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Volumn 117, Issue 3, 2011, Pages 195-208

A new era for brown adipose tissue: New insights into brown adipocyte function and differentiation

Author keywords

Brown adipose tissue; differentiation; obesity; transcription factors; type 2 diabetes

Indexed keywords

ANIMAL; BROWN ADIPOSE TISSUE; CELL DIFFERENTIATION; CONFERENCE PAPER; CYTOLOGY; ENERGY METABOLISM; HUMAN; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY; WHITE ADIPOSE TISSUE;

EID: 79959266968     PISSN: 13813455     EISSN: 17444160     Source Type: Journal    
DOI: 10.3109/13813455.2011.560951     Document Type: Conference Paper
Times cited : (9)

References (139)
  • 1
    • 9644260361 scopus 로고    scopus 로고
    • Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice
    • DOI 10.2337/diabetes.53.12.3274
    • Almind K, Kahn CR. (2004). Genetic determinants of energy expenditure and insulin resistance in diet-induced obesity in mice. Diabetes 53, 3274-85. (Pubitemid 39571714)
    • (2004) Diabetes , vol.53 , Issue.12 , pp. 3274-3285
    • Almind, K.1    Kahn, C.R.2
  • 3
    • 47149118684 scopus 로고    scopus 로고
    • 3- adrenoceptor agonists
    • DOI 10.1007/s00210-008-0271-1
    • Arch JR. (2008). Te discovery of drugs for obesity, the metabolic efects of leptin and variable receptor pharmacology: perspectives from beta3-adrenoceptor agonists. Naunyn Schmiedebergs Arch Pharmacol 378, 225-40. (Pubitemid 351977641)
    • (2008) Naunyn-Schmiedeberg's Archives of Pharmacology , vol.378 , Issue.2 , pp. 225-240
    • Arch, J.R.S.1
  • 4
    • 0242496535 scopus 로고    scopus 로고
    • Role of IRS-3 in the Insulin Signaling of IRS-1-deficient Brown Adipocytes
    • DOI 10.1074/jbc.M301185200
    • Arribas M, Valverde AM, Benito M. (2003). Role of IRS-3 in the insulin signaling of IRS-1-defcient brown adipocytes. J Biol Chem 278, 45189-99. (Pubitemid 37432652)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.46 , pp. 45189-45199
    • Arribas, M.1    Valverde, A.M.2    Benito, M.3
  • 5
    • 0023266408 scopus 로고
    • Immunological, histological and biochemical assessment of brown adipose tissue activity in neonatal, control and β-stimulant-treated adult dogs
    • Ashwell M, Stirling D, Freeman S, Holloway BR. (1987). Immunological, histological and biochemical assessment of brown adipose tissue activity in neonatal, control and beta-stimulant-treated adult dogs. Int J Obes 11, 357-65. (Pubitemid 17138412)
    • (1987) International Journal of Obesity , vol.11 , Issue.4 , pp. 357-365
    • Ashwell, M.1    Stirling, D.2    Freeman, S.3    Holloway, B.R.4
  • 8
    • 0035847001 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell
    • DOI 10.1074/jbc.M006246200
    • Barbera MJ, Schluter A, Pedraza N, Iglesias R, Villarroya F, Giralt M. (2001). Peroxisome proliferator-activated receptor alpha activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell. J Biol Chem 276, 1486-93. (Pubitemid 32096582)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.2 , pp. 1486-1493
    • Barbera, M.J.1    Schluter, A.2    Pedraza, N.3    Iglesias, R.4    Villarroya, F.5    Giralt, M.6
  • 9
    • 33747484566 scopus 로고    scopus 로고
    • Targeting dinitrophenol to mitochondria: Limitations to the development of a self-limiting mitochondrial protonophore
    • DOI 10.1007/s10540-006-9018-8
    • Blaikie FH, Brown SE, Samuelsson LM, Brand MD, Smith RA, Murphy MP. (2006). Targeting dinitrophenol to mitochondria: limitations to the development of a self-limiting mitochondrial protonophore. Biosci Rep 26, 231-43. (Pubitemid 44259491)
    • (2006) Bioscience Reports , vol.26 , Issue.3 , pp. 231-243
    • Blaikie, F.H.1    Brown, S.E.2    Samuelsson, L.M.3    Brand, M.D.4    Smith, R.A.J.5    Murphy, M.P.6
  • 10
    • 14544298335 scopus 로고    scopus 로고
    • The role of MAPKs in adipocyte differentiation and obesity
    • DOI 10.1016/j.biochi.2004.10.018
    • Bost F, Aouadi M, Caron L, Binetruy B. (2005). Te role of MAPKs in adipocyte diferentiation and obesity. Biochimie 87, 51-6. (Pubitemid 40298765)
    • (2005) Biochimie , vol.87 , Issue.SPEC. ISS. 1 , pp. 51-56
    • Bost, F.1    Aouadi, M.2    Caron, L.3    Binetruy, B.4
  • 13
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: Function and physiological significance
    • DOI 10.1152/physrev.00015.2003
    • Cannon B, Nedergaard J. (2004). Brown adipose tissue: function and physiological signifcance. Physiol Rev 84, 277-359. (Pubitemid 38054374)
    • (2004) Physiological Reviews , vol.84 , Issue.1 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 14
    • 77956433431 scopus 로고    scopus 로고
    • Tyroid hormones: Igniting brown fat via the brain
    • Cannon B, Nedergaard J. (2010). Tyroid hormones: igniting brown fat via the brain. Nat Med 16, 965-7.
