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Volumn 11, Issue 3, 2011, Pages 229-240

BMP-9 induced osteogenic differentiation of mesenchymal stem cells: Molecular mechanism and therapeutic potential

(29)  Luther, Gaurav a   Wagner, Eric R a   Zhu, Gaohui a,b   Kang, Quan a,b   Luo, Qing a,b   Lamplot, Joseph a   Bi, Yang a   Luo, Xiaoji a,c   Luo, Jinyong a,c   Teven, Chad a   Shi, Qiong a,c   Kim, Stephanie H a   Gao, Jian Li a,d   Huang, Enyi a,e   Yang, Ke a,f   Rames, Richard a   Liu, Xing a,b   Li, Mi a,b   Hu, Ning a,c   Liu, Hong a,c   more..


Author keywords

BMP 9; Bone formation; Bone regeneration; Cell based gene therapy; Fracture healing; GDF 2; Mesenchymal stem cells

Indexed keywords

ADENOVIRUS BONE MORPHOGENETIC PROTEIN 9 VECTOR; ADENOVIRUS VECTOR; BETA CATENIN; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 10; BONE MORPHOGENETIC PROTEIN 11; BONE MORPHOGENETIC PROTEIN 12; BONE MORPHOGENETIC PROTEIN 14; BONE MORPHOGENETIC PROTEIN 15; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 5; BONE MORPHOGENETIC PROTEIN 6; BONE MORPHOGENETIC PROTEIN 8; BONE MORPHOGENETIC PROTEIN 9; BONE MORPHOGENETIC PROTEIN 9 PLASMID VECTOR; CONNECTIVE TISSUE GROWTH FACTOR; GROWTH DIFFERENTIATION FACTOR 6; OSTEOGENIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLASMID VECTOR; RETINOIC ACID; SMAD PROTEIN; SOMATOMEDIN; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; WNT PROTEIN;

EID: 79958202199     PISSN: 15665232     EISSN: 18755631     Source Type: Journal    
DOI: 10.2174/156652311795684777     Document Type: Article
Times cited : (151)

References (162)
  • 1
    • 20144389396 scopus 로고    scopus 로고
    • Gene therapy for bone regeneration
    • 2005 Apr
    • Luo J, Sun MH, Kang Q, et al. Gene therapy for bone regeneration. Curr Gene Ther 2005 Apr;5(2):167-179.
    • Curr Gene Ther , vol.5 , Issue.2 , pp. 167-179
    • Luo, J.1    Sun, M.H.2    Kang, Q.3
  • 2
    • 78349263031 scopus 로고    scopus 로고
    • Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation
    • Chen L, Jiang W, Huang J, et al. Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation. J Bone Miner Res 2010;25:2447-2459.
    • (2010) J Bone Miner Res , vol.25 , pp. 2447-2459
    • Chen, L.1    Jiang, W.2    Huang, J.3
  • 3
    • 0037024691 scopus 로고    scopus 로고
    • National Ambulatory Medical Care Survey: 2000 summary
    • Cherry DK, Woodwell DA. National Ambulatory Medical Care Survey: 2000 summary. Adv Data 2002; 5:1-32.
    • (2002) Adv Data , vol.5 , pp. 1-32
    • Cherry, D.K.1    Woodwell, D.A.2
  • 4
    • 4444329294 scopus 로고    scopus 로고
    • Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery
    • Kang Q, Sun MH, Cheng H, et al. Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. Gene Ther 2004;11:1312-1320.
    • (2004) Gene Ther , vol.11 , pp. 1312-1320
    • Kang, Q.1    Sun, M.H.2    Cheng, H.3
  • 5
    • 0035345137 scopus 로고    scopus 로고
    • Bone regeneration: New findings and potential clinical applications
    • Einhorn TA, Lee CA. Bone regeneration: new findings and potential clinical applications. J Am Acad Orthop Surg 2001;9:157-165.
    • (2001) J Am Acad Orthop Surg , vol.9 , pp. 157-165
    • Einhorn, T.A.1    Lee, C.A.2
  • 6
    • 0028297686 scopus 로고
    • Delayed unions and nonunions of open tibial fractures. Correlation with arteriography results
    • Dickson K, Katzman S, Delgado E, Contreras D. Delayed unions and nonunions of open tibial fractures. Correlation with arteriography results. Clin Orthop Relat Res 1994:189-193.
    • (1994) Clin Orthop Relat Res , pp. 189-193
    • Dickson, K.1    Katzman, S.2    Delgado, E.3    Contreras, D.4
  • 8
    • 0029986509 scopus 로고    scopus 로고
    • Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures
    • Marshall D, Johnell O, Wedel H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 1996;312:1254-1259.
    • (1996) BMJ , vol.312 , pp. 1254-1259
    • Marshall, D.1    Johnell, O.2    Wedel, H.3
  • 9
    • 0034151952 scopus 로고    scopus 로고
    • On the behavior of closed tibial fractures: Clinical/radiological correlations
    • Sarmiento A. On the behavior of closed tibial fractures: clinical/radiological correlations. J Orthop Trauma 2000;14:199-205.
    • (2000) J Orthop Trauma , vol.14 , pp. 199-205
    • Sarmiento, A.1
  • 10
    • 0035852034 scopus 로고    scopus 로고
    • Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: Results from the National Osteoporosis Risk Assessment
    • Siris ES, Miller PD, Barrett-Connor E, et al. Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the National Osteoporosis Risk Assessment. JAMA 2001;286:2815-2822.
    • (2001) JAMA , vol.286 , pp. 2815-2822
    • Siris, E.S.1    Miller, P.D.2    Barrett-Connor, E.3
  • 11
    • 0037103848 scopus 로고    scopus 로고
    • Overview of the biology of lumbar spine fusion and principles for selecting a bone graft substitute
    • Phila Pa 1976
    • Boden SD. Overview of the biology of lumbar spine fusion and principles for selecting a bone graft substitute. Spine (Phila Pa 1976) 2002;27:S26-S31.
    • (2002) Spine , vol.27
    • Boden, S.D.1
  • 12
    • 0026006594 scopus 로고
    • The use of bone morphogenetic protein in the treatment of non-union in a canine model
    • Heckman JD, Boyan BD, Aufdemorte TB, Abbott JT. The use of bone morphogenetic protein in the treatment of non-union in a canine model. J Bone Joint Surg Am 1991;73:750-764.
    • (1991) J Bone Joint Surg Am , vol.73 , pp. 750-764
    • Heckman, J.D.1    Boyan, B.D.2    Aufdemorte, T.B.3    Abbott, J.T.4
  • 13
    • 0027318019 scopus 로고
    • Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein
    • Gerhart TN, Kirker-Head CA, Kriz MJ, et al. Healing segmental femoral defects in sheep using recombinant human bone morphogenetic protein. Clin Orthop Relat Res 1993:317-326.
    • (1993) Clin Orthop Relat Res , pp. 317-326
    • Gerhart, T.N.1    Kirker-Head, C.A.2    Kriz, M.J.3
  • 14
    • 0028518485 scopus 로고    scopus 로고
    • Healing of large segmental defects in rat femurs is aided by RhBMP-2 in PLGA matrix
    • 1994 Oct
    • Lee SC, Shea M, Battle MA, et al. Healing of large segmental defects in rat femurs is aided by RhBMP-2 in PLGA matrix. J Biomed Mater Res 1994 Oct;28(10):1149-1156.
    • J Biomed Mater Res , vol.28 , Issue.10 , pp. 1149-1156
    • Lee, S.C.1    Shea, M.2    Battle, M.A.3
  • 15
    • 0031733643 scopus 로고    scopus 로고
    • Potential role of bone morphogenetic proteins in fracture healing
    • Bostrom MP, Camacho NP. Potential role of bone morphogenetic proteins in fracture healing. Clin Orthop Relat Res 1998:S274-S282.
