Brown vs white adipocytes: The PPARγ coregulator story

FEBS Letters

Volumn 584, Issue 15, 2010, Pages 3250-3259

  Koppen, Arjen ^a,b   Kalkhoven, Eric ^a,b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b NETHERLANDS METABOLOMICS CENTRE   (Netherlands)

Author keywords

Adipogenesis; Coactivator; Corepressor; PPARgamma; Transcription; White and brown adipose tissue

Indexed keywords

BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; GLITAZONE DERIVATIVE; NUCLEAR RECEPTOR COACTIVATOR 2; NUCLEAR RECEPTOR COREPRESSOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1BETA; PROTEIN MED14; PROTEIN P300; PROTEIN PRDM16; PROTEIN TRAP220; REGULATOR PROTEIN; SILENCING MEDIATOR OF RETINOID AND THYROID HORMONE RECEPTOR; STEROID RECEPTOR COACTIVATOR 1; STEROID RECEPTOR COACTIVATOR 3; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ADIPOGENESIS; AMINO TERMINAL SEQUENCE; BROWN ADIPOSE TISSUE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; FOOD INTAKE; HUMAN; INSULIN RESISTANCE; LIPID METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; THERMOGENESIS; TRANSCRIPTION REGULATION; WEIGHT GAIN; WHITE ADIPOSE TISSUE;

ADIPOCYTES, BROWN; ADIPOCYTES, WHITE; ADIPOGENESIS; ADIPOSE TISSUE, BROWN; ADIPOSE TISSUE, WHITE; ANIMALS; HUMANS; PPAR GAMMA;

EID: 77955266460     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.06.035     Document Type: Review

References (120)

1. Rosen E.D., Spiegelman B.M. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 2006, 444:847-853.
2. Lafontan M. Lafontan advances in adipose tissue metabolism. Int. J. Obes. (Lond) 2008, (32 Suppl. 7):S39-S51.
3. Trayhurn P. Endocrine and signalling role of adipose tissue: new perspectives on fat. Acta Physiol. Scand. 2005, 184:285-293.
4. Cannon B., Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 2004, 84:277-359.
5. Lean M.E., James W.P., Jennings G., Trayhurn P. Brown adipose tissue uncoupling protein content in human infants, children and adults. Clin. Sci. (Lond) 1986, 71:291-297.
6. Frontini A., Cinti S. Distribution and development of brown adipocytes in the murine and human adipose organ. Cell Metab. 2010, 11:253-256.
7. Cypess A.M., Lehman S., Williams G., Tal I., Rodman D., Goldfine A.B., Kuo F.C., Palmer E.L., Tseng Y.H., Doria A., Kolodny G.M., Kahn C.R. Identification and importance of brown adipose tissue in adult humans. N. Engl. J. Med. 2009, 360:1509-1517.
8. van Marken Lichtenbelt W.D., Vanhommerig J.W., Smulders N.M., Drossaerts J.M., Kemerink G.J., Bouvy N.D., Schrauwen P., Teule G.J. Cold-activated brown adipose tissue in healthy men. N. Engl. J. Med. 2009, 360:1500-1508.
9. Virtanen K.A., Lidell M.E., Orava J., Heglind M., Westergren R., Niemi T., Taittonen M., Laine J., Savisto N.J., Enerback S., Nuutila P. Functional brown adipose tissue in healthy adults. N. Engl. J. Med. 2009, 360:1518-1525.
10. Park K.W., Halperin D.S., Tontonoz P. Before they were fat: adipocyte progenitors. Cell Metab. 2008, 8:454-457.
11. Seale P., Bjork B., Yang W., Kajimura S., Chin S., Kuang S., Scime A., Devarakonda S., Conroe H.M., Erdjument-Bromage H., Tempst P., Rudnicki M.A., Beier D.R., Spiegelman B.M. PRDM16 controls a brown fat/skeletal muscle switch. Nature 2008, 454:961-967.
12. Guerra C., Koza R.A., Yamashita H., Walsh K., Kozak L.P. Emergence of brown adipocytes in white fat in mice is under genetic control. J. Clin. Invest. 1998, 102:412-420.