    • (2010) Nat Med , vol.16 , pp. 965-7
    • Cannon, B.1    Nedergaard, J.2
  • 15
  • 17
    • 0024592001 scopus 로고
    • Sequential changes in the expression of mitochondrial protein mRNA during the development of brown adipose tissue in bovine and ovine species. Sudden occurrence of uncoupling protein mRNA during embryogenesis and its disappearance after birth
    • Casteilla L, Champigny O, Bouillaud F, Robelin J, Ricquier D. (1989). Sequential changes in the expression of mitochondrial protein mRNA during the development of brown adipose tissue in bovine and ovine species. Sudden occurrence of uncoupling protein mRNA during embryogenesis and its disappearance after birth. Biochem J 257, 665-71. (Pubitemid 19050120)
    • (1989) Biochemical Journal , vol.257 , Issue.3 , pp. 665-671
    • Casteilla, L.1    Champigny, O.2    Bouillaud, F.3    Robelin, J.4    Ricquier, D.5
  • 18
    • 17944377509 scopus 로고    scopus 로고
    • FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance
    • DOI 10.1016/S0092-8674(01)00474-3
    • Cederberg A, Gronning LM, Ahren B, Tasken K, Carlsson P, Enerback S. (2001). FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell 106, 563-73. (Pubitemid 32879318)
    • (2001) Cell , vol.106 , Issue.5 , pp. 563-573
    • Cederberg, A.1    Gronning, L.M.2    Ahren, B.3    Tasken, K.4    Carlsson, P.5    Enerback, S.6
  • 23
    • 0029737861 scopus 로고    scopus 로고
    • Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A
    • DOI 10.1038/382622a0
    • Cummings DE, Brandon EP, Planas JV, Motamed K, Idzerda RL, McKnight GS. (1996). Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A. Nature 382, 622-6. (Pubitemid 26268953)
    • (1996) Nature , vol.382 , Issue.6592 , pp. 622-626
    • Cummings, D.E.1    Brandon, E.P.2    Planas, J.V.3    Motamed, K.4    Idzerda, R.L.5    McKnight, G.S.6
  • 25
    • 29244434833 scopus 로고    scopus 로고
    • AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2α in adipocytes
    • DOI 10.1016/j.bbrc.2005.11.159, PII S0006291X05027117
    • Dagon Y Avraham Y, Berry EM. (2006). AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2alpha in adipocytes. Biochem Biophys Res Commun 340, 43-7. (Pubitemid 41827645)
    • (2006) Biochemical and Biophysical Research Communications , vol.340 , Issue.1 , pp. 43-47
    • Dagon, Y.1    Avraham, Y.2    Berry, E.M.3
  • 26
    • 34347261400 scopus 로고    scopus 로고
    • Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specific peroxisome proliferator activated receptor isoforms and estrogen-related receptor α
    • DOI 10.1210/me.2007-0103
    • Debevec D, Christian M, Morganstein D, Seth A, Herzog B, Parker M, White R. (2007). Receptor interacting protein 140 regulates expression of uncoupling protein 1 in adipocytes through specifc peroxisome proliferator activated receptor isoforms and estrogen-related receptor alpha. Mol Endocrinol 21, 1581-92. (Pubitemid 47001083)
    • (2007) Molecular Endocrinology , vol.21 , Issue.7 , pp. 1581-1592
    • Debevec, D.1    Christian, M.2    Morganstein, D.3    Seth, A.4    Herzog, B.5    Parker, M.6    White, R.7
  • 29
    • 0041355316 scopus 로고    scopus 로고
    • Bi-directional regulation of brown fat adipogenesis by the insulin receptor
    • DOI 10.1074/jbc.M303056200
    • Entingh AJ, Taniguchi CM, Kahn CR. (2003). Bi-directional regulation of brown fat adipogenesis by the insulin receptor. J Biol Chem 278, 33377-83. (Pubitemid 37055790)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.35 , pp. 33377-33383
    • Entingh, A.J.1    Taniguchi, C.M.2    Kahn, C.R.3
  • 30
    • 4444349217 scopus 로고    scopus 로고
    • Differential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I
    • DOI 10.1074/jbc.M313201200
    • Entingh-Pearsall A, Kahn CR. (2004). Diferential roles of the insulin and insulin-like growth factor-I (IGF-I) receptors in response to insulin and IGF-I. J Biol Chem 279, 38016-24. (Pubitemid 39195517)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.36 , pp. 38016-38024
    • Entingh-Pearsall, A.1    Kahn, C.R.2
  • 31
    • 58749091645 scopus 로고    scopus 로고
    • UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality
    • Feldmann HM, Golozoubova V, Cannon B, Nedergaard J. (2009). UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab 9, 203-9.
    • (2009) Cell Metab , vol.9 , pp. 203-9
    • Feldmann, H.M.1    Golozoubova, V.2    Cannon, B.3    Nedergaard, J.4
  • 32
    • 70349490370 scopus 로고    scopus 로고
    • Proteome diferences between brown and white fat mitochondria reveal specialized metabolic functions
    • Forner F, Kumar C, Luber CA, Fromme T, Klingenspor M, Mann M. (2009). Proteome diferences between brown and white fat mitochondria reveal specialized metabolic functions. Cell Metab 10, 324-35.
    • (2009) Cell Metab , vol.10 , pp. 324-35
    • Forner, F.1    Kumar, C.2    Luber, C.A.3    Fromme, T.4    Klingenspor, M.5    Mann, M.6
  • 33
    • 77950190436 scopus 로고    scopus 로고
    • Distribution and development of brown adipocytes in the murine and human adipose organ
    • Frontini A, Cinti S. (2010). Distribution and development of brown adipocytes in the murine and human adipose organ. Cell Metab 11, 253-56.