    • (1998) Clin Orthop Relat Res
    • Bostrom, M.P.1    Camacho, N.P.2
  • 16
    • 0035073210 scopus 로고    scopus 로고
    • In vitro and in vivo induction of bone formation using a recombinant adenoviral vector carrying the human BMP-2 gene
    • Cheng SL, Lou J, Wright NM, Lai CF, Avioli LV, Riew KD. In vitro and in vivo induction of bone formation using a recombinant adenoviral vector carrying the human BMP-2 gene. Calcif Tissue Int 2001;68:87-94.
    • (2001) Calcif Tissue Int , vol.68 , pp. 87-94
    • Cheng, S.L.1    Lou, J.2    Wright, N.M.3    Lai, C.F.4    Avioli, L.V.5    Riew, K.D.6
  • 17
    • 0034690624 scopus 로고    scopus 로고
    • Gene therapy-directed osteogenesis: BMP-7-transduced human fibroblasts form bone in vivo
    • Krebsbach PH, Gu K, Franceschi RT, Rutherford RB. Gene therapy-directed osteogenesis: BMP-7-transduced human fibroblasts form bone in vivo. Hum Gene Ther 2000;11:1201-1210.
    • (2000) Hum Gene Ther , vol.11 , pp. 1201-1210
    • Krebsbach, P.H.1    Gu, K.2    Franceschi, R.T.3    Rutherford, R.B.4
  • 18
    • 0036295715 scopus 로고    scopus 로고
    • Adenoviral BMP-2 gene transfer in mesenchymal stem cells: In vitro and in vivo bone formation on biodegradable polymer scaffolds
    • Partridge K, Yang X, Clarke NM, et al. Adenoviral BMP-2 gene transfer in mesenchymal stem cells: in vitro and in vivo bone formation on biodegradable polymer scaffolds. Biochem Biophys Res Commun 2002;292:144-152.
    • (2002) Biochem Biophys Res Commun , vol.292 , pp. 144-152
    • Partridge, K.1    Yang, X.2    Clarke, N.M.3
  • 19
    • 0031685274 scopus 로고    scopus 로고
    • Induction of bone formation using a recombinant adenoviral vector carrying the human BMP-2 gene in a rabbit spinal fusion model
    • Riew KD, Wright NM, Cheng S, Avioli LV, Lou J. Induction of bone formation using a recombinant adenoviral vector carrying the human BMP-2 gene in a rabbit spinal fusion model. Calcif Tissue Int 1998;63:357-360.
    • (1998) Calcif Tissue Int , vol.63 , pp. 357-360
    • Riew, K.D.1    Wright, N.M.2    Cheng, S.3    Avioli, L.V.4    Lou, J.5
  • 21
    • 0035831609 scopus 로고    scopus 로고
    • Morphologic analysis of BMP-9 gene therapy-induced osteogenesis
    • Varady P, Li JZ, Cunningham M, et al. Morphologic analysis of BMP-9 gene therapy-induced osteogenesis. Hum Gene Ther 2001;12:697-710.
    • (2001) Hum Gene Ther , vol.12 , pp. 697-710
    • Varady, P.1    Li, J.Z.2    Cunningham, M.3
  • 22
    • 0034127731 scopus 로고    scopus 로고
    • Use of bone morphogenetic protein-9 gene therapy to induce spinal arthrodesis in the rodent
    • Helm GA, Alden TD, Beres EJ, et al. Use of bone morphogenetic protein-9 gene therapy to induce spinal arthrodesis in the rodent. J Neurosurg 2000;92:191-196.
    • (2000) J Neurosurg , vol.92 , pp. 191-196
    • Helm, G.A.1    Alden, T.D.2    Beres, E.J.3
  • 23
    • 0034778361 scopus 로고    scopus 로고
    • Demineralized bone matrix, bone morphogenetic proteins, and animal models of spine fusion: An overview
    • Sandhu HS, Khan SN, Suh DY, Boden SD. Demineralized bone matrix, bone morphogenetic proteins, and animal models of spine fusion: an overview. Eur Spine J 2001;10:S122-S131.
    • (2001) Eur Spine J , vol.10
    • Sandhu, H.S.1    Khan, S.N.2    Suh, D.Y.3    Boden, S.D.4
  • 24
    • 0033954803 scopus 로고    scopus 로고
    • The use of rhBMP-2 in interbody fusion cages. Definitive evidence of osteoinduction in humans: A preliminary report
    • Phila Pa 1976
    • Boden SD, Zdeblick TA, Sandhu HS, Heim SE. The use of rhBMP-2 in interbody fusion cages. Definitive evidence of osteoinduction in humans: a preliminary report. Spine (Phila Pa 1976) 2000;25:376-381.
    • (2000) Spine , vol.25 , pp. 376-381
    • Boden, S.D.1    Zdeblick, T.A.2    Sandhu, H.S.3    Heim, S.E.4
  • 27
    • 0034128748 scopus 로고    scopus 로고
    • The family of bone morphogenetic proteins
    • Ducy P, Karsenty G. The family of bone morphogenetic proteins. Kidney Int 2000;57:2207-2214.
    • (2000) Kidney Int , vol.57 , pp. 2207-2214
    • Ducy, P.1    Karsenty, G.2
  • 28
    • 0033560784 scopus 로고    scopus 로고
    • A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development
    • Ducy P, Starbuck M, Priemel M, et al. A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. Genes Dev 1999;13:1025-1036.
    • (1999) Genes Dev , vol.13 , pp. 1025-1036
    • Ducy, P.1    Starbuck, M.2    Priemel, M.3
  • 29
    • 0031909665 scopus 로고    scopus 로고
    • Role of morphogenetic proteins in skeletal tissue engineering and regeneration
    • Reddi AH. Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nat Biotechnol 1998;16:247-252.
    • (1998) Nat Biotechnol , vol.16 , pp. 247-252
    • Reddi, A.H.1
  • 30
    • 34250019537 scopus 로고
    • Bone: Formation by autoinduction
    • Urist MR. Bone: formation by autoinduction. Science 1965;150:893-899.
    • (1965) Science , vol.150 , pp. 893-899
    • Urist, M.R.1
  • 31
    • 0024256133 scopus 로고
    • Novel regulators of bone formation: Molecular clones and activities
    • Wozney JM, Rosen V, Celeste AJ, et al. Novel regulators of bone formation: molecular clones and activities. Science 1988;242:1528-1534.
    • (1988) Science , vol.242 , pp. 1528-1534
    • Wozney, J.M.1    Rosen, V.2    Celeste, A.J.3
  • 32
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003;113:685-700.
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 33
    • 0037204990 scopus 로고    scopus 로고
    • Signal transduction by the TGF-beta superfamily
    • Attisano L, Wrana JL. Signal transduction by the TGF-beta superfamily. Science 2002;296:1646-1647.
    • (2002) Science , vol.296 , pp. 1646-1647
    • Attisano, L.1    Wrana, J.L.2
  • 34
    • 24644507896 scopus 로고    scopus 로고
    • The disparate role of BMP in stem cell biology
    • Varga AC, Wrana JL. The disparate role of BMP in stem cell biology. Oncogene 2005;24:5713-5721.
    • (2005) Oncogene , vol.24 , pp. 5713-5721
    • Varga, A.C.1    Wrana, J.L.2
  • 35
    • 23244432429 scopus 로고    scopus 로고
    • BMP signaling and stem cell regulation
    • Zhang J, Li L. BMP signaling and stem cell regulation. Dev Biol 2005;284:1-11.
    • (2005) Dev Biol , vol.284 , pp. 1-11
    • Zhang, J.1    Li, L.2
  • 36
    • 34248355601 scopus 로고    scopus 로고
    • Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells
    • Luu HH, Song WX, Luo X, et al. Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells. J Orthop Res 2007;25:665-677.
    • (2007) J Orthop Res , vol.25 , pp. 665-677
    • Luu, H.H.1    Song, W.X.2    Luo, X.3
  • 39
    • 7644244354 scopus 로고    scopus 로고
    • Developmental expression and function of Bmp4 in spermatogenesis and in maintaining epididymal integrity
    • Hu J, Chen YX, Wang D, et al. Developmental expression and function of Bmp4 in spermatogenesis and in maintaining epididymal integrity. Developmental biology 2004;276:158-171.