13. Green H., Kehinde O. An established pre-adipose cell line and its differentiation in culture. Cell 1974, 1:113-116.
14. Rosen E.D., MacDougald O.A. Adipocyte differentiation from the inside out. Nat. Rev. Mol. Cell Biol. 2006, 7:885-896.
15. Wabitsch M., Brenner R.E., Melzner I., Braun M., Moller P., Heinze E., Debatin K.M., Hauner H. Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation. Int. J. Obes. Relat. Metab. Disord. 2001, 25:8-15.
16. Rodriguez A.M., Elabd C., Delteil F., Astier J., Vernochet C., Saint-Marc P., Guesnet J., Guezennec A., Amri E.Z., Dani C., Ailhaud G. Adipocyte differentiation of multipotent cells established from human adipose tissue. Biochem. Biophys. Res. Commun. 2004, 315:255-263.
17. Barak Y., Nelson M.C., Ong E.S., Jones Y.Z., Ruiz-Lozano P., Chien K.R., Koder A., Evans R.M. PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol. Cell 1999, 4:585-595.
18. Kubota N., Terauchi Y., Miki H., Tamemoto H., Yamauchi T., Komeda K., Satoh S., Nakano R., Ishii C., Sugiyama T., Eto K., Tsubamoto Y., Okuno A., Murakami K., Sekihara H., Hasegawa G., Naito M., Toyoshima Y., Tanaka S., Shiota K., Kitamura T., Fujita T., Ezaki O., Aizawa S., Kadowaki T. PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol. Cell 1999, 4:597-609.
19. Rosen E.D., Sarraf P., Troy A.E., Bradwin G., Moore K., Milstone D.S., Spiegelman B.M., Mortensen R.M. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol. Cell 1999, 4:611-617.
20. Issemann I., Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 1990, 347:645-650.
21. Dreyer C., Krey G., Keller H., Givel F., Helftenbein G., Wahli W. Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Cell 1992, 68:879-887.
22. Graves R.A., Tontonoz P., Spiegelman B.M. Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression. Mol. Cell Biol. 1992, 12:1202-1208.
23. Zhu Y., Alvares K., Huang Q., Rao M.S., Reddy J.K. Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver. J. Biol. Chem. 1993, 268:26817-26820.
24. Gearing K.L., Gottlicher M., Teboul M., Widmark E., Gustafsson J.A. Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor. Proc. Natl. Acad. Sci. USA 1993, 90:1440-1444.
25. Issemann I., Prince R.A., Tugwood J.D., Green S. The retinoid X receptor enhances the function of the peroxisome proliferator activated receptor. Biochimie 1993, 75:251-256.
26. Yki-Jarvinen H. Thiazolidinediones. N. Engl. J. Med. 2004, 351:1106-1118.
27. van Beekum O., Fleskens V., Kalkhoven E. Posttranslational modifications of PPAR-gamma: fine-tuning the metabolic master regulator. Obesity (Silver. Spring) 2009, 17:213-219.
28. Zhu Y., Qi C., Korenberg J.R., Chen X.N., Noya D., Rao M.S., Reddy J.K. Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms. Proc. Natl. Acad. Sci. USA 1995, 92:7921-7925.
29. Morrison R.F., Farmer S.R. Role of PPARgamma in regulating a cascade expression of cyclin-dependent kinase inhibitors, p18(INK4c) and p21(Waf1/Cip1), during adipogenesis. J. Biol. Chem. 1999, 274:17088-17097.
30. Lehrke M., Lazar M.A. The many faces of PPARgamma. Cell 2005, 123:993-999.
31. Schoonjans K., Peinado-Onsurbe J., Lefebvre A.M., Heyman R.A., Briggs M., Deeb S., Staels B., Auwerx J. PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J. 1996, 15:5336-5348.
32. Frohnert B.I., Hui T.Y., Bernlohr D.A. Identification of a functional peroxisome proliferator-responsive element in the murine fatty acid transport protein gene. J. Biol. Chem. 1999, 274:3970-3977.
33. Chui P.C., Guan H.P., Lehrke M., Lazar M.A. PPARgamma regulates adipocyte cholesterol metabolism via oxidized LDL receptor 1. J. Clin. Invest. 2005, 115:2244-2256.
34. Guan H.P., Li Y., Jensen M.V., Newgard C.B., Steppan C.M., Lazar M.A. A futile metabolic cycle activated in adipocytes by antidiabetic agents. Nat. Med. 2002, 8:1122-1128.