    • (2010) Cell Metab , vol.11 , pp. 253-56
    • Frontini, A.1    Cinti, S.2
  • 34
    • 65349152290 scopus 로고    scopus 로고
    • Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white adipocytes: Novel mechanisms integrating HSL and ATGL
    • Gaidhu MP, Fediuc S, Anthony NM, So M, Mirpourian M, Perry RL, Ceddia RB. (2009). Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white adipocytes: novel mechanisms integrating HSL and ATGL. J Lipid Res 50, 704-15.
    • (2009) J Lipid Res , vol.50 , pp. 704-15
    • Gaidhu, M.P.1    Fediuc, S.2    Anthony, N.M.3    So, M.4    Mirpourian, M.5    Perry, R.L.6    Ceddia, R.B.7
  • 36
    • 0031011161 scopus 로고    scopus 로고
    • Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats
    • Ghorbani M, Himms-Hagen J. (1997). Appearance of brown adipocytes in white adipose tissue during CL 316,243-induced reversal of obesity and diabetes in Zucker fa/fa rats. Int J Obes Relat Metab Disord 21, 465-75. (Pubitemid 27236965)
    • (1997) International Journal of Obesity , vol.21 , Issue.6 , pp. 465-475
    • Ghorbani, M.1    Himms-Hagen, J.2
  • 37
    • 0032528169 scopus 로고    scopus 로고
    • Emergence of brown adipocytes in white fat in mice is under genetic control effects on body weight and adiposity
    • Guerra C, Koza RA, Yamashita H, Walsh K, Kozak LP. (1998). Emergence of brown adipocytes in white fat in mice is under genetic control. Efects on body weight and adiposity. J Clin Invest 102, 412-20. (Pubitemid 28335201)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.2 , pp. 412-420
    • Guerra, C.1    Koza, R.A.2    Yamashita, H.3    Walsh, K.4    Kozak, L.P.5
  • 41
    • 33748366392 scopus 로고    scopus 로고
    • Regulatory circuits controlling white versus brown adipocyte differentiation
    • DOI 10.1042/BJ20060402
    • Hansen JB, Kristiansen K. (2006). Regulatory circuits controlling white versus brown adipocyte diferentiation. Biochem J 398, 153-68. (Pubitemid 44338472)
    • (2006) Biochemical Journal , vol.398 , Issue.2 , pp. 153-168
    • Hansen, J.B.1    Kristiansen, K.2
  • 42
    • 0035853702 scopus 로고    scopus 로고
    • Efects of genetic background on thermoregulation and fatty acid-induced uncoupling of mitochondria in UCP1-defcient mice
    • Hofmann WE, Liu X, Bearden CM, Harper ME, Kozak LP. (2001). Efects of genetic background on thermoregulation and fatty acid-induced uncoupling of mitochondria in UCP1-defcient mice. J Biol Chem 276, 12460-65.
    • (2001) J Biol Chem , vol.276 , pp. 12460-65
    • Hofmann, W.E.1    Liu, X.2    Bearden, C.M.3    Harper, M.E.4    Kozak, L.P.5
  • 43
    • 33646782581 scopus 로고    scopus 로고
    • Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1α gene transcription: An autoregulatory loop controls PGC-1α expression in adipocytes via peroxisome proliferator-activated receptor-γ coactivation
    • DOI 10.1210/en.2006-0070
    • Hondares E, Mora O, Yubero P, Rodriguez de la CM, Iglesias R, Giralt M, Villarroya F. (2006). Tiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor-co-activator (PGC)-1alpha gene transcription: an autoregulatory loop controls PGC-1alpha expression in adipocytes via peroxisome proliferator-activated receptor-gamma coactivation. Endocrinology 147, 2829-38. (Pubitemid 43764595)
    • (2006) Endocrinology , vol.147 , Issue.6 , pp. 2829-2838
    • Hondares, E.1    Mora, O.2    Yubero, P.3    De La Concepcion, M.R.4    Iglesias, R.5    Giralt, M.6    Villarroya, F.7
  • 48
    • 34548317506 scopus 로고    scopus 로고
    • C/EBPβ reprograms white 3T3-L1 preadipocytes to a brown adipocyte pattern of gene expression
    • DOI 10.1074/jbc.M703101200
    • Karamanlidis G, Karamitri A, Docherty K, Hazlerigg DG, Lomax MA. (2007). C/EBPbeta reprograms white 3T3-L1 preadipocytes to a Brown adipocyte pattern of gene expression. J Biol Chem 282, 24660-69. (Pubitemid 47347526)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.34 , pp. 24660-24669
    • Karamanlidis, G.1    Karamitri, A.2    Docherty, K.3    Hazlerigg, D.G.4    Lomax, M.A.5
  • 50
    • 36549039059 scopus 로고    scopus 로고
    • RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes
    • DOI 10.1038/sj.emboj.7601908, PII 7601908
    • Kiskinis E, Hallberg M, Christian M, Olofsson M, Dilworth SM, White R, Parker MG. (2007). RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes. EMBO J 26, 4831-40. (Pubitemid 350191305)
    • (2007) EMBO Journal , vol.26 , Issue.23 , pp. 4831-4840
    • Kiskinis, E.1    Hallberg, M.2    Christian, M.3    Olofsson, M.4    Dilworth, S.M.5    White, R.6    Parker, M.G.7
  • 51
    • 0028865142 scopus 로고
    • Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity
    • Kopecky J, Clarke G, Enerback S, Spiegelman B, Kozak LP. (1995). Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J Clin Invest 96, 2914-23.