    • (2004) Developmental Biology , vol.276 , pp. 158-171
    • Hu, J.1    Chen, Y.X.2    Wang, D.3
  • 43
    • 0029737070 scopus 로고    scopus 로고
    • Bone morphogenetic proteins: Multifunctional regulators of vertebrate development
    • Hogan BL. Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev 1996;10:1580-1594.
    • (1996) Genes Dev , vol.10 , pp. 1580-1594
    • Hogan, B.L.1
  • 44
    • 0037250476 scopus 로고    scopus 로고
    • Consequences of knocking out BMP signaling in the mouse
    • Zhao GQ. Consequences of knocking out BMP signaling in the mouse. Genesis 2003;35:43-56.
    • (2003) Genesis , vol.35 , pp. 43-56
    • Zhao, G.Q.1
  • 45
    • 0029904671 scopus 로고    scopus 로고
    • Serine/threonine kinase receptors: Mediators of transforming growth factor beta family signals
    • Massague J, Weis-Garcia F. Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals. Cancer Surv 1996;27:41-64.
    • (1996) Cancer Surv , vol.27 , pp. 41-64
    • Massague, J.1    Weis-Garcia, F.2
  • 47
    • 0031438047 scopus 로고    scopus 로고
    • TGF-beta signalling from cell membrane to nucleus through SMAD proteins
    • Heldin CH, Miyazono K, ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 1997;390:465-471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.H.1    Miyazono, K.2    ten Dijke, P.3
  • 48
    • 0031685620 scopus 로고    scopus 로고
    • TGF-beta signal transduction
    • Massague J. TGF-beta signal transduction. Annu Rev Biochem 1998;67:753-791.
    • (1998) Annu Rev Biochem , vol.67 , pp. 753-791
    • Massague, J.1
  • 49
    • 0034695511 scopus 로고    scopus 로고
    • Regulation of Smad activity
    • Wrana JL. Regulation of Smad activity. Cell 2000;100:189-192.
    • (2000) Cell , vol.100 , pp. 189-192
    • Wrana, J.L.1
  • 50
    • 0032534524 scopus 로고    scopus 로고
    • Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds
    • Whang K, Tsai DC, Nam EK, et al. Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds. J Biomed Mater Res 1998;42:491-499.
    • (1998) J Biomed Mater Res , vol.42 , pp. 491-499
    • Whang, K.1    Tsai, D.C.2    Nam, E.K.3
  • 51
    • 0032904360 scopus 로고    scopus 로고
    • Percutaneous spinal fusion using bone morphogenetic protein-2 gene therapy
    • Alden TD, Pittman DD, Beres EJ, et al. Percutaneous spinal fusion using bone morphogenetic protein-2 gene therapy. J Neurosurg 1999;90:109-114.
    • (1999) J Neurosurg , vol.90 , pp. 109-114
    • Alden, T.D.1    Pittman, D.D.2    Beres, E.J.3
  • 52
    • 0033063747 scopus 로고    scopus 로고
    • Retrovirally transduced bone marrow stromal cells isolated from a mouse model of human osteogenesis imperfecta (oim) persist in bone and retain the ability to form cartilage and bone after extended passaging
    • Oyama M, Tatlock A, Fukuta S, et al. Retrovirally transduced bone marrow stromal cells isolated from a mouse model of human osteogenesis imperfecta (oim) persist in bone and retain the ability to form cartilage and bone after extended passaging. Gene Ther 1999;6:321-329.
    • (1999) Gene Ther , vol.6 , pp. 321-329
    • Oyama, M.1    Tatlock, A.2    Fukuta, S.3
  • 53
    • 0033198839 scopus 로고    scopus 로고
    • In vivo endochondral bone formation using a bone morphogenetic protein 2 adenoviral vector
    • Alden TD, Pittman DD, Hankins GR, et al. In vivo endochondral bone formation using a bone morphogenetic protein 2 adenoviral vector. Hum Gene Ther 1999;10:2245-2253.
    • (1999) Hum Gene Ther , vol.10 , pp. 2245-2253
    • Alden, T.D.1    Pittman, D.D.2    Hankins, G.R.3
  • 54
    • 85047699915 scopus 로고    scopus 로고
    • Genetic enhancement of fracture repair: Healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene
    • Baltzer AW, Lattermann C, Whalen JD, et al. Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene. Gene Ther 2000;7:734-739.
    • (2000) Gene Ther , vol.7 , pp. 734-739
    • Baltzer, A.W.1    Lattermann, C.2    Whalen, J.D.3
  • 55
    • 0033771095 scopus 로고    scopus 로고
    • Potential role of direct adenoviral gene transfer in enhancing fracture repair
    • Baltzer AW, Lattermann C, Whalen JD, et al. Potential role of direct adenoviral gene transfer in enhancing fracture repair. Clin Orthop Relat Res 2000:S120-S125.
    • (2000) Clin Orthop Relat Res
    • Baltzer, A.W.1    Lattermann, C.2    Whalen, J.D.3
  • 57
    • 0032941836 scopus 로고    scopus 로고
    • Gene-enhanced tissue engineering: Applications for bone healing using cultured periosteal cells transduced retrovirally with the BMP-7 gene
    • Breitbart AS, Grande DA, Mason JM, Barcia M, James T, Grant RT. Gene-enhanced tissue engineering: applications for bone healing using cultured periosteal cells transduced retrovirally with the BMP-7 gene. Ann Plast Surg 1999;42:488-495.
    • (1999) Ann Plast Surg , vol.42 , pp. 488-495
    • Breitbart, A.S.1    Grande, D.A.2    Mason, J.M.3    Barcia, M.4    James, T.5    Grant, R.T.6
  • 58
    • 0033914783 scopus 로고    scopus 로고
    • Gene therapy for bone formation: In vitro and in vivo osteogenic activity of an adenovirus expressing BMP7
    • Franceschi RT, Wang D, Krebsbach PH, Rutherford RB. Gene therapy for bone formation: in vitro and in vivo osteogenic activity of an adenovirus expressing BMP7. J Cell Biochem 2000;78:476-486.
    • (2000) J Cell Biochem , vol.78 , pp. 476-486
    • Franceschi, R.T.1    Wang, D.2    Krebsbach, P.H.3    Rutherford, R.B.4
  • 59
    • 0033084785 scopus 로고    scopus 로고
    • Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: A novel cell-mediated gene therapy
    • Gazit D, Turgeman G, Kelley P, et al. Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy. J Gene Med 1999;1:121-133.
    • (1999) J Gene Med , vol.1 , pp. 121-133
    • Gazit, D.1    Turgeman, G.2    Kelley, P.3
  • 60
    • 0032077625 scopus 로고    scopus 로고
    • Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents
    • Lieberman JR, Le LQ, Wu L, et al. Regional gene therapy with a BMP-2-producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents. J Orthop Res 1998;16:330-339.
    • (1998) J Orthop Res , vol.16 , pp. 330-339
    • Lieberman, J.R.1    Le, L.Q.2    Wu, L.3
  • 61
    • 0032973123 scopus 로고    scopus 로고
    • Gene therapy: Adenovirusmediated human bone morphogenetic protein-2 gene transfer induces mesenchymal progenitor cell proliferation and differentiation in vitro and bone formation in vivo
    • Lou J, Xu F, Merkel K, Manske P. Gene therapy: adenovirusmediated human bone morphogenetic protein-2 gene transfer induces mesenchymal progenitor cell proliferation and differentiation in vitro and bone formation in vivo. J Orthop Res 1999;17:43-50.
    • (1999) J Orthop Res , vol.17 , pp. 43-50
    • Lou, J.1    Xu, F.2    Merkel, K.3    Manske, P.4
  • 62
    • 0031718624 scopus 로고    scopus 로고
    • Expression of human bone morphogenic protein 7 in primary rabbit periosteal cells: Potential utility in gene therapy for osteochondral repair
    • Mason JM, Grande DA, Barcia M, Grant R, Pergolizzi RG, Breitbart AS. Expression of human bone morphogenic protein 7 in primary rabbit periosteal cells: potential utility in gene therapy for osteochondral repair. Gene Ther 1998;5:1098-1104.
