4
    • 0037524354 scopus 로고    scopus 로고
    • LKB1, a protein kinase regulating cell proliferation and polarity
    • Boudeau J, Sapkota G & Alessi DR (2003). LKB1, a protein kinase regulating cell proliferation and polarity. FEBS Lett 546, 159-165.
    • (2003) FEBS Lett , vol.546 , pp. 159-165
    • Boudeau, J.1    Sapkota, G.2    Alessi, D.R.3
  • 5
    • 33645766204 scopus 로고    scopus 로고
    • Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
    • Bowker SL, Majumdar SR, Veugelers P & Johnson JA (2006). Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 29, 254-258.
    • (2006) Diabetes Care , vol.29 , pp. 254-258
    • Bowker, S.L.1    Majumdar, S.R.2    Veugelers, P.3    Johnson, J.A.4
  • 7
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC (2002). The phosphoinositide 3-kinase pathway. Science 296, 1655-1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 8
    • 7244261884 scopus 로고    scopus 로고
    • TOR signaling in mammals
    • Carrera AC (2004). TOR signaling in mammals. J Cell Sci 117, 4615-4616.
    • (2004) J Cell Sci , vol.117 , pp. 4615-4616
    • Carrera, A.C.1
  • 9
    • 1942469564 scopus 로고    scopus 로고
    • Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status
    • Cheng SW, Fryer LG, Carling D & Shepherd PR (2004). Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status. J Biol Chem 279, 15719-15722.
    • (2004) J Biol Chem , vol.279 , pp. 15719-15722
    • Cheng, S.W.1    Fryer, L.G.2    Carling, D.3    Shepherd, P.R.4
  • 10
    • 0033593316 scopus 로고    scopus 로고
    • Size control in animal development
    • Conlon I & Raff M (1999). Size control in animal development. Cell 96, 235-244.
    • (1999) Cell , vol.96 , pp. 235-244
    • Conlon, I.1    Raff, M.2
  • 11
    • 0028406897 scopus 로고
    • Role of the AMP-activated protein kinase in the cellular stress response
    • Corton JM, Gillespie JG & Hardie DG (1994). Role of the AMP-activated protein kinase in the cellular stress response. Curr Biol 4, 315-324.
    • (1994) Curr Biol , vol.4 , pp. 315-324
    • Corton, J.M.1    Gillespie, J.G.2    Hardie, D.G.3
  • 13
    • 23244446639 scopus 로고    scopus 로고
    • The effects of statins on endothelium, inflammation and cardioprotection
    • Elrod JW & Lefer DJ (2005). The effects of statins on endothelium, inflammation and cardioprotection. Drug News Perspect 18, 229-236.
    • (2005) Drug News Perspect , vol.18 , pp. 229-236
    • Elrod, J.W.1    Lefer, D.J.2
  • 15
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • Fingar DC & Blenis J (2004). Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23, 3151-3171.
    • (2004) Oncogene , vol.23 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 16
    • 0345732640 scopus 로고    scopus 로고
    • mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
    • Fingar DC, Richardson CJ, Tee AR, Cheatham L, Tsou C & Blenis J (2004). mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol 24, 200-216.
    • (2004) Mol Cell Biol , vol.24 , pp. 200-216
    • Fingar, D.C.1    Richardson, C.J.2    Tee, A.R.3    Cheatham, L.4    Tsou, C.5    Blenis, J.6
  • 17
    • 0037097863 scopus 로고    scopus 로고
    • Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
    • Fingar DC, Salama S, Tsou C, Harlow E & Blenis J (2002). Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev 16, 1472-1487.
    • (2002) Genes Dev , vol.16 , pp. 1472-1487
    • Fingar, D.C.1    Salama, S.2    Tsou, C.3    Harlow, E.4    Blenis, J.5
  • 18
    • 21144470441 scopus 로고    scopus 로고
    • Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity
    • Forcet C, Etienne-Manneville S, Gaude H, Fournier L, Debilly S, Salmi M, Baas A, Olschwang S, Clevers H & Billaud M (2005). Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity. Hum Mol Genet 14, 1283-1292.
    • (2005) Hum Mol Genet , vol.14 , pp. 1283-1292
    • Forcet, C.1    Etienne-Manneville, S.2    Gaude, H.3    Fournier, L.4    Debilly, S.5    Salmi, M.6    Baas, A.7    Olschwang, S.8    Clevers, H.9    Billaud, M.10
  • 19
    • 0032511053 scopus 로고    scopus 로고
    • AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes
    • Foretz M, Carling D, Guichard C, Ferre P & Foufelle F (1998). AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes. J Biol Chem 273, 14767-14771.