    • (1995) J Clin Invest , vol.96 , pp. 2914-23
    • Kopecky, J.1    Clarke, G.2    Enerback, S.3    Spiegelman, B.4    Kozak, L.P.5
  • 52
    • 0029894407 scopus 로고    scopus 로고
    • Reduction of dietary obesity in aP2-Ucp transgenic mice: Mechanism and adipose tissue morphology
    • Kopecky J, Rossmeisl M, Hodny Z, Syrovy I, Horakova M, Kolarova P. (1996). Reduction of dietary obesity in aP2-Ucp transgenic mice: mechanism and adipose tissue morphology. Am J Physiol 270, E776-86
    • (1996) Am J Physiol , vol.270
    • Kopecky, J.1    Rossmeisl, M.2    Hodny, Z.3    Syrovy, I.4    Horakova, M.5    Kolarova, P.6
  • 53
    • 77955266460 scopus 로고    scopus 로고
    • Brown vs white adipocytes: The PPARgamma coregulator story
    • Koppen A, Kalkhoven E. (2010). Brown vs white adipocytes: the PPARgamma coregulator story. FEBS Lett 584, 3250-59.
    • (2010) FEBS Lett , vol.584 , pp. 3250-59
    • Koppen, A.1    Kalkhoven, E.2
  • 54
    • 78651084546 scopus 로고    scopus 로고
    • Both liver-X receptor (LXR) isoforms control energy expenditure by regulating Brown Adipose Tissue activity
    • Korach-André M, Archer A, Barros RP, Parini P, Gustafsson JA. (2011). Both liver-X receptor (LXR) isoforms control energy expenditure by regulating Brown Adipose Tissue activity. Proc Natl Acad Sci USA 108, 403-8.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 403-8
    • Korach-André, M.1    Archer, A.2    Barros, R.P.3    Parini, P.4    Gustafsson, J.A.5
  • 58
    • 77957577776 scopus 로고    scopus 로고
    • A critical appraisal of the prevalence and metabolic signifcance of brown adipose tissue in adult humans
    • Lee P, Greenfeld JR, Ho KK, Fulham MJ. (2010). A critical appraisal of the prevalence and metabolic signifcance of brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 299, E601-6
    • (2010) Am J Physiol Endocrinol Metab , vol.299
    • Lee, P.1    Greenfeld, J.R.2    Ho, K.K.3    Fulham, M.J.4
  • 59
    • 67449143258 scopus 로고    scopus 로고
    • Diferentiation and characterization in primary culture of white adipose tissue brown adipocyte-like cells
    • Lehr L, Canola K, Leger B, Giacobino JP. (2009). Diferentiation and characterization in primary culture of white adipose tissue brown adipocyte-like cells. Int J Obes (Lond) 33, 680-86.
    • (2009) Int J Obes (Lond) , vol.33 , pp. 680-86
    • Lehr, L.1    Canola, K.2    Leger, B.3    Giacobino, J.P.4
  • 64
    • 0027763185 scopus 로고
    • IGF-I is a mitogen involved in differentiation-related gene expression in fetal rat brown adipocytes
    • DOI 10.1083/jcb.123.6.1567
    • Lorenzo M, Valverde AM, Teruel T, Benito M. (1993). IGF-I is a mitogen involved in diferentiation-related gene expression in fetal rat brown adipocytes. J Cell Biol 123, 1567-75. (Pubitemid 24012033)
    • (1993) Journal of Cell Biology , vol.123 , Issue.I6 , pp. 1567-1575
    • Lorenzo, M.1    Valverde, A.M.2    Teruel, T.3    Benito, M.4
  • 65
    • 0034611678 scopus 로고    scopus 로고
    • Towards a molecular understanding of adaptive thermogenesis
    • Lowell BB, Spiegelman BM. (2000). Towards a molecular understanding of adaptive thermogenesis. Nature 404, 652-60. (Pubitemid 30205070)
    • (2000) Nature , vol.404 , Issue.6778 , pp. 652-660
    • Lowell, B.B.1    Spiegelman, B.M.2
  • 67
    • 0242580188 scopus 로고    scopus 로고
    • Reduced Fat Mass in Mice Lacking Orphan Nuclear Receptor Estrogen-Related Receptor α
    • DOI 10.1128/MCB.23.22.7947-7956.2003
    • Luo J, Sladek R, Carrier J, Bader JA, Richard, D, Giguere V (2003). Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha. Mol Cell Biol 23, 7947-56. (Pubitemid 37377488)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.22 , pp. 7947-7956
    • Luo, J.1    Sladek, R.2    Carrier, J.3    Bader, J.-A.4    Richard, D.5    Giguere, V.6
  • 69
    • 33751245573 scopus 로고    scopus 로고
    • Remodeling of white adipose tissue after retinoic acid administration in mice
    • DOI 10.1210/en.2006-0760
    • Mercader J, Ribot J, Murano I, Felipe F, Cinti S, Bonet ML, Palou A. (2006). Remodeling of white adipose tissue after retinoic acid administration in mice. Endocrinology 147, 5325-32. (Pubitemid 44790587)
    • (2006) Endocrinology , vol.147 , Issue.11 , pp. 5325-5332
    • Mercader, J.1    Ribot, J.2    Murano, I.3    Felipe, F.4    Cinti, S.5    Bonet, M.L.6    Palou, A.7
  • 70
    • 74449087655 scopus 로고    scopus 로고
    • Benefcial efects of PTP1B defciency on brown adipocyte diferentiation and protection against apoptosis induced by pro-and anti-infammatory stimuli
    • Miranda S, Gonzalez-Rodriguez A, Revuelta-Cervantes J, Rondinone CM, Valverde AM. (2010). Benefcial efects of PTP1B defciency on brown adipocyte diferentiation and protection against apoptosis induced by pro-and anti-infammatory stimuli. Cell Signal 22, 645-59.