    • (1998) Gene Ther , vol.5 , pp. 1098-1104
    • Mason, J.M.1    Grande, D.A.2    Barcia, M.3    Grant, R.4    Pergolizzi, R.G.5    Breitbart, A.S.6
  • 63
    • 0032904745 scopus 로고    scopus 로고
    • Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone
    • Musgrave DS, Bosch P, Ghivizzani S, Robbins PD, Evans CH, Huard J. Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone. Bone 1999;24:541-547.
    • (1999) Bone , vol.24 , pp. 541-547
    • Musgrave, D.S.1    Bosch, P.2    Ghivizzani, S.3    Robbins, P.D.4    Evans, C.H.5    Huard, J.6
  • 64
    • 0034614470 scopus 로고    scopus 로고
    • Osteoinduction by bone morphogenetic protein-2 via adenoviral vector under transient immunosuppression
    • Okubo Y, Bessho K, Fujimura K, Iizuka T, Miyatake SI. Osteoinduction by bone morphogenetic protein-2 via adenoviral vector under transient immunosuppression. Biochem Biophys Res Commun 2000;267:382-387.
    • (2000) Biochem Biophys Res Commun , vol.267 , pp. 382-387
    • Okubo, Y.1    Bessho, K.2    Fujimura, K.3    Iizuka, T.4    Miyatake, S.I.5
  • 66
    • 0034917376 scopus 로고    scopus 로고
    • Effect of bone morphogenetic protein-2-expressing muscle-derived cells on healing of critical-sized bone defects in mice
    • Lee JY, Musgrave D, Pelinkovic D, et al. Effect of bone morphogenetic protein-2-expressing muscle-derived cells on healing of critical-sized bone defects in mice. J Bone Joint Surg Am 2001;83:1032-1039.
    • (2001) J Bone Joint Surg Am , vol.83 , pp. 1032-1039
    • Lee, J.Y.1    Musgrave, D.2    Pelinkovic, D.3
  • 67
    • 0036899744 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: A prospective, controlled, randomized study of four hundred and fifty patients
    • Govender S, Csimma C, Genant HK, et al. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am 2002;84:2123-2134.
    • (2002) J Bone Joint Surg Am , vol.84 , pp. 2123-2134
    • Govender, S.1    Csimma, C.2    Genant, H.K.3
  • 68
    • 0036897076 scopus 로고    scopus 로고
    • Randomized radiostereometric study comparing osteogenic protein-1 (BMP-7) and autograft bone in human noninstrumented posterolateral lumbar fusion: 2002 Volvo Award in clinical studies
    • Phila Pa 1976
    • Johnsson R, Stromqvist B, Aspenberg P. Randomized radiostereometric study comparing osteogenic protein-1 (BMP-7) and autograft bone in human noninstrumented posterolateral lumbar fusion: 2002 Volvo Award in clinical studies. Spine (Phila Pa 1976) 2002;27:2654-2661.
    • (2002) Spine , vol.27 , pp. 2654-2661
    • Johnsson, R.1    Stromqvist, B.2    Aspenberg, P.3
  • 69
    • 0032134684 scopus 로고    scopus 로고
    • Use of an osteoinductive biomaterial (rhOP-1) in healing large segmental bone defects
    • Cook SD, Salkeld SL, Brinker MR, Wolfe MW, Rueger DC. Use of an osteoinductive biomaterial (rhOP-1) in healing large segmental bone defects. J Orthop Trauma 1998;12:407-412.
    • (1998) J Orthop Trauma , vol.12 , pp. 407-412
    • Cook, S.D.1    Salkeld, S.L.2    Brinker, M.R.3    Wolfe, M.W.4    Rueger, D.C.5
  • 71
    • 67649271549 scopus 로고    scopus 로고
    • A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells
    • Kang Q, Song WX, Luo Q, et al. A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev 2009;18:545-559.
    • (2009) Stem Cells Dev , vol.18 , pp. 545-559
    • Kang, Q.1    Song, W.X.2    Luo, Q.3
  • 73
    • 0039598632 scopus 로고    scopus 로고
    • Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9
    • Lopez-Coviella I, Berse B, Krauss R, Thies RS, Blusztajn JK. Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9. Science 2000;289:313-316.
    • (2000) Science , vol.289 , pp. 313-316
    • Lopez-Coviella, I.1    Berse, B.2    Krauss, R.3    Thies, R.S.4    Blusztajn, J.K.5
  • 74
    • 0037338037 scopus 로고    scopus 로고
    • An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis
    • Chen C, Grzegorzewski KJ, Barash S, et al. An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis. Nat Biotechnol 2003;21:294-301.
    • (2003) Nat Biotechnol , vol.21 , pp. 294-301
    • Chen, C.1    Grzegorzewski, K.J.2    Barash, S.3
  • 75
    • 33745898241 scopus 로고    scopus 로고
    • Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6
    • Truksa J, Peng H, Lee P, Beutler E. Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Proc Natl Acad Sci USA 2006;103:10289-10293.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 10289-10293
    • Truksa, J.1    Peng, H.2    Lee, P.3    Beutler, E.4
  • 76
    • 77956516276 scopus 로고    scopus 로고
    • TGFbeta/BMP type I receptors ALK1 and ALK2 are essential for BMP9-induced osteogenic signaling in mesenchymal stem cells
    • Luo J, Tang M, Huang J, et al. TGFbeta/BMP type I receptors ALK1 and ALK2 are essential for BMP9-induced osteogenic signaling in mesenchymal stem cells. J Biol Chem 2010;285:29588-29598.
    • (2010) J Biol Chem , vol.285 , pp. 29588-29598
    • Luo, J.1    Tang, M.2    Huang, J.3
  • 77
    • 0042134565 scopus 로고    scopus 로고
    • Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs)
    • Cheng H, Jiang W, Phillips FM, et al. Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs). J Bone Joint Surg Am 2003;85:1544-1552.
    • (2003) J Bone Joint Surg Am , vol.85 , pp. 1544-1552
    • Cheng, H.1    Jiang, W.2    Phillips, F.M.3
  • 78
    • 0345305861 scopus 로고    scopus 로고
    • Transcriptional characterization of bone morphogenetic proteins (BMPs)-mediated osteogenic signaling
    • Peng Y, Kang Q, Cheng H, et al. Transcriptional characterization of bone morphogenetic proteins (BMPs)-mediated osteogenic signaling. J Cell Biochem 2003;90:1149-1165.
    • (2003) J Cell Biochem , vol.90 , pp. 1149-1165
    • Peng, Y.1    Kang, Q.2    Cheng, H.3
  • 79
    • 3543041812 scopus 로고    scopus 로고
    • Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells
    • Peng Y, Kang Q, Luo Q, et al. Inhibitor of DNA binding/differentiation helix-loop-helix proteins mediate bone morphogenetic protein-induced osteoblast differentiation of mesenchymal stem cells. J Biol Chem 2004;279:32941-32949.
    • (2004) J Biol Chem , vol.279 , pp. 32941-32949
    • Peng, Y.1    Kang, Q.2    Luo, Q.3
  • 80
    • 19944427451 scopus 로고    scopus 로고
    • Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells
    • Luo Q, Kang Q, Si W, et al. Connective tissue growth factor (CTGF) is regulated by Wnt and bone morphogenetic proteins signaling in osteoblast differentiation of mesenchymal stem cells. J Biol Chem 2004;279:55958-55968.
    • (2004) J Biol Chem , vol.279 , pp. 55958-55968
    • Luo, Q.1    Kang, Q.2    Si, W.3
  • 81
    • 33645816535 scopus 로고    scopus 로고
    • CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3Ainduced osteoblast differentiation of mesenchymal stem cells
    • Si W, Kang Q, Luu HH, et al. CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3Ainduced osteoblast differentiation of mesenchymal stem cells. Mol Cell Biol 2006;26:2955-2964.