    • (1998) J Biol Chem , vol.273 , pp. 14767-14771
    • Foretz, M.1    Carling, D.2    Guichard, C.3    Ferre, P.4    Foufelle, F.5
  • 20
    • 0038433304 scopus 로고    scopus 로고
    • Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
    • Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H et al. (2003). Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell 11, 1457-1466.
    • (2003) Mol Cell , vol.11 , pp. 1457-1466
    • Garami, A.1    Zwartkruis, F.J.2    Nobukuni, T.3    Joaquin, M.4    Roccio, M.5    Stocker, H.6
  • 22
    • 2942687834 scopus 로고    scopus 로고
    • Adiponectin: A novel adipokine linking adipocytes and vascular function
    • Goldstein BJ & Scalia R (2004). Adiponectin: A novel adipokine linking adipocytes and vascular function. J Clin Endocrinol Metab 89, 2563-2568.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2563-2568
    • Goldstein, B.J.1    Scalia, R.2
  • 23
    • 0029119740 scopus 로고
    • Cell cycle control in mammalian cells: Role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs)
    • Grana X & Reddy EP (1995). Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 11, 211-219.
    • (1995) Oncogene , vol.11 , pp. 211-219
    • Grana, X.1    Reddy, E.P.2
  • 24
    • 0344081177 scopus 로고    scopus 로고
    • Minireview: The AMP-activated protein kinase cascade: The key sensor of cellular energy status
    • Hardie DG (2003). Minireview: The AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology 144, 5179-5183.
    • (2003) Endocrinology , vol.144 , pp. 5179-5183
    • Hardie, D.G.1
  • 25
    • 10944247187 scopus 로고    scopus 로고
    • The AMP-activated protein kinase pathway - New players upstream and downstream
    • Hardie DG (2004). The AMP-activated protein kinase pathway - new players upstream and downstream. J Cell Sci 117, 5479-5487.
    • (2004) J Cell Sci , vol.117 , pp. 5479-5487
    • Hardie, D.G.1
  • 26
    • 15044358594 scopus 로고    scopus 로고
    • New roles for the LKB1 →AMPK pathway
    • Hardie DG (2005). New roles for the LKB1 →AMPK pathway. Curr Opin Cell Biol 17, 167-173.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 167-173
    • Hardie, D.G.1
  • 27
    • 0031007065 scopus 로고    scopus 로고
    • The AMP-activated protein kinase - Fuel gauge of the mammalian cell?
    • Hardie DG & Carling D (1997). The AMP-activated protein kinase - fuel gauge of the mammalian cell? Eur J Biochem 246, 259-273.
    • (1997) Eur J Biochem , vol.246 , pp. 259-273
    • Hardie, D.G.1    Carling, D.2
  • 28
    • 0031717105 scopus 로고    scopus 로고
    • The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
    • Hardie DG, Carling D & Carlson M (1998). The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67, 821-855.
    • (1998) Annu Rev Biochem , vol.67 , pp. 821-855
    • Hardie, D.G.1    Carling, D.2    Carlson, M.3
  • 29
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
    • Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Makela TP, Alessi DR & Hardie DG (2003). Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2, 28.
    • (2003) J Biol , vol.2 , pp. 28
    • Hawley, S.A.1    Boudeau, J.2    Reid, J.L.3    Mustard, K.J.4    Udd, L.5    Makela, T.P.6    Alessi, D.R.7    Hardie, D.G.8
  • 30
    • 0029005507 scopus 로고
    • Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase
    • Henin N, Vincent MF, Gruber HE & Van den Berghe G (1995). Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase. FASEB J 9, 541-546.
    • (1995) FASEB J , vol.9 , pp. 541-546
    • Henin, N.1    Vincent, M.F.2    Gruber, H.E.3    Van den Berghe, G.4
  • 31
    • 0037143449 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis
    • Horman S, Browne G, Krause U, Patel J, Vertommen D, Bertrand L et al. (2002). Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis. Curr Biol 12, 1419-1423.
    • (2002) Curr Biol , vol.12 , pp. 1419-1423
    • Horman, S.1    Browne, G.2    Krause, U.3    Patel, J.4    Vertommen, D.5    Bertrand, L.6
  • 32
    • 0027938209 scopus 로고
    • Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age
    • Hunter T & Pines J (1994). Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. Cell 79, 573-582.