    • (2010) Cell Signal , vol.22 , pp. 645-59
    • Miranda, S.1    Gonzalez-Rodriguez, A.2    Revuelta-Cervantes, J.3    Rondinone, C.M.4    Valverde, A.M.5
  • 71
    • 77950546031 scopus 로고    scopus 로고
    • Human fetal mesenchymal stem cells diferentiate into brown and white adipocytes: A role for ERRalpha in human UCP1 expression
    • Morganstein DL, Wu P, Mane MR, Fisk NM, White R, Parker MG. (2010). Human fetal mesenchymal stem cells diferentiate into brown and white adipocytes: a role for ERRalpha in human UCP1 expression. Cell Res 20, 434-44.
    • (2010) Cell Res , vol.20 , pp. 434-44
    • Morganstein, D.L.1    Wu, P.2    Mane, M.R.3    Fisk, N.M.4    White, R.5    Parker, M.G.6
  • 72
    • 0036310140 scopus 로고    scopus 로고
    • Increased insulin sensitivity in IGF-I receptor-deficient brown adipocytes
    • Mur C, Valverde AM, Kahn CR, Benito M. (2002). Increased insulin sensitivity in IGF-I receptor-defcient brown adipocytes. Diabetes 51, 743-54. (Pubitemid 34760184)
    • (2002) Diabetes , vol.51 , Issue.3 , pp. 743-754
    • Mur, C.1    Valverde, A.M.2    Ronald Kahn, C.3    Benito, M.4
  • 74
    • 0027669006 scopus 로고
    • Te beta 3-adrenoceptor agonist ICI-D7114 is not as efcient on reinduction of uncoupling protein mRNA in sheep as it is in dogs and smaller species
    • Nougues J, Reyne Y Champigny O, Holloway B, Casteilla L, Ricquier D. (1993). Te beta 3-adrenoceptor agonist ICI-D7114 is not as efcient on reinduction of uncoupling protein mRNA in sheep as it is in dogs and smaller species. J Anim Sci 71, 2388-94.
    • (1993) J Anim Sci , vol.71 , pp. 2388-94
    • Nougues, J.1    Reyne Champigny Y, O.2    Holloway, B.3    Casteilla, L.4    Ricquier, D.5
  • 75
    • 0030717887 scopus 로고    scopus 로고
    • Uncoupling protein gene: Quantification of expression levels in adipose tissues of obese and non-obese humans
    • Oberkofer H, Dallinger G, Liu YM, Hell E, Krempler F, Patsch W. (1997). Uncoupling protein gene: quantifcation of expression levels in adipose tissues of obese and non-obese humans. J Lipid Res 38, 2125-33. (Pubitemid 27468020)
    • (1997) Journal of Lipid Research , vol.38 , Issue.10 , pp. 2125-2133
    • Oberkofler, H.1    Dallinger, G.2    Liu, Y.-M.3    Hell, E.4    Krempler, F.5    Patsch, W.6
  • 76
    • 0037053326 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) γ coactivator-1 recruitment regulates PPAR subtype specificity
    • DOI 10.1074/jbc.M200475200
    • Oberkofer H, Esterbauer H, Linnemayr V, Strosberg AD, Krempler F, Patsch W. (2002). Peroxisome proliferator-activated receptor (PPAR) gamma co-activator-1 recruitment regulates PPAR subtype specifcity. J Biol Chem 277, 16750-57. (Pubitemid 34967696)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.19 , pp. 16750-16757
    • Oberkofler, H.1    Esterbauer, H.2    Linnemayr, V.3    Donny Strosberg, A.4    Krempler, F.5    Patsch, W.6
  • 77
    • 78650098848 scopus 로고    scopus 로고
    • Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans
    • Ouellet V, Routhier-Labadie A, Bellemare W, Lakhal-Chaieb L, Turcotte E, Carpentier AC, Richard D. (2011). Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans. J Clin Endocrinol Metab 96, 192-9.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 192-9
    • Ouellet, V.1    Routhier-Labadie, A.2    Bellemare, W.3    Lakhal-Chaieb, L.4    Turcotte, E.5    Carpentier, A.C.6    Richard, D.7
  • 78
    • 63049083171 scopus 로고    scopus 로고
    • Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism
    • Pan D, Fujimoto M, Lopes A, and Wang YX. (2009). Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism. Cell 137, 73-86.
    • (2009) Cell , vol.137 , pp. 73-86
    • Pan, D.1    Fujimoto, M.2    Lopes, A.3    Wang, Y.X.4
  • 80
    • 77950226740 scopus 로고    scopus 로고
    • Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes
    • Petrovic N, Walden TB, Shabalina IG, Timmons JA, Cannon B, Nedergaard J. (2010). Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes. J Biol Chem 285, 7153-64.