    • (2006) Mol Cell Biol , vol.26 , pp. 2955-2964
    • Si, W.1    Kang, Q.2    Luu, H.H.3
  • 82
    • 21644461778 scopus 로고    scopus 로고
    • Crystal structure of BMP-9 and functional interactions with pro-region and receptors
    • Brown MA, Zhao Q, Baker KA, et al. Crystal structure of BMP-9 and functional interactions with pro-region and receptors. J Biol Chem 2005;280:25111-25118.
    • (2005) J Biol Chem , vol.280 , pp. 25111-25118
    • Brown, M.A.1    Zhao, Q.2    Baker, K.A.3
  • 84
    • 0037841469 scopus 로고    scopus 로고
    • Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: A novel protein with protease inhibitor and follistatin domains
    • Hill JJ, Qiu Y, Hewick RM, Wolfman NM. Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains. Mol Endocrinol 2003;17:1144-1154.
    • (2003) Mol Endocrinol , vol.17 , pp. 1144-1154
    • Hill, J.J.1    Qiu, Y.2    Hewick, R.M.3    Wolfman, N.M.4
  • 85
    • 0242668869 scopus 로고    scopus 로고
    • Bone morphogenetic proteins, their antagonists, and the skeleton
    • Canalis E, Economides AN, Gazzerro E. Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr Rev 2003;24:218-235.
    • (2003) Endocr Rev , vol.24 , pp. 218-235
    • Canalis, E.1    Economides, A.N.2    Gazzerro, E.3
  • 86
    • 0141516375 scopus 로고    scopus 로고
    • Osteogenic potential of five different recombinant human bone morphogenetic protein adenoviral vectors in the rat
    • Li JZ, Li H, Sasaki T, et al. Osteogenic potential of five different recombinant human bone morphogenetic protein adenoviral vectors in the rat. Gene Ther 2003;10:1735-1743.
    • (2003) Gene Ther , vol.10 , pp. 1735-1743
    • Li, J.Z.1    Li, H.2    Sasaki, T.3
  • 87
    • 1842842840 scopus 로고    scopus 로고
    • Fluorescence-based functional assay for Wnt/beta-catenin signaling activity
    • 2002 Nov, 30, 32 passim
    • Zhou L, An N, Jiang W, et al. Fluorescence-based functional assay for Wnt/beta-catenin signaling activity. Biotechniques 2002 Nov;33(5):1126-1128, 30, 32 passim.
    • Biotechniques , vol.33 , Issue.5 , pp. 1126-1128
    • Zhou, L.1    An, N.2    Jiang, W.3
  • 88
    • 77951021015 scopus 로고    scopus 로고
    • Synergistic antitumor effect of the activated PPARgamma and retinoid receptors on human osteosarcoma
    • He BC, Chen L, Zuo GW, et al. Synergistic antitumor effect of the activated PPARgamma and retinoid receptors on human osteosarcoma. Clin Cancer Res 2010;16:2235-2245.
    • (2010) Clin Cancer Res , vol.16 , pp. 2235-2245
    • He, B.C.1    Chen, L.2    Zuo, G.W.3
  • 89
    • 0035236997 scopus 로고    scopus 로고
    • Regulation of osteoblast formation and function
    • Aubin JE. Regulation of osteoblast formation and function. Rev Endocr Metab Disord 2001;2:81-94.
    • (2001) Rev Endocr Metab Disord , vol.2 , pp. 81-94
    • Aubin, J.E.1
  • 90
    • 38449093315 scopus 로고    scopus 로고
    • Regulation of osteogenic differentiation during skeletal development
    • Deng ZL, Sharff KA, Tang N, et al. Regulation of osteogenic differentiation during skeletal development. Front Biosci 2008;13:2001-2021.
    • (2008) Front Biosci , vol.13 , pp. 2001-2021
    • Deng, Z.L.1    Sharff, K.A.2    Tang, N.3
  • 91
    • 79955099600 scopus 로고    scopus 로고
    • Therapeutic Implications of PPARgamma in Human Osteosarcoma
    • Wagner ER, He BC, Chen L, et al. Therapeutic Implications of PPARgamma in Human Osteosarcoma. PPAR Res 2010;2010:956427.
    • (2010) PPAR Res , vol.2010 , pp. 956427
    • Wagner, E.R.1    He, B.C.2    Chen, L.3
  • 93
    • 33644521697 scopus 로고    scopus 로고
    • Distinct osteogenic activity of BMPs and their orthopaedic applications
    • He TC. Distinct osteogenic activity of BMPs and their orthopaedic applications. J Musculoskelet Neuronal Interact 2005;5:363-366.
    • (2005) J Musculoskelet Neuronal Interact , vol.5 , pp. 363-366
    • He, T.C.1
  • 94
    • 0034455051 scopus 로고    scopus 로고
    • Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1
    • Yamaguchi A, Komori T, Suda T. Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1. Endocr Rev 2000;21:393-411.
    • (2000) Endocr Rev , vol.21 , pp. 393-411
    • Yamaguchi, A.1    Komori, T.2    Suda, T.3
  • 95
    • 33845987376 scopus 로고    scopus 로고
    • Networks and hubs for the transcriptional control of osteoblastogenesis
    • Lian JB, Stein GS, Javed A, et al. Networks and hubs for the transcriptional control of osteoblastogenesis. Rev Endocr Metab Disord 2006;7:1-16.
    • (2006) Rev Endocr Metab Disord , vol.7 , pp. 1-16
    • Lian, J.B.1    Stein, G.S.2    Javed, A.3
  • 96
    • 0034488148 scopus 로고    scopus 로고
    • Role of Cbfa1 in osteoblast differentiation and function
    • Karsenty G. Role of Cbfa1 in osteoblast differentiation and function. Semin Cell Dev Biol 2000;11:343-346.
    • (2000) Semin Cell Dev Biol , vol.11 , pp. 343-346
    • Karsenty, G.1
  • 97
    • 33751197049 scopus 로고    scopus 로고
    • Regulation of osteoblast differentiation by transcription factors
    • Komori T. Regulation of osteoblast differentiation by transcription factors. J Cell Biochem 2006;99:1233-1239.
    • (2006) J Cell Biochem , vol.99 , pp. 1233-1239
    • Komori, T.1
  • 98
    • 0030684749 scopus 로고    scopus 로고
    • Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    • Komori T, Yagi H, Nomura S, et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell 1997;89:755-764.
    • (1997) Cell , vol.89 , pp. 755-764
    • Komori, T.1    Yagi, H.2    Nomura, S.3
  • 99
    • 0032949156 scopus 로고    scopus 로고
    • Maturational disturbance of chondrocytes in Cbfa1-deficient mice
    • Inada M, Yasui T, Nomura S, et al. Maturational disturbance of chondrocytes in Cbfa1-deficient mice. Dev Dyn 1999;214:279-290.
    • (1999) Dev Dyn , vol.214 , pp. 279-290
    • Inada, M.1    Yasui, T.2    Nomura, S.3
  • 100
    • 0035938250 scopus 로고    scopus 로고
    • Wnts differentially regulate colony growth and differentiation of chondrogenic rat calvaria cells
    • Bergwitz C, Wendlandt T, Kispert A, Brabant G. Wnts differentially regulate colony growth and differentiation of chondrogenic rat calvaria cells. Biochim Biophys Acta 2001;1538:129-140.
    • (2001) Biochim Biophys Acta , vol.1538 , pp. 129-140
    • Bergwitz, C.1    Wendlandt, T.2    Kispert, A.3    Brabant, G.4
  • 101
    • 0036157079 scopus 로고    scopus 로고
    • Wnt signaling during BMP-2 stimulation of mesenchymal chondrogenesis
    • Fischer L, Boland G, Tuan RS. Wnt signaling during BMP-2 stimulation of mesenchymal chondrogenesis. J Cell Biochem 2002;84:816-831.