35. Hibuse T., Maeda N., Funahashi T., Yamamoto K., Nagasawa A., Mizunoya W., Kishida K., Inoue K., Kuriyama H., Nakamura T., Fushiki T., Kihara S., Shimomura I. Aquaporin 7 deficiency is associated with development of obesity through activation of adipose glycerol kinase. Proc. Natl. Acad. Sci. USA 2005, 102:10993-10998.
36. Tontonoz P., Hu E., Devine J., Beale E.G., Spiegelman B.M. PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Mol. Cell Biol. 1995, 15:351-357.
37. Jeninga E.H., Bugge A., Nielsen R., Kersten S., Hamers N., Dani C., Wabitsch M., Berger R., Stunnenberg H.G., Mandrup S., Kalkhoven E. Peroxisome proliferator-activated receptor gamma regulates expression of the anti-lipolytic G-protein-coupled receptor 81 (GPR81/Gpr81). J. Biol. Chem. 2009, 284:26385-26393.
38. Rangwala S.M., Lazar M.A. Peroxisome proliferator-activated receptor gamma in diabetes and metabolism. Trends Pharmacol. Sci. 2004, 25:331-336.
39. Lefterova M.I., Zhang Y., Steger D.J., Schupp M., Schug J., Cristancho A., Feng D., Zhuo D., Stoeckert C.J., Liu X.S., Lazar M.A. PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes Dev. 2008, 22:2941-2952.
40. Nielsen R., Pedersen T.A., Hagenbeek D., Moulos P., Siersbaek R., Megens E., Denissov S., Borgesen M., Francoijs K.J., Mandrup S., Stunnenberg H.G. Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis. Genes Dev. 2008, 22:2953-2967.
41. Hamza M.S., Pott S., Vega V.B., Thomsen J.S., Kandhadayar G.S., Ng P.W., Chiu K.P., Pettersson S., Wei C.L., Ruan Y., Liu E.T. De-novo identification of PPARgamma/RXR binding sites and direct targets during adipogenesis. PLoS ONE 2009, 4:e4907.
42. Kalkhoven E. CBP and p300: HATs for different occasions. Biochem. Pharmacol. 2004, 68:1145-1155.
43. Roeder R.G. Transcriptional regulation and the role of diverse coactivators in animal cells. FEBS Lett. 2005, 579:909-915.
44. Lonard D.M., O'Malley B.W. Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation. Mol. Cell 2007, 27:691-700.
45. Conaway R.C., Sato S., Tomomori-Sato C., Yao T., Conaway J.W. The mammalian mediator complex and its role in transcriptional regulation. Trends Biochem. Sci. 2005, 30:250-255.
46. Heery D.M., Kalkhoven E., Hoare S., Parker M.G. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 1997, 387:733-736.
47. Onate S.A., Tsai S.Y., Tsai M.J., O'Malley B.W. Sequence and characterization of a coactivator for the steroid hormone receptor superfamily. Science 1995, 270:1354-1357.
48. Chen J.D., Evans R.M. A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 1995, 377:454-457.
49. Horlein A.J., Naar A.M., Heinzel T., Torchia J., Gloss B., Kurokawa R., Ryan A., Kamei Y., Soderstrom M., Glass C.K. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 1995, 377:397-404.
50. Hu X., Lazar M.A. The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors. Nature 1999, 402:93-96.
51. DiRenzo J., Soderstrom M., Kurokawa R., Ogliastro M.H., Ricote M., Ingrey S., Horlein A., Rosenfeld M.G., Glass C.K. Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid X receptor heterodimers with ligands, coactivators, and corepressors. Mol. Cell Biol. 1997, 17:2166-2176.
52. Zhu Y., Qi C., Calandra C., Rao M.S., Reddy J.K. Cloning and identification of mouse steroid receptor coactivator-1 (mSRC-1), as a coactivator of peroxisome proliferator-activated receptor gamma. Gene Expr. 1996, 6:185-195.
53. Picard F., Gehin M., Annicotte J., Rocchi S., Champy M.F., O'Malley B.W., Chambon P., Auwerx J. SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell 2002, 111:931-941.
