Sputum analysis, bronchial hyperresponsiveness, and airway function in asthma: Results of a factor analysis

Journal of Allergy and Clinical Immunology

Volumn 103, Issue 2 II, 1999, Pages 232-237

  Rosi, Elisabetta ^a   Ronchi, Maria Cristina ^a   Grazzini, Michela ^a   Duranti, Roberto ^a   Scano, Giorgio ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Airway inflammation; Asthma; Bronchial hyperresponsiveness; Factor analysis; Induced sputum

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; LUNG LAVAGE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROVOCATION TEST; SPIROMETRY; SPUTUM ANALYSIS; SPUTUM CYTODIAGNOSIS;

ADOLESCENT; ADULT; AGED; ASTHMA; BLOOD PROTEINS; BRONCHIAL HYPERREACTIVITY; BRONCHITIS; CHRONIC DISEASE; EOSINOPHIL GRANULE PROTEINS; EOSINOPHILS; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; MALE; MIDDLE AGED; RIBONUCLEASES; SPUTUM;

EID: 0033007431     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0091-6749(99)70496-3     Document Type: Article

References (34)

1. American Thoracic Society. Standard for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 1987;136:225-44.
2. Kirby JG, Hargreave FE, Gleich GJ, O'Byrne PM. Bronchoalveolar cell profile of asthmatic and non asthmatic subjects. Am Rev Respir Dis 1987;136:379-83.
3. Wardlaw AJ, Dunette S, Gleich GJ, Collins JV, Kay AB. Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma: relation to bronchial hyperreactivity. Am Rev Respir Dis 1988;137:62-9.
4. Djukanovic R, Roche WR, Wilson JW, Beasley RW, Twentyman OP, Howart PH, et al. Mucosal inflammation in asthma. State of the art. Am Rev Respir Dis 1990;142:434-57.
5. Bousquet J, Chanez P, Lacoste JY, Barneon G, Ghavanian N, Enander I, et al. Eosinophilic inflammation in asthma. N Engl J Med 1990;323:1033-9.
6. Jeffery PK. Morphology of the airway wall in asthma and in obstructive pulmonary disease. Am Rev Respir Dis 1991;143:1152-8.
7. Bradley BL, Azzawy M, Jacobson M, Assoufi B, Collins JV, Irani AM A, et al. Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness. J Allergy Clin Immunol 1991;88:661-74.
8. Corrigan CJ, Kay AB. The roles of inflammatory cells in the pathogenesis of asthma and of chronic obstructive pulmonary disease. Am Rev Respir Dis 1991;143:1165-8.
9. Ollerenshaw SL, Woolcock AJ. Characteristics of the inflammation in biopsies from large airways of subjects with asthma and subjects with chronic airway limitation. Am Rev Respir Dis 1992;145:922-7.
10. Venge P, Dahl R, Fredens K, Peterson C. Epithelial injury of human eosinophils. Am Rev Respir Dis 1988;138:S54-7.
11. Gleich GJ, Flavahan NA, Fujisawa T, Vanhoutte PM. The eosinophil as a mediator of damage to respiratory epithelium: a model for bronchial hypersensitivity (Aspen Allergy Conference). J Allergy Clin Immunol 1988;81:776-81.
12. Ronchi MC, Piragino C, Rosi E, Stendardi L, Tanini A, Galli G, et al. Do sputum eosinophils and ECP relate to the severity of asthma? Eur Respir J 1997;10:1809-13.
13. Pizzichini E, Pizzichini MMM, Efthimiadis A, Evans S, Morris MM, Squillace D, et al. Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements. Am J Respir Crit Care Med 1996;154:308-17.
14. Pin I, Gibson PG, Kolendowicz R, Girgis-Gabardo A, Denburg JA, Hargreave FE, et al. Use of sputum cell counts to investigate airway inflammation in asthma. Thorax 1992;47:25-9.
15. Fahy JV, Liu J, Wong H, Boushey HA. Cellular and biochemical analysis of induced sputum from asthmatics and from healthy subjects. Am Rev Respir Dis 1993;147:1126-31.
