Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma

Thorax

Volumn 53, Issue 2, 1998, Pages 91-95

  Jatakanon, A ^a   Lim, S ^a   Kharitonov, S A ^a   Chung, K F ^a   Barnes, P J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Asthma; Bronchial hyperresponsiveness; Eosinophils; Exhaled nitric oxide; Induced sputum

Indexed keywords

METHACHOLINE; NITRIC OXIDE;

ADULT; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; EOSINOPHIL; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; LEUKOCYTE COUNT; MALE; PRIORITY JOURNAL; PROVOCATION TEST; SPUTUM ANALYSIS;

EID: 0031900026     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.53.2.91     Document Type: Article

References (23)

1. Sont JK, Han J, van Krieken JM, et al. Relationship between the inflammatory infiltrate in bronchial biopsy specimens and clinical severity of asthma in patients treated with inhaled steroids. Thorax 1996;51:496-502.
2. Kharitonov SA, O'Connor BJ, Evans DJ, Barnes PJ. Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide. Am J Respir Crit Care Med 1995;151:1894-9.
3. Massaro AF, Gaston B, Kita D, Fanta C, Stamler JS, Drazen JM. Expired nitric oxide levels during treatment of acute asthma. Am J Respir Crit Care Med 1995;152:800-3.
4. Kharitonov SA, Yates D, Springall DR, et al. Exhaled nitric oxide is increased in asthma. Chest 1995;107:156S-7S.
5. 2 agonists on exhaled nitric oxide in asthmatic patients. Eur Respir J 1997;10:1483-8.
6. Kharitonov SA, Yates DH, Barnes PJ. Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients. Am J Respir Crit Care Med 1996;153:454-7.
7. Baigelman W, Chodosh S, Pizzuto D, Cupples LA. Sputum and blood eosinophils during corticosteroid treatment of acute exacerbations of asthma. Am J Med 1983;75:929-36.
8. Alfaro C, Sharma OP, Navarro L, Glovsky MM. Inverse correlation of expiratory lung flows and sputum eosinophils in status asthmaticus. Ann Allergy 1989;63:251-4.
9. Virchow JC Jr, Holscher U, Virchow C Sr. Sputum ECP levels correlate with parameters of airflow obstruction. Am Rev Respir Dis 1992;146:604-6.
10. Gibson PG, Wong BJ, Hepperle MJ, et al. A research method to induce and examine a mild exacerbation of asthma by withdrawal of inhaled corticosteroid. Clin Exp Allergy 1992;22:525-32.
11. Turner MO, Hussack P, Sears MR, Dolovich J, Hargreave FE. Exacerbations of asthma without sputum eosinophilia. Thorax 1995;50:1057-61.
12. Claman DM, Boushey HA, Liu J, Wong H, Fahy JV. Analysis of induced sputum to examine the effects of prednisone on airway inflammation in asthmatic subjects. J Allergy Clin Immunol 1994;94:861-9.
13. Keatings VM, Jatakanon A, Worsdell YM, Barnes PJ. Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD. Am J Respir Crit Care Med 1997;155:542-8.
14. Juniper EF, Frith PA, Hargreave FE. Airway responsiveness to histamine and methacholine: relationship to minimum treatment to control symptoms of asthma. Thorax 1981; 36:575-9.
15. Kharitonov SA, Chung KF, Evans D, O'Connor BJ, Barnes PJ. Increased exhaled nitric oxide in asthma is mainly derived from the lower respiratory tract. Am J Respir Clin Care Med 1996;153:1773-80.
16. Bernareggi M, Mitchell JA, Bames PJ, Belvisi MG. Dual action of nitric oxide on airway plasma leakage. Am J Respir Crit Care Med 1997;155:869-74.
17. Kung TT, Chapman RW, Egan RW, et al. Nitric oxide synthase inhibitors reduce pulmonary eosinophilia in allergic mice. Am J Respir Cri Care Med 1996;153:A797.
18. Nijkamp FP, Folkerts G. Nitric oxide and bronchial reactivity. Clin Exp Allergy 1994;24:905-14.
19. Sadeghi Hashjin G, Folkerts G, Henricks PA, et al. Peroxynitrite induces airway hyperresponsiveness in guinea pigs in vitro and in vivo. Am J Respir Crit Care Med 1996; 153:1697-701.
20. ten Hacken NHT, Meijer RJ, Kerstjens HAM, van der Mark TW, Postma DS. Expired nitric oxide in stable asthmatic patients does not relate to parameters of disease severity. Eur Respir J 1997;9:416S.
21. Taylor DA, Lim S, Barnes PJ, O'Connor BJ. Exhaled nitric oxide production and increased airway responsiveness in asthma reflect different inflammatory pathways. Eur Respir J 1997;9:416S.
22. Barnes PJ, Liew FY. Nitric oxide and asthmatic inflammation. Immunol Today 1995;16:128-30.
23. Barnes PJ, Kharitonov SA. Exhaled nitric oxide: a new lung function test. Thorax 1996;51:233-7.