54. Kodera Y., Takeyama K., Murayama A., Suzawa M., Masuhiro Y., Kato S. Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators. J. Biol. Chem. 2000, 275:33201-33204.
55. Koppen A., Houtman R., Pijnenburg D., Jeninga E.H., Ruijtenbeek R., Kalkhoven E. Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor. Mol. Cell Proteomics 2009, 8:2212-2226.
56. Louet J.F., Coste A., Amazit L., Tannour-Louet M., Wu R.C., Tsai S.Y., Tsai M.J., Auwerx J., O'Malley B.W. Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program. Proc. Natl. Acad. Sci. USA 2006, 103:17868-17873.
57. Wang Z., Qi C., Krones A., Woodring P., Zhu X., Reddy J.K., Evans R.M., Rosenfeld M.G., Hunter T. Critical roles of the p160 transcriptional coactivators p/CIP and SRC-1 in energy balance. Cell Metab. 2006, 3:111-122.
58. Bannister A.J., Kouzarides T. The CBP co-activator is a histone acetyltransferase. Nature 1996, 384:641-643.
59. Ogryzko V.V., Schiltz R.L., Russanova V., Howard B.H., Nakatani Y. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 1996, 87:953-959.
60. Gelman L., Zhou G., Fajas L., Raspe E., Fruchart J.C., Auwerx J. P300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively. J. Biol. Chem. 1999, 274:7681-7688.
61. Takahashi N., Kawada T., Yamamoto T., Goto T., Taimatsu A., Aoki N., Kawasaki H., Taira K., Yokoyama K.K., Kamei Y., Fushiki T. Overexpression and ribozyme-mediated targeting of transcriptional coactivators CREB-binding protein and p300 revealed their indispensable roles in adipocyte differentiation through the regulation of peroxisome proliferator-activated receptor gamma. J. Biol. Chem. 2002, 277:16906-16912.
62. Yamauchi T., Oike Y., Kamon J., Waki H., Komeda K., Tsuchida A., Date Y., Li M.X., Miki H., Akanuma Y., Nagai R., Kimura S., Saheki T., Nakazato M., Naitoh T., Yamamura K., Kadowaki T. Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice. Nat. Genet. 2002, 30:221-226.
63. Yao T.P., Oh S.P., Fuchs M., Zhou N.D., Ch'ng L.E., Newsome D., Bronson R.T., Li E., Livingston D.M., Eckner R. Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell 1998, 93:361-372.
64. Bugge A., Grontved L., Aagaard M.M., Borup R., Mandrup S. The PPARgamma2 A/B-domain plays a gene-specific role in transactivation and cofactor recruitment. Mol. Endocrinol. 2009, 23:794-808.
65. Puigserver P., Wu Z., Park C.W., Graves R., Wright M., Spiegelman B.M. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998, 92:829-839.
66. Lin J., Puigserver P., Donovan J., Tarr P., Spiegelman B.M. Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta), a novel PGC-1-related transcription coactivator associated with host cell factor. J. Biol. Chem. 2002, 277:1645-1648.
67. Lin J., Handschin C., Spiegelman B.M. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 2005, 1:361-370.
68. Wu Y., Chin W.W., Wang Y., Burris T.P. Ligand and coactivator identity determines the requirement of the charge clamp for coactivation of the peroxisome proliferator-activated receptor gamma. J. Biol. Chem. 2003, 278:8637-8644.
69. Wolfrum C., Stoffel M. Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion. Cell Metab. 2006, 3:99-110.
70. Kawakami Y., Tsuda M., Takahashi S., Taniguchi N., Esteban C.R., Zemmyo M., Furumatsu T., Lotz M., Belmonte J.C., Asahara H. Transcriptional coactivator PGC-1alpha regulates chondrogenesis via association with Sox9. Proc. Natl. Acad. Sci. USA 2005, 102:2414-2419.
71. Lin J., Yang R., Tarr P.T., Wu P.H., Handschin C., Li S., Yang W., Pei L., Uldry M., Tontonoz P., Newgard C.B., Spiegelman B.M. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell 2005, 120:261-273.
72. Puigserver P., Rhee J., Donovan J., Walkey C.J., Yoon J.C., Oriente F., Kitamura Y., Altomonte J., Dong H., Accili D., Spiegelman B.M. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 2003, 423:550-555.