16. Pin I, Radford S, Kolendowicz R, Jennings B, Denburg JA, Hargreave FE, et al. Airway inflammation in symptomatic and asymptomatic children with methacholine hyperresponsiveness. Eur Respir J 1993;6:1249-56.
17. Iredale MJ, Wankllin SAR, Phillips IP, Kraautstz T, Ind PW. Noninvasive assessment of bronchial inflammation in asthma: no correlation between eosinophilia of induced sputum and bronchial responsiveness to inhaled hypertonic saline. Clin Exp Allergy 1994;24:940-5.
18. Crimi E, Spanevello A, Neri M, Ind PW, Rossi GA, Brusasco V. Dissociation between airway inflammation and airway hyperresponsiveness in allergic asthma. Am J Respir Crit Care Med 1998;157:4-9.
19. Ronchi MC, Piragino C, Rosi E, Amendola M, Duranti R, Scano G. Role of sputum differential count in detecting airway inflammation in patients with chronic bronchial asthma. Thorax 1996;51:1-5.
20. Virchow JC Jr, Holscher V, Virchow C. Sputum ECP levels correlate with parameters of airflow obstruction. Am Rev Respir Dis 1992;146:604-6.
21. NHLBI. International consensus report on diagnosis and management of asthma. Eur Respir J 1992;5:601-41.
22. Scano G, Garcia Herreros P, Stendardi L, Degre S, De Coster A, Sergysels R. Cardiopulmonary adaptation to exercise in coal miners. Arch Environ Health 1990;35:360-6.
23. European Community for Coal and Steel. Standardization of lung function tests. Eur Respir J 1993;6(suppl 16):1-100.
24. Fanelli A, Duranti R, Gorini M, Spinelli A, Gigliotti F, Scano G. Histamine induced changes in breathing pattern may precede broncho constriction in selected patients with bronchial asthma. Thorax 1994;49:639-43.
25. Linderman RH, Merenda PF, Gold RZ. Introduction to bivariate and multivariate analysis. Glenview (IL): Scott Foresman; 1980.
26. Woolcock AJ, Peat JK, Salome CM. Prevalence of bronchial hyperresponsiveness and asthma in a rural adult population. Thorax 1987;42:361-8.
27. Gibson PJ, Girgis-Gabardo A, Morris MM, Mattoli S, Kay JM, Dolovich J, et al. Cellular characteristics of sputum from patients with asthma and chronic bronchitis. Thorax 1989;44:693-9.
28. Popov T, Gottschalk R, Kolendowicz R, Dolovich J, Powers P, Hargreave FE. The evaluation of a cell dispersion method of sputum examination. Clin Exp Allergy 1995;24:778-83.
29. Pizzichini E, Pizzichini MMM, Efthimiadis A, Dolovich J, Hargreave FE. Measuring airway inflammation in asthma; eosinophils and eosinophilic cartionic protein in induced sputum compared with peripheral blood. J Allergy Clin Immunol 1997;99:539-44.
30. Claman DM, Boushey HA, Liu J, Wong H, Fahy JV. Analysis of induced sputum to examine the effect of prednisone on airway inflammation in asthmatic subjects. J Allergy Clin Immunol 1994;94:861-9.
31. Foresi A, Leone C, Pelucchi A, Mastropasqua B, Chetta A, D'lppolito R, et al. Eosinophils, mast cells, and basophils in induced sputum from patients with seasonal allergic rhinitis and perennial asthma: relationship to methacoline responsiveness. J Allergy Clin Immunol 1997;100:58-64.
32. Chetta A, Foresi A, Del Donno M, Consigli GF, Bertorelli G, Pesci A, et al. Bronchial responsiveness to distilled water and methacholine and its relationship to inflammation and remodeling of the airways in asthma. Am J Respir Crit Care Med 1996;153:910-7.
33. Wiggs BR, Bosken C, Pare PD, James A, Hogg JC. A model of airway narrowing in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis 1992;145:1251-8.
34. Sklott G, Permutt S, Togias AG. Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation with inspiration. J Clin Invest 1995;96:2393-403.