    • (2002) J Cell Biochem , vol.84 , pp. 816-831
    • Fischer, L.1    Boland, G.2    Tuan, R.S.3
  • 102
    • 5444243641 scopus 로고    scopus 로고
    • The canonical Wnt pathway in early mammalian embryogenesis and stem cell maintenance/differentiation
    • Wang J, Wynshaw-Boris A. The canonical Wnt pathway in early mammalian embryogenesis and stem cell maintenance/differentiation. Curr Opin Genet Dev 2004;14:533-539.
    • (2004) Curr Opin Genet Dev , vol.14 , pp. 533-539
    • Wang, J.1    Wynshaw-Boris, A.2
  • 103
    • 22044436959 scopus 로고    scopus 로고
    • How Wnt signaling affects bone repair by mesenchymal stem cells from the bone marrow
    • Gregory CA, Gunn WG, Reyes E, et al. How Wnt signaling affects bone repair by mesenchymal stem cells from the bone marrow. Ann N Y Acad Sci 2005;1049:97-106.
    • (2005) Ann N Y Acad Sci , vol.1049 , pp. 97-106
    • Gregory, C.A.1    Gunn, W.G.2    Reyes, E.3
  • 104
    • 0025696476 scopus 로고
    • Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development
    • Gavin BJ, McMahon JA, McMahon AP. Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development. Genes Dev 1990;4:2319-2332.
    • (1990) Genes Dev , vol.4 , pp. 2319-2332
    • Gavin, B.J.1    McMahon, J.A.2    McMahon, A.P.3
  • 105
    • 0032557302 scopus 로고    scopus 로고
    • Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud
    • Kengaku M, Capdevila J, Rodriguez-Esteban C, et al. Distinct WNT pathways regulating AER formation and dorsoventral polarity in the chick limb bud. Science 1998;280:1274-1277.
    • (1998) Science , vol.280 , pp. 1274-1277
    • Kengaku, M.1    Capdevila, J.2    Rodriguez-Esteban, C.3
  • 107
    • 0346363760 scopus 로고    scopus 로고
    • The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
    • Tian E, Zhan F, Walker R, et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med 2003;349:2483-2494.
    • (2003) N Engl J Med , vol.349 , pp. 2483-2494
    • Tian, E.1    Zhan, F.2    Walker, R.3
  • 108
    • 0036888309 scopus 로고    scopus 로고
    • Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma
    • Haydon RC, Deyrup A, Ishikawa A, et al. Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma. Int J Cancer 2002;102:338-342.
    • (2002) Int J Cancer , vol.102 , pp. 338-342
    • Haydon, R.C.1    Deyrup, A.2    Ishikawa, A.3
  • 109
    • 34250848174 scopus 로고    scopus 로고
    • In vivo analysis of Wnt signaling in bone
    • Glass DA, 2nd, Karsenty G. In vivo analysis of Wnt signaling in bone. Endocrinology 2007;148:2630-2634.
    • (2007) Endocrinology , vol.148 , pp. 2630-2634
    • Glass, D.A.1    Karsenty, G.2
  • 110
    • 33847199795 scopus 로고    scopus 로고
    • Wnt signaling and human diseases: What are the therapeutic implications?
    • Luo J, Chen J, Deng ZL, et al. Wnt signaling and human diseases: what are the therapeutic implications? Lab Invest 2007;87:97-103.
    • (2007) Lab Invest , vol.87 , pp. 97-103
    • Luo, J.1    Chen, J.2    Deng, Z.L.3
  • 111
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005;434:843-850.
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 113
    • 33846038681 scopus 로고    scopus 로고
    • Osteosarcoma and osteoblastic differentiation: A new perspective on oncogenesis
    • Haydon RC, Luu HH, He TC. Osteosarcoma and osteoblastic differentiation: a new perspective on oncogenesis. Clin Orthop Relat Res 2007;454:237-246.
    • (2007) Clin Orthop Relat Res , vol.454 , pp. 237-246
    • Haydon, R.C.1    Luu, H.H.2    He, T.C.3
  • 114
    • 56649094497 scopus 로고    scopus 로고
    • Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects
    • Luo X, Chen J, Song WX, et al. Osteogenic BMPs promote tumor growth of human osteosarcomas that harbor differentiation defects. Lab Invest 2008;88:1264-1277.
    • (2008) Lab Invest , vol.88 , pp. 1264-1277
    • Luo, X.1    Chen, J.2    Song, W.X.3
  • 115
    • 79951686783 scopus 로고    scopus 로고
    • Non-viral gene delivery to mesenchymal stem cells: Methods, strategies and application in bone tissue engineering and regeneration
    • Santos JL, Pandita D, Rodrigues J, Pego AP, Granja PL, Tomas H. Non-viral gene delivery to mesenchymal stem cells: methods, strategies and application in bone tissue engineering and regeneration. Curr Gene Ther 2011;11:46-57.
    • (2011) Curr Gene Ther , vol.11 , pp. 46-57
    • Santos, J.L.1    Pandita, D.2    Rodrigues, J.3    Pego, A.P.4    Granja, P.L.5    Tomas, H.6
  • 117
    • 33646562814 scopus 로고    scopus 로고
    • Nucleofection-based ex vivo nonviral gene delivery to human stem cells as a platform for tissue regeneration
    • Aslan H, Zilberman Y, Arbeli V, et al. Nucleofection-based ex vivo nonviral gene delivery to human stem cells as a platform for tissue regeneration. Tissue Eng 2006;12:877-889.
    • (2006) Tissue Eng , vol.12 , pp. 877-889
    • Aslan, H.1    Zilberman, Y.2    Arbeli, V.3
  • 118
    • 72649096994 scopus 로고    scopus 로고
    • Murine preosteoblast differentiation induced by a peptide derived from bone morphogenetic proteins-9
    • 2009 Nov
    • Bergeron E, Senta H, Mailloux A, Park H, Lord E, Faucheux N. Murine preosteoblast differentiation induced by a peptide derived from bone morphogenetic proteins-9. Tissue Eng Part A 2009 Nov;15(11):3341-3349.
    • Tissue Eng Part A , vol.15 , Issue.11 , pp. 3341-3349
    • Bergeron, E.1    Senta, H.2    Mailloux, A.3    Park, H.4    Lord, E.5    Faucheux, N.6
  • 119
    • 0036019199 scopus 로고    scopus 로고
    • Enhancement of bone healing based on ex vivo gene therapy using human muscle-derived cells expressing bone morphogenetic protein 2
    • Lee JY, Peng H, Usas A, et al. Enhancement of bone healing based on ex vivo gene therapy using human muscle-derived cells expressing bone morphogenetic protein 2. Hum Gene Ther 2002;13:1201-1211.
    • (2002) Hum Gene Ther , vol.13 , pp. 1201-1211
    • Lee, J.Y.1    Peng, H.2    Usas, A.3
  • 120
    • 1342279195 scopus 로고    scopus 로고
    • Osteogenesis in rats induced by a novel recombinant helperdependent bone morphogenetic protein-9 (BMP-9) adenovirus
    • Li JZ, Hankins GR, Kao C, Li H, Kammauff J, Helm GA. Osteogenesis in rats induced by a novel recombinant helperdependent bone morphogenetic protein-9 (BMP-9) adenovirus. J Gene Med 2003;5:748-756.
    • (2003) J Gene Med , vol.5 , pp. 748-756
    • Li, J.Z.1    Hankins, G.R.2    Kao, C.3    Li, H.4    Kammauff, J.5    Helm, G.A.6
  • 121
    • 0036871171 scopus 로고    scopus 로고
    • Ex vivo bone morphogenetic protein-9 gene therapy using human mesenchymal stem cells induces spinal fusion in rodents
    • 2002 Nov, discussion 44-45
    • Dumont RJ, Dayoub H, Li JZ, et al. Ex vivo bone morphogenetic protein-9 gene therapy using human mesenchymal stem cells induces spinal fusion in rodents. Neurosurgery 2002 Nov;51(5):1239-1244; discussion 44-45.