    • (2010) J Biol Chem , vol.285 , pp. 7153-64
    • Petrovic, N.1    Walden, T.B.2    Shabalina, I.G.3    Timmons, J.A.4    Cannon, B.5    Nedergaard, J.6
  • 82
  • 83
    • 0032230339 scopus 로고    scopus 로고
    • P42/p44 mitogen-activated protein kinases activation is required for the insulin-like growth factor-i/insulin induced proliferation, but inhibits differentiation, in rat fetal brown adipocytes
    • Porras A, Alvarez AM, Valladares A, Benito M. (1998). p42/p44 mitogen-activated protein kinases activation is required for the insulin-like growth factor-I/insulin induced proliferation, but inhibits diferentiation, in rat fetal brown adipocytes. Mol Endocrinol 12, 825-34. (Pubitemid 30659056)
    • (1998) Molecular Endocrinology , vol.12 , Issue.6 , pp. 825-834
    • Porras, A.1    Alvarez, A.M.2    Valladares, A.3    Benito, M.4
  • 86
    • 0037326196 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α): Transcriptional coactivator and metabolic regulator
    • DOI 10.1210/er.2002-0012
    • Puigserver P, Spiegelman BM. (2003). Peroxisome proliferator-activated receptor-gamma co-activator 1 alpha (PGC-1 alpha): transcriptional co-activator and metabolic regulator. Endocr Rev 24, 78-90. (Pubitemid 36223280)
    • (2003) Endocrine Reviews , vol.24 , Issue.1 , pp. 78-90
    • Puigserver, P.1    Spiegelman, B.M.2
  • 87
    • 1842867001 scopus 로고    scopus 로고
    • Uncoupling proteins: Gender dependence and their relation to body weight control
    • DOI 10.1038/sj.ijo.0802588
    • Rodriguez AM, Palou A. (2004). Uncoupling proteins: gender dependence and their relation to body weight control. Int J Obes Relat Metab Disord 28, 500-02. (Pubitemid 38491139)
    • (2004) International Journal of Obesity , vol.28 , Issue.4 , pp. 500-502
    • Rodriguez, A.M.1    Palou, A.2
  • 92
    • 0029878068 scopus 로고    scopus 로고
    • Thermogenesis in brown adipose tissue with age: Post-receptor activation by forskolin
    • DOI 10.1007/BF02207276
    • Scarpace PJ, Matheny M. (1996). Termogenesis in brown adipose tissue with age: post-receptor activation by forskolin. Pfugers Arch 431, 388-94. (Pubitemid 26081390)
    • (1996) Pflugers Archiv European Journal of Physiology , vol.431 , Issue.3 , pp. 388-394
    • Scarpace, P.J.1    Matheny, M.2
  • 94
    • 33645064540 scopus 로고    scopus 로고
    • Rb and p107 regulate preadipocyte diferentiation into white versus brown fat through repression of PGC-1alpha
    • Scime A, Grenier G, Huh MS, Gillespie MA, Bevilacqua L, Harper ME, and Rudnicki MA. (2005). Rb and p107 regulate preadipocyte diferentiation into white versus brown fat through repression of PGC-1alpha. Cell Metab 2, 283-95.
    • (2005) Cell Metab , vol.2 , pp. 283-95
    • Scime, A.1    Grenier, G.2    Huh, M.S.3    Gillespie, M.A.4    Bevilacqua, L.5    Harper, M.E.6    Rudnicki, M.A.7
  • 97
    • 64349121056 scopus 로고    scopus 로고
    • Transcriptional control of brown adipocyte development and physiological function\of mice and men
    • Seale P, Kajimura S, Spiegelman BM. (2009). Transcriptional control of brown adipocyte development and physiological function\of mice and men. Genes Dev 23, 788-97.
    • (2009) Genes Dev , vol.23 , pp. 788-97
    • Seale, P.1    Kajimura, S.2    Spiegelman, B.M.3
  • 103
    • 0033595591 scopus 로고    scopus 로고
    • PPARα activation by Wy 14643 induces transactivation of the Rat UCP-1 promoter without increasing UCP-1 mRNA levels and attenuates PPARγ-mediated increases in UCP-1 mRNA levels induced by rosiglitazone in fetal rat brown adipocytes
    • DOI 10.1006/bbrc.1999.1526
    • Teruel T, Clapham JC, Smith SA. (1999). PPARalpha activation by Wy 14643 induces transactivation of the rat UCP-1 promoter without increasing UCP-1 mRNA levels and attenuates PPARgamma-mediated increases in UCP-1 mRNA levels induced by rosiglitazone in fetal rat brown adipocytes. Biochem Biophys Res Commun 264, 311-15. (Pubitemid 29516083)
    • (1999) Biochemical and Biophysical Research Communications , vol.264 , Issue.2 , pp. 311-315
    • Teruel, T.1    Clapham, J.C.2    Smith, S.A.3
  • 104
    • 0037414826 scopus 로고    scopus 로고
    • Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes
    • DOI 10.1074/jbc.M207200200
    • Teruel T, Hernandez R, Benito M, Lorenzo M. (2003). Rosiglitazone and retinoic acid induce uncoupling protein-1 (UCP-1) in a p38 mitogen-activated protein kinase-dependent manner in fetal primary brown adipocytes. J Biol Chem 278, 263-9. (Pubitemid 36043571)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.1 , pp. 263-269
    • Teruel, T.1    Hernandez, R.2    Benito, M.3    Lorenzo, M.4
  • 105
    • 21344449736 scopus 로고    scopus 로고
    • Rosiglitazone up-regulates lipoprotein lipase, hormone-sensitive lipase and uncoupling protein-1, and down-regulates insulin-induced fatty acid synthase gene expression in brown adipocytes of Wistar rats
    • DOI 10.1007/s00125-005-1744-0
    • Teruel T, Hernandez R, Rial E, Martin-Hidalgo A, Lorenzo M. (2005). Rosiglitazone up-regulates lipoprotein lipase, hormone-sensitive lipase and uncoupling protein-1, and down-regulates insulin-induced fatty acid synthase gene expression in brown adipocytes of Wistar rats. Diabetologia 48, 1180-88. (Pubitemid 40909655)
    • (2005) Diabetologia , vol.48 , Issue.6 , pp. 1180-1188
    • Teruel, T.1    Hernandez, R.2    Rial, E.3    Martin-Hidalgo, A.4    Lorenzo, M.5
  • 106
    • 0029828493 scopus 로고    scopus 로고
    • Insulin-like growth factor I and insulin induce adipogenic-related gene expression in fetal brown adipocyte primary cultures
    • Teruel T, Valverde AM, Benito M, Lorenzo M. (1996). Insulin-like growth factor I and insulin induce adipogenic-related gene expression in fetal brown adipocyte primary cultures. Biochem J 319 (Pt 2), 627-32. (Pubitemid 26372226)
    • (1996) Biochemical Journal , vol.319 , Issue.2 , pp. 627-632
    • Teruel, T.1    Valverde, A.M.2    Benito, M.3    Lorenzo, M.4
  • 107
    • 0031836663 scopus 로고    scopus 로고
    • Inhibition of PI 3-kinase and RAS blocks IGF-I and insulin-induced uncoupling protein 1 gene expression in brown adipocytes
    • DOI 10.1002/(SICI)1097-4652(199807)176:1<99::AID-JCP12>3.0.CO;2-J
    • Teruel T, Valverde AM, Navarro P, Benito M, Lorenzo M. (1998). Inhibition of PI 3-kinase and RAS blocks IGF-I and insulin-induced uncoupling protein 1 gene expression in brown adipocytes. J Cell Physiol 176, 99-109. (Pubitemid 28277200)
    • (1998) Journal of Cellular Physiology , vol.176 , Issue.1 , pp. 99-109
    • Teruel, T.1    Valverde, A.M.2    Navarro, P.3    Benito, M.4    Lorenzo, M.5
  • 110
    • 51449123610 scopus 로고    scopus 로고
    • Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 defcient mice
    • Toh SY, Gong J, Du G, Li JZ, Yang S, Ye J, Yao H, Zhang Y, Xue B, Li Q, et al. (2008). Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 defcient mice. PLoS One 3, e2890.
