The α1 and α2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro

FEBS Letters

Volumn 397, Issue 2-3, 1996, Pages 347-351

  Woods, Angela ^a   Salt, Ian ^b   Scott, James ^a   Hardie, D Grahame ^b   Carling, David ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

AMP activated protein kinase; Consensus sequence; Specificity determinant; Subunit isoform

Indexed keywords

ADENOSINE PHOSPHATE; PROTEIN KINASE; 5' AMP ACTIVATED PROTEIN KINASE; 5'-AMP-ACTIVATED PROTEIN KINASE; COMPLEMENTARY DNA; ISOENZYME; MULTIENZYME COMPLEX; OLIGOPEPTIDE; PROTEIN SERINE THREONINE KINASE;

ANIMAL TISSUE; ARTICLE; ENZYME SPECIFICITY; IN VITRO STUDY; LIVER; NONHUMAN; PRIORITY JOURNAL; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; COMPARATIVE STUDY; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; RAT;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; DNA, COMPLEMENTARY; ISOENZYMES; KINETICS; LIVER; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; OLIGOPEPTIDES; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RATS; SUBSTRATE SPECIFICITY; TRANSFECTION;

EID: 0030592623     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(96)01209-4     Document Type: Article

References (18)

1. [1] Corton, J.M., Gillespie, J.G. and Hardie, D.G. (1994) Curr. Biol. 4, 315-324.
2. [2] Hardie, D.G., Carling, D. and Halford, N. (1994) Semin. Cell Biol. 5, 409-416.
3. [3] Stapleton, D., Gao, G., Michell, B.J., Widmer, J., Mitchelhill, K.I., Teh, T., House, C.M., Witters, L.A. and Kemp, B.E. (1994) J. Biol. Chem. 269, 29343-29346.
4. [4] Woods, A., Cheung, P.C.F., Smith, F.C., Davison, M.D., Scott, J., Beri, R.K. and Carling, D. (1996) J. Biol. Chem. 271, 10280-10290.
5. [5] Hawley, S.A., Selbert, M.A., Goldstein, E.G., Edelman, A.M., Carling, D. and Hardie, D.G. (1995) J. Biol. Chem. 270, 27186-27191.
6. [6] Davies, S.P., Helps, N.R., Cohen, P.T.W. and Hardie, D.G. (1995) FEBS Lett. 377, 421-425.
7. [7] Hawley, S.A., Davison, M.D., Woods, A., Davies, S.P., Beri, R.K., Carling, D. and Hardie, D.G. (1996) J. Biol. Chem. (in press).
8. [8] Carling, D., Aguan, K., Woods, A., Verhoeven, A.J.M., Beri, R.K., Brennan, C.H., Sidebottom, C., Davison, M.D. and Scott, J. (1994) J. Biol. Chem. 269, 11442-11448.
9. [9] Mitchelhill, K.I., Stapleton, D., Gao, G., House, C., Michell, B., Kateis, F., Witters, L.A. and Kemp, B.E. (1994) J. Biol. Chem. 269, 2361-2364.
10. [10] Celenza, J.L. and Carlson, M. (1986) Science 233, 1175-1180.
11. [11] Yang, X., Jiang, R. and Carlson, M. (1994) EMBO J. 13, 5878-5886.
12. [12] Alderson, A., Sabelli, P.A., Dickinson, J.R., Cole, D., Richardson, M., Kreis, M., Shewry, P.R. and Halford, N.G. (1991) Proc. Natl. Acad. Sci. USA 88, 8602-8605.
13. [13] Stapleton, D., Mitchelhill, K.I., Gao, G., Widmer, J., Michell, B.J., Teh, T., House, C.M., Fernandez, C.S., Cox, T., Witters, L.A. and Kemp, B.E. (1996) J. Biol. Chem. 271, 611-614.
14. [14] Dale, S., Wilson, W.A., Edelman, A.M. and Hardie, D.G. (1995) FEBS Lett. 361, 191-195.
15. [15] Davies, S.P., Hawley, S.A., Woods, A., Carling, D., Haystead, T.A.J. and Hardie, D.G. (1994) Eur. J. Biochem. 223, 351-357.
16. [16] Duggan, M.J. and Stephenson, F.A. (1990) J. Biol. Chem. 265, 3831-3835.
17. [17] Chen, C. and Okayama, H. (1987) Mol. Cell. Biol. 7, 2745-2752.
18. [18] Davies, S.P., Carling, D. and Hardie, D.G. (1989) Eur. J. Biochem. 186, 123-128.