    • Neurosurgery , vol.51 , Issue.5 , pp. 1239-1244
    • Dumont, R.J.1    Dayoub, H.2    Li, J.Z.3
  • 122
    • 78650877069 scopus 로고    scopus 로고
    • Targeted geneand-host progenitor cell therapy for nonunion bone fracture repair
    • Kimelman-Bleich N, Pelled G, Zilberman Y, et al. Targeted geneand-host progenitor cell therapy for nonunion bone fracture repair. Mol Ther 2011;19:53-59.
    • (2011) Mol Ther , vol.19 , pp. 53-59
    • Kimelman-Bleich, N.1    Pelled, G.2    Zilberman, Y.3
  • 123
    • 0032601532 scopus 로고    scopus 로고
    • Bone morphogenetic protein (BMP) receptors and signal transduction
    • Yamashita H, Miyazono K. [Bone morphogenetic protein (BMP) receptors and signal transduction]. Nippon Rinsho 1999;57:220-226.
    • (1999) Nippon Rinsho , vol.57 , pp. 220-226
    • Yamashita, H.1    Miyazono, K.2
  • 124
    • 34247331476 scopus 로고    scopus 로고
    • BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis
    • Scharpfenecker M, van Dinther M, Liu Z, et al. BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis. J Cell Sci 2007;120:964-972.
    • (2007) J Cell Sci , vol.120 , pp. 964-972
    • Scharpfenecker, M.1    van Dinther, M.2    Liu, Z.3
  • 125
    • 67650188576 scopus 로고    scopus 로고
    • Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells
    • Upton PD, Davies RJ, Trembath RC, Morrell NW. Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells. J Biol Chem 2009;284:15794-15804.
    • (2009) J Biol Chem , vol.284 , pp. 15794-15804
    • Upton, P.D.1    Davies, R.J.2    Trembath, R.C.3    Morrell, N.W.4
  • 126
    • 70349260659 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor is coordinately regulated by the activinlike kinase receptors 1 and 5 in endothelial cells
    • Shao ES, Lin L, Yao Y, Bostrom KI. Expression of vascular endothelial growth factor is coordinately regulated by the activinlike kinase receptors 1 and 5 in endothelial cells. Blood 2009;114):2197-2206.
    • (2009) Blood , vol.114 , pp. 2197-2206
    • Shao, E.S.1    Lin, L.2    Yao, Y.3    Bostrom, K.I.4
  • 127
    • 77957306392 scopus 로고    scopus 로고
    • Identification and analysis of type II TGF-{beta} receptors in BMP-9-induced osteogenic differentiation of C3H10T1/2 mesenchymal stem cells
    • Wu N, Zhao Y, Yin Y, Zhang Y, Luo J. Identification and analysis of type II TGF-{beta} receptors in BMP-9-induced osteogenic differentiation of C3H10T1/2 mesenchymal stem cells. Acta Biochim Biophys Sin (Shanghai) 2010;42:699-708.
    • (2010) Acta Biochim Biophys Sin (Shanghai) , vol.42 , pp. 699-708
    • Wu, N.1    Zhao, Y.2    Yin, Y.3    Zhang, Y.4    Luo, J.5
  • 128
    • 0034471262 scopus 로고    scopus 로고
    • ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis
    • Norton JD. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis. J Cell Sci 2000;113:3897-3905.
    • (2000) J Cell Sci , vol.113 , pp. 3897-3905
    • Norton, J.D.1
  • 129
    • 0042347689 scopus 로고    scopus 로고
    • Id proteins in development, cell cycle and cancer
    • Ruzinova MB, Benezra R. Id proteins in development, cell cycle and cancer. Trends Cell Biol 2003;13:410-418.
    • (2003) Trends Cell Biol , vol.13 , pp. 410-418
    • Ruzinova, M.B.1    Benezra, R.2
  • 130
    • 0026582871 scopus 로고
    • Inhibition of myeloid differentiation by the helix-loop-helix protein Id
    • Kreider BL, Benezra R, Rovera G, Kadesch T. Inhibition of myeloid differentiation by the helix-loop-helix protein Id. Science 1992;255:1700-1702.
    • (1992) Science , vol.255 , pp. 1700-1702
    • Kreider, B.L.1    Benezra, R.2    Rovera, G.3    Kadesch, T.4
  • 131
    • 0033541389 scopus 로고    scopus 로고
    • The CCN family of angiogenic regulators: The integrin connection
    • Lau LF, Lam SC. The CCN family of angiogenic regulators: the integrin connection. Exp Cell Res 1999;248:44-57.
    • (1999) Exp Cell Res , vol.248 , pp. 44-57
    • Lau, L.F.1    Lam, S.C.2
  • 132
    • 0033813903 scopus 로고    scopus 로고
    • Connective tissue growth factor: What's in a name?
    • Moussad EE, Brigstock DR. Connective tissue growth factor: what's in a name? Mol Genet Metab 2000;71:276-292.
    • (2000) Mol Genet Metab , vol.71 , pp. 276-292
    • Moussad, E.E.1    Brigstock, D.R.2
  • 133
    • 0036775477 scopus 로고    scopus 로고
    • Gene regulation of connective tissue growth factor: New targets for antifibrotic therapy?
    • Blom IE, Goldschmeding R, Leask A. Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy? Matrix Biol 2002;21:473-482.
    • (2002) Matrix Biol , vol.21 , pp. 473-482
    • Blom, I.E.1    Goldschmeding, R.2    Leask, A.3
  • 134
    • 0042855012 scopus 로고    scopus 로고
    • The CCN family: A new stimulus package
    • Brigstock DR. The CCN family: a new stimulus package. J Endocrinol 2003;178:169-175.
    • (2003) J Endocrinol , vol.178 , pp. 169-175
    • Brigstock, D.R.1
  • 136
    • 0346130954 scopus 로고    scopus 로고
    • A structural approach to the role of CCN (CYR61/CTGF/NOV) proteins in tumourigenesis
    • Planque N, Perbal B. A structural approach to the role of CCN (CYR61/CTGF/NOV) proteins in tumourigenesis. Cancer Cell Int 2003;3:15.
    • (2003) Cancer Cell Int , vol.3 , pp. 15
    • Planque, N.1    Perbal, B.2
  • 137
    • 0038093327 scopus 로고    scopus 로고
    • Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development
    • Ivkovic S, Yoon BS, Popoff SN, et al. Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 2003;130:2779-2791.
    • (2003) Development , vol.130 , pp. 2779-2791
    • Ivkovic, S.1    Yoon, B.S.2    Popoff, S.N.3
  • 138
    • 33847241259 scopus 로고    scopus 로고
    • CCN2 is necessary for the function of mouse embryonic fibroblasts
    • Kennedy L, Liu S, Shi-Wen X, et al. CCN2 is necessary for the function of mouse embryonic fibroblasts. Exp Cell Res 2007;313:952-964.
    • (2007) Exp Cell Res , vol.313 , pp. 952-964
    • Kennedy, L.1    Liu, S.2    Shi-Wen, X.3
  • 139
    • 0036838772 scopus 로고    scopus 로고
    • Pathogenesis of fibrosis: Role of TGF-beta and CTGF
    • 2002 Nov
    • Ihn H. Pathogenesis of fibrosis: role of TGF-beta and CTGF. Curr Opin Rheumatol 2002 Nov;14(6):681-685.
    • Curr Opin Rheumatol , vol.14 , Issue.6 , pp. 681-685
    • Ihn, H.1
  • 140
    • 77953403597 scopus 로고    scopus 로고
    • The CCN proteins: Important signaling mediators in stem cell differentiation and tumorigenesis
    • Zuo GW, Kohls CD, He BC, et al. The CCN proteins: important signaling mediators in stem cell differentiation and tumorigenesis. Histol Histopathol 2010;25:795-806.
    • (2010) Histol Histopathol , vol.25 , pp. 795-806
    • Zuo, G.W.1    Kohls, C.D.2    He, B.C.3
  • 141
    • 58649085508 scopus 로고    scopus 로고
    • Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells
    • Sharff KA, Song WX, Luo X, et al. Hey1 basic helix-loop-helix protein plays an important role in mediating BMP9-induced osteogenic differentiation of mesenchymal progenitor cells. J Biol Chem 2009;284:649-659.