    • (1994) Cell , vol.79 , pp. 573-582
    • Hunter, T.1    Pines, J.2
  • 33
    • 26844527037 scopus 로고    scopus 로고
    • Adenosine monophosphate-activated protein kinase suppresses vascular smooth muscle cell proliferation through the inhibition of cell cycle progression
    • Igata M, Motoshima H, Tsuruzoe K, Kojima K, Matsumura T, Kondo T et al. (2005). Adenosine monophosphate-activated protein kinase suppresses vascular smooth muscle cell proliferation through the inhibition of cell cycle progression. Circ Res 97, 837-844.
    • (2005) Circ Res , vol.97 , pp. 837-844
    • Igata, M.1    Motoshima, H.2    Tsuruzoe, K.3    Kojima, K.4    Matsumura, T.5    Kondo, T.6
  • 34
    • 0035929359 scopus 로고    scopus 로고
    • Cell cycle regulation via p53 phosphorylation by a 5′-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line
    • Imamura K, Ogura T, Kishimoto A, Kaminishi M & Esumi H (2001). Cell cycle regulation via p53 phosphorylation by a 5′-AMP activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line. Biochem Biophys Res Commun 287, 562-567.
    • (2001) Biochem Biophys Res Commun , vol.287 , pp. 562-567
    • Imamura, K.1    Ogura, T.2    Kishimoto, A.3    Kaminishi, M.4    Esumi, H.5
  • 35
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki K, Li Y, Zhu T, Wu J & Guan KL (2002). TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4, 648-657.
    • (2002) Nat Cell Biol , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 36
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K, Zhu T & Guan KL (2003). TSC2 mediates cellular energy response to control cell growth and survival. Cell 115, 577-590.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 38
    • 0037444404 scopus 로고    scopus 로고
    • Growth and molecular profile of lung cancer cells expressing ectopic LKB1: Down-regulation of the phosphatidylinositol 3′-phosphate kinase/PTEN pathway
    • Jimenez AI, Fernandez P, Dominguez O, Dopazo A & Sanchez-Cespedes M (2003). Growth and molecular profile of lung cancer cells expressing ectopic LKB1: Down-regulation of the phosphatidylinositol 3′-phosphate kinase/PTEN pathway. Cancer Res 63, 1382-1388.
    • (2003) Cancer Res , vol.63 , pp. 1382-1388
    • Jimenez, A.I.1    Fernandez, P.2    Dominguez, O.3    Dopazo, A.4    Sanchez-Cespedes, M.5
  • 41
    • 0034964446 scopus 로고    scopus 로고
    • The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
    • Karuman P, Gozani O, Odze RD, Zhou XC, Zhu H, Shaw R et al. (2001). The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. Mol Cell 7, 1307-1319.
    • (2001) Mol Cell , vol.7 , pp. 1307-1319
    • Karuman, P.1    Gozani, O.2    Odze, R.D.3    Zhou, X.C.4    Zhu, H.5    Shaw, R.6
  • 43
    • 0037276069 scopus 로고    scopus 로고
    • A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway
    • Kimura N, Tokunaga C, Dalal S, Richardson C, Yoshino K, Hara K et al. (2003). A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway. Genes Cells 8, 65-79.
    • (2003) Genes Cells , vol.8 , pp. 65-79
    • Kimura, N.1    Tokunaga, C.2    Dalal, S.3    Richardson, C.4    Yoshino, K.5    Hara, K.6
  • 44
    • 0036364274 scopus 로고    scopus 로고
    • Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes
    • Krause U, Bertrand L & Hue L (2002). Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes. Eur J Biochem 269, 3751-3759.
    • (2002) Eur J Biochem , vol.269 , pp. 3751-3759
    • Krause, U.1    Bertrand, L.2    Hue, L.3
  • 46
    • 0345714892 scopus 로고    scopus 로고
    • At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation
    • Kyriakis JM (2003). At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation. J Biol 2, 26.
    • (2003) J Biol , vol.2 , pp. 26
    • Kyriakis, J.M.1
  • 47
    • 0032541083 scopus 로고    scopus 로고
    • The 5′-AMP-activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex
    • Leclerc I, Kahn A & Doiron B (1998). The 5′-AMP-activated protein kinase inhibits the transcriptional stimulation by glucose in liver cells, acting through the glucose response complex. FEBS Lett 431, 180-184.