    • (2008) PLoS One , vol.3
    • Toh, S.Y.1    Gong, J.2    Du, G.3    Li, J.Z.4    Yang, S.5    Ye, J.6    Yao, H.7    Zhang, Y.8    Xue, B.9    Li, Q.10
  • 112
    • 50649097541 scopus 로고    scopus 로고
    • Fat and beyond: The diverse biology of PPARgamma
    • Tontonoz P, Spiegelman B.M. (2008). Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem 77, 289-312.
    • (2008) Annu Rev Biochem , vol.77 , pp. 289-312
    • Tontonoz, P.1    Spiegelman, B.M.2
  • 114
    • 1342282912 scopus 로고    scopus 로고
    • Differential roles of insulin receptor substrates in Brown adipocyte differentiation
    • DOI 10.1128/MCB.24.5.1918-1929.2004
    • Tseng YH, Kriauciunas KM, Kokkotou E, Kahn CR. (2004). Diferential roles of insulin receptor substrates in brown adipocyte diferentiation. Mol Cell Biol 24, 1918-29. (Pubitemid 38248933)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.5 , pp. 1918-1929
    • Tseng, Y.-H.1    Kriauciunas, K.M.2    Kokkotou, E.3    Kahn, C.R.4
  • 116
    • 33646124709 scopus 로고    scopus 로고
    • Complementary action of the PGC-1 co-activators in mitochondrial biogenesis and brown fat diferentiation
    • Uldry M, Yang W, St-Pierre J, Lin J, Seale P, Spiegelman BM. (2006). Complementary action of the PGC-1 co-activators in mitochondrial biogenesis and brown fat diferentiation. Cell Metab 3, 333-41.
    • (2006) Cell Metab , vol.3 , pp. 333-41
    • Uldry, M.1    Yang, W.2    St-Pierre, J.3    Lin, J.4    Seale, P.5    Spiegelman, B.M.6
  • 117
    • 0038532266 scopus 로고    scopus 로고
    • Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes
    • DOI 10.1074/jbc.M209363200
    • Valverde AM, Arribas M, Mur C, Navarro P, Pons S, Cassard-Doulcier AM, Kahn CR, Benito M. (2003). Insulin-induced up-regulated uncoupling protein-1 expression is mediated by insulin receptor substrate 1 through the phosphatidylinositol 3-kinase/Akt signaling pathway in fetal brown adipocytes. J Biol Chem 278, 10221-31. (Pubitemid 36800283)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.12 , pp. 10221-10231
    • Valverde, A.M.1    Arribas, M.2    Mur, C.3    Navarro, P.4    Pons, S.5    Cassard-Doulcier, A.-M.6    Kahn, C.R.7    Benito, M.8
  • 118
    • 13244258505 scopus 로고    scopus 로고
    • The brown adipose cell: A model for understanding the molecular mechanisms of insulin resistance
    • DOI 10.1111/j.1365-201X.2004.01384.x
    • Valverde AM, Benito M, Lorenzo M. (2005). Te brown adipose cell: a model for understanding the molecular mechanisms of insulin resistance. Acta Physiol Scand 183, 59-73. (Pubitemid 40188036)
    • (2005) Acta Physiologica Scandinavica , vol.183 , Issue.1 , pp. 59-73
    • Valverde, A.M.1    Benito, M.2    Lorenzo, M.3
  • 119
    • 0032752007 scopus 로고    scopus 로고
    • Insulin signaling in insulin receptor substrate (IRS)-1-deficient brown adipocytes: Requirement of IRS-1 for lipid synthesis
    • DOI 10.2337/diabetes.48.11.2122
    • Valverde AM, Kahn CR, Benito M. (1999). Insulin signaling in insulin receptor substrate (IRS)-1-defcient brown adipocytes: requirement of IRS-1 for lipid synthesis. Diabetes 48, 2122-31. (Pubitemid 29521840)
    • (1999) Diabetes , vol.48 , Issue.11 , pp. 2122-2131
    • Valverde, A.M.1    Kahn, C.R.2    Benito, M.3
  • 120
    • 0030982829 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is a requirement for insulin-like growth factor I-induced differentiation, but not for mitogenesis, in fetal brown adipocytes
    • Valverde AM, Lorenzo M, Navarro P, Benito M. (1997). Phosphatidylinositol 3-kinase is a requirement for insulin-like growth factor I-induced diferentiation, but not for mitogenesis, in fetal brown adipocytes. Mol Endocrinol 11, 595-607. (Pubitemid 27193795)
    • (1997) Molecular Endocrinology , vol.11 , Issue.5 , pp. 595-607
    • Valverde, A.M.1    Lorenzo, M.2    Navarro, P.3    Benito, M.4
  • 121
    • 0035099372 scopus 로고    scopus 로고
    • Association of insulin receptor substrate 1 (IRS-1) Y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis
    • DOI 10.1128/MCB.21.7.2269-2280.2001
    • Valverde AM, Mur C, Pons S, Alvarez AM, White MF, Kahn CR, Benito M. (2001). Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-defcient brown adipocyte mitogenesis. Mol Cell Biol 21, 2269-80. (Pubitemid 32222081)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.7 , pp. 2269-2280
    • Valverde, A.M.1    Mur, C.2    Pons, S.3    Alvarez, A.M.4    White, M.F.5    Kahn, C.R.6    Benito, M.7
  • 124
    • 77149154335 scopus 로고    scopus 로고
    • Adenosine 5'-monophosphate-activated protein kinase-mammalian target of rapamycin cross talk regulates brown adipocyte diferentiation
    • Vila-Bedmar R, Lorenzo M, Fernandez-Veledo S. (2010). Adenosine 5'-monophosphate-activated protein kinase-mammalian target of rapamycin cross talk regulates brown adipocyte diferentiation. Endocrinology 151, 980-92.
