Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 1, 2011, Pages 403-408

  Korach André, Marion ^a   Archer, Amena ^a   Barros, Rodrigo P ^b   Parini, Paolo ^a,c   Gustafsson, Jan Åke ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b University of Houston   (United States)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

FAT DROPLET; GLUCOSE TRANSPORTER 4; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR ALPHABETA; LIVER X RECEPTOR BETA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CARBOHYDRATE DIET; CONTROLLED STUDY; ENERGY EXPENDITURE; FEMALE; GENE CONTROL; IMMUNOHISTOCHEMISTRY; LIPID STORAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; WILD TYPE;

ADIPOSE TISSUE, BROWN; ANALYSIS OF VARIANCE; ANIMALS; BENZOIC ACIDS; BENZYLAMINES; BLOOD GLUCOSE; BLOTTING, WESTERN; CALORIMETRY; ENERGY METABOLISM; FEMALE; GLUCOSE TRANSPORTER TYPE 4; IMMUNOHISTOCHEMISTRY; ION CHANNELS; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; ORPHAN NUCLEAR RECEPTORS; POLYMERASE CHAIN REACTION; PROTEIN ISOFORMS; THERMOGENESIS; TRIGLYCERIDES;

MUS;

EID: 78651084546     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1017884108     Document Type: Article

References (44)

1. Cannon B, Nedergaard J (2010) Metabolic consequences of the presence or absence of the thermogenic capacity of brown adipose tissue in mice (and probably in humans). Int J Obes (Lond) 34(Suppl 1):S7-S16.
2. Nedergaard J, Cannon B (2010) The changed metabolic world with human brown adipose tissue: Therapeutic visions. Cell Metab 11:268-272.
3. Cannon B, Nedergaard J (2004) Brown adipose tissue: Function and physiological significance. Physiol Rev 84:277-359.
4. Hansen JB, Kristiansen K (2006) Regulatory circuits controlling white versus brown adipocyte differentiation. Biochem J 398:153-168.
5. Smith RE, Horwitz BA (1969) Brown fat and thermogenesis. Physiol Rev 49:330-425.
6. Trayhurn P (1995) Fuel selection in brown adipose tissue. Proc Nutr Soc 54:39-47.
7. Trayhurn P, Duncan JS, Rayner DV (1995) Acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: Mediation by the sympathetic system. Biochem J 311:729-733.
8. Cypess AM, Kahn CR (2010) The role and importance of brown adipose tissue in energy homeostasis. Curr Opin Pediatr 22:478-484.
9. Cypess AM, Kahn CR (2010) Brown fat as a therapy for obesity and diabetes. Curr Opin Endocrinol Diabetes Obes 17:143-149.
10. Tseng YH, Cypess AM, Kahn CR (2010) Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov 9:465-482.
11. Cannon B, Nedergaard J (2009) Thermogenesis challenges the adipostat hypothesis for body-weight control. Proc Nutr Soc 68:401-407.
12. Nedergaard J, Bengtsson T, Cannon B (2007) Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab 293:E444-E452.
13. Valverde AM, Benito M, Lorenzo M (2005) The brown adipose cell: A model for understanding the molecular mechanisms of insulin resistance. Acta Physiol Scand 183:59-73. (Pubitemid 40188036)
14. Escher P, et al. (2001) Rat PPARs: Quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology 142:4195-4202.
15. Steffensen KR, et al. (2003) Gene expression profiling in adipose tissue indicates different transcriptional mechanisms of liver X receptors alpha and beta, respectively. Biochem Biophys Res Commun 310:589-593.
16. Anthonisen EH, et al. (2010) Nuclear receptor liver X receptor is O-GlcNAc-modified in response to glucose. J Biol Chem 285:1607-1615.
17. Kalaany NY, et al. (2005) LXRs regulate the balance between fat storage and oxidation. Cell Metab 1:231-244.
18. Korach-André M, et al. (2010) Separate and overlapping metabolic functions of LXRalpha and LXRbeta in C57Bl/6 female mice. Am J Physiol Endocrinol Metab 298:E167-E178.
19. Mitro N, et al. (2007) The nuclear receptor LXR is a glucose sensor. Nature 445:219-223.
20. Wang H, et al. (2008) Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype. Mol Cell Biol 28:2187-2200.
21. Gabbi C, et al. (2008) Pancreatic exocrine insufficiency in LXRbeta-/- mice is associated with a reduction in aquaporin-1 expression. Proc Natl Acad Sci USA 105:15052-15057.
22. Gerin I, et al. (2005) LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function. J Biol Chem 280:23024-23031.
23. Rothwell NJ, Stock MJ (1983) Diet-induced thermogenesis. Adv Nutr Res 5:201-220.
24. Collins JL, et al. (2002) Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem 45:1963-1966.
25. Kajimura S, Seale P, Spiegelman BM (2010) Transcriptional control of brown fat development. Cell Metab 11:257-262.
26. Cannon B, Shabalina IG, Kramarova TV, Petrovic N, Nedergaard J (2006) Uncoupling proteins: A role in protection against reactive oxygen species - or not? Biochim Biophys Acta 1757:449-458.
27. Nikami H, Shimizu Y, Endoh D, Yano H, Saito M (1992) Cold exposure increases glucose utilization and glucose transporter expression in brown adipose tissue. Biochem Biophys Res Commun 185:1078-1082.
28. Slot JW, Geuze HJ, Gigengack S, Lienhard GE, James DE (1991) Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat. J Cell Biol 113:123-135.
29. Sell H, Deshaies Y, Richard D (2004) The brown adipocyte: update on its metabolic role. Int J Biochem Cell Biol 36:2098-2104.
30. Janowski BA,Willy PJ, Devi TR, Falck JR, Mangelsdorf DJ (1996) An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature 383:728-731.
31. Schultz JR, et al. (2000) Role of LXRs in control of lipogenesis. Genes Dev 14:2831-2838.
32. Stulnig TM, et al. (2002) Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue. Mol Pharmacol 62:1299-1305.
33. Ide T, et al. (2003) Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling. Molecular Endocrinol 17:1255-1267.
34. Yoshikawa T, et al. (2003) Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling. Molecular Endocrinol 17:1240-1254.
35. Géloën A, Collet AJ, Guay G, Bukowiecki LJ (1988) Beta-adrenergic stimulation of brown adipocyte proliferation. Am J Physiol 254:C175-C182.
36. Rehnmark S, Nedergaard J (1989) DNA synthesis in mouse brown adipose tissue is under beta-adrenergic control. Exp Cell Res 180:574-579.
37. Bronnikov G, et al. (1999) beta1 to beta3 switch in control of cyclic adenosine monophosphate during brown adipocyte development explains distinct beta-adrenoceptor subtype mediation of proliferation and differentiation. Endocrinology 140:4185-4197.
38. Enerbäck S, et al. (1997) Mice lacking mitochondrial uncoupling protein are coldsensitive but not obese. Nature 387:90-94.
39. Feldmann HM, Golozoubova V, Cannon B, Nedergaard J (2009) UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab 9:203-209.
40. Silva JE, Bianco SD (2008) Thyroid-adrenergic interactions: Physiological and clinical implications. Thyroid 18:157-165.
41. Silva JE (2006) Thermogenic mechanisms and their hormonal regulation. Physiol Rev 86:435-464.
42. Christoffolete MA, et al. (2010) Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway. J Endocrinol 205:179-186.
43. Alberti S, et al. (2001) Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice. J Clin Invest 107:565-573.
44. Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497-509.