73. Leone T.C., Lehman J.J., Finck B.N., Schaeffer P.J., Wende A.R., Boudina S., Courtois M., Wozniak D.F., Sambandam N., Bernal-Mizrachi C., Chen Z., Holloszy J.O., Medeiros D.M., Schmidt R.E., Saffitz J.E., Abel E.D., Semenkovich C.F., Kelly D.P. PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol. 2005, 3:e101.
74. Lin J., Wu P.H., Tarr P.T., Lindenberg K.S., St-Pierre J., Zhang C.Y., Mootha V.K., Jager S., Vianna C.R., Reznick R.M., Cui L., Manieri M., Donovan M.X., Wu Z., Cooper M.P., Fan M.C., Rohas L.M., Zavacki A.M., Cinti S., Shulman G.I., Lowell B.B., Krainc D., Spiegelman B.M. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 2004, 119:121-135.
75. Lelliott C.J., Medina-Gomez G., Petrovic N., Kis A., Feldmann H.M., Bjursell M., Parker N., Curtis K., Campbell M., Hu P., Zhang D., Litwin S.E., Zaha V.G., Fountain K.T., Boudina S., Jimenez-Linan M., Blount M., Lopez M., Meirhaeghe A., Bohlooly Y., Storlien L., Stromstedt M., Snaith M., Oresic M., Abel E.D., Cannon B., Vidal-Puig A. Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. PLoS Biol. 2006, 4:e369.
76. Sonoda J., Mehl I.R., Chong L.W., Nofsinger R.R., Evans R.M. PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis. Proc. Natl. Acad. Sci. USA 2007, 104:5223-5228.
77. Hondares E., Mora O., Yubero P., Rodriguez de la C.M., Iglesias R., Villarroya F. Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1alpha gene transcription: an autoregulatory loop controls PGC-1alpha expression in adipocytes via peroxisome proliferator-activated receptor-gamma coactivation. Endocrinology 2006, 147:2829-2838.
78. He W., Barak Y., Hevener A., Olson P., Liao D., Le J., Nelson M., Ong E., Olefsky J.M., Evans R.M. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc. Natl. Acad. Sci. USA 2003, 100:15712-15717.
79. Guan H.P., Ishizuka T., Chui P.C., Lehrke M., Lazar M.A. Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes. Genes Dev. 2005, 19:453-461.
80. Zhu Y., Qi C., Jain S., Rao M.S., Reddy J.K. Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J. Biol. Chem. 1997, 272:25500-25506.
81. Yuan C.X., Ito M., Fondell J.D., Fu Z.Y., Roeder R.G. The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc. Natl. Acad. Sci. USA 1998, 95:7939-7944.
82. Ge K., Guermah M., Yuan C.X., Ito M., Wallberg A.E., Spiegelman B.M., Roeder R.G. Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature 2002, 417:563-567.
83. Ge K., Cho Y.W., Guo H., Hong T.B., Guermah M., Ito M., Yu H., Kalkum M., Roeder R.G. Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression. Mol. Cell Biol. 2008, 28:1081-1091.
84. Ito M., Yuan C.X., Okano H.J., Darnell R.B., Roeder R.G. Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action. Mol. Cell 2000, 5:683-693.
85. Zhu Y., Qi C., Jia Y., Nye J.S., Rao M.S., Reddy J.K. Deletion of PBP/PPARBP, the gene for nuclear receptor coactivator peroxisome proliferator-activated receptor-binding protein, results in embryonic lethality. J. Biol. Chem. 2000, 275:14779-14782.
86. Jain S., Pulikuri S., Zhu Y., Qi C., Kanwar Y.S., Yeldandi A.V., Rao M.S., Reddy J.K. Differential expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) and its coactivators steroid receptor coactivator-1 and PPAR-binding protein PBP in the brown fat, urinary bladder, colon, and breast of the mouse. Am. J. Pathol. 1998, 153:349-354.
87. Chen W., Yang Q., Roeder R.G. Dynamic interactions and cooperative functions of PGC-1alpha and MED1 in TRalpha-mediated activation of the brown-fat-specific UCP-1 gene. Mol. Cell 2009, 35:755-768.
88. Grontved L., Madsen M.S., Boergesen M., Roeder R.G., Mandrup S. MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis. Mol. Cell Biol. 2010, 30:2155-2169.
