Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma

Journal of Allergy and Clinical Immunology

Volumn 99, Issue 5, 1997, Pages 657-665

  Humbert, Marc ^b,d   Durham, Stephen R ^b   Kimmitt, Patrick ^b   Powell, Nicholas ^b   Assoufi, Basil ^b   Pfister, Rudi ^c   Menz, Günter ^c   Kay, A Barry ^b   Corrigan, Chris J ^a  

^a CHARING CROSS HOSPITAL   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^c Hochgebirgsklinik   (Switzerland)

^d HÔPITAL ANTOINE BÉCLÈRE   (France)

Author keywords

Asthma; atopy; eosinophil; IL 13; pathogenesis

Indexed keywords

ALLERGEN; INTERLEUKIN 13; MESSENGER RNA; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ARTICLE; ASTHMA; BRONCHUS MUCOSA; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; EOSINOPHILIA; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MOLECULAR INTERACTION; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; RNA ANALYSIS;

EID: 0030922389     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(97)70028-9     Document Type: Article

References (24)

1. Corrigan CJ, Kay AB. T cells and eosinophils in the pathogenesis of asthma. Immunol Today 1992;13:501-7.
2. Rackemann FM. A working classification of asthma. Am J Med 1947;3:601-6.
3. Schleimer RP, Sterbinsky SA, Kaiser J, et al. IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endotheliurn: association with expression of VCAM-1. J Immunol 1992;148: 1086-92.
4. Del Prete GF, Maggi E, Parronchi P, et al. IL-4 is an essential co-factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants. J Immunol 1988;140:4193-8.
5. Brown KD, Zurawski SM, Mosmann TR, Zurawski G. A family of small inducible proteins secreted by leukocytes are members of a new superfamily that includes leukocyte and fibroblast-derived inflammatory agents, growth factors and indicators of various activation processes. J Immunol 1989;142:679-87.
6. McKenzie ANJ, Largaespada DA, Sato A, et al. Structural comparison and chromosomal localization of the human and mouse IL-13 genes. J Immunol 1993;150:5436-44.
7. Minty A, Chalon P, Derocq JM, et al. Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature 1993;362:248-50.
8. Zurawski SM, Chomarat P, Djossou O, et al. The primary binding subunit of the human interleukin-4 receptor is also a component of the interleukin-13 receptor. J Biol Chem 1995;270:13869-78.
9. Smerz-Bertling C, Duschl A. Both interleukin 4 and interleukin 13 induce tyrosine phosphorylation of the 140-kDa subunit of the interleukin 4 receptor. J Biol Chem 1995;270:966-70.
10. Bochner BS, Klunk DA, Sterbinsky SA, Coffman RL, Schleimer RP. IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells. J Immunol 1995;154:799-803.
11. Punnonen J, Aversa G, Cocks BG, et al. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc Natl Acad Sci U S A 1993;90:3730-4.
12. de Waal Malefyt R, Figdor CG, Huijbens R, et al. Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes: comparison with IL-4 and modulation by IFN-gamma or IL-10. J Immunol 1993;151:6370-81.
13. Humbert M, Durham SR, Ying S, et al. IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against "intrinsic" asthma being a distinct immunopathologic entity. Am J Respir Crit Care Med 1996;154: 1497-504.
14. Humbert M, Grant JA, Taborda-Barata L, et al. High-affinity IgE receptor (FcεRI)-bearing cells in bronchial biopsies from atopic and non-atopic asthma. Am J Respir Crit Care Med 1996;153:1931-7.
15. Burrows B, Martinez FD, Halonen M, Barbee RA, Cline MG. Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med 1989;320:271-7.
16. Bentley AM, Menz G, Storz C, et al. Identification of T lymphocytes, macrophages and activated eosinophils in the bronchial mucosa in intrinsic asthma: relationship to symptoms and bronchial responsiveness. Am Rev Respir Dis 1992;146:500-6.
17. Doi S, Gemou-Engesaeth V, Kay AB, Corrigan CJ. Polymerase chain reaction quantification of cytokine messenger RNA expression in peripheral blood mononuclear cells of patients with acute exacerbation of asthma: effect of glucocorticoid therapy. Clin Exp Allergy 1994;24:854-67.
18. Ghaffar O, Durham S, Laberge S, et al. Expression of IL-13 in allergen-induced late nasal reaction and in response to topical steroids [Abstract]. J Allergy Clin Immunol 1996;97:194.
19. Naseer T, Hamid QA, Minshall EM, et al. In vivo expression of interleukin-12 and interleukin-13 in atopic dermatitis [Abstract]. J Allergy Clin Immunol 1996;97:423.
20. Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, et al. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nature Med 1996;2:449-56.
21. Hamid Q, Azzawi M, Ying S, et al. Expression of mRNA for interleukin-5 in bronchial mucosal biopsies from asthma. J Clin Invest 1991;87:1541-6.
22. Huang SK, Xiao HQ, Kleine-Tebbe J, et al. IL-13 expression at the sites of allergen challenge in patients with asthma. J Immunol 1995;155:2688-94.
23. Corrigan CJ, Hamid Q, North J, et al. Peripheral blood CD4 but not CD8 T-lymphocytes in patients with exacerbation of asthma transcribe and translate messenger RNA encoding cytokines which prolong eosinophil survival in the context of a Th2-type pattern: effect of glucocorticoid therapy. Am J Respir Cell Mol Biol 1995;12:567-78.
24. Li H, Sim TC, Alam R. IL-13 released by and localized in human basophils. J Immunol 1996;156:4833-8.