    • (2010) Endocrinology , vol.151 , pp. 980-92
    • Vila-Bedmar, R.1    Lorenzo, M.2    Fernandez-Veledo, S.3
  • 127
    • 77955502218 scopus 로고    scopus 로고
    • PPARalpha does not suppress muscle-associated gene expression in brown adipocytes but does infuence expression of factors that fngerprint the brown adipocyte
    • Walden TB, Petrovic N, Nedergaard J. (2010). PPARalpha does not suppress muscle-associated gene expression in brown adipocytes but does infuence expression of factors that fngerprint the brown adipocyte. Biochem Biophys Res Commun 397, 146-51.
    • (2010) Biochem Biophys Res Commun , vol.397 , pp. 146-51
    • Walden, T.B.1    Petrovic, N.2    Nedergaard, J.3
  • 128
    • 58149217061 scopus 로고    scopus 로고
    • Distinct expression of muscle-specifc microRNAs (myomirs) in brown adipocytes
    • Walden TB, Timmons JA, Keller P, Nedergaard J, Cannon B. (2009). Distinct expression of muscle-specifc microRNAs (myomirs) in brown adipocytes. J Cell Physiol 218, 444-9.
    • (2009) J Cell Physiol , vol.218 , pp. 444-9
    • Walden, T.B.1    Timmons, J.A.2    Keller, P.3    Nedergaard, J.4    Cannon, B.5
  • 130
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity
    • DOI 10.1016/S0092-8674(03)00269-1
    • Wang YX, Lee CH, Tiep S, Yu RT, Ham J, Kang H, Evans RM. (2003). Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity. Cell 113, 159-70. (Pubitemid 36514968)
    • (2003) Cell , vol.113 , Issue.2 , pp. 159-170
    • Wang, Y.-X.1    Lee, C.-H.2    Tiep, S.3    Yu, R.T.4    Ham, J.5    Kang, H.6    Evans, R.M.7
  • 131
    • 43649102434 scopus 로고    scopus 로고
    • 18F-FDG by hypermetabolic brown adipose tissue on PET
    • DOI 10.2214/AJR.07.3205
    • Williams G, Kolodny G.M. (2008). Method for decreasing uptake of 18F-FDG by hypermetabolic brown adipose tissue on PET. AJR Am J Roentgenol 190, 1406-9. (Pubitemid 351684941)
    • (2008) American Journal of Roentgenology , vol.190 , Issue.5 , pp. 1406-1409
    • Williams, G.1    Kolodny, G.M.2
  • 132
    • 24344476219 scopus 로고    scopus 로고
    • Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots
    • DOI 10.1128/MCB.25.18.8311-8322.2005
    • Xue B, Coulter A, Rim JS, Koza RA, Kozak LP. (2005). Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots. Mol Cell Biol 25, 8311-22. (Pubitemid 41263019)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.18 , pp. 8311-8322
    • Xue, B.1    Coulter, A.2    Rim, J.S.3    Koza, R.A.4    Kozak, L.P.5
  • 133
    • 33845977987 scopus 로고    scopus 로고
    • Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat
    • DOI 10.1194/jlr.M600287-JLR200
    • Xue B, Rim JS, Hogan JC, Coulter AA, Koza RA, Kozak LP. (2007). Genetic variability afects the development of brown adipocytes in white fat but not in interscapular brown fat. J Lipid Res 48, 41-51. (Pubitemid 46052896)
    • (2007) Journal of Lipid Research , vol.48 , Issue.1 , pp. 41-51
    • Xue, B.1    Rim, J.-S.2    Hogan, J.C.3    Coulter, A.A.4    Koza, R.A.5    Kozak, L.P.6
  • 139
    • 70349334680 scopus 로고    scopus 로고
    • Te presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue
    • Zingaretti MC, Crosta F, Vitali A, Guerrieri M, Frontini A, Cannon B, Nedergaard J, Cinti S. (2009). Te presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J 23, 3113-20.
    • (2009) FASEB J , vol.23 , pp. 3113-20
    • Zingaretti, M.C.1    Crosta, F.2    Vitali, A.3    Guerrieri, M.4    Frontini, A.5    Cannon, B.6    Nedergaard, J.7    Cinti, S.8


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