    • (1998) FEBS Lett , vol.431 , pp. 180-184
    • Leclerc, I.1    Kahn, A.2    Doiron, B.3
  • 48
    • 0029910364 scopus 로고    scopus 로고
    • Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint
    • Lukas J, Bartkova J & Bartek J (1996). Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint. Mol Cell Biol 16, 6917-6925.
    • (1996) Mol Cell Biol , vol.16 , pp. 6917-6925
    • Lukas, J.1    Bartkova, J.2    Bartek, J.3
  • 50
    • 17444431201 scopus 로고    scopus 로고
    • Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
    • Ma L, Chen Z, Erdjument-Bromage H, Tempst P & Pandolfi PP (2005). Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 121, 179-193.
    • (2005) Cell , vol.121 , pp. 179-193
    • Ma, L.1    Chen, Z.2    Erdjument-Bromage, H.3    Tempst, P.4    Pandolfi, P.P.5
  • 51
    • 0036342294 scopus 로고    scopus 로고
    • Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
    • Manning BD, Tee AR, Logsdon MN, Blenis J & Cantley LC (2002). Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 10, 151-162.
    • (2002) Mol Cell , vol.10 , pp. 151-162
    • Manning, B.D.1    Tee, A.R.2    Logsdon, M.N.3    Blenis, J.4    Cantley, L.C.5
  • 53
    • 0032471851 scopus 로고    scopus 로고
    • Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity
    • Mehenni H, Gehrig C, Nezu J, Oku A, Shimane M, Rossier C et al. (1998). Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity. Am J Hum Genet 63, 1641-1650.
    • (1998) Am J Hum Genet , vol.63 , pp. 1641-1650
    • Mehenni, H.1    Gehrig, C.2    Nezu, J.3    Oku, A.4    Shimane, M.5    Rossier, C.6
  • 54
    • 12344278357 scopus 로고    scopus 로고
    • Fatty acid synthase-catalyzed de novo fatty acid biosynthesis: From anabolic-energy-storage pathway in normal tissues to jack-of-all-trades in cancer cells
    • Menendez JA & Lupu R (2004). Fatty acid synthase-catalyzed de novo fatty acid biosynthesis: From anabolic-energy-storage pathway in normal tissues to jack-of-all-trades in cancer cells. Arch Immunol Ther Exp 52, 414-426.
    • (2004) Arch Immunol Ther Exp , vol.52 , pp. 414-426
    • Menendez, J.A.1    Lupu, R.2
  • 57
    • 0842332231 scopus 로고    scopus 로고
    • Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL
    • Motoshima H, Wu X, Mahadev K & Goldstein BJ (2004). Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL. Biochem Biophys Res Commun 315, 264-271.
    • (2004) Biochem Biophys Res Commun , vol.315 , pp. 264-271
    • Motoshima, H.1    Wu, X.2    Mahadev, K.3    Goldstein, B.J.4
  • 58
    • 3342915617 scopus 로고    scopus 로고
    • AMP-activated protein kinase inhibits angiotensin II-stimulated vascular smooth muscle cell proliferation
    • Nagata D, Takeda R, Sata M, Satonaka H, Suzuki E, Nagano T & Hirata Y (2004). AMP-activated protein kinase inhibits angiotensin II-stimulated vascular smooth muscle cell proliferation. Circulation 110, 444-451.
    • (2004) Circulation , vol.110 , pp. 444-451
    • Nagata, D.1    Takeda, R.2    Sata, M.3    Satonaka, H.4    Suzuki, E.5    Nagano, T.6    Hirata, Y.7
  • 59
    • 0031743906 scopus 로고    scopus 로고
    • Connections between growth and the cell cycle
    • Neufeld TP & Edgar BA (1998). Connections between growth and the cell cycle. Curr Opin Cell Biol 10, 784-790.
    • (1998) Curr Opin Cell Biol , vol.10 , pp. 784-790
    • Neufeld, T.P.1    Edgar, B.A.2
  • 60
    • 0346463030 scopus 로고    scopus 로고
    • Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells
    • Ouchi N, Kobayashi H, Kihara S, Kumada M, Sato K, Inoue T, Funahashi T & Walsh K (2004). Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem 279, 1304-1309.
    • (2004) J Biol Chem , vol.279 , pp. 1304-1309
    • Ouchi, N.1    Kobayashi, H.2    Kihara, S.3    Kumada, M.4    Sato, K.5    Inoue, T.6    Funahashi, T.7    Walsh, K.8
  • 61
    • 28244466264 scopus 로고    scopus 로고
    • 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase
    • Rattan R, Giri S, Singh AK & Singh I (2005). 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase. J Biol Chem 280, 39582-39593.
