Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase

European Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2010, Pages 447-454

  Weber, Jane E ^a   Oakley, Aaron J ^b   Christ, Angelika N ^a   Clark, Alan G ^c   Hayes, John D ^d   Hall, Rhonda ^a   Hume, David A ^e   Board, Philip G ^f   Smythe, Mark L ^a   Flanagan, Jack U ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^c VICTORIA UNIVERSITY OF WELLINGTON   (New Zealand)

^d UNIVERSITY OF DUNDEE   (United Kingdom)

^e UNIVERSITY OF EDINBURGH   (United Kingdom)

^f Biology and Environment   (Australia)

Author keywords

Docking; Glutathione transferase; Inhibition; Prostaglandin synthase; Structure

Indexed keywords

4 BENZHYDRYLOXY 1 [3 (1H TETRAZOL 5 YL)PROPYL]PIPERIDINE; 5 (6 CARBOXYHEXYL) 1 (3 CYCLOHEXYL 3 HYDROXYPROPYL)HYDANTOIN; BROMSULFOPHTHALEIN; CIBACRON BLUE F3GA; DICLOFENAC; ETACRYNIC ACID; HTS 03989; HYDROGEN; INDOMETACIN; JFD 03900; LICOFELONE; NOCODAZOLE; NSC 151248; NSC 4502; OXFENDAZOLE; PROSTAGLANDIN D2 SYNTHASE; PROSTAGLANDIN D2 SYNTHASE INHIBITOR; PROSTAGLANDIN INHIBITOR; RAMATROBAN; SALAZOSULFAPYRIDINE; THIOPHENE DERIVATIVE; TIENILIC ACID; UNCLASSIFIED DRUG; ZOMEPIRAC;

AB INITIO CALCULATION; ARTICLE; CALCULATION; CONFORMATION; DRUG BINDING; DRUG BINDING SITE; DRUG IDENTIFICATION; DRUG STRUCTURE; HYDROGEN BOND; PREDICTION; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GLUTATHIONE TRANSFERASE; HEMATOPOIESIS; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; LIPOCALINS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NOCODAZOLE;

EID: 73549084724     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.10.025     Document Type: Article

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