89. Peterfy M., Phan J., Xu P., Reue K. Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat. Genet. 2001, 27:121-124.
90. Phan J., Peterfy M., Reue K. Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro. J. Biol. Chem. 2004, 279:29558-29564.
91. Koh Y.K., Lee M.Y., Kim J.W., Kim M., Moon J.S., Lee Y.J., Ahn Y.H., Kim K.S. Lipin1 is a key factor for the maturation and maintenance of adipocytes in the regulatory network with CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma 2. J. Biol. Chem. 2008, 283:34896-34906.
92. Donkor J., Sariahmetoglu M., Dewald J., Brindley D.N., Reue K. Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns. J. Biol. Chem. 2007, 282:3450-3457.
93. van Beekum O., Brenkman A.B., Grontved L., Hamers N., van den Broek N.J., Berger R., Mandrup S., Kalkhoven E. The adipogenic acetyltransferase Tip60 targets activation function 1 of peroxisome proliferator-activated receptor gamma. Endocrinology 2008, 149:1840-1849.
94. Brandi M.L., Gagel R.F., Angeli A., Bilezikian J.P., Beck-Peccoz P., Bordi C., Conte-Devolx B., Falchetti A., Gheri R.G., Libroia A., Lips C.J., Lombardi G., Mannelli M., Pacini F., Ponder B.A., Raue F., Skogseid B., Tamburrano G., Thakker R.V., Thompson N.W., Tomassetti P., Tonelli F., Wells S.A., Marx S.J. Guidelines for diagnosis and therapy of MEN type 1 and type 2. J. Clin. Endocrinol. Metab. 2001, 86:5658-5671.
95. Dreijerink K.M., Varier R.A., van B.O., Jeninga E.H., Hoppener J.W., Lips C.J., Kummer J.A., Kalkhoven E., Timmers H.T. The multiple endocrine neoplasia type 1 (MEN1) tumor suppressor regulates peroxisome proliferator-activated receptor gamma-dependent adipocyte differentiation. Mol. Cell Biol. 2009, 29:5060-5069.
96. Li D., Kang Q., Wang D.M. Constitutive coactivator of peroxisome proliferator-activated receptor (PPARgamma), a novel coactivator of PPARgamma that promotes adipogenesis. Mol. Endocrinol. 2007, 21:2320-2333.
97. Lee J.W., Choi H.S., Gyuris J., Brent R., Moore D.D. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. Mol. Endocrinol. 1995, 9:243-254.
98. Zhu Y., Kan L., Qi C., Kanwar Y.S., Yeldandi A.V., Rao M.S., Reddy J.K. Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR. J. Biol. Chem. 2000, 275:13510-13516.
99. Castillo G., Brun R.P., Rosenfield J.K., Hauser S., Park C.W., Troy A.E., Wright M.E., Spiegelman B.M. An adipogenic cofactor bound by the differentiation domain of PPARgamma. EMBO J. 1999, 18:3676-3687.
100. Seale P., Kajimura S., Yang W., Chin S., Rohas L.M., Uldry M., Tavernier G., Langin D., Spiegelman B.M. Transcriptional control of brown fat determination by PRDM16. Cell Metab. 2007, 6:38-54.
101. Nishikata I., Sasaki H., Iga M., Tateno Y., Imayoshi S., Asou N., Nakamura T., Morishita K. A novel EVI1 gene family, MEL1, lacking a PR domain (MEL1S) is expressed mainly in t(1;3)(p36;q21)-positive AML and blocks G-CSF-induced myeloid differentiation. Blood 2003, 102:3323-3332.
102. Perissi V., Jepsen K., Glass C.K., Rosenfeld M.G. Deconstructing repression: evolving models of co-repressor action. Nat. Rev. Genet. 2010, 11:109-123.
103. Cohen R.N., Brzostek S., Kim B., Chorev M., Wondisford F.E., Hollenberg A.N. The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains. Mol. Endocrinol. 2001, 15:1049-1061.
104. Nagy L., Kao H.Y., Love J.D., Li C., Banayo E., Gooch J.T., Krishna V., Chatterjee K., Evans R.M., Schwabe J.W. Mechanism of corepressor binding and release from nuclear hormone receptors. Genes Dev. 1999, 13:3209-3216.