    • (2005) J Biol Chem , vol.280 , pp. 39582-39593
    • Rattan, R.1    Giri, S.2    Singh, A.K.3    Singh, I.4
  • 62
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle T & Hall MN (2000). TOR, a central controller of cell growth. Cell 103, 253-262.
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 64
  • 66
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr CJ (1996). Cancer cell cycles. Science 274, 1672-1677.
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 67
    • 0030667702 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    • Shieh SY, Ikeda M, Taya Y & Prives C (1997). DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91, 325-334.
    • (1997) Cell , vol.91 , pp. 325-334
    • Shieh, S.Y.1    Ikeda, M.2    Taya, Y.3    Prives, C.4
  • 69
    • 0037096833 scopus 로고    scopus 로고
    • Growth arrest by the LKB1 tumor suppressor: Induction of p21 (WAF1/CIP1)
    • Tiainen M, Vaahtomeri K, Ylikorkala A & Makela TP (2002). Growth arrest by the LKB1 tumor suppressor: Induction of p21 (WAF1/CIP1). Hum Mol Genet 11, 1497-1504.
    • (2002) Hum Mol Genet , vol.11 , pp. 1497-1504
    • Tiainen, M.1    Vaahtomeri, K.2    Ylikorkala, A.3    Makela, T.P.4
  • 72
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg RA (1995). The retinoblastoma protein and cell cycle control. Cell 81, 323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 73
    • 0033815967 scopus 로고    scopus 로고
    • Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase
    • Woods A, Azzout-Marniche D, Foretz M, Stein SC, Lemarchand P, Ferre P, Foufelle F & Carling D (2000). Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase. Mol Cell Biol 20, 6704-6711.
    • (2000) Mol Cell Biol , vol.20 , pp. 6704-6711
    • Woods, A.1    Azzout-Marniche, D.2    Foretz, M.3    Stein, S.C.4    Lemarchand, P.5    Ferre, P.6    Foufelle, F.7    Carling, D.8
  • 74
    • 0037983775 scopus 로고    scopus 로고
    • Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes
    • Wu X, Motoshima H, Mahadev K, Stalker TJ, Scalia R & Goldstein BJ (2003). Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes 52, 1355-1363.
    • (2003) Diabetes , vol.52 , pp. 1355-1363
    • Wu, X.1    Motoshima, H.2    Mahadev, K.3    Stalker, T.J.4    Scalia, R.5    Goldstein, B.J.6
  • 75
    • 3543025724 scopus 로고    scopus 로고
    • AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms
    • Xiang X, Saha AK, Wen R, Ruderman NB & Luo Z (2004). AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms. Biochem Biophys Res Commun 321, 161-167.
    • (2004) Biochem Biophys Res Commun , vol.321 , pp. 161-167
    • Xiang, X.1    Saha, A.K.2    Wen, R.3    Ruderman, N.B.4    Luo, Z.5
  • 76
    • 0036851817 scopus 로고    scopus 로고
    • Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
    • Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S et al. (2002). Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8, 1288-1295.
    • (2002) Nat Med , vol.8 , pp. 1288-1295
    • Yamauchi, T.1    Kamon, J.2    Minokoshi, Y.3    Ito, Y.4    Waki, H.5    Uchida, S.6
  • 77
    • 0032906537 scopus 로고    scopus 로고
    • Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer
    • Ylikorkala A, Avizienyte E, Tomlinson IP, Tiainen M, Roth S, Loukola A et al. (1999). Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer. Hum Mol Genet 8, 45-51.
    • (1999) Hum Mol Genet , vol.8 , pp. 45-51
    • Ylikorkala, A.1    Avizienyte, E.2    Tomlinson, I.P.3    Tiainen, M.4    Roth, S.5    Loukola, A.6
  • 78
    • 0034284038 scopus 로고    scopus 로고
    • Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages
    • Yokota T, Oritani K, Takahashi I, Ishikawa J, Matsuyama A, Ouchi N et al. (2000). Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 96, 1723-1732.
    • (2000) Blood , vol.96 , pp. 1723-1732
    • Yokota, T.1    Oritani, K.2    Takahashi, I.3    Ishikawa, J.4    Matsuyama, A.5    Ouchi, N.6
  • 79
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J et al. (2001). Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108, 1167-1174.
    • (2001) J Clin Invest , vol.108 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3    Chen, Y.4    Shen, X.5    Fenyk-Melody, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.