    • (2009) J Biol Chem , vol.284 , pp. 649-659
    • Sharff, K.A.1    Song, W.X.2    Luo, X.3
  • 142
    • 72949110602 scopus 로고    scopus 로고
    • BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signalling
    • Tang N, Song WX, Luo J, et al. BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signalling. J Cell Mol Med 2009;13:2448-2464.
    • (2009) J Cell Mol Med , vol.13 , pp. 2448-2464
    • Tang, N.1    Song, W.X.2    Luo, J.3
  • 143
    • 0036225281 scopus 로고    scopus 로고
    • Reaching a genetic and molecular understanding of skeletal development
    • Karsenty G, Wagner EF. Reaching a genetic and molecular understanding of skeletal development. Dev Cell 2002;2:389-406.
    • (2002) Dev Cell , vol.2 , pp. 389-406
    • Karsenty, G.1    Wagner, E.F.2
  • 144
    • 0031456158 scopus 로고    scopus 로고
    • Wnt signaling: A common theme in animal development
    • Cadigan KM, Nusse R. Wnt signaling: a common theme in animal development. Genes Dev 1997;11:3286-3305.
    • (1997) Genes Dev , vol.11 , pp. 3286-3305
    • Cadigan, K.M.1    Nusse, R.2
  • 145
    • 33745034435 scopus 로고    scopus 로고
    • Molecular bases of the regulation of bone remodeling by the canonical Wnt signaling pathway
    • Glass DA, 2nd, Karsenty G. Molecular bases of the regulation of bone remodeling by the canonical Wnt signaling pathway. Curr Top Dev Biol 2006;73:43-84.
    • (2006) Curr Top Dev Biol , vol.73 , pp. 43-84
    • Glass, D.A.1    Karsenty, G.2
  • 146
    • 18044386744 scopus 로고    scopus 로고
    • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    • Gong Y, Slee RB, Fukai N, et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 2001;107:513-523.
    • (2001) Cell , vol.107 , pp. 513-523
    • Gong, Y.1    Slee, R.B.2    Fukai, N.3
  • 147
    • 34249023565 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors (PPARs) in the control of bone metabolism
    • Giaginis C, Tsantili-Kakoulidou A, Theocharis S. Peroxisome proliferator-activated receptors (PPARs) in the control of bone metabolism. Fundam Clin Pharmacol 2007;21:231-244.
    • (2007) Fundam Clin Pharmacol , vol.21 , pp. 231-244
    • Giaginis, C.1    Tsantili-Kakoulidou, A.2    Theocharis, S.3
  • 148
    • 59149093623 scopus 로고    scopus 로고
    • Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: Cross talk with the osteoblastogenic program
    • Muruganandan S, Roman AA, Sinal CJ. Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: cross talk with the osteoblastogenic program. Cell Mol Life Sci 2009;66:236-253.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 236-253
    • Muruganandan, S.1    Roman, A.A.2    Sinal, C.J.3
  • 149
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism
    • Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 1999;20:649-688.
    • (1999) Endocr Rev , vol.20 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 150
    • 0028802627 scopus 로고
    • Differential activation of peroxisome proliferator-activated receptors by eicosanoids
    • Yu K, Bayona W, Kallen CB, et al. Differential activation of peroxisome proliferator-activated receptors by eicosanoids. J Biol Chem 1995;270:23975-23983.
    • (1995) J Biol Chem , vol.270 , pp. 23975-23983
    • Yu, K.1    Bayona, W.2    Kallen, C.B.3
  • 151
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
    • Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 1994;79:1147-1156.
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 152
    • 0033213631 scopus 로고    scopus 로고
    • PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro
    • Rosen ED, Sarraf P, Troy AE, et al. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell1999;4:611-617.
    • (1999) Mol Cell , vol.4 , pp. 611-617
    • Rosen, E.D.1    Sarraf, P.2    Troy, A.E.3
  • 153
    • 0033213637 scopus 로고    scopus 로고
    • PPAR gamma is required for placental, cardiac, and adipose tissue development
    • Barak Y, Nelson MC, Ong ES, et al. PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell 1999;4:585-595.
    • (1999) Mol Cell , vol.4 , pp. 585-595
    • Barak, Y.1    Nelson, M.C.2    Ong, E.S.3
  • 154
    • 0031667127 scopus 로고    scopus 로고
    • Association of the Pro12Ala variant in the peroxisome proliferator-activated receptorgamma2 gene with obesity in two Caucasian populations
    • Beamer BA, Yen CJ, Andersen RE, et al. Association of the Pro12Ala variant in the peroxisome proliferator-activated receptorgamma2 gene with obesity in two Caucasian populations. Diabetes 1998;47:1806-1808.
    • (1998) Diabetes , vol.47 , pp. 1806-1808
    • Beamer, B.A.1    Yen, C.J.2    Andersen, R.E.3
  • 155
    • 0031595923 scopus 로고    scopus 로고
    • A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
    • Deeb SS, Fajas L, Nemoto M, et al. A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 1998;20:284-287.
    • (1998) Nat Genet , vol.20 , pp. 284-287
    • Deeb, S.S.1    Fajas, L.2    Nemoto, M.3
  • 156
    • 77955626799 scopus 로고    scopus 로고
    • Retinoic acids potentiate BMP9-induced osteogenic differentiation of mesenchymal progenitor cells
    • Zhang W, Deng ZL, Chen L, et al. Retinoic acids potentiate BMP9-induced osteogenic differentiation of mesenchymal progenitor cells. PLoS One 2010;5:e11917.
    • (2010) PLoS One , vol.5
    • Zhang, W.1    Deng, Z.L.2    Chen, L.3
  • 157
    • 26244463395 scopus 로고    scopus 로고
    • The role of the insulin-like growth factor system in prenatal growth
    • Randhawa R, Cohen P. The role of the insulin-like growth factor system in prenatal growth. Mol Genet Metab 2005;86:84-90.
    • (2005) Mol Genet Metab , vol.86 , pp. 84-90
    • Randhawa, R.1    Cohen, P.2
  • 158
    • 0032127906 scopus 로고    scopus 로고
    • Insulin-like growth factor II (IGF-II)
    • O'Dell SD, Day IN. Insulin-like growth factor II (IGF-II). Int J Biochem Cell Biol 1998;30:767-771.
    • (1998) Int J Biochem Cell Biol , vol.30 , pp. 767-771
    • O'Dell, S.D.1    Day, I.N.2
  • 159
    • 51549116267 scopus 로고    scopus 로고
    • Retinoic acid synthesis and signaling during early organogenesis
    • Duester G. Retinoic acid synthesis and signaling during early organogenesis. Cell 2008;134:921-931.
    • (2008) Cell , vol.134 , pp. 921-931
    • Duester, G.1
  • 160
    • 45549091674 scopus 로고    scopus 로고
    • Retinoic acid in development: Towards an integrated view
    • Niederreither K, Dolle P. Retinoic acid in development: towards an integrated view. Nat Rev Genet 2008;9:541-553.
    • (2008) Nat Rev Genet , vol.9 , pp. 541-553
    • Niederreither, K.1    Dolle, P.2
  • 161
    • 33144488245 scopus 로고    scopus 로고
    • Function of retinoid nuclear receptors: Lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis
    • Mark M, Ghyselinck NB, Chambon P. Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis. Annu Rev Pharmacol Toxicol 2006;46:451-480.
    • (2006) Annu Rev Pharmacol Toxicol , vol.46 , pp. 451-480
    • Mark, M.1    Ghyselinck, N.B.2    Chambon, P.3
  • 162
    • 0035976638 scopus 로고    scopus 로고
    • Nuclear receptors and lipid physiology: Opening the X-files
    • Chawla A, Repa JJ, Evans RM, Mangelsdorf DJ. Nuclear receptors and lipid physiology: opening the X-files. Science 2001;294:1866-1870.
    • (2001) Science , vol.294 , pp. 1866-1870
    • Chawla, A.1    Repa, J.J.2    Evans, R.M.3    Mangelsdorf, D.J.4


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