105. Perissi V., Staszewski L.M., McInerney E.M., Kurokawa R., Krones A., Rose D.W., Lambert M.H., Milburn M.V., Glass C.K., Rosenfeld M.G. Molecular determinants of nuclear receptor-corepressor interaction. Genes Dev. 1999, 13:3198-3208.
106. Yu C., Markan K., Temple K.A., Deplewski D., Brady M.J., Cohen R.N. The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis. J. Biol. Chem. 2005, 280:13600-13605.
107. Jepsen K., Hermanson O., Onami T.M., Gleiberman A.S., Lunyak V., McEvilly R.J., Kurokawa R., Kumar V., Liu F., Seto E., Hedrick S.M., Mandel G., Glass C.K., Rose D.W., Rosenfeld M.G. Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell 2000, 102:753-763.
108. Jepsen K., Solum D., Zhou T., McEvilly R.J., Kim H.J., Glass C.K., Hermanson O., Rosenfeld M.G. SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron. Nature 2007, 450:415-419.
109. Nofsinger R.R., Li P., Hong S.H., Jonker J.W., Barish G.D., Ying H., Cheng S.Y., Leblanc M., Xu W., Pei L., Kang Y.J., Nelson M., Downes M., Yu R.T., Olefsky J.M., Lee C.H., Evans R.M. SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis. Proc. Natl. Acad. Sci. USA 2008, 105:20021-20026.
110. Sutanto M.M., Ferguson K.K., Sakuma H., Ye H., Brady M.J., Cohen R.N. The silencing mediator of retinoid and thyroid hormone receptors (SMRT) regulates adipose tissue accumulation and adipocyte insulin sensitivity in vivo. J. Biol. Chem. 2010, 285:18485-18495.
111. Picard F., Kurtev M., Chung N., Topark-Ngarm A., Senawong T., hado De O.R., Leid M., McBurney M.W., Guarente L. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 2004, 429:771-776.
112. Timmons J.A., Wennmalm K., Larsson O., Walden T.B., Lassmann T., Petrovic N., Hamilton D.L., Gimeno R.E., Wahlestedt C., Baar K., Nedergaard J., Cannon B. Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc. Natl. Acad. Sci. USA 2007, 104:4401-4406.
113. White R., Morganstein D., Christian M., Seth A., Herzog B., Parker M.G. Role of RIP140 in metabolic tissues: connections to disease. FEBS Lett. 2008, 582:39-45.
114. Treuter E., Albrektsen T., Johansson L., Leers J., Gustafsson J.A. A regulatory role for RIP140 in nuclear receptor activation. Mol. Endocrinol. 1998, 12:864-881.
115. Leonardsson G., Steel J.H., Christian M., Pocock V., Milligan S., Bell J., So P.W., Medina-Gomez G., Vidal-Puig A., White R., Parker M.G. Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc. Natl. Acad. Sci. USA 2004, 101:8437-8442.
116. Powelka A.M., Seth A., Virbasius J.V., Kiskinis E., Nicoloro S.M., Guilherme A., Tang X., Straubhaar J., Cherniack A.D., Parker M.G., Czech M.P. Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes. J. Clin. Invest. 2006, 116:125-136.
117. Qi L., Heredia J.E., Altarejos J.Y., Screaton R., Goebel N., Niessen S., Macleod I.X., Liew C.W., Kulkarni R.N., Bain J., Newgard C., Nelson M., Evans R.M., Yates J., Montminy M. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science 2006, 312:1763-1766.
118. Takahashi Y., Ohoka N., Hayashi H., Sato R. TRB3 suppresses adipocyte differentiation by negatively regulating PPARgamma transcriptional activity. J. Lipid Res. 2008, 49:880-892.
119. Kanai F., Marignani P.A., Sarbassova D., Yagi R., Hall R.A., Donowitz M., Hisaminato A., Fujiwara T., Ito Y., Cantley L.C., Yaffe M.B. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J. 2000, 19:6778-6791.
120. Hong J.H., Hwang E.S., McManus M.T., Amsterdam A., Tian Y., Kalmukova R., Mueller E., Benjamin T., Spiegelman B.M., Sharp P.A., Hopkins N., Yaffe M.B. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 2005, 309:1074-1078.